370 Results for "

Complement

" in MedChemExpress (MCE) Product Catalog:
Products (370)

370 Results for "Complement" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-P1345A
Target:  

Complement System

Research Areas:  

Neurological Disease Endocrinology

TLQP-21 TFA, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor1 (C3aR1) agonist (EC50: mouse TLQP-21=10.3 μM; human TLQP-21=68.8μM). TLQP-21 TFA activates C3aR1 to induce an increase of intracellular Ca 2+. TLQP-21 TFA is used for the research in regulation of nociception and other relevant physiologic functions .
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2
2 Cited Publications
Cat. No.: HY-139588
CAS No.: 2086178-00-7
Purity:  98.61%
Synonyms: ALXN2050; ACH 0145228; ACH-5228
Vemircopan (ALXN2050) is an orally active complement factor D (FD) inhibitor. Vemircopan can be used in the research of diseases such as myasthenia gravis, lupus nephritis, IgA nephropathy, and paroxysmal nocturnal hemoglobinuria .
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2
2 Cited Publications
Cat. No.: HY-P70485
Purity:  ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: VTN; Vitronectin; VN; Serum Spreading Factor; Serum-Spreading Factor; Complement S-Protein; Somatomedin B; S-Protein; V75; Vitronectin (Serum Spreading Factor, Somatomedin B, Complement S-Protein); Epibolin; VNT
Species:  
Human
Source:  
HEK293
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2
2 Cited Publications
Cat. No.: HY-N9481
CAS No.: 56411-57-5
Lipoteichoic acid is an orally effect anti-inflammatory and antitumor agent. Lipoteichoic acid is a crucial immune molecule in Gram-positive bacteria that activates the complement system by inducing C3 and inhibiting CD55. Lipoteichoic acid regulates macrophage autophagy through the PI3K/Akt/mTOR pathway. Lipoteichoic acid induces lung damage in mice. Lipoteichoic acid inhibits the production of melanin .
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2
2 Cited Publications
Cat. No.: HY-A0183
CAS No.: 1446756-47-3
Synonyms: Phospholipids, phosphatidylserines; Serine glycerophosphatides
Category:  

Animals

Target:  

Akt TGF-β Receptor

Phosphatidylserine (Phospholipids) is a well-conserved anti-inflammatory and immunosuppressive signal. Phosphatidylserine is involved in membrane translocation and the activation of protein kinase C, participating in Akt signaling through its interaction with PIP3. The local exposure of Phosphatidylserine can interact with complement and other proteins, promoting microglial phagocytosis during critical periods of synaptic refinement. Phosphatidylserine can promote blood coagulation in the extracellular environment and acts as a "eat me" signal to clear out apoptotic cells. Phosphatidylserine can suppress inflammation in tissues by inducing TGF-β secretion and inhibiting immune responses .
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1
1 Cited Publications
Cat. No.: HY-128342
CAS No.: 2365402-67-9
Purity:  99.14%
Target:  

Complement System

Research Areas:  

Inflammation/Immunology

Complement C5-IN-1 is a Complement C5 inhibitor with an IC50 of less than 0.005 μM in serum inhibition assays. Complement C5-IN-1 stabilizes the α-helical conformation, thereby burying the cleavage site and preventing cleavage of C5 by C5 convertase. Complement C5-IN-1 inhibits membrane attack complex deposition in human serum and whole blood complement activation assays. Complement C5-IN-1 can be used in research related to complement-mediated diseases, such as paroxysmal nocturnal hemoglobinuria .
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1
1 Cited Publications
Cat. No.: HY-P1505A
Synonyms: Complement 3a (70-77) TFA
Target:  

Complement System

Research Areas:  

Inflammation/Immunology

C3a (70-77) TFA (Complement 3a (70-77) TFA) is an octapeptide corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a .
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1
1 Cited Publications
Cat. No.: HY-P74375
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: C2; Complement Component 2; Complement C2; Complement Protein; C3/C5 Convertase; ARMD14; Complement Component C2; CO2
Species:  
Human
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P75464
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: C1QB; Complement Subcomponent C1q Chain B; Complement C1q B Chain; Complement C1q Chain B; Complement Component 1, Q Subcomponent, Beta Polypeptide; Complement Component C1q, B Chain; Complement Component 1, Q Subcomponent, B Chain; C1QD2; Complement C1q
Species:  
Human
Source:  
Sf9 insect cells
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1
1 Cited Publications
Cat. No.: HY-P81185
Synonyms: C5; C6; C7; C8; C9; Complement component 5; Complement component 6; Complement component 7; Complement component 8; Complement component 9; MAC; Membrane attack complex; TCC; Terminal Complement complex.

Host:  

Rabbit

Application:  

WB, IHC-P, IHC-F, ICC/IF

Reactivity:  

Human, Rat

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1
1 Cited Publications
Cat. No.: HY-P7864
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: C5; C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 4; Complement C5; C5a Anaphylatoxin; CPAMD4; Prepro-C5; Complement Component 5; Anaphylatoxin C5a Analog; C5a; ECLZB; C5b; C5D
Species:  
Human
Source:  
E. coli
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1
1 Cited Publications
Cat. No.: HY-P700862
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: C5; C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 4; Complement C5; C5a Anaphylatoxin; CPAMD4; Prepro-C5; Complement Component 5; Anaphylatoxin C5a Analog; C5a; ECLZB; C5b; C5D
Species:  
Human
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P78247
Purity:  ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: C3; Complement Component 3; Complement C3; C3a Anaphylatoxin; CPAMD1; Prepro-C3; ARMD9; Epididymis Secretory Sperm Binding Protein Li 62p; C3a; Acylation-Stimulating Protein Cleavage Product; C3b; HEL-S-62p; C3 And PZP-Like Alpha-2-Macroglobulin Domain-Co
Species:  
Mouse
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P72137
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CFB; Complement Factor B Preproprotein; Prev. BFD; Glycine-Rich Beta Glycoprotein; Prev. BF; C3 Proaccelerator; Properdin Factor B; C3 Proactivator; C3/C5 Convertase; ARMD14; H2-Bf; AHUS4; B-Factor, Properdin; FBI12; Properdin B; CFAB; PBF2; CFBD; GBG; FB
Species:  
Mouse
Source:  
E. coli
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1
1 Cited Publications
Cat. No.: HY-P71718
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: C1QA; Complement Component 1, Q Subcomponent, A Chain; Complement C1q A Chain; Complement C1q Chain A; Complement C1q Subcomponent Subunit A; Complement Component C1q, A Chain; Complement Component 1, Q Subcomponent, Alpha Polypeptide; C1QD1
Species:  
Mouse
Source:  
P. pastoris
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1
1 Cited Publications
Cat. No.: HY-P3204
CAS No.: 934461-40-2
Synonyms: AL-78898A
Target:  

Complement System

Research Areas:  

Metabolic Disease

POT-4 (AL-78898A), a Compstatin derivative, is a potent inhibitor of complement factor C3 activation. POT-4 can be used for age-related macular degeneration research
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1
1 Cited Publications
Cat. No.: HY-P73484
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: VTN; Vitronectin; VN; Serum Spreading Factor; Serum-Spreading Factor; Complement S-Protein; Somatomedin B; S-Protein; V75; Vitronectin (Serum Spreading Factor, Somatomedin B, Complement S-Protein); Epibolin; VNT
Species:  
Mouse
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P99905
CAS No.: 2375661-82-6
Synonyms: IBI302

Target:  

VEGFR

Efdamrofusp alfa is a bispecific fusion protein. Efdamrofusp alfa is capable of neutralizing both VEGF isoforms and C3b/C4b. Efdamrofusp alfa can be used for the research of neovascular age-related macular degeneration (nAMD) and other complement-related ocular conditions .
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1
1 Cited Publications
Cat. No.: HY-P99730
CAS No.: 2227490-52-8
Synonyms: TAK-079

Target:  

CD38 Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Mezagitamab (TAK-079) is a IgG1λ anti-CD38 monoclonal antibody. Mezagitamab depletes tumor cells expressing CD38 through antibody and complement dependent cytotoxicity. Mezagitamab has potential application in relapsed/refractory multiple myeloma (RRMM) and idiopathic thrombocytopenic purpura (ITP) .
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1
1 Cited Publications
Cat. No.: HY-119442
CAS No.: 143816-42-6
Target:  

Leukotriene Receptor

Research Areas:  

Cardiovascular Disease

Quininib is a cysteinyl leukotriene 1 and 2 receptor antagonist with IC50s of 1.2 and 52 μM for CysLT1R and CysLT2R, respectively. Quininib is a potent inhibitor of developmental angiogenesis in the zebrafish eye. Quininib can be used for the research of ocular neovascular pathologies and may complement current anti-VEGF biological agents .
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