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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
3-AP
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "3-AP" in MCE Product Catalog:
11
11 Publications Verification
Synonyms: 3-AP; PAN-811; OCX191
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Triapine (3-AP; PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer.
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Human Gut Microbiota Metabolites Natural Products Microorganisms Neurological Disease Endogenous metabolite Disease Research Fields Cancer
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Cat. No.: HY-108546
CAS No.: 23052-80-4
Synonyms: 3-Phosphono-L-alanine
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L-AP3, metabotropic glutamate receptor (mGluR) antagonist, inhibits D-phosphoserine and L-phosphoserine with IC50s of 368 μM and 2087 μM, respectively .
Cat. No.: HY-10082B
CAS No.: 216240-62-9
Synonyms: 3-AP hydrochloride; PAN-811 hydrochloride; OCX191 hydrochloride
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Triapine (hydrochloride) is the hydrochloride form of Triapine (HY-10082). Triapine (3-AP; PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer .
Cat. No.: HY-10082A
CAS No.: 200933-27-3
Synonyms: (E)-PAN-811; (E)-NSC# 663249; (E)-OCX191
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(E)-3-AP is the E configuration of 3-AP. 3-AP is a potent ribonucleotide reductase inhibitor. 3-AP shows anti-proliferative activity. 3-AP shows anticancer activity in L1210 leukemia model. 3-AP inhibits RR activity and DNA synthesis .
Cat. No.: HY-10082R
CAS No.: 143621-35-6
Synonyms: 3-AP (Standard); PAN-811 (Standard); OCX191 (Standard)
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Triapine (Standard) is the analytical standard of Triapine (HY-10082). This product is intended for research and analytical applications. Triapine (3-AP; PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer.
Cat. No.: HY-138844
CAS No.: 1184391-57-8
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3-AP-Me is a dimethyl derivative of the nucleotide reductase inhibitor 3-AP (SML0568). 3-AP-Me can activate the endoplasmic reticulum (ER) stress pathway by promoting the phosphorylation of eIF2α and increasing the gene expression of transcription factors ATF4 and ATF6, leading to cell apoptosis. Additionally, 3-AP-Me can activate the stress kinases c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases. 3-AP-Me also leads to the upregulation of the spliced mRNA variant XBP1, can be used in cancer research .
Cat. No.: HY-10082S1
Synonyms: 3-AP-d3; PAN-811-d3; OCX191-d3
Cat. No.: HY-P2434
CAS No.: 846569-60-6
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Cat. No.: HY-RS08236
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MCM3AP Human Pre-designed siRNA Set A contains three designed siRNAs for MCM3AP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS10510
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PIK3AP1 Human Pre-designed siRNA Set A contains three designed siRNAs for PIK3AP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS22016
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Pik3ap1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pik3ap1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS28534
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Pik3ap1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pik3ap1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P11606
Cat. No.: HY-184176
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DBCO-PEG3-AP1867 is a bifunctional molecular building block that binds to FKBP12 F36V, and also a SPAAC-compatible reagent suitable for synthesizing O-GlcNAcylation-targeting chimeras (OGTACs) against c-Myc. DBCO-PEG3-AP1867 is applicable to cancer-related research .
Cat. No.: HY-181500
Research Areas:
AP1867-NH-PEG3-acid (Compound S15) is a Target Protein Ligand-Linker Conjugate that contains the FKBP12 F36V ligand AP1867 (HY-114434) and a PROTAC linker, and recruits E3 ligase. JQ-1-Azidopropylamine is available for the synthesis of PROTAC RAFKBP12 (HY-181498) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
