10010 Results for "

endogenously

" in MedChemExpress (MCE) Product Catalog:
Products (10010)

10010 Results for "endogenously" in MCE Product Catalog:

13
13 Cited Publications
Cat. No.: HY-W011249
CAS No.: 72556-74-2
Phosphorylcholine chloride calcium salt tetrahydrate is an endogenous metabolite.
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11
11 Cited Publications
Cat. No.: HY-100806
CAS No.: 492-27-3
Purity:  99.21%
Synonyms: Quinurenic acid
Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.
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11
11 Cited Publications
Cat. No.: HY-107512
CAS No.: 2439-02-3
Purity:  99.79%
Kynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8.
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10
10 Cited Publications
Cat. No.: HY-P0202
CAS No.: 117399-94-7
Synonyms: ET-1 (swine, human)
Endothelin 1 (swine, human) (ET-1) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB .
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10
10 Cited Publications
Cat. No.: HY-P0202A
CAS No.: 394693-38-0
Synonyms: ET-1 (swine, human) TFA
Target:  

Endothelin Receptor

Research Areas:  

Cardiovascular Disease

Endothelin 1 (swine, human) (ET-1) TFA is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 TFA acts through two types of receptors ETA and ETB .
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10
10 Cited Publications
Cat. No.: HY-P1944A
Apelin-13 TFA is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC 50 value of 0.37 nM. Apelin-13 TFA has vasodilatory and antihypertensive effects. Apelin-13 TFA also can be used for researching type 2 diabetes and metabolic syndrome .
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10
10 Cited Publications
Cat. No.: HY-P1944
CAS No.: 217082-58-1
Apelin-13 is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC 50 value of 0.37 nM. Apelin-13 is widely distributed in the central and peripheral nervous systems. Apelin-13 has vasodilatory and antihypertensive effects. Apelin-13 also can be used for researching type 2 diabetes and metabolic syndrome .
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9
9 Cited Publications
Cat. No.: HY-19317
CAS No.: 448906-42-1
Research Areas:  

Inflammation/Immunology Cancer

ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), binding directly to AHR, with a Ki of 3 nM. ITE also has immunosuppressive activity.
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8
8 Cited Publications
Cat. No.: HY-W018512
CAS No.: 4651-67-6
Synonyms: 3α-Hydroxy-7-oxo-5β-cholanic acid
7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid), a bile acid, can be absorbed and suppresses endogenous bile acid production and biliary cholesterol secretion .
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8
8 Cited Publications
Cat. No.: HY-D1159
CAS No.: 2138472-08-7
HKOH-1r is a highly sensitive green fluorescent probe for the specific detection of ·OH in living cells with a maximum excitation wavelength and emission wavelength of 500 nm and 520 nm, respectively .
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8
8 Cited Publications
Cat. No.: HY-17417
CAS No.: 357-08-4
Target:  

Opioid Receptor

Research Areas:  

Neurological Disease

Naloxone hydrochloride is an orally active opioid receptor antagonist. Naloxone hydrochloride attenuates spinal cord stimulation‑associated anti‑hyperalgesic effects, antagonizes physiologic effects of endogenous opioid peptides linked to central nervous system injury sequelae, functions as a pressor agent to induce modest elevations in mean arterial blood pressure, exerts neuroprotective effects to improve post‑traumatic neurologic motor function, blocks opioid receptor‑mediated amnesic pathways, enhances memory consolidation, reverses Adrenocorticotropic hormone (ACTH) (HY-106373)- and epinephrine‑induced amnesia, and potentiates the memory‑facilitatory effects of ACTH and epinephrine .
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8
8 Cited Publications
Cat. No.: HY-17417A
CAS No.: 465-65-6
Target:  

Opioid Receptor

Research Areas:  

Neurological Disease

Naloxone hydrochloride is an orally active opioid receptor antagonist. Naloxone hydrochloride attenuates spinal cord stimulation‑associated anti‑hyperalgesic effects, antagonizes physiologic effects of endogenous opioid peptides linked to central nervous system injury sequelae, functions as a pressor agent to induce modest elevations in mean arterial blood pressure, exerts neuroprotective effects to improve post‑traumatic neurologic motor function, blocks opioid receptor‑mediated amnesic pathways, enhances memory consolidation, reverses Adrenocorticotropic hormone (ACTH) (HY-106373)‑ and epinephrine‑induced amnesia, and potentiates the memory‑facilitatory effects of ACTH and epinephrine .
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8
8 Cited Publications
Cat. No.: HY-D0720
CAS No.: 2315-97-1
Synonyms: NSC-151912; L-6868
Lucigenin is a chemiluminescence probe. Lucigenin can be used to detect the production of endogenous superoxide anion radical (O 2-). Lucigenin is extremely sensitive to chloride ions, while it combined with chloride ions, the fluorescence will be quenched. Lucigenin also can be used as a chloride indicator. Ex/Em=455/505 nm .
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8
8 Cited Publications
Cat. No.: HY-Y1362
CAS No.: 617-35-6
Ethyl pyruvate is a simple derivative of the endogenous metabolite pyruvate. Ethyl pyruvate is an HMGB1 release inhibitor. Ethyl pyruvate can induce apoptosis by autophagy. Ethyl pyruvate has anti-inflammatory, antioxidant and anti-tumor activity. Ethyl pyruvate can be used in the study of neurodegenerative diseases such as Alzheimer's and Parkinson's disease .
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7
7 Cited Publications
Cat. No.: HY-W010347
CAS No.: 6027-13-0
L-Homocysteine, an amino acid, is a homocysteine that has L configuration. Homocysteine is an essential intermediate in normal mammalian metabolism of methionine. L-Homocysteine induces upregulation of Cathepsin V that mediates vascular endothelial inflammation in hyperhomocysteinaemia .
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7
7 Cited Publications
Cat. No.: HY-W015851
CAS No.: 13613-65-5
Synonyms: (R)-(-)-3-Hydroxybutanoic acid sodium; (R)-3-Hydroxybutyric acid sodium
(R)-3-Hydroxybutanoic acid ((R)-3-Hydroxybutyric acid) sodium is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones .
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7
7 Cited Publications
Cat. No.: HY-116429
CAS No.: 1268720-28-0
Purity:  99.00%
Research Areas:  

Inflammation/Immunology

Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca 2+] and secretion. Maresin 1 possesses anti-inflammatory activity .
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7
7 Cited Publications
Cat. No.: HY-B0234
CAS No.: 53-16-7
Synonyms: E1; Oestrone
Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells .
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7
7 Cited Publications
Cat. No.: HY-100236
CAS No.: 374913-63-0
Purity:  99.17%
Synonyms: DDD00107587
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

Madrasin (DDD00107587) is a splicing inhibitor that prevents formation of both splicing intermediates and products in vitro and interferes with one or more early steps in the pathway of spliceosome assembly. Madrasin also can inhibit pre-mRNA splicing in vitro and modify splicing of endogenous pre-mRNA in cells .
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7
7 Cited Publications
Cat. No.: HY-100807
CAS No.: 89-00-9
Purity:  99.85%
Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis .
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