Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
397 Results for "
Complement
" in MedChemExpress (MCE) Product Catalog:
Products (397)
397 Results for "Complement" in MCE Product Catalog:
Cat. No.: HY-145720A
Purity: 96.02%
Synonyms: ALN-CC5 sodium
Research Areas:
Cemdisiran sodium (ALN-CC5 sodium) is an N-acetylgalactosamine-conjugated RNAi agent and also a complement component C5 inhibitor. Cemdisiran sodium targets C5 mRNA, cleaves C5 mRNA via the endogenous RNA interference pathway, and inhibits the production of C5 protein in the liver. Cemdisiran sodium exerts a dose-dependent inhibitory effect on total C5 concentrations in cynomolgus monkeys. When used in combination with Pozelimab (HY-P99786) in cynomolgus monkeys, Cemdisiran sodium achieves a more sustained and complete inhibitory effect on complement activity. Cemdisiran sodium can be used in the research of paroxysmal nocturnal hemoglobinuria and other complement-mediated diseases .
Cat. No.: HY-N12189
CAS No.: 18376-53-9
Target:
Cat. No.: HY-P1398
CAS No.: 301544-78-5
Target:
Research Areas:
Target:
Research Areas:
FD-IN-1 (Compound 12) is an orally bioavailable and selective factor D (FD) inhibitor with an IC50 of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5 µM, respectively .
Cat. No.: HY-P990952
CAS No.: 2527079-60-1
Synonyms: OMS906
Target:
Research Areas:
Cat. No.: HY-N7401
CAS No.: 138916-58-2
Target:
Cat. No.: HY-P10274
CAS No.: 3037805-45-8
Target:
Research Areas:
Cat. No.: HY-P1398A
Target:
Research Areas:
Cat. No.: HY-E70390
Synonyms: masp-2, c1 esterase, c1-esterase
Target:
Research Areas:
C1s Enzyme is a subunit of the complement C1 complex, which activates the complement as a serine protease. C1s Enzyme cleaves LRP5 and LRP6, and thus activates the Wnt/β-Catenin signaling pathway. C1s Enzyme promotes the macrophage M2 polarization and inhibits M1 polarization. C1s Enzyme enhances efferocytosis, exhibits anti-inflammatory activity .
Cat. No.: HY-N12265
CAS No.: 108885-62-7
Category:
Human Gut Microbiota Metabolites Plant Terpenoids Sesquiterpenes Violaceae Extract Viola philippica Cav. Extract Endogenous metabolite
Target:
Cat. No.: HY-160901
CAS No.: 1349637-14-4
Target:
Research Areas:
CP-289,503 is an inhibitor of the complement C5a receptor with an IC50 of 1 μM. C5a acts as an activator of leukocytes and phagocytes during complement system activation. The C5a receptor can bind to C5a, which can stimulate the upregulation of cell surface integrins and degranulation of inflammatory cells, leading to endothelial cell damage. C5a receptor inhibitors can block C5a signaling and inhibit a variety of inflammatory diseases .
Cat. No.: HY-P991067
CAS No.: 2724922-85-2
Synonyms: KP-104
Target:
Research Areas:
Cat. No.: HY-P88245A
Synonyms: Complement C1r subcomponent; Complement component 1 subcomponent r; C1R
Target:
Research Areas:
Solasulfone (Solapsone; Sulfetrone) is an inhibitor of complement protein C1q and β-lactamase. Solasulfone also acts as a chemotherapeutic agent and can be used in cancer research .
Cat. No.: HY-E70389
Target:
Research Areas:
Human Kallikrein is a serine protease that can be found in plasma and tissue. Human Kallikrein has the potential for the research of blood pressure, complement activation, and mediation and maintenance of inflammatory responses .
Cat. No.: HY-N19128
CAS No.: 1476801-10-1
Category:
Triterpenes Plant Terpenoids Pulsatilla chinensis (Bunge) Regel Extract Ranunculaceae Extract
Target:
Cat. No.: HY-W587516
CAS No.: 10040-44-5
Target:
Research Areas:
Bisphenol A bissulfate disodium is a metabolite of Bisphenol A (HY-18260) . Bisphenol A bissulfate disodium (compound 7) show complement-inhibiting activity with an IC50 of 247 μM .
Cat. No.: HY-P990025
CAS No.: 2579031-19-7
Synonyms: ARGX-117
Target:
Research Areas:
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
