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Results for "

CTSB

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

2

Natural
Products

4

Recombinant Proteins

1

Antibodies

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-119293
    K777
    3 Publications Verification

    		 Cathepsin Cytochrome P450 Parasite SARS-CoV Filovirus Infection Inflammation/Immunology Cancer
    K777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC50 of 60 nM. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 inhibits SARS-CoV and EBOV pseudovirus entry with IC50 values of 0.68 nM and 0.87 nM, respectively .
    K777
  • HY-W074890
    Palmitoylglycine
    1 Publications Verification

    N-palmitoyl glycine

    		 Calcium Channel NO Synthase Neurological Disease Inflammation/Immunology
    Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA .
    Palmitoylglycine
  • HY-RS03322
    CTSB Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Cathepsin Others

    CTSB Human Pre-designed siRNA Set A contains three designed siRNAs for CTSB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CTSB Human Pre-designed siRNA Set A
    CTSB Human Pre-designed siRNA Set A
  • HY-178819
    NM-001

    		Integrin Drug Intermediate Cancer
    NM-001 is a theranostic prodrug that targets ανβ3 integrin. NM-001 consists of cRGD and GFLG peptides, a DCM fluorophore and Chlorambucil (HY-13593). NM-001 internalizes into lysosomes of tumor cells via the cRGD peptide, and generates NM-002 (HY-178820) and Chlorambucil through intracellular cleavage at the GFLG peptide by overexpressed Cathepsin B (CTSB). NM-001 exhibits green fluorescence under physiological conditions, and converts to NIR fluorescence by CTSB activation. NM-001 has significant antitumor activity with low toxicity in HeLa cell xenografts mouse models. NM-001 can be used for real-time drug release monitoring research .
    NM-001
  • HY-119293A
    K777 tosylate

    		Cathepsin Cytochrome P450 Parasite SARS-CoV Filovirus Infection Inflammation/Immunology Cancer
    K777 tosylate is a potent, orally active and irreversible cysteine protease inhibitor. K777 tosylate is also a potent CYP3A4 inhibitor with an IC50 of 60 nM. K777 tosylate irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 tosylate is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 tosylate inhibits SARS-CoV and EBOV pseudovirus entry with IC50 values of 0.68 nM and 0.87 nM, respectively .
    K777 tosylate
  • HY-W074890R
    Palmitoylglycine (Standard)

    N-palmitoyl glycine (Standard)

    		 Reference Standards Calcium Channel NO Synthase Neurological Disease Inflammation/Immunology
    Palmitoylglycine (Standard) is the analytical standard of Palmitoylglycine. This product is intended for research and analytical applications. Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA[1][2][3].
    Palmitoylglycine (Standard)
  • HY-163029
    CTSL/B-IN-1

    		Cathepsin SARS-CoV Infection
    CTSLCTSB-IN-1 (compound 212-148) is a bispecific inhibitor of host viral spike cleaver proteins CTSL/CTSB and TMPRSS2 with IC50s of 2.13/64.07 nM and 1.38 μM, respectively. CTSLCTSB-IN-1 blocks two relevant SARS-CoV-2 viral entry pathways by inhibiting the viral spike cleavage and can be applied to anti-SARS-CoV-2 research .
    CTSL/B-IN-1
  • HY-159172
    HDAC3-IN-4

    		HDAC Cancer
    HDAC3-IN-4 is a selective and orally active HDAC3 inhibitor with an IC50 of 89 nM. HDAC3-IN-4 induces the degradation of PD-L1 by regulating cathepsin B (CTSB) in the lysosomes, with a DC50 of 5.7 μM. HDAC3-IN-4 shows better selectivity for HDAC3 over HDAC1, HDAC6, HDAC7, and HDAC8 .
    HDAC3-IN-4
  • HY-RS03323
    Ctsb Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Cathepsin Others

    Ctsb Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ctsb gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ctsb Mouse Pre-designed siRNA Set A
    Ctsb Mouse Pre-designed siRNA Set A
  • HY-RS03324
    Ctsb Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Cathepsin Others

    Ctsb Rat Pre-designed siRNA Set A contains three designed siRNAs for Ctsb gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ctsb Rat Pre-designed siRNA Set A
    Ctsb Rat Pre-designed siRNA Set A
  • HY-178820
    NM-002

    		Drug Metabolite Cancer
    NM-002 is a metabolite of prodrug NM-001 (HY-178819), with NIR emission. NM-002 generates through activates the prodrug NM-001 by overexpressed Cathepsin B (CTSB) within tumor cells. NM-002 has no toxicity towards tumor cells and can escape from the lysosomes into the cytoplasm. NM-002 can be used for real-time drug release monitoring research .
    NM-002

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