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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
144 Results for "
Pim
" in MedChemExpress (MCE) Product Catalog:
Products (144)
144 Results for "Pim" in MCE Product Catalog:
Cat. No.: HY-RS10555
Target:
Research Areas:
Pim3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pim3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-184268
Pim-1 kinase-IN-17 is a non-orthosteric inhibitor of PIM-1 onco-protein. Pim-1 kinase-IN-17 physically interacts with PIM-1 via a non-orthosteric binding site (Kd of 1.38 μM), does not inhibit PIM-1 kinase function, and decreases PIM-1 concentration under cellular conditions. Pim-1 kinase-IN-17 reduces tumor burden. Pim-1 kinase-IN-17 can be used for the research of triple-negative breast cancer .
Cat. No.: HY-18088
CAS No.: 1036380-87-6
PIM-IN-4 is a Pim kinase inhibitor with Ki values of 2, 3, and 0.5 nM against Pim-1, 2, 3, respectively. PIM-IN-4 blocks the phosphorylation of the pro-apoptotic protein Bad. PIM-IN-4 inhibits the growth of leukemia cells. PIM-IN-4 is applicable for leukemia-related research .
Cat. No.: HY-111552R
CAS No.: 1417630-95-5
Target:
Research Areas:
PIM1-IN-1 (Standard) is the analytical standard of PIM1-IN-1 (HY-111552). This product is intended for research and analytical applications. PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC50 of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity .
Cat. No.: HY-181125
Pim-1 kinase-IN-16 is a potent PIM-1 kinase inhibitor. Pim-1 kinase-IN-16 can inhibit cancer cells proliferation, induce necrosis and late apoptosis. Pim-1 kinase-IN-16 can be used for the research of cancer, such as prostate cancer, colon cancer, lung cancer .
Cat. No.: HY-182957
CAS No.: 3081482-46-1
Research Areas:
MNK/PIM-IN-2 is a Mnk/Pim kinase inhibitor with an IC50 of 32 nM for Mnk1, 3 nM for Mnk2, and 37 nM for Pim1. MNK/PIM-IN-2 reduces the levels of p-eIF4E and p-4EBP1. MNK/PIM-IN-2 induces cell cycle arrest, apoptosis (apoptosis) and exerts antiproliferative effects in leukemia cells. MNK/PIM-IN-2 can be used in studies related to leukemia .
Cat. No.: HY-189297
Target:
Research Areas:
HDAC8/PIM1-IN-1 is a synthetic multi-target-directed ligand (MTDL) derived from 2-ureido-6-nitrobenzamide, and computational simulations predict it to be a dual-target inhibitor of HDAC8 and PIM1. HDAC8/PIM1-IN-1 holds potential for applications in research related to cancer and neurodegenerative diseases .
Cat. No.: HY-10371R
CAS No.: 1093222-27-5
Synonyms: LKB1/AAK1 dual inhibitor (Standard)
Target:
Research Areas:
Pim1/AKK1-IN-1 (Standard) is the analytical standard of Pim1/AKK1-IN-1 (HY-10371). This product is intended for research and analytical applications. Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.
Cat. No.: HY-101947R
CAS No.: 587852-28-6
Synonyms: Pim1/2 Kinase Inhibitor VI (Standard)
Target:
Research Areas:
SMI-16a (Standard) is the analytical standard of SMI-16a (HY-101947). This product is intended for research and analytical applications. SMI-16a is a selective Pim kinase inhibitor with IC50 values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, respectively.
Cat. No.: HY-P701746
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Pim2; Pim-2h; Pim-2 Proto-Oncogene, Serine/Threonine Kinase; Proto-Oncogene Pim-2 (Serine Threonine Kinase); Serine/Threonine-Protein Kinase Pim-2; Non-Specific Serine/Threonine Protein Kinase; Pim-2 Oncogene
Species:
Human
Source:
E. coli
Cat. No.: HY-P701749
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Pim3; Non-Specific Serine/Threonine Protein Kinase; Pim-3 Proto-Oncogene, Serine/Threonine Kinase; Serine/Threonine Kinase Pim-3; Serine/Threonine-Protein Kinase Pim-3; Pim-3; Pim-3 Oncogene
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P701747
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Pim2; Pim-2h; Pim-2 Proto-Oncogene, Serine/Threonine Kinase; Proto-Oncogene Pim-2 (Serine Threonine Kinase); Serine/Threonine-Protein Kinase Pim-2; Non-Specific Serine/Threonine Protein Kinase; Pim-2 Oncogene
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
