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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
99 Results for "
left
" in MedChemExpress (MCE) Product Catalog:
Products (99)
99 Results for "left" in MCE Product Catalog:
Cat. No.: HY-129511
CAS No.: 1129433-63-1
Synonyms: YM 087-d4
Conivaptan-d4 (YM 087-d4) is the deuterated-labeled Conivaptan (HY-18347). Conivaptan (YM 087 free base) is an orally active dual vasopressin V1a/V2 receptor antagonist with Ki values of 0.48 nM and 3.04 nM for vasopressin V1a receptor and V2 receptor, respectively. Conivaptan competitively and reversibly blocks vasopressin-mediated antidiuresis, vasoconstriction, and cellular hypertrophy, while inhibiting CYP3A4. Conivaptan inhibits vasopressin-induced intracellular calcium, cAMP, and mitogen-activated kinase activation in vascular smooth muscle cells and cardiomyocytes. Conivaptan induces water diuresis while improving hemodynamics in heart failure models, reducing left ventricular end-diastolic pressure, vascular resistance, and organ weight. Conivaptan is used for research on hyponatremia and congestive heart failure .
Cat. No.: HY-P4890A
Target:
RXFP Receptor Reactive Oxygen Species (ROS) Pyroptosis Caspase Interleukin Related TGF-beta/Smad AMPK Apoptosis
Research Areas:
Cat. No.: HY-B0331S1
CAS No.: 1356847-94-3
Synonyms: MK-421-d3
Cat. No.: HY-P70191
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: leftY2; left-Right Determination Factor A; Prev. TGFB4; Protein lefty-2; Prev. EBAF; Protein lefty-A; leftYA; TGF-Beta-4; leftA; Endometrial Bleeding Associated Factor (left-Right Determination, Factor A; Transforming Growth Factor Beta Superfamily); Endo
Species:
Human
Source:
HEK293
Cat. No.: HY-118991
CAS No.: 47487-05-8
Target:
Research Areas:
KT-1 is a vasodilator. KT 1 can decrease aortic pressure, renal blood flow, left ventricular enddiastolic pressure and resistances of total peripheral, vertebral, coronary and renal vasculatures and increase aortic blood flow, vertebral blood flow, coronary blood flow, peak positive left ventricular dP/dt and heart rate in anesthetized open-chest dogs. KT-1 can be used for the research of cardiovascular disease .
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Erythrityl tetranitrate (Tetranitrate; Nitroerythrite), a nitrate ester, is a long-acting vasodilator with properties similar to nitroglycerin. Erythrityl tetranitrate decreases the counter load of the heart and improvement of the pump function of left ventricle in an acute experiment in case of chronic cardiac insufficiency with stasis .
Cat. No.: HY-P3776
CAS No.: 87549-53-9
Target:
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Cat. No.: HY-106369R
CAS No.: 223749-46-0
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HMR 1556 (Standard) is the analytical standard of HMR 1556 (HY-106369). This product is intended for research and analytical applications. HMR 1556, a chromanol derivative, is a potent IKs blocker with IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively .
Cat. No.: HY-19088
CAS No.: 114856-44-9
Synonyms: CID-3047798
Research Areas:
Oberadilol (CID-3047798) is a Phosphodiesterase III inhibitor, non-selective β-adrenergic receptor blocker, vasodilator and positive inotropic agent. Oberadilol reduces left ventricular end-diastolic volume. Oberadilol is used in research related to chronic congestive heart failure and SARS-CoV-2 infection .
Cat. No.: HY-188045
Research Areas:
AS3513678 is a positive allosteric modulator of skeletal muscle-type nicotinic acetylcholine receptor (m-nAChR). AS3513678 promotes acetylcholine (ACh) signaling via m-nAChR, shifts the ACh concentration-response curve to the left, and does not activate the receptor in the absence of ACh. AS3513678 can be used for research on myasthenia gravis and congenital myasthenic syndrome .
Cat. No.: HY-19088A
CAS No.: 114856-47-2
Synonyms: CID-3047798 (monoethyl maleate); TZC 5665
Research Areas:
Oberadilol monoethyl maleate (CID-3047798 monoethyl maleate) is a Phosphodiesterase III inhibitor, non-selective β-adrenergic receptor blocker, vasodilator and positive inotropic agent. Oberadilol monoethyl maleate reduces left ventricular end-diastolic volume. Oberadilol monoethyl maleate is used in research related to chronic congestive heart failure and SARS-CoV-2 infection .
Cat. No.: HY-106458
CAS No.: 22609-73-0
Synonyms: Bay a 7168
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Niludipine (Bay a 7168) is an orally active calcium channel blocker and vasodilator with antihypertensive effects. Niludipine can improve early fatal ventricular arrhythmias induced by acute myocardial ischemia in rats. Niludipine can reduce left ventricular systolic and diastolic loads during pacing-induced angina pectoris. Niludipine can be used in the research of cardiovascular diseases such as coronary heart disease and myocardial ischemia .
Cat. No.: HY-177762
CAS No.: 3103594-37-9
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Pan-RAS-IN-8 (Page 152, third row, third from left to right) is a pan-RAS inhibitor. Pan-RAS-IN-8 blocks the binding of RAS to downstream effector molecules by forming a ternary complex, thereby inhibiting the activation of the MAPK and PI3K-AKT signaling pathways. Pan-RAS-IN-8 can be used for the research of cancer, inflammatory diseases and autoimmune diseases .
Cat. No.: HY-106509R
CAS No.: 77858-21-0
Synonyms: BW 12C (Standard); 12C79 (Standard); BW 12C79 (Standard)
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Velaresol (Standard) is the analytical standard of Velaresol. This product is intended for research and analytical applications. Velaresol (BW 12C) is a small molecule oxyhemoglobin stabilizer. Velaresol stabilizes hemoglobin’s oxy-conformation, shifts oxygen dissociation curves left, induces tumor hypoxia, alters radiosensitivity, protects normal tissues from radiation damage, and reduces sickled cell counts. Velaresol can be used for the research of cancer and sickle cell disease .
Cat. No.: HY-106961R
CAS No.: 176391-41-6
Synonyms: ONO-AP 500-02 (Standard)
Research Areas:
ONO 1301 (Standard) (ONO-AP 500-02 (Standard)) is the analytical standard of ONO 1301 (HY-106961). This product is intended for research and analytical applications. ONO 1301 (ONO-AP 500-02), a prostaglandin (PG) I2 mimetic, is an orally active, long-acting prostacyclin agonist with thromboxane-synthase inhibitory activity. ONO 1301 promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig .
Cat. No.: HY-112654R
CAS No.: 2183470-12-2
Research Areas:
GCN2iB (Standard) is the analytical standard of GCN2iB (HY-112654). This product is intended for research and analytical applications. GCN2iB is an ATP-competitive, selective GCN2 inhibitor with an IC50 of 2.4 nM. GCN2iB inhibits the activation of the GCN2 pathway and upregulates GPX4. GCN2iB enhances the anticancer effect of ASNase against acute lymphoblastic leukemia. GCN2iB increases left ventricular ejection fraction, while reducing fasting blood glucose and myocardial fibrosis. GCN2iB can be used in research related to acute lymphoblastic leukemia, acute myeloid leukemia and diabetic cardiomyopathy .
Cat. No.: HY-124940
CAS No.: 446877-42-5
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CPU-228 is a complex class III antiarrhythmic agent. CPU-228 concentration-dependently blocks the activities of the rapid component 50 of the delayed rectifier potassium channel (IKr) and the L-type calcium channel (ICa,L), with an IC50 value of 0.909 μM for ICa,L current. CPU-228 produces negative inotropic effects and induces mild, non-frequency-dependent prolongation of the effective refractory period (ERP) in isolated left atria. CPU-228 reduces the incidence of torsades de pointes (TDP) in anesthetized rabbits and inhibits ischemia/reperfusion-induced arrhythmias in rats. CPU-228 can be used in studies related to torsades de pointes .
Cat. No.: HY-107428R
CAS No.: 199850-67-4
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Research Areas:
PD-166793 (Standard) is the analytical standard of PD-166793 (HY-107428). This product is intended for research and analytical applications. PD-166793 is a potent, selective, orally active and wide-broad spectrum inhibitor of MMP, exhibiting nanomolar potency against MMP-2, MMP-3 and MMP-13 (IC50=4, 7, and 8 nM, respectively) and micromolar potency vs MMP-1, -7 and -9 (IC50=6.0, 7.2, and 7.9 μM, respectively). PD-166793 can attenuate left ventricular remodeling and dysfunction in a rat model of progressive heart failure .
Cat. No.: HY-18729B
CAS No.: 141968-19-6
Synonyms: NG-Nitro-D-arginine methyl ester
Target:
Research Areas:
D-NAME (NG-Nitro-D-arginine methyl ester) is an orally active enantiomer of L-NAME (HY-18729). D-NAME inhibits Nitric oxide synthase activity in myocardium and aorta (Note: D-NAME was once classified as an inactive substance and used as a negative control in nitric oxide synthase inhibition studies), induces increases in systolic blood pressure and mean arterial blood pressure, reduces mesenteric arterial conductance, elevates the ratio of left ventricular weight to body weight, induces myocardial fibrosis, increases the cross-sectional area of aortic wall, enhances mesenteric vasodilation induced by nitrovasodilators, and releases nitric oxide via its guanidino nitro group. D-NAME has no effect on ovalbumin-induced pulmonary eosinophilia in sensitized mice. D-NAME can be used in hypertension-related research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
