Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
457 Results for "
O2
" in MedChemExpress (MCE) Product Catalog:
Products (457)
457 Results for "O2" in MCE Product Catalog:
Cat. No.: HY-15914
CAS No.: 54970-72-8
Synonyms: DCHBS
Cat. No.: HY-178139
CAS No.: 3087062-50-5
Target:
Research Areas:
hMAO-B-IN-12 (Compound 6E) is a highly selective human monoamine oxidase B (hMAO-B) inhibitor (IC50=17.7 nM). hMAO-B-IN-12 reduces oxidative stress/lipid metabolism-derived products (e.g., H2O2). hMAO-B-IN-12 is promising for research of atherosclerosis .
Cat. No.: HY-W455884
CAS No.: 26281-43-6
Target:
Research Areas:
3,5-Dichloro-2-hydroxybenzenesulfonic acid is used in conjunction with Ampyrone (HY-B1398) (4-AAP) and hydrogen peroxide (H2O2) for chromogenic quantification of peroxidase in coupled enzymatic reactions. 3,5-Dichloro-2-hydroxybenzenesulfonic acid is used to measure hydrogen peroxide production in conjunction with peroxidase .
Cat. No.: HY-N3287
CAS No.: 83011-43-2
Cat. No.: HY-P2848B
Target:
Research Areas:
Cholesterol Oxidase, Streptomyces sp. (EC 1.1.3.6) is a monomeric flavoprotein containing FAD that catalyzes the first step in cholesterol catabolism. This bifunctional enzyme oxidizes cholesterol to cholest-5-en-3-one in an FAD-requiring step, which is then isomerized to cholest-4-en-3-one with the release of H2O2.
Cat. No.: HY-159515
Research Areas:
PBE-AMF is a prodrug that activates H2O2 with anticancer activity. PBE-AMF impedes tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing apoptosis, and arresting the cell cycle. PBE-AMF potently and selectively inhibits the proliferation of MDA-MB-231 cells (IC50=6.4 μM) while sparing non-cancerous MCF-10A cells .
Cat. No.: HY-181176
Research Areas:
DEMAMP is an antioxidant. DEMAMP exhibits scavenging effects on DPPH and H2O2 free radicals, with IC50 values of 0.60 and 0.48 mg/mL, respectively. Molecular docking simulations show that DEMAMP potently inhibits NADPH oxidase and the Mpro and RdRp proteins of SARS-CoV-2, and ADMET analysis confirms that it has favorable oral bioavailability. DEMAMP can be used in studies related to COVID-19 .
Cat. No.: HY-W011168
CAS No.: 13389-03-2
Research Areas:
8-Bromo-2'-deoxyguanosine is an inflammation-related DNA halogenated adduct and an early biomarker of inflammation-induced oxidative tissue damage. The formation of 8-Bromo-2'-deoxyguanosine precedes that of oxidative and nitrative products, and it can be generated via the MPO-H2O2-Cl --Br - system. 8-Bromo-2'-deoxyguanosine serves as the immunogen for preparing the monoclonal antibody mAb8B3, which can be used to detect early DNA modifications in preclinical models; its urinary level also increases significantly in inflammatory disease models. 8-Bromo-2'-deoxyguanosine can also be produced in the dermis of UV-B irradiated mice, and the extract of Coprinus comatus significantly reduces its level. 8-Bromo-2'-deoxyguanosine finds applications in studies related to inflammatory diseases, diabetes, hepatocellular carcinoma, and UV-B induced skin inflammation [2] .
Cat. No.: HY-174460
Target:
Research Areas:
pCR8 is a prodrug of CR8 (HY-18340). pCR8 is amphiphilic and can self-assemble into nanoparticles. pCR8 can release CR8 under the action of high concentration of H2O2 in the tumor microenvironment. CR8 is a molecular glue degrader that can effectively degrade cell cycle-related proteins and has antitumor activity. pCR8 can be used in the research of tumors such as breast cancer .
Target:
Research Areas:
Sphingomyelin phosphodiesterase, Bacillus cereus is a sphingomyelin hydrolase and Insecticide. Sphingomyelin phosphodiesterase, Bacillus cereus catalyzes the decomposition of sphingomyelin into ceramide and phosphorylcholine. Sphingomyelin phosphodiesterase, Bacillus cereus causes rapid paralysis and death in injected insects, including German cockroaches and black cutworms. Sphingomyelin phosphodiesterase, Bacillus cereus reduces H2O2 production. Sphingomyelin phosphodiesterase, Bacillus cereus can be used in studies related to sepsis and endophthalmitis [2] .
Cat. No.: HY-141712
CAS No.: 2696407-32-4
Target:
Research Areas:
ZA18 is a selective TRPM2 channel inhibitor, with an IC50 value of 6.2 μM. ZA18 can effectively suppress intracellular Ca 2+ overload triggered by TRPM2 channel activation. ZA18 significantly reduce the mortality of SH-SY5Y cells induced by H2O2. ZA18 can be used for the study of ischemia-reperfusion injury, inflammation, or other neurodegenerative diseases .
Cat. No.: HY-141713
CAS No.: 2696407-24-4
Target:
Research Areas:
ZA10 is a selective TRPM2 channel inhibitor, with an IC50 value of 8.1 μM. ZA10 can effectively suppress intracellular Ca 2+ overload triggered by TRPM2 channel activation. ZA10 significantly reduce the mortality of SH-SY5Y cells induced by H2O2. ZA10 can be used for the study of ischemia-reperfusion injury, inflammation, or other neurodegenerative diseases .
Cat. No.: HY-W008048
CAS No.: 362-75-4
Target:
Research Areas:
2',3'-O-Isopropylideneadenosine is a nucleoside compound and also a Golgi-targeting moiety. 2',3'-O-Isopropylideneadenosine constitutes a furanose ribose group that undergoes cyclization at the O (2') and O (3') atoms. As a component of the fluorescent probe TPE-Ade, 2',3'-O-Isopropylideneadenosine enables specific Golgi localization for fluorescence imaging. 2',3'-O-Isopropylideneadenosine participates in the synthesis of aggregation-induced emission (AIE) fluorescent probes [2].
Cat. No.: HY-174869
CAS No.: 2412056-40-5
Research Areas:
Pomalidomide-5-C7-NH2 is an E3 ligase ligand-linker conjugate that incorporates the 5-Aminothalidomide (HY-W023573) based CRBN ligand (HY-103596) and linker. Pomalidomide-5-C7-NH2 can be used for synthesis of PROTAC BT-O2C (HY-174866) .
Cat. No.: HY-W112021
CAS No.: 3117-03-1
Synonyms: 2,5-Dimethoxybenzoquinone
Target:
Research Areas:
2,5-DMBQ (2,5-Dimethoxybenzoquinone) serves as an extracellular reductant. 2,5-DMBQ is involved in a crucial redox cycle, namely the extracellular hydroquinone-quinone redox cycle. In this cycle, 2,5-DMBQ is capable of reducing extracellular Fe ³⁺ and generating H2O2. 2,5-DMBQ plays a pivotal role in the biodegradation mechanism of brown rot fungal, assisting the fungi in decomposing and utilizing organic matter [2].
Cat. No.: HY-W112021R
CAS No.: 3117-03-1
Synonyms: 2,5-Dimethoxybenzoquinone (Standard)
Research Areas:
2,5-DMBQ (2,5-Dimethoxybenzoquinone) serves as an extracellular reductant. 2,5-DMBQ is involved in a crucial redox cycle, namely the extracellular hydroquinone-quinone redox cycle. In this cycle, 2,5-DMBQ is capable of reducing extracellular Fe³⁺ and generating H2O2. 2,5-DMBQ plays a pivotal role in the biodegradation mechanism of brown rot fungal, assisting the fungi in decomposing and utilizing organic matter [2].
Cat. No.: HY-175862
CAS No.: 2135481-84-2
Target:
Free Radical Scavengers Aldose Reductase Reactive Oxygen Species (ROS) PI3K Akt SOD p38 MAPK Keap1-Nrf2
Research Areas:
ALR2-IN-9 is a potent ALR2 inhibitor (IC50 = 21.8 nM) with excellent antioxidant activity (EC50 for DPPH radical scavenging = 2.8 μM). ALR2-IN-9 interacts directly with Reactive Oxygen Species (ROS)/Reactive Nitrogen Species (RNS) and interrupts the free radical chain reactions, and as an endogenous enzymatic antioxidant regulator, which regulates enzyme functions of CAT and SOD. ALR2-IN-9 regulates PI3K/Akt/Nrf2 pathway to attenuate hyperglycemia-mediated mitochondrial superoxide overproduction in vitro, and ameliorates CuSO4- and H2O2-induced oxidative stress in vivo. ALR2-IN-9 prolongs lifespan of C. elegans via the regulation of stress response genes such as PMK-1. ALR2-IN-9 is a promising anti-aging drug candidate. ALR2-IN-9 can be used for diabetic complication research .
Cat. No.: HY-162860
CAS No.: 1030759-58-0
Target:
Research Areas:
FO-4-15 is an mGluR1/CaMKIIα activator. FO-4-15 has a protective effect against H2O2 in human neuroblastoma (SH-SY5Y) cells. FO-4-15 can improve cognitive impairment in Alzheimer’s disease mice by activating the mGluR1/CaMKIIα pathway, and can reduce Aβ accumulation, hyperphosphorylated Tau, and synaptic damage .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
