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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
29 Results for "
CD74
" in MedChemExpress (MCE) Product Catalog:
Products (29)
29 Results for "CD74" in MCE Product Catalog:
7
1
Cat. No.: HY-P11303
CAS No.: 161147-59-7
Research Areas:
Cat. No.: HY-P990728
CAS No.: 2763746-69-4
Synonyms: SP-7219; STRO-001 Antibody
Target:
Research Areas:
Cat. No.: HY-RS02266
Target:
Research Areas:
CD74 Human Pre-designed siRNA Set A contains three designed siRNAs for CD74 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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SPL-410 is an orally active, highly potent and selective hydroxyethylamine based SPPL2a (Signal Peptide Peptidase Like 2a) inhibitor, with an IC50 of 9 nM .
Cat. No.: HY-N2245
CAS No.: 98619-25-1
Category:
Plant Monophenols Lignans Schisandra chinensis (Turcz.) Baill. Extract Phenols Phenylpropanoids Schisandraceae Extract Disease Research Fields Cancer
Target:
Cat. No.: HY-P1826
CAS No.: 648881-58-7
Target:
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Cat. No.: HY-159147
CAS No.: 2570251-69-1
Target:
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SIAIS039 is an orally active c-ros oncogene 1 (ROS1)-specific PROTAC with DC50s of 154.46 nM, 126.47 nM, 143.69 nM for HCC78 cells, Ba/F3 expressing the CD74-ROS1 fusion and Ba/F3 expressing the SDC4-ROS1 fusion, respectively. SIAIS039 suppresses cell proliferation, induces cell cycle arrest and apoptosis, and inhibits clonogenicity against ROS1-positive cells. SIAIS039 demonstrates anti-tumour effects against ROS1-driven tumor growth vivo. SIAIS039 is composed of the ALK inhibitor Brigatinib (HY-12857), a linker EM-12 (HY-138793), and a VHL ligand E3 ubiquitin ligase 1-Butyne (Red: Brigatinib; Blue: VHL ligand; Black: linker) .
Synonyms: N-Vanillylarachidonamide
Research Areas:
Arvanil (N-Vanillylarachidonamide) is a mixed agonist of CB1 and TRPV1 receptors. Arvanil downregulates CD25, HLA-DR, CD134/OX40, blocks G1/S phase transition, and induces phosphorylation of Akt. Arvanil does not induce apoptosis in cells. Arvanil inhibits lymphocyte activation and ameliorates autoimmune encephalomyelitis. Arvanil can be used in research related to Huntington's disease, vomiting, and multiple sclerosis .
The product specifications provided below refer solely to the active content of Arvanil.
The product specifications provided below refer solely to the active content of Arvanil.
Cat. No.: HY-RS16600
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Cd74 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cd74 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23034
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Cd74 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cd74 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Synonyms: PG 701; LLDT-8; 5α-Hydroxytriptolide
Research Areas:
(5R)-5-Hydroxytriptolide (PG 701) is an orally active, CNS-penetrant NF-κB and TLR4 inhibitor. (5R)-5-Hydroxytriptolide suppresses IκB degradation, NF-κB nuclear translocation, inhibits NO release and pro-inflammatory cytokine expression. (5R)-5-Hydroxytriptolide upregulates Tp53 transcription, induces p53-mediated apoptosis. (5R)-5-Hydroxytriptolide can be used for the research of cerebral ischemia/reperfusion injury, non-small cell lung cancer brain metastasis, and rheumatoid arthritis .
Cat. No.: HY-156086
CAS No.: 2937544-01-7
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TRK-IN-24 (compound 10g) is a Trk Receptor inhibitor that inhibits TRKA, TRKC, TRKA G595R, TRKA G667C and TRKA F589L IC50s are 5.21, 4.51, 6.77, 1.42 and 6.13 nM respectively. TRK-IN-24 has antitumor efficacy in BaF3-CD74-NTRK1 G595R and BaF3-CD74-NTRK1 G667C xenograft models. TRK-IN-24 inhibits the proliferation of Ba/F3 cells transfected with single mutants such as SF, GK, and xDFG, with an IC50 of 1.43-47.56 nM .
Cat. No.: HY-126287
CAS No.: 2366216-76-2
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JND4135 is a Type II TRK inhibitor with IC50 values of 2.79, 3.19, and 3.01 nM against TRKA, TRKB, TRKC, respectively. JND4135 can overcome resistance from TRK xDFG and other mutant forms in the BaF3 stable model, inhibiting phosphorylation of both WT and xDFG mutant TRKs, along with their downstream signaling molecules. JND4135 can induce G0/G1 phase arrest and apoptosis in BaF3–CD74-TRKA-G667C cells. JND4135 shows tumor growth inhibition activity in the BaF3-CD74-TRKA-G667C mouse xenograft model .
Cat. No.: HY-P705402
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD74; Ia-Associated Invariant Chain; Prev. DHLAG; HLA-DR-Gamma; CLIP; Ia Antigen-Associated Invariant Chain; CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex, Class II Antigen-Associated); CD74 Antigen; CD74 Molecule, Major Histocom
Species:
Human
Source:
HEK293
Cat. No.: HY-P78262
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CD74; Ia-Associated Invariant Chain; Prev. DHLAG; HLA-DR-Gamma; CLIP; Ia Antigen-Associated Invariant Chain; CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex, Class II Antigen-Associated); CD74 Antigen; CD74 Molecule, Major Histocom
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P72931
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CD74; Ia-Associated Invariant Chain; Prev. DHLAG; HLA-DR-Gamma; CLIP; Ia Antigen-Associated Invariant Chain; CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex, Class II Antigen-Associated); CD74 Antigen; CD74 Molecule, Major Histocom
Species:
Human
Source:
HEK293
Cat. No.: HY-146807
CAS No.: 2937543-72-9
Target:
Research Areas:
Type II TRK inhibitor 1 is a potent TRK inhibitor, which inhibits various TRK fusion protein variants and wild type. Type II TRK inhibitor 1 exhibits antiproliferative activity against Ba/F3 cells harboring CD74-TRKA G667C and ETV6-TRKC G696C fusion proteins with IC50s of 6 nM and 1.7 nM, respectively . Type II TRK inhibitor 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-P72710
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD74; Ia-Associated Invariant Chain; Prev. DHLAG; HLA-DR-Gamma; CLIP; Ia Antigen-Associated Invariant Chain; CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex, Class II Antigen-Associated); CD74 Antigen; CD74 Molecule, Major Histocom
Species:
Mouse
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
