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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
42 Results for "
senescent
" in MedChemExpress (MCE) Product Catalog:
Products (42)
42 Results for "senescent" in MCE Product Catalog:
Cat. No.: HY-157329
CAS No.: 311315-04-5
Target:
Research Areas:
AD16 (Acetamide) is a LINE-1 retrotransposon endonuclease inhibitor with the IC50 of 4.7 μM. AD16 (Acetamide) reduce LINE-1 retrotransposition, L1-induced DNA damage, and inflammation reinforced by L1 in senescent cells .
Cat. No.: HY-126222B
Synonyms: MitoTax iodide, hydriodide
Target:
Research Areas:
(E/Z)-MitoTam (iodide, hydriodide) (MitoTam (iodide, hydriodide)) is the E/Z mixture of MitoTam iodide, hydriodide. MitoTam iodide, hydriodide is a Tamoxifen derivative , an electron transport chain (ETC) inhibitor, spreduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology . MitoTam iodide, hydriodide is an effective anticancer agent, suppresses respiratory complexes (CI-respiration) and disrupts respiratory supercomplexes (SCs) formation in breast cancer cells . MitoTam iodide, hydriodide causes apoptosis .
Cat. No.: HY-177945
CAS No.: 3055593-63-7
Synonyms: Gal-MS99
Research Areas:
MS99-β-Gal (Gal-MS99) is a galactose-modified NPM-ALK PROTAC degrader. MS99-β-Gal is only hydrolyzed by SA-β-gal and esterase in senescent cancer cells, releasing MS99, which specifically degrades the NPM-ALK fusion protein. MS99-β-Gal shows an IC50 of 454.8 nM for aging Karpas 299 cells, significantly lower than that of normal Karpas 299 cells (IC50 = 2.162 μM). MS99-β-Gal can be used for the research of cancer .
Cat. No.: HY-N15138
CAS No.: 70561-31-8
Target:
Cat. No.: HY-N1458R
CAS No.: 52012-29-0
Cat. No.: HY-170994
Target:
Research Areas:
I2-IRs ligand-1 (Compound 12d) is an orally active and BBB-penetrable compound. I2-IRs ligand-1 has a high affinity for imidazoline I2 receptors (I2-IRs) (pKi: 9.98). I2-IRs ligand-1 can improve cognitive impairment in senescent mice and exhibits analgesic, anti-inflammatory, and neuroprotective activities. I2-IRs ligand-1 can be used for the research of Alzheimer's disease and related pain disorders .
Cat. No.: HY-178984
CAS No.: 3095278-75-1
Research Areas:
PI3Kα-IN-28 (Compound 23) is an efficient dual targeted PI3K/BRD4 inhibitor. PI3Kα-IN-28 can inhibit the proliferation of various cells, such as KYSE180 and KYSE450 cells. PI3Kα-IN-28 can concentration dependently inhibit migration and colony formation, induce G0/G1 phase arrest, significantly inhibit DNA synthesis, and significantly increase the proportion of senescent cells. PI3Kα-IN-28 can inhibit the expression of p-AKT and c-Myc and activate the AMPK-p27 pathway. PI3Kα-IN-28 can be used for research on cancers such as esophageal cancer .
Cat. No.: HY-182898
CAS No.: 3051812-84-8
Target:
Research Areas:
Gal-dMor-Gem is a selective senescent cell scavenger, Apoptosis inducer, and a prodrug of Gemcitabine (HY-17026). Gal-dMor-Gem releases Gemcitabine upon activation by Esterases and β-gal. Gal-dMor-Gem reduces SA-β-gal, preferentially induces apoptosis in senescent cells, regulates apoptosis-related proteins, accumulates in senescent tissues, and ameliorates senescence-related organ phenotypes. Gal-dMor-Gem is applicable to research on chemotherapy-induced senescence .
Cat. No.: HY-N18193
CAS No.: 151649-54-6
Target:
Cat. No.: HY-187365
Target:
Research Areas:
UCM-17017 is a tetrasubstituted cyclohexene inhibitor that inhibits the activity of senescent cell SA-β-gal with an IC50 of 0.4 μM. UCM-17017 selectively reduces the viability of senescent cancer cells, and this effect is stronger than its impact on proliferating cells. UCM-17017 binds to human serum albumin with a KD of 230 μM. UCM-17017 reduces collagen deposition and decreases the expression of the inflammatory marker Ccl2 in a mouse model of pulmonary fibrosis. UCM-17017 can be used in studies related to senescence and pulmonary fibrosis .
Cat. No.: HY-P72064
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LIMS1; LIM And senescent Cell Antigen-Like Domains 1; LIM Zinc Finger Domain Containing 1; Renal Carcinoma Antigen NY-REN-48; Particularly Interesting New Cys-His Protein 1; LIM-Type Zinc Finger Domains 1; PINCH1; senescent Cell Antigen; PINCH; PINCH-1; L
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-183307
Research Areas:
mTOR-IN-29 (Compound 4k) is an mTOR inhibitor with a IC50 of ~120 nM. mTOR-IN-29 inhibits mTOR kinase activity without affecting the phosphorylation of STAT3. mTOR-IN-29 acts as a cytotoxic agent against proliferating and senescent cells. mTOR-IN-29 can be used in studies related to glioblastoma .
Cat. No.: HY-152179
CAS No.: 2143464-25-7
Target:
Research Areas:
PZ15227 is a potent and selective Bcl-XL PROTAC degrader with a DC50 of 46 nM, and its Ki values for Bcl-XL, Bcl-2 and Bcl-w are 1.90 nM, 3.52 nM and >1 mM, respectively. PZ15227 recruits Bcl-XL to CRBN, induces polyubiquitination of Bcl-XL and promotes its proteasome-dependent degradation, thereby selectively killing senescent cells that rely on Bcl-XL for survival without causing severe thrombocytopenia. PZ15227 can be used for research related to age-related diseases, aging and renal cancer .
Cat. No.: HY-182824
CAS No.: 25915-57-5
Sucrose dilaurate acts as an emulsifier, dispersant and stabilizer. Sucrose dilaurate reduces the release of HMGB1 from UVB-irradiated keratinocytes. Sucrose dilaurate inhibits melanogenesis and decreases bilirubin levels. Sucrose dilaurate induces autophagy in human epidermal keratinocytes, thereby reducing carboxymethyl lysine (CML) levels. Sucrose dilaurate reduces the secretion of insulin-like growth factor-binding protein 3 (IGFBP3) and nerve growth factor (NGF) by senescent keratinocytes. Sucrose dilaurate is investigated as an emulsifier, dispersant or stabilizer in the cosmetics, food and pharmaceutical industries .
Cat. No.: HY-134310
CAS No.: 1353586-18-1
Target:
Research Areas:
QC-308 hydrochloride is a HO-1/HO-2 inhibitor, with an IC50 of 0.27 μM against rat HO-1 and an IC50 of 0.46 μM against rat HO-2. QC-308 hydrochloride inhibits the activities of rat HO-1 and HO-2 in carbon monoxide generation assays using spleen and brain microsomes, respectively. QC-308 hydrochloride also exhibits senolytic activity, reducing the survival rate of adipogenic progenitor cells in skeletal muscle fibers of senescent mice and human skeletal muscle myoblasts. QC-308 hydrochloride is applicable for senescence-related research .
Cat. No.: HY-182604
CAS No.: 1353712-58-9
Target:
Research Areas:
QC-308 is a HO-1/HO-2 inhibitor, with an IC50 of 0.27 μM against rat HO-1 and an IC50 of 0.46 μM against rat HO-2. QC-308 inhibits the activities of rat HO-1 and HO-2 in carbon monoxide generation assays using spleen and brain microsomes, respectively. QC-308 also exhibits senolytic activity, reducing the survival rate of adipogenic progenitor cells in skeletal muscle fibers of senescent mice and human skeletal muscle myoblasts. QC-308 is applicable for senescence-related research .
Cat. No.: HY-135146R
CAS No.: 2170136-65-7
Synonyms: (R)-GSK3482364 (Standard)
Research Areas:
GSK-3484862 (Standard) is the analytical standard of GSK-3484862 (HY-135146). This product is intended for research and analytical applications. GSK-3484862 is a highly potent non-covalent inhibitor and demethylating agent of DNMT1. GSK-3484862 induces genome-wide DNA demethylation, including the regulatory elements of DNMT3B and the promoter region of TERT, and significantly inhibits cell viability, growth, proliferation and self-renewal. GSK-3484862 blocks the transformation of young AT2 cells, induces apoptosis, and generates transcriptomic features similar to those of senescent cells. GSK-3484862 is widely used in studies related to lung cancer, oral squamous cell carcinoma and lung adenocarcinoma .
Cat. No.: HY-135146G
CAS No.: 2170136-65-7
Synonyms: (R)-GSK3482364 (GMP)
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
