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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
122 Results for "
human microsomes
" in MedChemExpress (MCE) Product Catalog:
Products (122)
122 Results for "human microsomes" in MCE Product Catalog:
Cat. No.: HY-162409
CAS No.: 3057206-41-1
Research Areas:
PAR4 antagonist 4 (Compound 37) is a selective antagonist for protease activated receptor 4 (PAR4). PAR4 antagonist 3 exhibits antiplatelet efficacy with IC50 of 14.2 nM. PAR4 antagonist 3 improves metabolic stablility in human liver microsomes with T1/2 of 42.5 min .
Cat. No.: HY-162525
CAS No.: 2306328-43-6
Target:
Research Areas:
GS-9770 is an orally active inhibitor for HIV protease with Ki of 0.16 nM. GS-9770 exhibits antiviral activity aginst HIV-1 strains and HIV-2 strains with EC50 of 1.9-26 nM, and 26 nM. GS-9770 is metabolic stable in human liver microsomes. GS-9770 exhibits good pharmacokinetic characters in Sprague Dawley rats .
Cat. No.: HY-N7454
CAS No.: 23893-13-2
Category:
Infection Macrolide Antibiotics Antibiotics Disease Research Antibacterial Endogenous metabolite Disease Research Fields
Target:
Cat. No.: HY-10864R
CAS No.: 546141-08-6
Synonyms: KDS-4103 (Standard)
Target:
Research Areas:
URB-597 (Standard) is the analytical standard of URB-597. This product is intended for research and analytical applications. URB-597 (KDS-4103) is an orally bioavailable and selective FAAH inhibitor. URB-597 inhibits FAAH activity with an IC50s of approximately 5 nM in rat brain membranes, 0.5 nM in intact rat neurons, 3 nM in human liver microsomes. Antidepressant-like effects. Analgesic activity .
Cat. No.: HY-146410
CAS No.: 2709031-17-2
Target:
Research Areas:
AT2R antagonist 1 (compound 21) is a potent and high selective AT2R (angiotensin II AT2 receptor) ligand. AT2R antagonist 1 exhibits a fair AT2R affinity, with a Ki of 29 nM. AT2R antagonist 1 also inhibits common agent-metabolizing CYP enzymes. AT2R antagonist 1 shows high stability in human, rat and mouse liver microsomes .
Cat. No.: HY-117428
CAS No.: 1513828-41-5
Target:
Research Areas:
INU-101 is a potent, selective and orally active 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 inhibitor. INU-101 has highly potent inhibitory activity in mouse, monkey and human 11β-HSD1, derived from liver microsomes. INU-101 can enhance insulin sensitivity and lower the fasting blood glucose level. INU-101 can be used for the research of metabolic disease, such as diabetes .
Cat. No.: HY-113777
CAS No.: 90780-46-4
Synonyms: 22-Hydroxy Docosahexaenoic acid; 22-OH DHA
Target:
Research Areas:
22-HDHA (22-Hydroxy Docosahexaenoic acid) is an oxidation product of docosahexaenoic acid. In vitro, it is formed upon incubation of rat liver microsomes with DHA and NADPH and also by the human cytochrome P450 (CYP) isoform CYP4F3B in BTI-TN-5B1-4 microsomes. Serum levels of 22-HDHA increase following dietary DHA supplementation in humans.
Cat. No.: HY-112690
CAS No.: 625095-60-5
Target:
Research Areas:
Pradefovir is a good substrate for liver CYP3A4. Pradefovir is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with a Km of 60 μM.
Cat. No.: HY-137580
CAS No.: 153525-55-4
Target:
Research Areas:
N-desmethyl Eletriptan is a metabolite of Eletriptan (HY-A0039). It is formed from eletriptan primarily by the cytochrome P450 (CYP) isoform CYP3A4 in human liver microsomes.
Cat. No.: HY-N8094
CAS No.: 101236-51-5
Category:
Flavanonols Flavonoids Other Diseases Phenols Polyphenols Leguminosae Extract Plants Sophora flavescens Aiton Disease Research Fields
Target:
Cat. No.: HY-100644
CAS No.: 27653-68-5
Synonyms: Trimethoprim 1-N-oxide
Target:
Research Areas:
Trimethoprim N-oxide (Trimethoprim 1-N-oxide) belongs to human urinary metabolites. Trimethoprim N-oxide is generated by oxidation of nitrogen atoms in the pyrimidine ring. Trimethoprim N-oxide is formed predominantly by CYP1A2 in human liver microsomes .
Cat. No.: HY-113986B
CAS No.: 102676-86-8
Synonyms: (S)-Fadrozole; (S)-CGS 16949A free base; (S)-FAD286
Target:
Research Areas:
(S)-Dexfadrostat ((S)-Fadrozole) is an aromatase inhibitor with an IC50 of 4.6 nM in human placental microsomes in vitro. (S)-Dexfadrostat can be used in the study of estrogen-dependent breast cancer, gynecomastia, and systemic lupus erythematosus .
Cat. No.: HY-171278
CAS No.: 1095750-94-9
Target:
Research Areas:
Casein kinase 1δ-IN-28 (Compound 4) is the inhibitor for CK1ε with an IC50 of 0.0146 μM. Casein kinase 1δ-IN-28 exhibits a metabolite rate in human liver microsomes of 52% .
Cat. No.: HY-N11676
CAS No.: 1035154-49-4
Target:
Cat. No.: HY-146111
CAS No.: 2667681-57-2
IRAK4-IN-13 (compound 21) is a potent and selective IRAK4 inhibitor with an IC50 of 0.6 nM. IRAK4-IN-13 shows high metabolic clearance with human liver microsomes (HLM) intrinsic clearance is 96 µL/min/mg .
Cat. No.: HY-N11827
CAS No.: 22672-74-8
Synonyms: (+)-Isocorybulbine
Category:
Alkaloids Monophenols Phenols Plants Papaveraceae Extract Alkaloid Dimers Corydalis turtschaninovii Bess.
Target:
Cat. No.: HY-139721
CAS No.: 2611373-80-7
Tenofovir-C3-O-C15-CF3 (ammonium) exhibits substantially longer t1/2 values than tenofovir in human liver microsomes, potent anti-HIV activity in vitro, and enhances pharmacokinetic properties in vivo.
Cat. No.: HY-151957
CAS No.: 2883173-23-5
Antitubercular agent 34 (compound 42g) is an antitubercular agent. Antitubercular agent 34 inhibits the growth of MtbH37Rv with a MIC90 value of 1.25 μg/mL with the ability of escaping metabolic degradation by human liver microsomes. Antitubercular agent 34 can be used for the research of tuberculosis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
