469 Results for "

O2

" in MedChemExpress (MCE) Product Catalog:
Products (469)

469 Results for "O2" in MCE Product Catalog:

Cat. No.: HY-125859B
CAS No.: 9003-99-0
Target:  

Bacterial

Research Areas:  

Infection

Lactoperoxidase, bovine milk is an antimicrobial protein that belongs to the mammalian heme peroxidase family. Lactoperoxidase, bovine milk uses H2O2 to catalyze the oxidation of its preferred halide substrates including I −, Br −, F −, or the pseudohalide SCN − .
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Cat. No.: HY-174868
CAS No.: 3055107-60-0
iP300w (Compound 9) is a Histone acetyltransferase p300 (KAT3B) inhibitor. iP300w can be used for synthesis of PROTAC BT-O2C (HY-174866) .
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Cat. No.: HY-N2203
CAS No.: 59282-55-2
Vitexin2''-O-p-coumarate is isolated from fenugreek seeds. Vitexin2''-O-p-coumarate strongly promotes 2BS cell proliferation induced by H2O2 [2].
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Cat. No.: HY-N2627
CAS No.: 53584-69-3
Isorhamnetin 3-O-robinobioside is a flavonoid compound. Isorhamnetin shows a protective effect against lipid peroxidation induced by H2O2. Isorhamnetin 3-O-robinobioside also inhibits the genotoxicity induced by hydroxyl radicals .
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Cat. No.: HY-W110905
CAS No.: 19381-50-1
Research Areas:  

Others

Naphthol green B is an iron-complex dye. Naphthol green B can be used in wool dyeing, silk dyeing and polyamide dyeing. Naphthol green B can be used to fabricate electrochemical sensor for the detection of H2O2 [2].
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Cat. No.: HY-161783
CAS No.: 3048532-05-1
HDAC6-IN-45 (Compound 15) is a selective inhibitor for HDAC6 with IC50 of 15.2 nM. HDAC6-IN-45 exhibits neurotrophic through the upregulation of GAP43 and Beta-3 tubulin markers. HDAC6-IN-45 activates the Nrf2 signaling pathway, reduces H2O2-induced ROS production, inhibits apoptosis in PC12, and exhibits neuroprotective efficacy in SCOP-induced zebrafish Alzheimer's Disease models. HDAC6-IN-45 exhibits antioxidant activity and good blood-brain barrier (BBB) permeability .
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Cat. No.: HY-P11474
FZ1 peptide is a cyclic heptapeptide and also an integrin αvβ3 agonist. FZ1 peptide activates the FAK/PI3K-AKT/ERK pathway and upregulates VEGFC to promote angiogenesis. FZ1 peptide exhibits antibacterial activity in extracts of HA-c-FZ1 hydrogel; it inhibits LPS-induced proinflammatory cytokine secretion in RAW264.7 macrophages; it reduces H2O2-induced ROS levels; it increases the healing rate of scratch wounds. FZ1 peptide can be used in studies related to diabetic skin wounds [2].
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Cat. No.: HY-116730
CAS No.: 886755-63-1
Research Areas:  

Others

CHS-111 is a benzyl indazole inhibitor of superoxide anion O 2- generation. CHS-111 inhibits the cell migration, and reduces the formyl-Met-Leu-Phe- but not phorbol ester-stimulated phospholipase D activity, with the IC50 of 3.9 μM .
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Cat. No.: HY-151109
Target:  

Fluorescent Dye

Research Areas:  

Others

IR-990 is an activatable NIR-II fluorescent probe with an acceptor-π-acceptor (A-π-A) skeleton for real-time detection of H2O2 in vivo. IR-990 is a powerful diagnosis of agent-induced liver injury (DILI) .
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Cat. No.: HY-157881
CAS No.: 3375-50-6
Synonyms: β-Mercaptoethanesulfonic acid (ampule, 3.0 M±0.1 M in H2O)
Research Areas:  

Inflammation/Immunology

2-Mercaptoethanesulfonic acid (ampule, 3.0 M±0.1 M in H2O) (β-Mercaptoethanesulfonic acid (ampule, 3.0 M±0.1 M in H2O)) is a thiol-containing urinary tract protective agent and aldehyde scavenger that detoxifies acrolein via its thiol group to form an inert thioether excreted in urine, and competitively inhibits human myeloperoxidase, thereby mitigating Cyclophosphamide (HY-17420)-induced cytogenetic damage. 2-Mercaptoethanesulfonic acid can be used for research on hemorrhagic cystitis [2] .
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Cat. No.: HY-119590
CAS No.: 31501-55-0
Synonyms: Lonchocarpine
Lonchocarpin (Lonchocarpine) is a Wnt/β-catenin signaling pathway inhibitor. The IC50 of Lonchocarpin in SW480 pBAR/Renilla cells is 4 μM. Acting downstream of β-catenin stabilization, Lonchocarpin inhibits β-catenin nuclear localization and TCF-mediated transcription, as well as the proliferation and migration of colorectal cancer cells. Lonchocarpin enhances Nrf2/ARE-mediated antioxidant responses in primary astrocytes via AMPK and JNK-related signaling, reduces H2O2-induced ROS production, and increases the expression of HO-1, NQO1 and MnSOD. Lonchocarpin can be used in research on colorectal cancer and oxidative stress [2].
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Cat. No.: HY-N20734
CAS No.: 64527-08-8
Synonyms: Polygalacin
Rhamnazin 3-O-rutinoside (Polygalacin) is a flavonoid compound. Rhamnazin 3-O-rutinoside can be extracted from Areca catechu L. Rhamnazin 3-O-rutinoside shows no significant inhibitory effect on recombinant hPTP1B, with an IC50 > 100 μM. Rhamnazin 3-O-rutinoside reduces Apoptotic cell death. Rhamnazin 3-O-rutinoside possesses cellular antioxidant activity and alleviates H2O2-induced oxidative stress. Rhamnazin 3-O-rutinoside lacks free radical scavenging activity. Rhamnazin 3-O-rutinoside can be used in the research of neurodegenerative diseases [2] .
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Cat. No.: HY-W587784
CAS No.: 542-40-5
Norbixin is an orally active natural product with multiple activities such as retinal protection and oxidative stress regulation. Norbixin scavenges ROS, chelates metal ions, regulates plasmid and genomic DNA breakage, inhibits H2O2-induced mutagenesis, activates PPAR-α, modulates lipid levels, restores or regulates antioxidant enzyme activity, and alters NO levels. Norbixin prevents A2E accumulation and protects photoreceptor cells and retinal pigment epithelial cells. Norbixin is a derivative of Bixin (HY-N6884). Norbixin can be used in research related to diseases such as macular degeneration and diabetes, and also serves as a natural textile dye [2] .
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Cat. No.: HY-N6595
CAS No.: 97653-92-4
Lucidone A is a lanostanoid isolated from the fruiting bodies of G. resinaceum. lucidone A showed inhibitory effects against the increase of ALT and AST levels in HepG2 cells induced by H2O2 compared to a control group in the range of their maximum non-toxic concentration (MNTC) .
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Cat. No.: HY-188136
Research Areas:  

Cancer

ASO-4625 is a 20-nucleotide gapmer antisense oligonucleotide with a full phosphorothioate backbone and 2'-O-(2-methoxy) ethyl ribose modifications, which targets BCL2 mRNA and BCL2L1 mRNA. ASO-4625 downregulates Bcl-2 expression via an RNase H-dependent antisense mechanism with 100% complementarity, and downregulates Bcl-xL expression via the same mechanism with three mismatches. ASO-4625 induces Apoptosis and acts as a chemosensitizer. ASO-4625 does not significantly modulate the expression of Bcl-W, survivin, Akt, or p53 mRNA. ASO-4625 can be used in studies of breast cancer and non-small cell lung cancer .
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Cat. No.: HY-N17611
CAS No.: 6563-66-2
Synonyms: 4'-O-Methylscutellarein
5,6,7-Trihydroxy-4'-methoxyflavone (4'-O-Methylscutellarein) is a flavonoid and a weak inhibitor of xanthine oxidase. 5,6,7-Trihydroxy-4'-methoxyflavone possesses antithrombotic and antioxidant activities. 5,6,7-Trihydroxy-4'-methoxyflavone has an IC50 value of 25.29 µM for DPPH free radical scavenging. 5,6,7-Trihydroxy-4'-methoxyflavone can also inhibit H2O2-induced damage to PC12 cells. 5,6,7-Trihydroxy-4'-methoxyflavone is applicable for the research of diseases such as cerebrovascular disorders [2].
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Cat. No.: HY-P5883
CAS No.: 2126166-03-6
Synonyms: tatM2NX
Target:  

TRP Channel

TAT-M2NX (tatM2NX) is a selective inhibitor targeting human TRPM2 channels and exerts inhibitory effects on ischemic stroke. TAT-M2NX reduces H2O2-induced calcium influx via TRPM2 channels. After traumatic brain injury in mice, TAT-M2NX preserves hippocampal long-term potentiation, improves memory function, and reduces infarct volume after middle cerebral artery occlusion, but it shows no effect on female mice. TAT-M2NX can be used in studies related to traumatic brain injury and ischemic stroke [2].
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Cat. No.: HY-159485
Target:  

Phosphatase

Research Areas:  

Cancer

NFh-ALP is an alkaline phosphatase (ALP)-activatable photosensitizer. NFh-ALP could be activated by ALP in cells and generate 1O2 under 808 nm excitation, effectively killing tumor cells by inducing apoptosis and having good biocompatibility. The maximum absorption wavelength of NFh-ALP is about 656 nm .
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Cat. No.: HY-N16417
CAS No.: 24512-87-6
Elsinochrome C is a photosensitizer. Elsinochrome C relies on light activation to generate reactive oxygen species (ROS) such as singlet oxygen (1O2), inducing apoptosis or directly disrupting pathogen structures. Elsinochrome C is promising for research of skin cancers, HIV-associated infections, and refractory skin diseases .
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Cat. No.: HY-D2986
CAS No.: 2634719-04-1
Research Areas:  

Infection

TBD–anchor is a water-soluble, positively charged AIE photosensitizer. TBD–anchor can specifically bind to bacterial membranes and efficiently produce 1O2. TBD–anchor has bactericidal activity against various bacteria and good biocompatibility. TBD–anchor can be used for research on bacterial infections .
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