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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
469 Results for "
O2
" in MedChemExpress (MCE) Product Catalog:
Products (469)
469 Results for "O2" in MCE Product Catalog:
Cat. No.: HY-108351R
CAS No.: 861891-50-1
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IM-54 (Standard) is the analytical standard of IM-54 (HY-108351). This product is intended for research and analytical applications. IM-54 is a selective inhibitor of oxidative stress-induced necrosis. IM-54 shows potent inhibitory activity against H2O2-induced necrosis. IM-54 acts as a potential cardioprotective agent and biological tool for investigating the molecular mechanisms of cell death [2].
Cat. No.: HY-109804R
CAS No.: 1001015-18-4
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CORM-401 (Standard) is the analytical standard of CORM-401 (HY-109804). This product is intended for research and analytical applications. CORM-401 is an oxidant-sensitive CO-releasing molecule. CORM-401 induces NO increase in the regulation of endothelial calcium signalling. CORM-401 reduces TNF-α/CHX and H2O2-induced ROS production. CORM-401 uncouples mitochondrial respiration and inhibits glycolysis [2] .
Cat. No.: HY-146172
CAS No.: 2710376-48-8
Research Areas:
Antioxidant agent-3 (Compound 14q), an potent antioxidant, displays potent DPPH radicals scavenging activity and ABTS + scavenging activity with IC50s of 26.58 and 30.31 μM, respectively. Antioxidant agent-3 (Compound 14q) increases reactive oxygen species (ROS), superoxide dismutase (SOD) and glutathione (GSH), and reduced lactate dehydrogenase (LDH) in H2O2-treated HepG2 cells .
Cat. No.: HY-178141
Research Areas:
AChE/BuChE-IN-7 is a dual-action inhibitor with an IC50 valueof 0.15 μM for AChE and 0.7 μM for BuChE, SI of 4.7. AChE/BuChE-IN-7 shows anti-oxidant activity and can mitigate H2O2-induced cytotoxicity. AChE/BuChE-IN-7 has genomic stability and prolonged systemic availability. AChE/BuChE-IN-7 can be used for the research of neurological disease, such as Alzheimer's disease .
Cat. No.: HY-N13174
CAS No.: 1802175-67-2
Cat. No.: HY-N7697E
CAS No.: 117436-78-9
Target:
Cat. No.: HY-W927359
CAS No.: 109653-47-6
Cat. No.: HY-172604
Research Areas:
Neuroprotective agent 10 is an orally active, blood-brain barrier permeable neuroprotective agent. Neuroprotective agent 10 scavenges ABTS, DPPH and superoxide anion free radicals. Neuroprotective agent 10 inhibits abnormal electrical discharges. At the cellular level, Neuroprotective agent 10 alleviates H2O2-induced oxidative damage and LPS (HY-D1056)-induced neuroinflammation, and relieves epileptic symptoms and oxidative damage in mice. Neuroprotective agent 10 can be used in the research of epilepsy .
Cat. No.: HY-124834
CAS No.: 75483-04-4
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Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent inducer for antioxidant response element (ARE) (EC50 is 2.7 μM) and an activator for Nrf2. Nrf2 activator-10 modifies Keap1, blocks Cul3-Keap1 ubiquitin ligase complex, activates the transcription of Nrf2. Nrf2 activator-10 protects cells from H2O2-induced apoptosis.
Cat. No.: HY-135876
CAS No.: 29873-99-2
Synonyms: (-)-γ-Elemene
Cat. No.: HY-170925
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AChE-IN-81 (compound 22) is a potent, irreversible and selective AChE inhibitor. AChE-IN-81 inhibits activity on AChE with inhibitory rates of 80.0%, with an IC50 of 3.7 μM. AChE-IN-81 binds to AChE with a binding affinity (Kd) of 5.37 μM. AChE-IN-81 effectively reduces in zebrafish brain cells. AChE-IN-81 exhibits potential neuroprotective activities on H2O2-induced SH-SY5Y cell injury model .
Cat. No.: HY-N10277
Category:
Target:
Cat. No.: HY-150563
CAS No.: 2361384-14-5
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Neuroinflammatory-IN-2 is a potent anti-neuroinflammatory agent with an IC50 value of 10.30 μM for MAO-B, and 96.33% inhibition of Aβ1-42 aggregation at 25 μM. Neuroinflammatory-IN-2 has neuroprotective activity in H2O2-induced PC-12 cell injury. Neuroinflammatory-IN-2 also has biometal chelating abilities, antioxidant activity, anti-neuroinflammatory activity and appropriate BBB permeability. Neuroinflammatory-IN-2 can be used for researching Alzheimer’s disease .
Cat. No.: HY-N0615R
CAS No.: 80418-24-2
Synonyms: Sanchinoside R1 (Standard); Sanqi glucoside R1 (Standard)
Category:
Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Extract Triterpenes Plant Terpenoids Araliaceae Extract
Target:
Cat. No.: HY-W423191
CAS No.: 534-42-9
Synonyms: 4-O-α-D-Glucopyranosyl-D-gluconic acid
Cat. No.: HY-D2965
CAS No.: 1219603-04-9
Synonyms: SPG1
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CMPDA is a positive allosteric modulator of AMPA receptors with EC50s of 45.4 ± 4.2 nM/63.4 ± 5.6 nM for GluA2i/GluA2o receptor.
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GSK 366 is a type II kynurenine-3-monooxygenase (KMO) inhibitor with IC50 values of 2.3 nM and 0.7 nM for human KMO and P. fluorescens-KMO (Pf-KMO). GSK 366 binds to KMO’s substrate site, prevents productive NADPH association, substrate binding, and FAD hydroperoxy species formation. GSK 366 does not stimulate hydrogen peroxide (H2O2) production and reduces H2O2 levels. GSK 366 can be used for the researches of inflammation and neurological disease, such as acute pancreatitis multiple organ dysfunction syndrome and Alzheimer’s disease .
Cat. No.: HY-114886
CAS No.: 351978-83-1
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IGP-5 is a mitochondrial sn-Glycerol 3-phosphate Dehydrogenase (mGPDH) inhibitor with the IC50 of 0.7 μM aganist mGPDH H2O2 production . IGP-5 can be used for study of energy metabolism .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
