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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
99 Results for "
ergosterol
" in MedChemExpress (MCE) Product Catalog:
Products (99)
99 Results for "ergosterol" in MCE Product Catalog:
Cat. No.: HY-187673
CAS No.: 61400-59-7
Parconazole is an orally active imidazole derivative and antifungal (fungal) agent. Parconazole inhibits sterol 14α-demethylase (CYP51) and Δ22-desaturase (CYP61), disrupting fungal Ergosterol (HY-N0181) biosynthesis by reducing the availability of ergosterol and promoting the accumulation of 14-methyl sterols. Parconazole exhibits in vitro antifungal activity against dermatophytes, Candida species, Blastomyces dermatitidis yeast, piedraia, and actinomycetes. Parconazole can be used in the study of fungal infections .
Cat. No.: HY-187376
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CZx-243 is an orally active broad-spectrum antifungal agent. CZx-243 binds to the active site of fungal CYP51 and interferes with ergosterol biosynthesis by depleting ergosterol and causing the accumulation of upstream sterol intermediates. CZx-243 blocks yeast-to-hypha transition; it inhibits the membrane integrity of fungi such as Candida glabrata and Cryptococcus neoformans. CZx-243 significantly reduces renal fungal burden in a systemic mouse model of invasive fungal infection resistant to Fluconazole (HY-B0101). CZx-243 can be used in the research of fungal infections .
Cat. No.: HY-E71944
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5α-Hydroxysteroid dehydratase (EC 4.2.1.62) is a lyase that can convert 5alpha-ergosta-7,22-diene-3beta,5-diol into ergosterol and H2O.
Cat. No.: HY-W748786
CAS No.: 473798-59-3
Fenpyrazamine is an antifungal agent. Fenpyrazamine possesses antifungal, preventative, systemic, and lesion-inhibiting activities, as well as a long-lasting effect. Fenpyrazamine targets 3-keto reductase in the ergosterol biosynthesis pathway. Fenpyrazamine is effective against gray mold, stem rot, and brown rot .
Cat. No.: HY-N19799
CAS No.: 1464778-45-7
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Cat. No.: HY-W281071
CAS No.: 67365-93-9
Antifungal agent 150 is an antifungal agent with activity against phytopathogenic fungi and in planta lesion suppression. Antifungal agent 150 inhibits ergosterol biosynthesis via targeted enzyme interaction. Antifungal agent 150 can be used for the research of plant diseases caused by Rhizoctonia solani, including banded leaf and sheath blight of maize .
Cat. No.: HY-183333
CAS No.: 3094676-22-6
CHNQD-02204 is a potent and selective antifungal agent with in vitro activity against Candida albicans, with a MIC of 0.025 μg/mL. CHNQD-02204 inhibits ergosterol biosynthesis, disrupts the membrane integrity and biofilm formation of Candida albicans, and suppresses the morphological transition of Candida albicans from yeast to hyphal form. CHNQD-02204 can be used in studies related to candidal infections .
Cat. No.: HY-76200C
CAS No.: 239807-03-5
Synonyms: (R,R)-UK-109496
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(R,R)-Voriconazole ((R,R)-UK-109496) is an enantiomer of Voriconazole (HY-76200). Voriconazole (UK-109496) is a second-generation broad-spectrum triazole antifungal compound that inhibits the biosynthesis of fungal ergosterol. Voriconazole exerts its antifungal activity by inhibiting the 14-α-lanosterol demethylation mediated by fungal cytochrome P450 enzymes. Voriconazole exhibits blood-brain barrier permeability .
Cat. No.: HY-179518
Antifungal agent 140 (compound 5p) is a potent antifungal agent with broad-spectrum antifungal activity. Antifungal agent 140 exerts a dual mechanism by targeting the Ras/cAMP/PKA pathway to inhibit hyphal formation and the ergosterol biosynthesis pathway. Antifungal agent 140 enhances survival, reduces fungal load in the kidneys, and strengthens host immune responses in a murine model of systemic candidiasis. Antifungal agent 140 can be used for research of resistant fungal infections .
Cat. No.: HY-180483
Antifungal agent 144 (Compound 3f) is a highly selective antifungal agent against Aspergillus niger, with an MIC of 7.5 μg/mL. Antifungal agent 144 simultaneously inhibits chitin deacetylase AngCDA and 1,3-β-glucan synthase. Antifungal agent 144 functions by disrupting the integrity of the fungal cell wall and does not bind to Ergosterol (HY-N0181). Antifungal agent 144 can be used for research on Aspergillus niger infections .
Cat. No.: HY-FL17514
CAS No.: 84625-61-6
Synonyms: R51211 solution
Itraconazole solution is mainly composed of Itraconazole (HY-17514). Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .
Cat. No.: HY-187437
CAS No.: 3133348-60-1
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CYP51-IN-33 is a CYP51 inhibitor with an IC50 of 0.35 μM against the sterol 14α-demethylase activity of Rhizoctonia solani CYP51. CYP51-IN-33 interferes with CYP51-associated ergosterol biosynthesis, accompanied by changes in hyphal morphology, increased membrane permeability and intracellular ROS accumulation. CYP51-IN-33 can be used in studies on CYP51-targeted antifungal activity and rice sheath blight .
Cat. No.: HY-W791931
CAS No.: 77174-66-4
710674-S is a synthetic imidazole derivative with antibacterial and antifungal activities. 710674-S exhibits potent activity against dermatophytes, and moderate activity against Candida species, other yeasts, Gram-positive aerobic bacteria and most anaerobic bacteria. 710674-S inhibits lanosterol 14α-demethylase (CYP51), a key enzyme in the fungal ergosterol biosynthetic pathway. The antifungal activity of 710674-S increases in alkaline culture media. 710674-S can be used in studies related to fungal infectious diseases .
Cat. No.: HY-189445
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CYP51/SE-IN-1 is a dual-target inhibitor of CYP51 and squalene epoxidase (SE), with IC50 values of 2.95 mg/L and 6.35 mg/L, respectively. CYP51/SE-IN-1 is also an Antifungal agent. CYP51/SE-IN-1 disrupts fungal cell membrane integrity, increases membrane permeability, and induces intracellular ROS accumulation. CYP51/SE-IN-1 inhibits ergosterol biosynthesis and exhibits broad-spectrum antifungal activity against plant pathogenic fungi .
Cat. No.: HY-P72165
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Lanosterol 14-alpha demethylase CYP51; EC:1.14.14.154; Cytochrome P450 51; Cytochrome P450-14DM; Cytochrome P450-LIA1; CYPLI; ergosterol biosynthetic protein 11; Lanosterol C14-C32 lyase; Sterol 14-alpha demethylase; ERG11; CYP51; YHR007C
Species:
Others
Source:
E. coli
Cat. No.: HY-184314
CAS No.: 3122934-62-4
Antifungal agent-166 is an antifungal agent. The combination of Antifungal agent-166 and Fluconazole exerts synergistic bacteriostatic effects against fluconazole-resistant Candida albicans. Antifungal agent-166 exhibits bacteriostatic activity against both Candida glabrata and Cryptococcus neoformans. Antifungal agent-166 reverses the fluconazole resistance of strains by downregulating ergosterol synthesis-related genes, drug resistance-related genes and virulence-related genes. Antifungal agent-166 can enhance the efficacy of Fluconazole in Galleria mellonella and mouse candidiasis models, reduce fungal load and improve survival rate. Antifungal agent-166 can be used in the research of fungal infections .
Cat. No.: HY-N17311
CAS No.: 243449-53-8
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Cat. No.: HY-W010201S1
Synonyms: (±)-Citronelloll-d3; (±)-β-Citronelloll-d3
Cat. No.: HY-N7435R
CAS No.: 54814-64-1
Synonyms: (±)-Massoia lactone (Standard)
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
