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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
396 Results for "
Complement
" in MedChemExpress (MCE) Product Catalog:
Products (396)
396 Results for "Complement" in MCE Product Catalog:
1
Research Areas:
1
1 Cited Publications
Cat. No.: HY-119442
CAS No.: 143816-42-6
Target:
Research Areas:
Quininib is a cysteinyl leukotriene 1 and 2 receptor antagonist with IC50s of 1.2 and 52 μM for CysLT1R and CysLT2R, respectively. Quininib is a potent inhibitor of developmental angiogenesis in the zebrafish eye. Quininib can be used for the research of ocular neovascular pathologies and may complement current anti-VEGF biological agents .
1
1
1 Cited Publications
Cat. No.: HY-P7535
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CLU; Complement-Associated Protein SP-40,40; Prev. APOJ; Complement Lysis Inhibitor; Prev. CLI; Ku70-Binding Protein 1; Apolipoprotein J; NA1/NA2; TRPM-2; Clusterin (Complement Lysis Inhibitor, SP-40,40, Sulfated Glycoprotein 2, Testosterone-Repressed Prostate Message 2, Apolipoprotein J); SGP-2; Epididymis Secretory Sperm Binding Protein; KUB1; Aging-Associated Gene 4 Protein; Testosterone-Repressed Prostate Message 2; Aging-Associated Protein 4; Sulfated Glycoprotein 2; APO-J; SP-40; Apo-J; CLU2; SGP2; CLU1; AAG4; Clusterin; Complement Cytolysis Inhibitor
Species:
Human
Source:
HEK293
1
1
1 Cited Publications
Cat. No.: HY-P9976
CAS No.: 1461640-62-9
Synonyms: ch38SB19; hu38SB19; SAR-650984
1
1 Cited Publications
Cat. No.: HY-N0899
CAS No.: 11088-09-8
1
1 Cited Publications
Cat. No.: HY-153229
Target:
Research Areas:
Firefly luciferase mRNA-LNP is a lipid nanoparticle (LNP) containing firefly luciferase mRNA. Firefly luciferase mRNA-LNP exhibits a stable nanostructure, in which LNP plays a key role in effectively protecting and transporting mRNA to cells. Luciferase is a bioluminescent reporter gene for gene regulation and functional studies. Firefly Luciferase mRNA-LNP expresses firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Firefly luciferase mRNA-LNP is studied in research for RNA delivery, cell viability, and translation efficiency .
1
1 Cited Publications
Cat. No.: HY-P9976A
CAS No.: 1461640-62-9
1
1 Cited Publications
Cat. No.: HY-P7691
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD93; DJ737E23.1; Prev. C1QR1; ECSM3; Prev. MXRA4; Matrix-Remodeling-Associated Protein 4; C1qR(P); Matrix-Remodelling Associated 4; CDw93; C1qR; Complement Component 1 Q Subcomponent Receptor 1; Complement Component 1, Q Subcomponent, Receptor 1; Complem
Species:
Human
Source:
HEK293
1
Target:
Research Areas:
1
1 Cited Publications
Cat. No.: HY-P76185
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: C1QBP; Splicing Factor SF2-Associated Protein; Prev. HABP1; ASF/SF2-Associated Protein P32; Complement Component 1 Q Subcomponent-Binding Protein, Mitochondrial; Glycoprotein GC1qBP; Mitochondrial Matrix Protein P32; SF2AP32; Hyaluronan-Binding Protein 1
Species:
Mouse
Source:
E. coli
Synonyms: ARC1905
Target:
Research Areas:
Avacincaptad pegol (ARC1905) sodium is a 40KDa PEG-conjugated aptamer. Avacincaptad pegol sodium targets complement factor 5 (C5), inhibits the cleavage of C5 into C5a and C5b, limits inflammatory stimulation and complement membrane attack complex (MAC), and is used to study age-related macular degeneration (AMD). Avacincaptad pegol sodium limits irregular cell apoptosis by targeting downstream factors in the complement cascade while preserving the early steps of the complement system .
Cat. No.: HY-NP004
Synonyms: CVF
Target:
Research Areas:
Cobra Venom Factor (CVF) is a selective activator targeting complement components C3, C5, and factor B in the complement system. After binding to factor B, Cobra Venom Factor is cleaved by factor D, forming a stable C3/C5 convertase resistant to regulatory proteins H and I. This continuously hydrolyzes C3 and C5, depleting serum complement while inducing neutrophil migration, vascular leakage, and increased TNF-α levels. Cobra Venom Factor can be used to deplete complement and mimic complement activation-related pathological states, and is applied in animal models of complement-mediated diseases such as acute respiratory distress syndrome (ARDS), sepsis, and shock. Cobra Venom Factor can be isolated from the venom of cobras (e.g., Naja atra, Naja melanoleuca, Naja kaouthia, etc.) .
Cat. No.: HY-P99358
CAS No.: 1662664-56-3
Synonyms: GSK 2398852; Anti-Serum Amyloid P/SAP Reference Antibody (dezamizumab)
Target:
Research Areas:
Cat. No.: HY-149278
CAS No.: 3033831-40-9
Target:
Research Areas:
Complement C1s-IN-1 is a potent, selective, orally active and cross the blood-brain barrier C1s inhibitor with an IC50 value of 36 nM .
Target:
Research Areas:
Complement factor D-IN-1 is a potent and selective small-molecule reversible factor d inhibitor, with IC50s of 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively.
Cat. No.: HY-NP0194C
and non-immune cells. C1q Protein (rat) can be used for the research of mutiple disease .
Cat. No.: HY-177611
CAS No.: 2985646-78-2
Target:
Research Areas:
Agazisiran, a siRNA,is a complement factor B synthesis reducer.
Cat. No.: HY-177094
CAS No.: 2489430-53-5
Synonyms: INF056
Target:
Research Areas:
Izicopan (INF056) is a complement factor C5a receptor (C5aR1) antagonist. Izicopan inhibits C5a-induced calcium mobilization with an IC50 of 10-100 nM. Izicopan is applicable for the research of complement-mediated inflammatory responses .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
