287 Results for "

Crumbs3 transcript

" in MedChemExpress (MCE) Product Catalog:
Products (287)

287 Results for "Crumbs3 transcript" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-N6973
CAS No.: 476-70-0
Boldine is an aporphine alkaloid telomerase (telomerase) inhibitor (IC50 of 0.17 μM for TERT) and a pannexin/connexin hemichannel blocker, with oral activity and blood-brain barrier permeability. Boldine inhibits telomerase activity through direct interaction with the telomerase ribonucleoprotein and non-competitive binding near the TERT active site, and downregulates hTERT mRNA while shifting alternative splicing toward non-functional transcripts. Boldine blocks Panx1, Cx43, Cx26, and Cx30 hemichannels as well as P2X7 receptor-mediated calcium influx. Boldine exhibits antioxidant, anti-inflammatory, antiproliferative, and cytotoxic activities by scavenging ROS, inhibiting NFκB, dephosphorylating SGK1, and reducing TNF-alpha levels. Boldine can be used in research on breast cancer, Alzheimer's disease, glioblastoma, diabetes, and spinal cord injury [3] .
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1
1 Cited Publications
Cat. No.: HY-P72895
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD36; Leukocyte Differentiation Antigen CD36; CD36 Molecule (CD36 Blood Group); Thrombospondin Receptor; Platelet Glycoprotein 4; CD36 Antigen; GPIIIB; PAS-4; GPIV; CD36 Molecule (CD36 Blood Group) transcript; GP3B; Scavenger Receptor Class B, Member 3; F
Species:  
Mouse
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P74303
Purity:  ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CD36; Leukocyte Differentiation Antigen CD36; CD36 Molecule (CD36 Blood Group); Thrombospondin Receptor; Platelet Glycoprotein 4; CD36 Antigen; GPIIIB; PAS-4; GPIV; CD36 Molecule (CD36 Blood Group) transcript; GP3B; Scavenger Receptor Class B, Member 3; F
Species:  
Rat
Source:  
HEK293
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Cat. No.: HY-132608
CAS No.: 1432726-13-0
Purity:  96.44%
Synonyms: ISIS-420915 sodium
Target:  

Transthyretin (TTR)

Research Areas:  

Neurological Disease

Inotersen (ISIS-420915) sodium is a 2′-O-methoxyethyl-modified antisense oligonucleotide. Inotersen sodium inhibits the production of transthyretin (TTR) protein by targeting the TTR RNA transcript and reduces the levels of the TTR transcript. Inotersen sodium can be used for the research of hereditary TTR amyloidosis polyneuropathy [3].
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Cat. No.: HY-145725A
CAS No.: 1698048-23-5
Synonyms: ISIS 598769; IONIS 598769; BIIB 065; ISIS-DMPK-2.5Rx
Target:  

Ser/Thr Kinase

Research Areas:  

Neurological Disease

Baliforsen (ISIS 5987690) is an antisense oligonucleotide (ASO) that inhibits DMPK mRNA. Baliforsen binds within exon 9 of the human DMPK transcript to promote RNase H1-mediated degradation Baliforsen can be used for the research of myotonic dystrophy type 1 .
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Cat. No.: HY-148410A
CAS No.: 2415330-05-9
Purity:  98.25%
Synonyms: STK-001 sodium
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

Zorevunersen sodium is an antisense oligonucleotide targeting the Scn1a gene based on TANGO technology. Zorevunersen sodium increases Scn1a mRNA transcripts and elevates the expression level of NaV1.1 protein. Zorevunersen sodium restores the excitability of PV interneurons, thereby reducing seizures and prolonging survival in mice. Zorevunersen sodium can be used for research on Dravet syndrome .
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Cat. No.: HY-147266
Purity:  95.83%
Synonyms: VIR-2218 sodium
Research Areas:  

Infection

Elebsiran (VIR-2218) sodium is a siRNA that targets and degrades hepatitis B virus (HBV) and hepatitis D virus (HDV) RNA transcripts. Elebsiran sodium leads to a significant decrease in HBV surface antigen (HBsAg) and a reduction in viral load. Elebsiran sodium binds to the sialic acid-depleted glycoprotein receptor (ASGPR) on the surface of liver cells through the GalNAc ligand, achieving liver-targeted delivery and demonstrating improved liver safety. Elebsiran sodium can be used for the study of chronic HBV/HDV infections [3].
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Cat. No.: HY-159828
CAS No.: 2568911-72-6
Synonyms: VH-499; VH4011499
Target:  

HIV

Research Areas:  

Infection

Dezecapavir (VH-499) is a HIV-1 capsid protein inhibitor. Dezecapavir exhibits picomolar-level antiviral activity against a variety of HIV-1 laboratory strains and clinical isolates in vitro. Dezecapavir inhibits the early and late stages of the HIV-1 life cycle, blocking nuclear import, reverse transcript production, virion assembly, maturation, and post-nuclear import/pre-integration replication processes. Dezecapavir can be used in studies related to HIV-1 infection .
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Cat. No.: HY-N2245
CAS No.: 98619-25-1
Schisandrone, a 4-aryltetralone lignan, is isolated from the dried fruits of Schisandra sphenanthera . Schisandrone is an alpha-hemolysin (Hla) inhibitor that downregulates the transcript levels of hla, agrA and RNAIII. Hla is an integral virulence determinant in Staphylococcus aureus that determines pathogenicity. Schisandrone is a potent inhibitor against MRSA pneumonia .
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Cat. No.: HY-148410
CAS No.: 2415330-04-8
Synonyms: STK-001
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

Zorevunersen is an antisense oligonucleotide targeting the Scn1a gene based on TANGO technology. Zorevunersen increases Scn1a mRNA transcripts and elevates the expression level of NaV1.1 protein. Zorevunersen restores the excitability of PV interneurons, thereby reducing seizures and prolonging survival in mice. Zorevunersen can be used for research on Dravet syndrome .
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Cat. No.: HY-P99226
CAS No.: 2245966-28-1
Synonyms: MEDI7734; VIB7734
Daxdilimab (MEDI7734; VIB7734) is a monoclonal antibody targeting immunoglobulin-like transcript 7 (ILT7) that depletes plasmacytoid dendritic cells and reduces IFN1 production by binding to the plasmacytoid dendritic cell-specific surface molecule ILT7 and recruiting effector natural killer cells. Daxdilimab (MEDI7734; VIB7734) can be used for research on systemic lupus erythematosus, systemic sclerosis, and polymyositis [3] .
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Cat. No.: HY-139098
CAS No.: 62828-64-2
Synonyms: m7Gp3G
Target:  

DNA/RNA Synthesis

Research Areas:  

Others

7-Methyl-diguanosine triphosphate (m7Gp3G) is an mRNA cap structure analog that inhibits in vitro protein synthesis by binding to the translation initiation complex. 7-Methyl-diguanosine triphosphate binds to eIF4E, promotes cap-dependent translation initiation, stabilizes mRNA, and acts as a translation enhancer. 7-Methyl-diguanosine triphosphate can be used to prepare synthetic capped RNA transcripts for studies related to mRNA translation, splicing, turnover, and intracellular transport .
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Cat. No.: HY-132581E
Synonyms: Scrambled BIIB078; Scrambled IONIS-C9Rx
Target:  

Ras

Research Areas:  

Neurological Disease

Scrambled Tadnersen is the Negative Control of Tadnersen sodium (HY-132581A). Tadnersen sodium, an antisense oligonucleotide (ASO), selectively targets C9ORF72 transcript variants 1 and 3 that carry the expansion .
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Cat. No.: HY-19731
CAS No.: 522606-67-3
Synonyms: MiR-544 Inhibitor 1
Target:  

MicroRNA Apoptosis

Research Areas:  

Cancer

SID 3712249 (MiR-544 Inhibitor 1) is a miR-544 biogenesis inhibitor. SID 3712249 binds directly to the precursor miRNA. SID 3712249 blocks production of the mature microRNA and decreases miR-544, HIF-1α, and ATM transcripts. SID 3712249 can be used in the research of cancers, such as breast cancer .
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Cat. No.: HY-147266A
CAS No.: 2648009-64-5
Synonyms: VIR-2218
Research Areas:  

Infection

Elebsiran (VIR-2218) is a siRNA that targets and degrades hepatitis B virus (HBV) and hepatitis D virus (HDV) RNA transcripts. Elebsiran leads to a significant decrease in HBV surface antigen (HBsAg) and a reduction in viral load. Elebsiran binds to the sialic acid-depleted glycoprotein receptor (ASGPR) on the surface of liver cells through the GalNAc ligand, achieving liver-targeted delivery and demonstrating improved liver safety. Elebsiran can be used for the study of chronic HBV/HDV infections [3].
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Cat. No.: HY-115451
CAS No.: 785708-33-0
Target:  

DNA/RNA Synthesis

Research Areas:  

Others

Photoregulin 3 (compound T4) can promote distal-to-proximal alternative polyadenylation (APA) activity in multiple transcripts .
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Cat. No.: HY-177651
CAS No.: 2834724-31-9
Synonyms: ION-582
Target:  

E1/E2/E3 Enzyme

Research Areas:  

Others

Obudanersen is an antisense oligonucleotide targeted to ubiquitin protein ligase E3A-antisense transcript (UBE3A-ATS). It is used for the study of Angelman syndrome.
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Cat. No.: HY-177615A
Synonyms: GTX-102 sodium
Target:  

E1/E2/E3 Enzyme

Research Areas:  

Others

Apazunersen sodium is an antisense oligonucleotide (ASO) that targets and inhibits expression of the UBE3A antisense transcript (UBE3A-AS) to prevent silencing of the paternally inherited allele of the UBE3A gene and reactivate expression of the deficient
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Cat. No.: HY-177615
CAS No.: 2919324-01-7
Synonyms: GTX-102
Target:  

E1/E2/E3 Enzyme

Research Areas:  

Others

Apazunersen is an antisense oligonucleotide (ASO) that targets and inhibits expression of the UBE3A antisense transcript (UBE3A-AS) to prevent silencing of the paternally inherited allele of the UBE3A gene and reactivate expression of the deficient protei
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Cat. No.: HY-W142437
CAS No.: 571-58-4
1,4-Dimethylnaphthalene acts as a sprout inhibitor, Antifungal agent and sporulation inhibitor. 1,4-Dimethylnaphthalene can be isolated from dormant potatoes. 1,4-Dimethylnaphthalene induces the expression of cell cycle regulators associated with G1-to-S phase transition arrest, reduces oxidative stress levels, downregulates specific transcripts including germin-like proteins and MYB transcription factors, and modulates transcripts regulated by ABI1/ABI2/ABI3 without altering endogenous ABA levels. 1,4-Dimethylnaphthalene inhibits postharvest sprouting of potato tubers. 1,4-Dimethylnaphthalene can be used in studies related to fungal infections .
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