Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
59 Results for "
DNA binding agent
" in MedChemExpress (MCE) Product Catalog:
Products (59)
59 Results for "DNA binding agent" in MCE Product Catalog:
Cat. No.: HY-N15327
CAS No.: 138355-07-4
Category:
Target:
Cat. No.: HY-189298
Research Areas:
Anticancer agent-365 is a pyrimidine-benzothiazole hybrid derivative that exhibits selective antiproliferative activity against A549 and MCF-7 tumor cells. Anticancer agent-365 is predicted to bind within the ATP-binding pocket of the VEGFR-2 kinase domain. Anticancer agent-365 possesses DNA intercalating binding ability, DNA oxidative damage protective activity, and antioxidant free radical scavenging activity. Anticancer agent-365 can be used for research on lung cancer and breast cancer .
Cat. No.: HY-180839
Target:
DNA Alkylator/Crosslinker Caspase Apoptosis Mitochondrial Metabolism Reactive Oxygen Species (ROS)
Research Areas:
anti-TNBC agent-14 (Compound 4l) is a selective anti-TNBC agent. anti-TNBC agent-14 is a potent and selective DNA-binding agent. anti-TNBC agent-14 induces caspase-3-dependent Apoptosis, mitochondrial ROS generation .
Cat. No.: HY-106091
CAS No.: 88303-60-0
Synonyms: CI 941; DuP-941; Biantrazole
Target:
Research Areas:
Losoxantrone (CI 941) is a DNA-binding agent. Losoxantrone has broad-spectrum antitumour activity. Losoxantrone induces dose-dependent leukopenia .
Cat. No.: HY-189124
Target:
Research Areas:
Antibacterial agent 372 is a potent antibacterial agent. Antibacterial agent 372 is a DNA gyrase inhibitor that binds to the ATP-binding pocket of the GyrB subunit, downregulates gyrB gene expression, and impedes DNA replication and supercoiling. Antibacterial agent 372 exhibits broad-spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Antibacterial agent 372 can be used for research on microbial infections .
Cat. No.: HY-124336
CAS No.: 152247-02-4
Target:
Research Areas:
CP 80080 is a Topoisomerase II ligand with almost no ability to stimulate topoisomerase II-mediated DNA cleavage. CP 80080 competes with DNA cleavage-enhancing antineoplastic agents for a common binding domain on Drosophila topoisomerase II, thereby attenuating the ability of these agents to stimulate topoisomerase II-mediated DNA cleavage. CP 80080 can be used in cancer-related research .
Cat. No.: HY-187106
CAS No.: 874968-47-5
Target:
Research Areas:
Antibacterial agent 361 is an antibacterial agent as well as a membrane-permeable prodrug. Antibacterial agent 361 binds to subsite I of the linear motif binding pocket of the Escherichia coli sliding clamp, disrupts the interaction between the sliding clamp and its chaperone protein, and inhibits sliding clamp-dependent in vitro DNA replication. Antibacterial agent 361 can be used in the research of bacterial infections .
Cat. No.: HY-119228
CAS No.: 492472-30-7
Research Areas:
SN-28049 is a new DNA-binding topoisomerase II-directed antitumor agent. SN-28049 activates the p53 pathway. SN-28049 exhibits anticancer activity against colorectal cancer .
Cat. No.: HY-187163
CAS No.: 78831-35-3
Target:
Research Areas:
Anticancer agent 355 is a highly selective and potent anticancer agent, with IC50 values of 64.66 μM and 13.35 μM against HeLa and MDA-MB-231 cancer cells, respectively. Anticancer agent 355 induces plasmid DNA degradation via intercalation or minor groove binding, and disrupts the tertiary structure of BSA by interfering with the interactions of amino acid side chains. Anticancer agent 355 can be used in the research of cervical cancer and breast cancer .
Cat. No.: HY-156789
CAS No.: 524055-93-4
Target:
Research Areas:
CD38-IN-4 is a CD38 inhibitor. CD38-IN-4 inhibits CD38 hydrolase enzymatic activity through mixed inhibition kinetics, binding partially inside and partially outside the NAD + catalytic pocket. CD38-IN-4 acts as a DNA-binding agent . CD38-IN-4 can be used for research on neuroblastoma .
Cat. No.: HY-187201
Target:
Research Areas:
Antimicrobial agent-54 is a ciprofloxacin-derived multi-target antimicrobial agent that inhibits E. coli DNA gyrase, S. aureus topoisomerase IV, LpxC and urease with IC50 values of 0.182, 3.501, 0.052 and 6.254 μM, respectively. The MIC of Antimicrobial agent-54 against E. coli ATCC 8739 is 0.20 μM. Antimicrobial agent-54 interferes with bacterial cell division, causes transient membrane disruption in Gram-positive bacteria, and induces aberrant penicillin-binding protein activity in Gram-negative bacteria. Antimicrobial agent-54 can be used in the research of bacterial infections, including multidrug-resistant bacterial infections and mycobacterial infections .
Cat. No.: HY-183623
CAS No.: 1296670-84-2
Target:
Research Areas:
ProAlk01 is a protein alkylating agent that serves as a toxin payload for ADCs. ProAlk01 localizes to the cytoplasm and exerts cytotoxic effects mainly by alkylating cytoplasmic proteins rather than binding to DNA. ProAlk01 induces cell cycle arrest, apoptosis, and immunogenic cell death. ProAlk01 can be used in the research of solid tumors .
Cat. No.: HY-128744A
CAS No.: 36983-81-0
Cat. No.: HY-184324
CAS No.: 2975573-18-1
Target:
NF-κB p38 MAPK Reactive Oxygen Species (ROS) Interleukin Related TNF Receptor COX IKK ERK JNK
Research Areas:
Anti-inflammatory agent 116 is an anti-inflammatory agent. Anti-inflammatory agent 116 inhibits the abnormal activation of the NF-κB/MAPK signaling pathway. Anti-inflammatory agent 116 binds to the p50 subunit and impairs the DNA-binding ability of the p65-p50 heterodimer. Anti-inflammatory agent 116 inhibits LPS-induced production of NO and MtROS, secretion of IL-1β and TNF-α, expression of iNOS and COX-2, phosphorylation of IKK, IκB, p65, p38, ERK and JNK, as well as nuclear translocation of p65. Anti-inflammatory agent 116 alleviates sepsis-associated acute liver injury in mice. Anti-inflammatory agent 116 can be used for the research of sepsis-associated acute liver injury .
Cat. No.: HY-184307
Target:
Research Areas:
FAK1/2 Ligand-1 is a FAK1/FAK2 ligand with KD values of 2.9 μM and 2.5 μM for binding to FAK1 and FAK2, respectively. FAK1/2 Ligand-1 induces G2/M phase arrest, activates DNA damage-related signaling pathways, and reduces the phosphorylation level of CDK1. Antitumor agent-220 is applicable to the research of triple-negative breast cancer .
Cat. No.: HY-133240
CAS No.: 1109241-72-6
Research Areas:
trans-AzoTAB is a photoresponsive potassium/sodium/calcium channel modulator and DNA-binding agent. trans-AzoTAB undergoes trans-cis isomerization driven by light, with variable polarity and DNA affinity. trans-AzoTAB also enhances voltage-gated potassium currents and inhibits sodium and calcium currents in cardiomyocytes, thereby reducing spontaneous electrical activity and excitation conduction velocity. In addition, trans-AzoTAB induces compaction and frozen conformation of λ-phage DNA, and non-sequence-dependently inhibits transcription and translation processes in the dark; its activity can be reversed and restored by visible light after activation with ultraviolet irradiation. trans-AzoTAB can serve as a probe for two-photon optical regulation of myocardial excitability, and is used to construct photoresponsive interfacial polymer structures .
Cat. No.: HY-182392
CAS No.: 925644-66-2
Target:
Research Areas:
NFYi5 is a nuclear transcription factor-Y (NF-Y) inhibitor. NFYi5 disrupts the binding of NF-Y to DNA, accelerates the ubiquitin-independent degradation of the NF-YA subunit, and reduces the transcriptional activity of NF-Y. As an antimitotic agent, NFYi5 decreases the mRNA levels of NF-Y target genes without affecting the expression of housekeeping genes, and inhibits cell proliferation. NFYi5 can be used in the research of tissue fibrosis .
Cat. No.: HY-181966
Research Areas:
Sideromycin 7 is an antibacterial agent. Sideromycin 7 forms a 7-Bi 3+ coordination complex with bismuth citrate, exerting a three-pronged antibacterial mode of action: direct DNA binding to induce damage and arrest replication, suppression of KdpC synthesis to block KdpFABC-mediated potas-sium transport, and inhibition of ATP production. Sideromycin 7 exhibits potent antibacterial activity against Ciprofloxacin (HY-B0356)-resistant Pseudomonas aeruginosa strains. Sideromycin 7 exerts antibiofilm activity against Pseudomonas aeruginosa. Sideromycin 7 can be used for the research of ciprofloxacin-resistant Pseudomonas aeruginosa infection .
Cat. No.: HY-N20682
CAS No.: 2866266-56-8
Target:
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
