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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
60 Results for "
LTC4
" in MedChemExpress (MCE) Product Catalog:
Products (60)
60 Results for "LTC4" in MCE Product Catalog:
Cat. No.: HY-117854
CAS No.: 141311-11-7
Target:
Research Areas:
SB 201146 is an LTB4 receptor antagonist with a potency range of 10 pM to 1 μM that plays a critical role in asthma-associated airway inflammation. Studies have focused on its effects on eosinophil survival, a hallmark of asthma pathology. Studies have shown that eosinophil-derived cysteinyl leukotrienes, including LTC4 and LTD4, as well as factors such as GM-CSF and fibronectin promote eosinophil survival. SB 201146 effectively reversed mast cell- and lymphocyte-induced eosinophil survival, highlighting its potential therapeutic role in disrupting the autocrine cysteinyl leukotriene pathway that maintains eosinophil viability. This antagonist also highlights the importance of LTB4 as a paracrine mediator that influences eosinophil survival in inflammatory settings such as asthma .
Cat. No.: HY-W511185
CAS No.: 5067-25-4
Research Areas:
ST026567 is a potent mast cell activator. ST026567 induces the secretion of PGD2, LTC4 from cells. ST026567 exhibits degranulation potency .
Cat. No.: HY-101676R
CAS No.: 120128-20-3
Synonyms: NID 525 (Standard)
Research Areas:
RG-12525 (Standard) is the analytical standard of RG-12525 (HY-101676). This product is intended for research and analytical applications. RG-12525 is a a specific, competitive and orally effective antagonist of the peptidoleukotrienes, LTC4, LTD4 and LTE4, inhibiting LTC4-, LTD4- and LTE4-inducd guinea pig parenchymal strips contractions, with IC50s of 2.6 nM, 2.5 nM and 7 nM, respectively; RG-12525 is also a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist with IC50 of appr 60 nM and a potent inhibitor of CYP3A4, with a Ki value of 0.5 μM.
Cat. No.: HY-182422
CAS No.: 134822-78-9
Target:
Research Areas:
CGS 23885 is an orally active 5-lipoxygenase (5-lipoxygenase) inhibitor. CGS 23885 reduces the production of 5-hydroxyeicosatetraenoic acid (5-hydroxyeicosatetraenoic acid), LTB4, and LTC4/D4/E4. CGS 23885 inhibits cell infiltration in rat pleurisy. CGS 23885 can be used in pleurisy-related research .
Cat. No.: HY-N19723
CAS No.: 139501-36-3
Synonyms: Verbascosaponin B
Target:
Cat. No.: HY-189117
CAS No.: 36857-46-2
Target:
Research Areas:
HPR-611 is a Tiaramide (HY-W838171) derivative. HPR-611 inhibits the release of histamine, i-LTB4, and i-LTC4 in rat peritoneal exudate cells, guinea pig lung fragments, and human lung fragments. HPR-611 can be used for research on bronchial asthma .
Cat. No.: HY-RS21637
Target:
Research Areas:
Ltc4s Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ltc4s gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS28155
Target:
Research Areas:
Ltc4s Rat Pre-designed siRNA Set A contains three designed siRNAs for Ltc4s gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-183433
CAS No.: 99435-38-8
Target:
Research Areas:
Ph CL 28A is a prostaglandin 15-hydroxydehydrogenase (15-PGDH) inhibitor. Ph CL 28A increases the output of PGE2, PGF2α and endogenous arachidonic acid-derived PGI2 in isolated rat lungs, reduces the output of TxB2 and LTC4 in isolated rat hearts, and exhibits protective effects in rat models of inflammation and gastric mucosal injury. Ph CL 28A can be used in research related to acute inflammation and gastric ulcers [4] .
Cat. No.: HY-182434
CAS No.: 97012-61-8
Target:
Research Areas:
CL 118326 is a potent, selective, competitive inhibitor of mammalian pancreatic phospholipase A2 (PLA2) and a weak antagonist of platelet-activating factor receptor (PAF receptor). CL 118326 competitively inhibits mammalian pancreatic PLA2 (porcine: IC50 = 1.55 μg/mL), and shows no activity against snake venom or bee venom PLA2. CL 118326 inhibits PAF-induced and thrombin-induced platelet aggregation, as well as the release of leukotriene (LTC4) and histamine from basophil-enriched leukocytes. CL 118326 can be used for research on inflammation and allergic reactions .
Cat. No.: HY-185709
CAS No.: 53847-31-7
Synonyms: 1-Lyso-2-arachidonoyl-sn-glycero-3-phosphoethanolamine
Research Areas:
2-ARA-LysoPtdEtn (1-Lyso-2-arachidonoyl-sn-glycero-3-phosphoethanolamine) is an orally active polyunsaturated acyl lysophosphatidylethanolamine. 2-ARA-LysoPtdEtn diminishes formation of LTC4, LTB4, and 12-HETE. 2-ARA-LysoPtdEtn lowers levels of IL-1β, IL-6, TNF-α, and NO. 2-ARA-LysoPtdEtn augments IL-10 levels and upgrades formation of 15-HETE and LXA4. 2-ARA-LysoPtdEtn can be used for the research of peritonitis .
Cat. No.: HY-113628A
CAS No.: 189498-56-4
Synonyms: VML-530 free base
Target:
Research Areas:
ABT-080 free base is an orally active inhibitor of leukotriene biosynthesis that targets 5-lipoxygenase-activating protein (FLAP). ABT-080 free base inhibits leukotriene production in intact human neutrophils, mouse peritoneal macrophages and human whole blood, with IC50 values of 20 nM, 0.16 nM and 13 μM, respectively. ABT-080 free base blocks the leukotriene pathway leading to the synthesis of LTB4 and LTC4, but does not block PGH2 biosynthesis. ABT-080 free base inhibits leukotriene biosynthesis and bronchoconstriction in mouse models. ABT-080 is used in research related to asthma, pleurisy and allergy .
Cat. No.: HY-W099504S2
CAS No.: 38007-42-0
Synonyms: n-Heptyl alcohol-d1
Cat. No.: HY-P72069
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ABCC1; ATP-Binding Cassette Sub-Family C Member 1; Prev. MRP1; LTC4 Transporter; Prev. MRP; ATP-Binding Cassette Transporter Variant ABCC1delta-Ex25; Glutathione-S-Conjugate-Translocating ATPase ABCC1; ATP-Binding Cassette Transporter Variant ABCC1delta-E
Species:
Human
Source:
E. coli
Cat. No.: HY-P701355
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ABCC1; ATP-Binding Cassette Sub-Family C Member 1; Prev. MRP1; LTC4 Transporter; Prev. MRP; ATP-Binding Cassette Transporter Variant ABCC1delta-Ex25; Glutathione-S-Conjugate-Translocating ATPase ABCC1; ATP-Binding Cassette Transporter Variant ABCC1delta-E
Species:
Bovine
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
