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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
100 Results for "
CLL
" in MedChemExpress (MCE) Product Catalog:
Products (100)
100 Results for "CLL" in MCE Product Catalog:
51
51 Publications Verification
Synonyms: Mitozantrone; NSC 301739
Category:
Target:
51
51 Publications Verification
Synonyms: Mitozantrone dihydrochloride; NSC 301739 dihydrochloride
37
Target:
Research Areas:
Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL). Acalabrutinib can be used for CLL research . Acalabrutinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
5
5 Cited Publications
Synonyms: TGR-1202; RP5264
Target:
Research Areas:
Umbralisib (TGR-1202) is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib can be used for haematological malignancies reseach .
5
5 Cited Publications
MT-802 is a BTK PROTAC degrader. MT-802 degrades wild-type BTK (DC50 = 14.6 nM) and BTK mutants including E41K, C481S (DC50 = 14.9 nM), C481R, C481Y, C481T, C481F, L528W, and inhibits their Y223 phosphorylation. BI-4732 can be used for the study of Ibrutinib (HY-10997)-resistant chronic lymphocytic leukemia (CLL). (Pink: BTK ligand (HY-150885), Blue: CRBN Ligand (HY-14658), Black: Linker (HY-141371), E3 ligase ligand-linker conjugate (HY-176340)) .
5
5 Cited Publications
Synonyms: TGR-1202 hydrochloride; RP5264 hydrochloride
Target:
Research Areas:
Umbralisib (TGR-1202) hydrochloride is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib hydrochloride exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib hydrochloride can be used for haematological malignancies reseach .
4
Research Areas:
PRT-060318 (PRT318) s a potent, selective and orally active tyrosine kinase Syk inhibitor with an IC50 of 3 nM. PRT-060318 suppresses chronic lymphocytic leukemia (CLL) B cell activation and migration, and induces apoptosis. PRT-060318 prevents Heparin (HY-17567)-induced thrombocytopenia and thrombosis in a transgenic mouse model. PRT-060318 dihydrochloride can be used for CLL and thrombus research .
4
Research Areas:
PRT-060318 (PRT318) dihydrochloride is a potent, selective and orally active tyrosine kinase Syk inhibitor with an IC50 of 3 nM. PRT-060318 dihydrochloride suppresses chronic lymphocytic leukemia (CLL) B cell activation and migration, and induces apoptosis. PRT-060318 dihydrochloride prevents Heparin (HY-17567)-induced thrombocytopenia and thrombosis in a transgenic mouse model. PRT-060318 dihydrochloride can be used for CLL and thrombus research .
3
3 Cited Publications
Fluorizoline selectively and directly binds to prohibitin 1 (PHB1) and 2 (PHB2), and induces apoptosis. Fluorizoline reduces chronic lymphocytic leukemia (CLL) cell viability through the upregulation of NOXA and BIM. Fluorizoline exerts antitumor action in a p53-independent manner .
2
2
2 Cited Publications
Cat. No.: HY-P71340
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: STUB1; CLL-Associated Antigen KW-8; STIP1 Homology And U-Box Containing Protein 1; Antigen NY-CO-7; CHIP; STIP1 Homology And U-Box Containing Protein 1, E3 Ubiquitin Protein Ligase; SDCCAG7; Heat Shock Protein A Binding Protein 2 (C-Terminal); HSPABP2; STIP1 Homology And U Box-Containing Protein 1; NY-CO-7; Serologically Defined Colon Cancer Antigen 7; UBOX1; RING-Type E3 Ubiquitin Transferase; Carboxy Terminus Of Hsp70-Interacting Protein; SCAR16; RING-Type E3 Ubiquitin Transferase CHIP; SCA48; E3 Ubiquitin-Protein Ligase CHIP
Species:
Human
Source:
E. coli
1
1 Cited Publications
Synonyms: Delphinidin 3-O-glucoside chloride; Delphinidin 3-O-β-glucoside chloride
1
1 Cited Publications
Cat. No.: HY-P99272
CAS No.: 1375830-34-4
Synonyms: BMS 936564; MDX 1338; Anti-Human CXCR4 Recombinant Antibody
1
Target:
Research Areas:
Flixebrutinib (TL-895) is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor. Flixebrutinib is active against recombinant BTK (average IC50: 1.5 nM) and inhibits only three additional kinases BLK, BMX (IC50 = 1.6 nM) and TXK with IC50 within tenfold of BTK activity. Flixebrutinib inhibits BTK auto-phosphorylation at the Y223 phosphorylation site (IC50: 1-10 nM). The Flixebrutinib effectively inhibits the production of inflammatory factors such as IL-8, IL-1β, MCP-1 and TNF-α by monocytes or macrophages, and reduces the chemotactic migration of MF cells towards SDF-1. Flixebrutinib is used be for studies of chronic lymphocytic leukemia (CLL), myelofibrosis (MF), and B-cell malignancies .
1
1 Cited Publications
Cat. No.: HY-P7537
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BCL2; Protein Phosphatase 1, Regulatory Subunit 50; BCL2 Apoptosis Regulator; B-Cell CLL/Lymphoma 2; Apoptosis Regulator Bcl-2; BCL2, Apoptosis Regulator; PPP1R50; BCL2 Protein; Bcl-2
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P72101
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BCL2; Protein Phosphatase 1, Regulatory Subunit 50; BCL2 Apoptosis Regulator; B-Cell CLL/Lymphoma 2; Apoptosis Regulator Bcl-2; BCL2, Apoptosis Regulator; PPP1R50; BCL2 Protein; Bcl-2
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P702687
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK6; Cell Division Protein Kinase 6; Cyclin Dependent Kinase 6; Cyclin-Dependent Kinase 6; PLSTIRE; MCPH12; Serine/Threonine-Protein Kinase PLSTIRE; CDKN6; CCND1; B-Cell CLL/Lymphoma 1; Prev. PRAD1; PRAD1 Oncogene; Prev. BCL1; Parathyroid Adenomatosis 1
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P702682
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDK4; Cyclin-Dependent Kinase 4; Cyclin Dependent Kinase 4; Cyclin-Dependent Kinase; PSK-J3; MCPH31; Cell Division Protein Kinase 4; CMM3; CCND1; B-Cell CLL/Lymphoma 1; Prev. PRAD1; PRAD1 Oncogene; Prev. BCL1; Parathyroid Adenomatosis 1; Prev. D11S287E; C
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-16466
CAS No.: 391611-36-2
Spliceostatin A, the FR901464 (HY-16212) methylated derivative, is a potent anti-tumor agent. Spliceostatin A inhibits splicing and promotes pre-mRNA accumulation by binding SF3B1. SF3B1 is a subcomplex of U2 small nuclear ribonucleoprotein in the spliceosome. Spliceostatin A induces Apoptosis in chronic lymphocytic leukemia (CLL) cells .
Cat. No.: HY-P9961
CAS No.: 679818-59-8
Synonyms: GSK1841157; OMB-157
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
