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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
199 Results for "
M4
" in MedChemExpress (MCE) Product Catalog:
Products (199)
199 Results for "M4" in MCE Product Catalog:
Cat. No.: HY-171981
CAS No.: 1934241-32-3
Target:
Research Areas:
VU6002703 (Compound 17) is a BBB-penetrable M4 mAChR positive allosteric modulator (PAM) with an EC50 of 0.6 μM for hM4. VU6002703 can be used for neuropsychiatric and rare genetic CNS disorders research .
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Tropicamide (Standard) is the analytical standard of Tropicamide. This product is intended for research and analytical applications. Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. Tropicamide produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops .
Cat. No.: HY-187957
Research Areas:
M1/M4 muscarinic agonist 4 is a dual-site muscarinic acetylcholine receptor ligand with potent agonistic activity at M1/M4 muscarinic acetylcholine receptors. M1/M4 muscarinic agonist 4 activates M1R to induce phosphorylation of ERK1/2, and activates M4R to induce GαoB protein activation as well as ERK1/2 phosphorylation. M1/M4 muscarinic agonist 4 exhibits higher binding affinity for M4R than for other muscarinic receptors, while its binding affinity for the W435A mutant M4R is reduced. M1/M4 muscarinic agonist 4 can be used in the research of schizophrenia .
Cat. No.: HY-P72234
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HNRNPM; CEAR; Prev. HNRPM; HnRNP M; Prev. NAGR1; Heterogenous Nuclear Ribonucleoprotein M4; HNRNPM4; N-Acetylglucosamine Receptor 1; HNRPM4; HnRNA-Binding Protein M4; HTGR1; Heterogeneous Nuclear Ribonucleoprotein M; CEA Receptor
Species:
Human
Source:
E. coli
Cat. No.: HY-167864
CAS No.: 3034840-18-8
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Research Areas:
M4K2308 is a selective ether-linked inhibitor of ALK2 with an IC50 of 2 nM. M4K2308 exhibits exceptional selectivity for ALK2 over ALK5 (IC50 of 224 nM). M4K2308 has the potential for the study of diffuse intrinsic pontine glioma (DIPG) research .
Cat. No.: HY-161377
CAS No.: 3034840-25-7
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Research Areas:
M4K2306 is a selective inhibitor for activin receptor-like kinase-2 (ALK2) with an IC50 of 7 nM. M4K2306 is blood brain permeable with a brain to plasma ratio of 75.6 .
Cat. No.: HY-161376
CAS No.: 3034840-19-9
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Research Areas:
M4K2281 is a selecitve inhibitor for activin receptor-like kinase-2 (ALK2) with an IC50 of 2 nM. M4K2281 exhibits a moderate blood brain permeability with a brain to plasma ratio of 3.7 at 4h .
Cat. No.: HY-P701226
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HNRNPM; CEAR; Prev. HNRPM; HnRNP M; Prev. NAGR1; Heterogenous Nuclear Ribonucleoprotein M4; HNRNPM4; N-Acetylglucosamine Receptor 1; HNRPM4; HnRNA-Binding Protein M4; HTGR1; Heterogeneous Nuclear Ribonucleoprotein M; CEA Receptor
Species:
Human
Source:
E. coli
Cat. No.: HY-183203
CAS No.: 1451993-12-6
Target:
Research Areas:
VU0476406 is a blood-brain barrier-permeable and selective muscarinic acetylcholine receptor subtype 4 (M4) activator with human EC50 of 91.0 nM and human pEC50 of 7.04. VU0476406 potentiates endogenous acetylcholine activity at M4 receptors. VU0476406 can be used for the research of Parkinson's disease .
Cat. No.: HY-128406
CAS No.: 1413431-46-5
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Morinidazole metabolite-1 (Compound M4-1) is a metabolite of Morinidazole (HY-15781) .
Cat. No.: HY-159829A
CAS No.: 3028447-14-2
Synonyms: NBI-1117568 citrate; HTL-0016878 citrate
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Research Areas:
Direclidine (NBI-1117568, HTL-0016878) citrate is a selective orthosteric agonist targeting the muscarinic acetylcholine M4 receptor, exhibiting very low affinity for M1, M2, M3, and M5 receptors. Direclidine citrate binds to the orthosteric site of the M4 receptor in a non-covalent, competitive manner. Direclidine citrate specifically activates the M4 receptor, inhibiting the release of acetylcholine from striatal cholinergic interneurons, thereby regulating the balance of the dopaminergic system and reducing psychiatric symptoms associated with excessive dopamine release. Direclidine citrate can improve symptoms associated with neuropsychiatric disorders and is used in research on schizophrenia and other neuropsychiatric disorders .
Cat. No.: HY-186014
CAS No.: 188707-40-6
Synonyms: DM-TAS-103
Target:
Research Areas:
IQO-X1 (DM-TAS-103) (Compound M4) is a metabolite of TAS-103 (HY-13758) .
Cat. No.: HY-183144
CAS No.: 141575-50-0
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Research Areas:
Vedaclidine is an orally active muscarinic acetylcholine receptor (mAChR) modulator with mixed receptor activity, which activates muscarinic M2 and M4 receptors and blocks muscarinic M1, M3 and M5 receptors. Vedaclidine exerts its activity through interaction with spinal M4 muscarinic receptors, and does not induce hypothermia or excessive salivation. Vedaclidine can be used in research related to pain, neuropathic pain and inflammatory pain states .
Cat. No.: HY-184172
CAS No.: 2102194-98-7
Synonyms: Merck-97
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Research Areas:
MK-97 (Merck-97) is an M4 mAChR positive allosteric modulator. MK-97 can be used for the research of neurological disorders .
Cat. No.: HY-186320
CAS No.: 1018846-42-8
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Research Areas:
Xanomeline-NH-Boc is a derivative of Xanomeline (HY-105182), which serves as the orthosteric pharmacophore of M1/M4 muscarinic agonist 4 (HY-187957) for activating mAChR1/4 .
Cat. No.: HY-126862
CAS No.: 139051-89-1
AQ-RA 721 is a muscarinic receptor antagonist with differential affinity for the m4 and M2 sites, which can be used to characterize muscarinic receptor subtypes. Other muscarinic receptor antagonists have differential affinity for the M1 (rat cerebral cortex), M2 (rat heart), M3 (rat submandibular gland), m4 (receptor expressed in Chinese hamster ovary cells transfected with CHO), and guinea pig uterine smooth muscle at the muscarinic binding site .
Cat. No.: HY-182384
CAS No.: 2264025-00-3
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Research Areas:
VU6015241 is a selective, blood-brain barrier-permeable M4 mAChR Antagonist with a Ki value of 43.3 nM. VU6015241 is used for the research of dystonia and related movement disorders .
Cat. No.: HY-119363
CAS No.: 2148929-11-5
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Research Areas:
VU6009453 (compound 15q) is a brain-penetrant M4 mAChR positive allosteric modulator (PAM) with an EC50 of 383 nM. VU6009453 can be used for research on neurological diseases .
Cat. No.: HY-181559S
Synonyms: AG06827
Target:
Research Areas:
VU6025733 (AG06827) is a highly selective, orally active and blood-brain barrier-penetrant positive allosteric modulator of the muscarinic acetylcholine receptor subtype M4 (M4 mAChR). VU6025733 exerts a potentiating effect on acetylcholine-induced receptor activation with an EC50 of 23 nM for hM4 and 55 nM for rM4. VU6025733 shows high selectivity over other muscarinic acetylcholine receptor subtypes, dose-dependently reduces amphetamine-induced hyperlocomotion in rats. VU6025733 is applicable to the research of schizophrenia, Parkinson's disease, and Alzheimer's disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
