Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
79 Results for "
At TK
" in MedChemExpress (MCE) Product Catalog:
Products (79)
79 Results for "At TK" in MCE Product Catalog:
Cat. No.: HY-173314
EGFR-IN-155 (compound 13a) is an EGFR inhibitor with IC50 values of 0.14 nM and 0.18 nM against EGFR TK and EGFR L858R, respectively. EGFR-IN-155 inhibits tumor growth, causes a cell cycle arrest at S phase, and and induces cell apoptosis .
Cat. No.: HY-104083
CAS No.: 156126-12-4
Synonyms: N-MCT
Target:
North-methanocarbathymidine (N-MCT) is a potent antiviral agent. North-methanocarbathymidine inhibits DNA synthesis. North-methanocarbathymidine demonstrates potent antiviral activity against HSV-1, HSV-2 and KSHV. North-methanocarbathymidine exhibits anticancer activity against colon adenocarcinoma expressing HSV-tk .
Cat. No.: HY-W770090
Cat. No.: HY-149846
CAS No.: 2151881-74-0
SIQ17 is an EGFR inhibitor that inhibits its activity by occupying the ATP-binding site, with IC50 of 0.62 nM. SIQ17 shows more effective EGFR-TK inhibitory activity compared to the known inhibitor Erlotinib (HY-50896) (IC50 of ∼20 nM). SIQ17 can be used for cancer research
EGFR-IN-78 (compound A5)，a 2-aminopyrimidine derivative，is a reversible inhibitor of EGFR C797S-TK，and also an inducer of apoptosis. EGFR-IN-78 shows anti-proliferative activity，inhibits EGFR phosphorylation and arrests cell cycle at G2/M phase .
Cat. No.: HY-158016
Antiproliferative agent-49 (Compound 5a) is a EGFR-TK inhibitor with an IC50 of 0.09 μM. Antiproliferative agent-49 is a anti-proliferative agent. Antiproliferative agent-49 displays good activities against HER3 and HER4 with IC50 values 0.18 and 0.37 µM. Antiproliferative agent-49 induces mitochondrial apoptotic pathway and increased accumulation of ROS .
Cat. No.: HY-170761
CAS No.: 3108079-75-7
Target:
Research Areas:
KEAP1-NRF2 PPI-IN-1 (compound 23) is an inhibitor targeting the KEAP1-NRF2 interaction. KEAP1-NRF2 PPI-IN-1 has IC50 values of 136 nM and 62 nM in the DNA damage assays of human TK6 and insect SF9 cell lines, respectively .
Cat. No.: HY-172897
Research Areas:
EGFR/DHFR-IN-2 (9b) is a dual h-DHFR/EGFR TK inhibitor, with IC50 values of 0.192 μM and 0.109 μM for h-DHFR and EGFR, respectively. EGFR/DHFR-IN-2 (9b) halts the cell cycle at the G1/S phase and induces apoptosis. EGFR/DHFR-IN-2 (9b) is a potential inhibitor of CYP2C9 and CYP3A4. EGFR/DHFR-IN-2 (9b) can be used in the cancer research .
Cat. No.: HY-118304A
CAS No.: 1175017-91-0
AKN-028 TFA, a novel tyrosine kinase (TK) inhibitor, is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. AKN-028 TFA inhibits FLT3 autophosphorylation. AKN-028 TFA induces dose-dependent cytotoxic response (mean IC50=1 μM). AKN-028 TFA induces apoptosisby activation of caspase 3. AKN-028 TFA can be used in research of acute myeloid leukemia (AML) .
Cat. No.: HY-146138
CAS No.: 2492382-37-1
Research Areas:
EGFR-IN-57 (Compound 25a) is a potent, orally active EGFR-TK inhibitor with an IC50 of 0.054 µM. EGFR-IN-57 also inhibits VEGFR-2, CK2α, topoisomerase IIβ and tubulin polymerization with IC50 values of 0.087, 0.171, 0.13 and 3.61 µM, respectively. EGFR-IN-57 induces cell cycle arrest at G2/M and pre-G1 phases. EGFR-IN-57 induces cancer cell apoptosis .
Cat. No.: HY-182362
Target:
Research Areas:
TK-285 is a potent TSLP inhibitor that suppresses the production of TSLP and inhibits the expression of interleukin-33 mRNA. TK-285 exhibits a selective binding preference for the BD1 domains of BRD2, BRD3, BRD4 and BRDT. TK-285 can be used in research related to atopic dermatitis .
Cat. No.: HY-179150
Target:
Research Areas:
EGFR-TK-IN-6 (compound 10B) is an EGFR-TK inhibitor (IC50 = 0.65 μM). EGFR-TK-IN-6 has anti proliferative activity against MCF-7 cells (IC50 = 37.7 μM). EGFR-TK-IN-6 has low toxicity to normal cells. EGFR-TK-IN-6 can be used for cancer research .
Cat. No.: HY-RS17046
Target:
Research Areas:
Tk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-180202
Target:
Research Areas:
Transketolase-IN-7 (compound 4m) is a potent herbicide that exhibits inhibitory activity against C. rotundus with an IC50 of 6.66 mg/L. Transketolase-IN-7 is a transketolase (TK) inhibitor that interacts with the TK enzyme by forming hydrogen bonds. Transketolase-IN-7 can be used for research of plant herbicides .
Cat. No.: HY-P12278
NP1 peptide is a cyclic peptide (CHSHGTRAC) and TK-EGFR inhibitor (IC50 = 0.58 nM, Kd = 18.40 μM). NP1 peptide blocks kinase activity by binding to the ATP-binding pocket of TK-EGFR and inhibits autophosphorylation at the EGFR Y1173 site, and it also serves as a pH-responsive nanocarrier for siRNA delivery. NP1 peptide is used in cancer research .
Cat. No.: HY-N0377S
Synonyms: 4',7-Dihydroxyflavanone-d4
Cat. No.: HY-183390
CAS No.: 136565-26-9
Cat. No.: HY-187334
CAS No.: 1923767-20-7
EGFR-IN-216 is an epidermal growth factor receptor (EGFR) tyrosine kinase (TK) inhibitor. EGFR-IN-216 inhibits EGFR tyrosine kinase phosphorylation, blocks downstream signaling pathway activation, suppresses cancer cell proliferation and promotes tumor cell apoptosis (apoptosis). EGFR-IN-216 can be used for the research of non-small cell lung cancer .
Cat. No.: HY-180823
Target:
Research Areas:
Topoisomerase II/EGFR-IN-2 (Compound 3) is an inhibitor of Topoisomerase IIα (IC50 = 0.122 μM) and EGFR-TK WT (IC50 = 16.8 μM). Topoisomerase II/EGFR-IN-2 inhibits the proliferation of HeLa and HepG2 cells, inducing cell cycle arrest and apoptosis. Topoisomerase II/EGFR-IN-2 upregulates caspase-3 and Bax, and downregulates Bcl-2. Topoisomerase II/EGFR-IN-2 can be used to study liver cancer and cervical cancer .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
