Search Result

Results for "

Calpain

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calpain (1) Amyloid-β (5) Antibiotic (1) Apoptosis (14) Autophagy (3) Bacterial (5) Calcineurin (1) Calcium Channel (2) Calmodulin (1) CaMK (1) Caspase (1) Cathepsin (8) Deubiquitinase (1) Endogenous Metabolite (6) Environmental Pollutants (1) Fluorescent Dye (4) Fungal (5) GABA Receptor (1) GLUT (1) iGluR (1) Interleukin Related (1) Isotope-Labeled Compounds (3) Leukotriene Receptor (1) NO Synthase (1) Parasite (1) Phospholipase (1) PKC (1) Potassium Channel (1) Proteasome (51) Reactive Oxygen Species (ROS) (7) Reference Standards (6) SARS-CoV (1) Ser/Thr Protease (2) Tau Protein (1) TNF Receptor (1)
By Research Areas:	Cancer (19) Cardiovascular Disease (7) Endocrinology (6) Infection (9) Inflammation/Immunology (11) Metabolic Disease (7) Neurological Disease (27)

By Targets:

Calpain (1)

Amyloid-β (5)

Antibiotic (1)

Apoptosis (14)

Autophagy (3)

Bacterial (5)

Calcineurin (1)

Calcium Channel (2)

Calmodulin (1)

CaMK (1)

Caspase (1)

Cathepsin (8)

Deubiquitinase (1)

Endogenous Metabolite (6)

Environmental Pollutants (1)

Fluorescent Dye (4)

Fungal (5)

GABA Receptor (1)

GLUT (1)

iGluR (1)

Interleukin Related (1)

Isotope-Labeled Compounds (3)

Leukotriene Receptor (1)

NO Synthase (1)

Parasite (1)

Phospholipase (1)

PKC (1)

Potassium Channel (1)

Proteasome (51)

Reactive Oxygen Species (ROS) (7)

Reference Standards (6)

SARS-CoV (1)

Ser/Thr Protease (2)

Tau Protein (1)

TNF Receptor (1)

By Research Areas:

Cancer (19)

Cardiovascular Disease (7)

Endocrinology (6)

Infection (9)

Inflammation/Immunology (11)

Metabolic Disease (7)

Neurological Disease (27)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

GMP Molecules

Targets Recommended: Calpain

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13259

MG-132 Maximum Cited Publications 1998 Publications Verification Z-Leu-Leu-Leu-al; MG132	Proteasome Autophagy Apoptosis	Cancer
MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and *calpain* inhibitor with IC₅₀s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis .

HY-100223

Calpeptin 25+ Cited Publications	Cathepsin Proteasome Apoptosis	Inflammation/Immunology
Calpeptin is a potent, cell penetrating *calpain* inhibitor, with an ID₅₀ of 40 nM for Calpain I in human platelets . Calpeptin is also an inhibitor of cathepsin K .

HY-P1002

Suc-Leu-Leu-Val-Tyr-AMC 15+ Cited Publications Suc-LLVY-AMC	Fluorescent Dye Proteasome	Others
Suc-Leu-Leu-Val-Tyr-AMC is a membrane-permeable *calpain*-specific fluorogenic substrate (Ex/Em = 390/480 nm) .

HY-18236

MDL-28170 15+ Cited Publications Calpain Inhibitor III	Proteasome	Neurological Disease Inflammation/Immunology
MDL-28170 (Calpain Inhibitor III) is a potent, selective and membrane-permeable cysteine protease inhibitor of *calpain* that rapidly penetrates the blood-brain barrier following systemic administration . MDL-28170 also block γ-secretase .

HY-100529

PD150606 10+ Cited Publications	Proteasome	Cancer
PD 150606 is a selective, cell-permeable non-peptide *calpain* inhibitor with K_i values of 0.21 μM and 0.37 μM for μ- and m-calpains respectively, which is neuroprotective .

HY-13817

IU1 20+ Cited Publications	Deubiquitinase Autophagy Apoptosis	Cardiovascular Disease Neurological Disease Endocrinology Cancer
IU1 is a selective, reversible USP14 inhibitor with an IC₅₀ of 4-5 μM. IU1 binds USP14’s catalytic cleft to block deubiquitinase activity. IU1 induces calpain-dependent Tau cleavage, causes ATP deficits, reduces E1~Ub thioester levels and 26S proteasome assembly. IU1 enhances 26S proteasome chymotrypsin-like activity, modulates LC3B-dependent autophagy flux, reduces cancer cell proliferation and migration, and blocks G0/G1 to S phase cell cycle transition in follicular thyroid cancer cells. IU1 activates autophagy-lysosomal and ubiquitin-proteasome pathways, triggers apoptosis, and reduces cervical cancer cell growth. IU1 enhances degradation of proteasome substrates linked to neurodegenerative disease, accelerates oxidized protein degradation, and increases oxidative stress resistance. IU1 can be used for the research of Alzheimer’s disease, follicular thyroid cancer, ischemic stroke, cervical cancer, and neurodegenerative disease .

HY-17001A

Flupirtine 1 Publications Verification D 9998	Potassium Channel iGluR GABA Receptor	Neurological Disease Inflammation/Immunology
Flupirtine (D 9998) is an orally active, blood-brain barrier-crossing non-opioid analgesic and neuroprotective agent. Flupirtine is a neuronal potassium channel opener (Kv7 activator), a NMDA receptor antagonist and a GABA receptor activator. Flupirtine stabilizes blood-brain-barrier integrity, reduces oxidative stress and brain leukocyte infiltration, enhances angioneurogenesis, suppresses calcium influx, stabilizes neuronal resting membrane potential, and counteracts focal cerebral ischemia. Flupirtine exhibits analgesic, muscle relaxant properties, protects neurons from excitotoxic, ischemic, or cytokine-mediated death. Flupirtine functions as a non-opioid analgesic without antipyretic or antiphlogistic properties, shows no relevant affinity to opiate receptor. Flupirtine can be used for the research of focal cerebral ischemia, pain, Alzheimer’s disease, or multiple sclerosis .

HY-18964

MG-101 10+ Cited Publications Calpain inhibitor I; Ac-LLnL-CHO; ALLN	Proteasome Apoptosis	Cancer
MG-101 (ALLN) is an inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with K_is of 190, 220, 150 and 500 pM, respectively. MG-101 induces apoptosis and inhibits tumor growth, it can be used for the research of colon cancer .

HY-155482

NA-184 1 Publications Verification	Proteasome	Neurological Disease
NA-184 is a selective and brain-penetrant *calpain-2* inhibitor with an IC₅₀ of 134 nM for mouse calpain-2. NA-184 has weak inhibitory activity on calpain-1 (IC₅₀ of 2826 nM). NA-184 does not exhibit significant inhibition on a variety of other cysteine-, serine- or metallo-proteases. NA-184 shows significant neuroprotection and can be used for the study of traumatic brain injury (TBI) .

HY-113221

Isovalerylcarnitine	Proteasome Endogenous Metabolite Apoptosis	Metabolic Disease Cancer
Isovalerylcarnitine is a metabolite of leucine. Isovalerylcarnitine can specifically activate *calpain* in human neutrophils. Isovalerylcarnitine inhibits tumor cell proliferation and induces apoptosis. Elevated circulating levels of Isovalerylcarnitine are negatively correlated with reduced lung cancer risk .

HY-B0914

10-Undecenoic acid,98% (stabilized with TBC) 2 Publications Verification Undecylenic acid	Environmental Pollutants Bacterial Fungal Proteasome Amyloid-β Reactive Oxygen Species (ROS)	Infection Neurological Disease Endocrinology Cancer
10-Undecenoic acid (Undecylenic acid) is an antifungal agent. 10-Undecenoic acid inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid has neuroprotective effects. 10-Undecenoic acid has anticancer effects on a variety of tumors. 10-Undecenoic acid inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa .

HY-109001

Alicapistat 1 Publications Verification ABT-957	Proteasome	Neurological Disease
Alicapistat (ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 for the potential application of Alzheimer's disease (AD) . Alicapistat mitigates the metabolic liability of carbonyl reduction and inhibits calpain 1 with an IC₅₀ value of 395 nM .

HY-B0914A

10-Undecenoic acid zinc salt 2 Publications Verification Zinc undecylenate	Fungal Bacterial Amyloid-β Reactive Oxygen Species (ROS) Proteasome	Infection Neurological Disease Endocrinology Cancer
10-Undecenoic acid zinc salt (Undecylenic acid zinc salt) is an antifungal agent. 10-Undecenoic acid zinc salt inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid zinc salt has neuroprotective effects. 10-Undecenoic acid zinc salt has anticancer effects on a variety of tumors. 10-Undecenoic acid zinc salt inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid zinc salt inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa .

HY-139066

Punicic acid 1 Publications Verification Trichosanic acid	TNF Receptor GLUT Proteasome Tau Protein PKC	Neurological Disease Metabolic Disease Inflammation/Immunology
Punicic acid is a bioactive compound of pomegranate seed oil. Punicic acid is an isomer of conjugated α-linolenic acid and ω-5 polyunsaturated fatty acids. Punicic acid has anti-inflammatory and antioxidant activities and can inhibit the expression of inflammatory mediators such as tumor necrosis factor α (TNF-α). Punicic acid can also reduce the formation of β-amyloid deposits and hyperphosphorylation of tau by increasing the expression of GLUT4 protein and inhibiting the overactivation of calpain, and is used to prevent and treat neurodegenerative diseases. In addition, punicic acid also has breast cancer inhibitor properties that depend on lipid peroxidation and PKC pathways .

HY-118355

ALLM 1 Publications Verification Calpain inhibitor II	Proteasome Cathepsin	Neurological Disease
ALLM (Calpain inhibitor II) is a potent inhibitor of *calpain* and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI) .

HY-132850

Dazcapistat BLD-2660	Proteasome Interleukin Related	Infection Inflammation/Immunology
Dazcapistat (BLD-2660) is an orally active small-molecule inhibitor of calpain 1, 2, and 9 (calpain 1, 2, 9). Dazcapistat reduces the expression/production level of IL-6 in injured lung tissue and alleviates fibrosis . Dazcapistat exerts anti-fibrotic effects in various animal models of fibrosis in the skin, liver and lung . Dazcapistat can be used in research related to coronavirus disease 2019 (COVID-19) and idiopathic pulmonary fibrosis .

HY-118933

Calpain Inhibitor VI 1 Publications Verification SJA6017	Proteasome	Others
Calpain Inhibitor VI (SJA6017) is a synthesized peptide aldehyde inhibitor of *calpain. Calpain* Inhibitor VI inhibits purified *m-calpain* with the IC₅₀ of 80 nM. Calpain Inhibitor VI can be used for the research of cataract .

HY-19749

PD 151746 5+ Cited Publications	Proteasome	Cardiovascular Disease
PD151746 is a calpain inhibitor, shows a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM).

HY-145155

Calpain-2-IN-1 2 Publications Verification	Proteasome	Neurological Disease
Calpain-2-IN-1 (Formula 1A) is a isoform-specific *calpain-2* inhibitor with K_is of 181 nM and 7.8 nM for calpain-1, and calpain-2, respectively. Calpain-2-IN-1 can be used for the research of neurodegenerative diseases and other diseases of synaptic function .

HY-136750

Z-LLY-FMK Calpain Inhibitor IV	Apoptosis Proteasome Parasite	Cancer
Z-LLY-FMK (Calpain Inhibitor IV) is a *calpain* inhibitor, involved in apoptosis of many cell systems. Z-LLY-FMK inhibits the intestine apoptosis after common bile duct ligation. Z-LLY-FMK reduces parasite burden in mice challenged with Taenia crassiceps cysts. Z-LLY-FMK can be used for the study of cysticercosis .

HY-145542

Isovalerylcarnitine chloride	Endogenous Metabolite Proteasome Apoptosis	Metabolic Disease Cancer
Isovalerylcarnitine chloride is a metabolite of leucine. Isovalerylcarnitine chloride can specifically activate *calpain* in human neutrophils. Isovalerylcarnitine chloride inhibits tumor cell proliferation and induces apoptosis. Elevated circulating levels of Isovalerylcarnitine chloride are negatively correlated with reduced lung cancer risk .

HY-115753

Calpain Inhibitor-1	Proteasome	Neurological Disease
Calpain Inhibitor-1 (compound 36) is a potent and selective cysteine protease calpain 1 (Cal1) inhibitor (IC₅₀=100 nM; K_i=2.89 μM) .

HY-P1081

Acetyl-Calpastatin(184-210)(human) 1 Publications Verification	Proteasome	Inflammation/Immunology
Acetyl-Calpastatin(184-210)(human) is a potent, selective and reversible *calpain* inhibitor with K_i values of 0.2 nM and 6 μM for μ-calpain and cathepsin L, respectively .

HY-P4310

Boc-Val-Leu-Lys-AMC	Ser/Thr Protease	Others
Boc-Val-Leu-Lys-AMC is a sensitive, fluorogenic, and specific substrate of plasmin, as well as acrosin from the ascidian Halocynthia roretzi, porcine calpain isozymes I and II, and papain .

HY-B0914R

10-Undecenoic acid (Standard) Undecylenic acid (Standard)	Reference Standards Fungal Amyloid-β Reactive Oxygen Species (ROS) Proteasome Bacterial	Infection Neurological Disease Endocrinology Cancer
10-Undecenoic acid (Standard) is the analytical standard of 10-Undecenoic acid. This product is intended for research and analytical applications. 10-Undecenoic acid (Undecylenic acid) is an antifungal agent. 10-Undecenoic acid inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid has neuroprotective effects. 10-Undecenoic acid has anticancer effects on a variety of tumors. 10-Undecenoic acid inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa .

HY-119378

AK 295 CX 295	Proteasome Apoptosis	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology
AK 295 (CX 295) is a selective *calpain* inhibitor. AK 295 can inhibit apoptosis through a calpain-dependent pathway. AK 295 shows potent neuroprotective effect. AK 295 can inhibit the activity of the cysteine protease calpain and reduce myocardial injury. AK 295 can be used for the researches of infection, inflammation, cardiovascular and neurological disease, such as stroke and viral myocarditis .

HY-116171

*(Rac)-Calpain* Inhibitor XII**	Proteasome	Cardiovascular Disease Neurological Disease
(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, K_i=19 nM). (Rac)-Calpain Inhibitor XII has lower affinities for calpain II (m-calpain, K_i=120 nM) and cathepsin B (K_i=750 nM). (Rac)-Calpain Inhibitor XII has the potential for studying the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury .

HY-P10050

Calpain substrate	Proteasome	Others
Calpain substrate is the membrane non-permeable fluorogenic calpain substrate and can be used in Calpain enzymatic activity assay .

HY-P5989

Calpain inhibitor V Mu-Val-HPh-FMK	Antibiotic	Infection
Calpain inhibitor V (Mu-Val-HPh-FMK) is a cell-permeable and irreversible inhibitor of calpain that has anti-chlamydial activity .

HY-135172

Suc-Leu-Tyr-AMC	Fluorescent Dye	Others
Suc-Leu-Tyr-AMC is a fluorometric peptide substrate for µ-calpain and m-calpain. The excitation wavelength is 360 nm and the emission wavelength is 460 nm .

HY-19230

DY-9760e	Calmodulin NO Synthase CaMK Calcineurin Proteasome Caspase	Cardiovascular Disease
DY-9760e is a calmodulin (CaM) inhibitor. DY-9760e selectively inhibits the activity of various calmodulin-dependent enzymes by antagonizing the Ca²⁺/CaM complex, exhibiting the strongest inhibitory activity against nNOS, CaM kinase II, and calcineurin (K_i: 0.9, 1.4, and 2.0 μM, respectively). DY-9760e inhibits excessive nitric oxide production and protein tyrosine nitration, as well as the activation of *calpain* and caspase-3. DY-9760e reduces infarct size, improves cardiac function, and inhibits oxidative stress and cell death. DY-9760e can be used in research on the treatment of myocardial infarction, cerebral ischemia, and other diseases .

HY-DY1060

Suc-Leu-Leu-Val-Tyr-AMC (solution)	Proteasome Fluorescent Dye	Others
Suc-Leu-Leu-Val-Tyr-AMC (solution) is a membrane-permeable *calpain*-specific fluorogenic substrate (Ex/Em = 390/480 nm) . Solvent and concentration: DMSO: 20 mM

HY-E70197

Calpain-1 (pig) μ-Calpain	Cathepsin	Others
Calpain-1 (pig) (μ-Calpain) is an intracellular Ca ²⁺-regulated cysteine protease. Calpain-1 (pig) exhibits neuroprotective effect .

HY-13259G

MG-132 Z-Leu-Leu-Leu-al	Proteasome Autophagy Apoptosis	Cancer
MG-132 (GMP) (Z-Leu-Leu-Leu-al (GMP)) is MG-132 (HY-13259) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and *calpain* inhibitor with IC₅₀s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis .

HY-148535

Calpain Inhibitor XI	Proteasome	Neurological Disease
Calpain Inhibitor XI is a reversible covalent inhibitor of *calpain-1. Calpain* Inhibitor XI can be used for the research of neurodegenerative disorders .

HY-136903

SNJ-1945	Calcium Channel Proteasome Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease Inflammation/Immunology
SNJ-1945 is an orally active *Calpain* inhibitor that can cross the blood-brain barrier. SNJ-1945 protects rat hearts against cardiac arrest-reperfusion injury by inhibiting the hydrolysis of α-fodrin. SNJ-1945 inhibits VEGF-induced angiogenesis in retinal endothelial cells. SNJ-1945 also protects SH-SY5Y cells from damage induced by MPP+ (HY-W008719) and Rotenone (HY-B1756). SNJ-1945 exhibits anti-inflammatory and neuroprotective activities in a mouse model of multiple sclerosis. SNJ-1945 can be used for the research of cardiovascular, nervous system and inflammatory diseases .

HY-18964G

MG-101 Calpain inhibitor I; Ac-LLnL-CHO; ALLN	Proteasome Apoptosis	Cancer
MG-101 (GMP) (Calpain inhibitor I (GMP)) is MG-101 (HY-18964) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MG-101 (ALLN) is an inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with K_is of 190, 220, 150 and 500 pM, respectively. MG-101 induces apoptosis and inhibits tumor growth, it can be used for the research of colon cancer .

HY-W409181

(Rac)-PD 151746	Proteasome	Neurological Disease
(Rac)-PD 151746 is the optically inactive racemate of PD 151746 (HY-19749). PD 151746 is a neuroprotective calpain inhibitor with Ki values of 0.26 μM (u-calpain) and 5.33 μM (m-calpain), respectively .

HY-P5379

Calpastatin subdomain B	Proteasome	Others
Calpastatin subdomain B is a biological active peptide. (inhibit calpain activity)

HY-P10169

Acetyl-Calpastatin(184-210)(human), Negative Control	Proteasome	Others
Acetyl-Calpastatin(184-210)(human), Negative Control is a control scramble peptide of Acetyl-Calpastatin(184-210)(human) (HY-P1081). Acetyl-Calpastatin(184-210)(human) is a potent, selective and reversible calpain inhibitor .

HY-145542R

Isovalerylcarnitine chloride (Standard)	Reference Standards Proteasome Endogenous Metabolite Apoptosis	Metabolic Disease Cancer
Isovalerylcarnitine chloride (Standard) is the analytical standard of Isovalerylcarnitine chloride (HY-145542). This product is intended for research and analytical applications. Isovalerylcarnitine chloride is a metabolite of leucine. Isovalerylcarnitine can specifically activate *calpain* in human neutrophils. Isovalerylcarnitine chloride inhibits tumor cell proliferation and induces apoptosis. Elevated circulating levels of Isovalerylcarnitine chloride are negatively correlated with reduced lung cancer risk .

HY-P10073

Calpain-1 substrate, fluorogenic	Fluorescent Dye	Others
Calpain-1 substrate, fluorogenic serves as a sensitive and specific substrate for calpain-1 that cleaves Tyr-Gly bond and results in enhanced fluorescence .(Ex/Em = 490 nm/518 nm)

HY-147734

Calpain Inhibitor-2	Calcium Channel	Cancer
Calpain Inhibitor-2 (compound 5) is a peptide inhibitor of *μ-calpain* (Ki=9 nM). Calpain Inhibitor-2 exhibits antiproliferative activity against melanoma cell lines (A-375 and B-16F1) and PC-3 prostate cancer cells in vitro .

HY-U00362A

(Rac)-Neurodegenerative Disorder-Targeting Compound 1	Cathepsin	Neurological Disease
(Rac)-Neurodegenerative Disorder-Targeting Compound 1 is a calpain inhibitor (extracted from patent WO2010128102A1, compound 63) .

HY-113639

A-933548	Proteasome	Neurological Disease
A-933548 is a potent and selective inhibitor of *calpain, with a K_i* of 18 nM. A-933548 can be used for the research of Alzheimer's disease .

HY-109001A

(1S,2R)-Alicapistat (1S,2R)-ABT-957	Proteasome	Neurological Disease
(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 for the potential application of Alzheimer's disease (AD) . (1S,2R)-Alicapistat mitigates the metabolic liability of carbonyl reduction and inhibits calpain 1 with an IC₅₀ value of 395 nM .

HY-P1081A

Acetyl-Calpastatin(184-210)(human) TFA	Proteasome	Inflammation/Immunology
Acetyl-Calpastatin(184-210)(human) TFA is a potent, selective and reversible *calpain* inhibitor with K_i values of 0.2 nM and 6 μM for µ-calpain and cathepsin L, respectively .

HY-P4293

Z-Leu-Tyr-Chloromethylketone	Proteasome Cathepsin	Others
Z-Leu-Tyr-Chloromethylketone is a *calpain* inhibitor .

HY-100223R

Calpeptin (Standard)	Reference Standards Cathepsin Proteasome Apoptosis	Inflammation/Immunology
Calpeptin (Standard) is the analytical standard of Calpeptin. This product is intended for research and analytical applications. Calpeptin is a potent, cell penetrating calpain inhibitor, with an ID50 of 40 nM for Calpain I in human platelets . Calpeptin is also an inhibitor of cathepsin K .

HY-127113

Q8	Leukotriene Receptor	Cardiovascular Disease
Q8, an effective antiangiogenic drug, is a CysLt₁ antagonist (IC₅₀ of 4.9 μM). Q8 is sufficient to reduce cellular levels of NF-κB and calpain-2 and secreted levels of the proangiogenic proteins intercellular adhesion molecule-1, vascular cell adhesion protein-1, and VEGF .

Cat. No.	Product Name	Type

HY-P1002

Suc-Leu-Leu-Val-Tyr-AMC 15+ Cited Publications Suc-LLVY-AMC	Fluorescent Dye
Suc-Leu-Leu-Val-Tyr-AMC is a membrane-permeable *calpain*-specific fluorogenic substrate (Ex/Em = 390/480 nm) .

HY-DY1060

Suc-Leu-Leu-Val-Tyr-AMC (solution)	Fluorescent Dye
Suc-Leu-Leu-Val-Tyr-AMC (solution) is a membrane-permeable *calpain*-specific fluorogenic substrate (Ex/Em = 390/480 nm) . Solvent and concentration: DMSO: 20 mM

HY-13259G

MG-132

Z-Leu-Leu-Leu-al

Fluorescent Dye

MG-132 (GMP) (Z-Leu-Leu-Leu-al (GMP)) is MG-132 (HY-13259) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC₅₀s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis .

HY-18964G

MG-101

Calpain inhibitor I; Ac-LLnL-CHO; ALLN

Fluorescent Dye

MG-101 (GMP) (Calpain inhibitor I (GMP)) is MG-101 (HY-18964) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MG-101 (ALLN) is an inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with K_is of 190, 220, 150 and 500 pM, respectively. MG-101 induces apoptosis and inhibits tumor growth, it can be used for the research of colon cancer .

Cat. No.	Product Name	Type

HY-13259G

MG-132

Z-Leu-Leu-Leu-al

Biochemical Assay Reagents

HY-18964G

MG-101

Calpain inhibitor I; Ac-LLnL-CHO; ALLN

Biochemical Assay Reagents

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113221

Isovalerylcarnitine	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Proteasome Endogenous Metabolite Apoptosis
Isovalerylcarnitine is a metabolite of leucine. Isovalerylcarnitine can specifically activate *calpain* in human neutrophils. Isovalerylcarnitine inhibits tumor cell proliferation and induces apoptosis. Elevated circulating levels of Isovalerylcarnitine are negatively correlated with reduced lung cancer risk .

HY-B0914

10-Undecenoic acid,98% (stabilized with TBC) 2 Publications Verification Undecylenic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Bacterial Fungal Proteasome Amyloid-β Reactive Oxygen Species (ROS)
10-Undecenoic acid (Undecylenic acid) is an antifungal agent. 10-Undecenoic acid inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid has neuroprotective effects. 10-Undecenoic acid has anticancer effects on a variety of tumors. 10-Undecenoic acid inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa .

HY-B0914A

10-Undecenoic acid zinc salt 2 Publications Verification Zinc undecylenate	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Fungal Bacterial Amyloid-β Reactive Oxygen Species (ROS) Proteasome
10-Undecenoic acid zinc salt (Undecylenic acid zinc salt) is an antifungal agent. 10-Undecenoic acid zinc salt inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid zinc salt has neuroprotective effects. 10-Undecenoic acid zinc salt has anticancer effects on a variety of tumors. 10-Undecenoic acid zinc salt inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid zinc salt inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa .

HY-139066

Punicic acid 1 Publications Verification Trichosanic acid	Structural Classification Punica granatum L. Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Punicaceae Plants Disease Research Fields Source Classification	TNF Receptor GLUT Proteasome Tau Protein PKC
Punicic acid is a bioactive compound of pomegranate seed oil. Punicic acid is an isomer of conjugated α-linolenic acid and ω-5 polyunsaturated fatty acids. Punicic acid has anti-inflammatory and antioxidant activities and can inhibit the expression of inflammatory mediators such as tumor necrosis factor α (TNF-α). Punicic acid can also reduce the formation of β-amyloid deposits and hyperphosphorylation of tau by increasing the expression of GLUT4 protein and inhibiting the overactivation of calpain, and is used to prevent and treat neurodegenerative diseases. In addition, punicic acid also has breast cancer inhibitor properties that depend on lipid peroxidation and PKC pathways .

HY-145542

Isovalerylcarnitine chloride	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Proteasome Apoptosis
Isovalerylcarnitine chloride is a metabolite of leucine. Isovalerylcarnitine chloride can specifically activate *calpain* in human neutrophils. Isovalerylcarnitine chloride inhibits tumor cell proliferation and induces apoptosis. Elevated circulating levels of Isovalerylcarnitine chloride are negatively correlated with reduced lung cancer risk .

HY-B0914R

10-Undecenoic acid (Standard) Undecylenic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Fungal Amyloid-β Reactive Oxygen Species (ROS) Proteasome Bacterial
10-Undecenoic acid (Standard) is the analytical standard of 10-Undecenoic acid. This product is intended for research and analytical applications. 10-Undecenoic acid (Undecylenic acid) is an antifungal agent. 10-Undecenoic acid inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid has neuroprotective effects. 10-Undecenoic acid has anticancer effects on a variety of tumors. 10-Undecenoic acid inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa .

HY-145542R

Isovalerylcarnitine chloride (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Proteasome Endogenous Metabolite Apoptosis
Isovalerylcarnitine chloride (Standard) is the analytical standard of Isovalerylcarnitine chloride (HY-145542). This product is intended for research and analytical applications. Isovalerylcarnitine chloride is a metabolite of leucine. Isovalerylcarnitine can specifically activate *calpain* in human neutrophils. Isovalerylcarnitine chloride inhibits tumor cell proliferation and induces apoptosis. Elevated circulating levels of Isovalerylcarnitine chloride are negatively correlated with reduced lung cancer risk .

HY-B0914AR

10-Undecenoic acid zinc salt (Standard) Zinc undecylenate (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Reference Standards Fungal Amyloid-β Reactive Oxygen Species (ROS) Proteasome Bacterial
10-Undecenoic acid (zinc salt) (Standard) is the analytical standard of 10-Undecenoic acid (zinc salt). This product is intended for research and analytical applications. 10-Undecenoic acid zinc salt (Undecylenic acid zinc salt) is an antifungal agent. 10-Undecenoic acid zinc salt inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid zinc salt has neuroprotective effects. 10-Undecenoic acid zinc salt has anticancer effects on a variety of tumors. 10-Undecenoic acid zinc salt inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid zinc salt inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa .

Species:	Human (2) Mouse (1)
Tag:	His (3)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72113

	CAPN1 Protein, Human (His) 1 Publications Verification Ca2 activated neutral protease; Calcium activated neutral proteinase; CANP1; CANPL 1; CANPL1; CAPN 1; CAPN1; Cell proliferation inducing protein 30; Cell proliferation-inducing gene 30 protein; Micromolar Calpain; Micromolar-Calpain; Mu Calpain; muCANP; muCL	Human	E. coli
	CAPN1 (Calpain-1) is a calcium-regulated non-lysosomal thiol protease that plays a critical role in the limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This protease catalyzes specific cleavage events, including CTBP1 cleavage at "Asn-375," "Gly-387," and "His-409," and activation of caspase-7 (CASP7). CAPN1 Protein, Human (His) is the recombinant human-derived CAPN1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P72114

	CAPN1 Protein, Mouse (His) Capn1; Canp1; Capa1Calpain-1 catalytic subunit; EC 3.4.22.52; Calcium-activated neutral proteinase 1; CANP 1; Calpain mu-type; Calpain-1 large subunit; Micromolar-Calpain; muCANP	Mouse	E. coli
	CAPN1 protein, a calcium-regulated non-lysosomal thiol-protease, facilitates cytoskeletal remodeling and signal transduction. It selectively cleaves substrates involved in these processes, including CTBP1 at 'Asn-375', 'Gly-388', and 'His-410'. CAPN1 also activates caspase-7 (CASP7), highlighting its role in regulating cellular functions. CAPN1 Protein, Mouse (His) is the recombinant mouse-derived CAPN1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P72115

	CAPN2 Protein, Human (His) Calcium-activated neutral proteinase 2; Calpain M-type; Millimolar-Calpain; CAPN2; CANPL2	Human	E. coli
	CAPN2 (Calpain-2) is a calcium-regulated, non-lysosomal thiol protease known for catalyzing the limited proteolysis of substrates critical for cytoskeletal remodeling and signaling. Notably, CAPN2 proteolytically cleaves MYOC at “Arg-226,” suggesting its involvement in regulating the function of this protein. CAPN2 Protein, Human (His) is the recombinant human-derived CAPN2 protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-W654243

Isovalerylcarnitine-d9-1 chloride
Isovalerylcarnitine-d₉-1 (chloride) is deuterium labeled Isovalerylcarnitine (chloride). Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca ²⁺-dependent proteinase (calpain) of human neutrophils .

HY-113221AS

Isovalerylcarnitine-d3 chloride

Isovalerylcarnitine-d₃ chloride is the deuterium labeled Isovalerylcarnitine chloride (HY-145542). Isovalerylcarnitine chloride is a metabolite of leucine. Isovalerylcarnitine chloride can specifically activate calpain in human neutrophils. Isovalerylcarnitine chloride inhibits tumor cell proliferation and induces apoptosis. Elevated circulating levels of Isovalerylcarnitine chloride are negatively correlated with reduced lung cancer risk .

HY-145542S

Isovalerylcarnitine-d9 chloride

Isovalerylcarnitine-d₉ chloride is the deuterium labeled Isovalerylcarnitine chloride (HY-145542). Isovalerylcarnitine chloride is a metabolite of leucine. Isovalerylcarnitine chloride can specifically activate calpain in human neutrophils. Isovalerylcarnitine chloride inhibits tumor cell proliferation and induces apoptosis. Elevated circulating levels of Isovalerylcarnitine chloride are negatively correlated with reduced lung cancer risk .

Host:	Mouse (6) Rabbit (4)
Reactivity:	Human (9) Rat (3) Mouse (3) human (1)
Application:	IHC-P (8) ICC/IF (4) IP (1) WB (5) FC (8) ELISA (2)
Isotype:	IgG (4) IgG1 (3) IgG2a (2) IgM (1)
Conjugation:	Non-conjugated (10)
Clonality:	Monoclonal (4) Monoclonal Antibody (1) Recombinant (3)
Modification:	Unmodified (7)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80443

	Calpain 1 Antibody (YA815) 1 Publications Verification	ICC/IF, IHC-P, FC	Human, Mouse, Rat
	Calpain 1 Antibody (YA815) is a Mouse-derived and non-conjugated IgM monoclonal antibody, targeting to Calpain 1.

HY-P80444

	Calpain 2 Antibody (YA572)	WB, IHC-P, ICC/IF, FC	Human
	Calpain 2 Antibody (YA572) is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to Calpain 2.

HY-P89990

	Calpain 6 Antibody (YA9334)	WB, IP, FC	human
	Calpain 6 Antibody (YA9334) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Calpain 6.

HY-P83990

	Calpain 1 Antibody (YA3687) CANP; muCL; CANP1; SPG76; CANPL1; muCANP	WB, IHC-P, FC, ELISA	Human
	Calpain 1 Antibody (YA3687) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Calpain 1.

HY-P83990A

	Calpain 1 Antibody (YA3687)(PBS only) CANP; muCL; CANP1; SPG76; CANPL1; muCANP	WB, IHC-P, FC, ELISA	Human
	Calpain 1 Antibody (YA3687) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Calpain 1.

HY-P88037

	Calpain Small Subunit 1 Antibody (YA7722)	WB, FC	Human
	Calpain Small Subunit 1 Antibody (YA7722) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Calpain Small Subunit 1.

HY-P81476

	Calpain Small Subunit 1 Antibody (YA1221) Calpain4; CalpainS1; CANP; CANPS; CAPN4; CAPNS; Capns1; CDPS; CSS1	IHC-P	Human
	Calpain Small Subunit 1 Antibody (YA1221) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Calpain Small Subunit 1.

HY-P81476A

	Calpain Small Subunit 1 Antibody (YA1221)(PBS only) Calpain4; CalpainS1; CANP; CANPS; CAPN4; CAPNS; Capns1; CDPS; CSS1	IHC-P	Human
	Calpain Small Subunit 1 Antibody (YA1221) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Calpain Small Subunit 1.

HY-P88561

	*CAPN9 (Calpain* 9) Antibody (YA8245)** GC36; nCL-4	IHC-P, ICC/IF, FC	Human, Mouse, Rat
	CAPN9 (Calpain 9) Antibody (YA8245) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CAPN9 (Calpain 9).

HY-P88561A

	*CAPN9 (Calpain* 9) Antibody (YA8245)(PBS only)** GC36; nCL-4	IHC-P, ICC/IF, FC	Human, Mouse, Rat
	CAPN9 (Calpain 9) Antibody (YA8245) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CAPN9 (Calpain 9).

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Targets Recommended: Calpain

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18964G

MG-101 Calpain inhibitor I; Ac-LLnL-CHO; ALLN	Proteasome Apoptosis	Cancer
MG-101 (GMP) (Calpain inhibitor I (GMP)) is MG-101 (HY-18964) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MG-101 (ALLN) is an inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with K_is of 190, 220, 150 and 500 pM, respectively. MG-101 induces apoptosis and inhibits tumor growth, it can be used for the research of colon cancer .

HY-13259G

MG-132 Z-Leu-Leu-Leu-al	Proteasome Autophagy Apoptosis	Cancer
MG-132 (GMP) (Z-Leu-Leu-Leu-al (GMP)) is MG-132 (HY-13259) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and *calpain* inhibitor with IC₅₀s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis .

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