Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
CSK kinase
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "CSK kinase" in MCE Product Catalog:
4
4 Cited Publications
Target:
Research Areas:
CSK-IN-1 (compound 13) is a potent, orally active c-terminal Src kinase (CSK) with IC50 values below 3 nM and 4 nM in CSK HTRF and Caliper assay, respectively. CSK-IN-1 shows the ability to increase T cell proliferation induced by T cell receptor signaling .
1
1 Cited Publications
PD173952 is a tyrosine kinases inhibitor with IC50s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk, respectively. PD173952 is also a potent Myt1 kinase inhibitor with a Ki of 8.1 nM. PD173952 induces apoptosis .
1
1 Cited Publications
Cat. No.: HY-P1181A
Research Areas:
Cardiovascular Disease Infection Inflammation/Immunology Cancer
Cat. No.: HY-P1181
CAS No.: 868247-72-7
Research Areas:
Cardiovascular Disease Infection Inflammation/Immunology Cancer
Target:
PROTACs Bcr-Abl CDK Salt-inducible Kinase (SIK) Cyclin G-associated Kinase (GAK) MAP4K MAPKAPK2 (MK2) Ferroptosis ULK LIM Kinase (LIMK)
Research Areas:
DB1113 is a multi-kinase PROTAC degrader. DB1113 induces the ubiquitination and degradation of ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. DB1113 can be used to study diseases or disorders mediated by aberrant kinase activity .
Target:
Research Areas:
DB-3-291 is a CSK-targeting agent with a human CSK Kd of 1 nM and high selectivity for CSK over other kinases bound by dasatinib. DB-3-291 induces targeted degradation of CSK via a ubiquitin-dependent pathway and incorporates dasatinib as the kinase binding ligand. DB-3-291 can be used for the research of innate immune responses to viral DNA .
Target:
PROTACs AAK1 Aurora Kinase CaMK CDK Ferroptosis Salt-inducible Kinase (SIK) LIM Kinase (LIMK) ULK NEKs
Research Areas:
DB0614 is a PROTAC based on Cereblon ligand, which is a selective and potent targeted protein degrader of NEK9 inhibitor. DB0614 can degrade ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2 and ULK1. DB0614 can be used for research of disease or disorder mediated by aberrant kinase activity .
Cat. No.: HY-156745
CAS No.: 3036944-98-3
PROTAC DDa-1 is a multi-targeted DCAF1-recruiting tyrosine kinase PROTAC degrader. PROTAC DDa-1 mediates the degradation of TNK2, CSK, LIMK2, TEC, and BTK, with a DC50 of 90 nM for BTK. PROTAC DDa-1 reduces the viability of BTK-dependent diffuse large B-cell lymphoma cells. PROTAC DDa-1 can be used for the research of diffuse large B-cell lymphoma .
Cat. No.: HY-P10527
Cat. No.: HY-P5527F
Target:
Research Areas:
Cat. No.: HY-W114420
CAS No.: 17028-03-4
Target:
Research Areas:
3-Methyl-L-tyrosine is a derivative of L-Tyrosine (HY-N0473). Structurally, 3-Methyl-L-tyrosine features a methyl modification at the third position of the aromatic ring of L-Tyrosine. As a substrate for the protein tyrosine kinase Csk, 3-Methyl-L-tyrosine's relative catalytic efficiency (kcat/Km) is 38% of L-Tyrosine, indicating that the methyl modification impacts the processing efficiency of Gsk significantly. 3-Methyl-L-tyrosine helps to deepen the understanding of Gsk's molecular recognition mechanisms of its substrates, which is crucial for developing specific inhibitors targeting Gsk .
Cat. No.: HY-P75322
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CSK; Protein-Tyrosine kinase CYL; C-Terminal Src kinase; C-Src Tyrosine kinase; CSK, Non-Receptor Tyrosine kinase; C-Src kinase; Tyrosine-Protein kinase CSK; Tyrosine-Protein kinase
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-P85546
Synonyms: C SRC; C SRC kinase; C src Tyrosine kinase; C-SRC kinase; c-src tyrosine kinase; CSK A; CSK; CSK_HUMAN; CYTOPLASMIC TYROSINE kinase; MGC112926; MGC117393; MGC154049; P60 Src; Protein tyrosine kinase CYL; Protein-tyrosine kinase CYL; Proto oncogene tyrosine protein kinase; Tyrosine protein kinase CSK; Tyrosine protein kinase CSK; Tyrosine-protein kinase CSK; zgc:154049.
Cat. No.: HY-P72956
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CSK; Protein-Tyrosine kinase CYL; C-Terminal Src kinase; C-Src Tyrosine kinase; CSK, Non-Receptor Tyrosine kinase; C-Src kinase; Tyrosine-Protein kinase CSK; Tyrosine-Protein kinase
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P72957
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CSK; Protein-Tyrosine kinase CYL; C-Terminal Src kinase; C-Src Tyrosine kinase; CSK, Non-Receptor Tyrosine kinase; C-Src kinase; Tyrosine-Protein kinase CSK; Tyrosine-Protein kinase
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-18909
CAS No.: 1157857-36-7
Multi-kinase-IN-11 (Compound 1a) is a DFG-out conformation-targeted multi-kinase inhibitor, including SRC, LCK, ABL, PYK2, CSK, HCK, P38 and C-KIT. Multi-kinase-IN-11 serves as a scaffold for the preparation of fluorescently labeled binding probes and affinity matrices .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
