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ISGs

" in MedChemExpress (MCE) Product Catalog:

36

Inhibitors & Agonists

1

Inhibitory Antibodies

1

Natural
Products

8

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-131454
    SR-717
    Maximum Cited Publications
    30 Publications Verification

    		 STING Inflammation/Immunology Cancer
    SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity .
    SR-717
  • HY-W063968
    RO8191
    20+ Cited Publications

    CDM-3008; RO4948191

    		 IFNAR JAK STAT HCV HBV Infection
    RO8191 (CDM-3008), an imidazonaphthyridine compound, is an orally active and potent interferon (IFN) receptor agonist. RO8191 directly binds to IFNα/β receptor 2 (IFNAR2) and activates IFN-stimulated genes (ISGs) expression and JAK/STAT phosphorylation. RO8191 shows antiviral activity against both HCV and EMCV with an IC50 of 200 nM for HCV replicon . RO8191 is a cccDNA modulator (CDM) through interferon-like activity and has anti-HBV activity .
    RO8191
  • HY-147124
    RIG012
    5 Publications Verification

    		 IFNAR Infection Cancer
    RIG012 is a potent RIG-I inhibitor with an IC50 of 0.71 μM using the NADH-coupled ATPase assay. RIG012 inhibits IFN-β and ISG hRsad2 expression .
    RIG012
  • HY-50856A
    Ruxolitinib (S enantiomer)
    3 Publications Verification

    S-Ruxolitinib; S-INCB18424

    		 JAK Cancer
    Ruxolitinib (S enantiomer) (S-Ruxolitinib) is the S-enantiomer of Ruxolitinib (HY-50856). Ruxolitinib (S enantiomer) is an orally active, potent JAK inhibitor .
    Ruxolitinib (S enantiomer)
  • HY-172969
    ZHAWOC8655

    		Deubiquitinase Inflammation/Immunology
    ZHAWOC8655 is a USP18 inhibitor with a IC50 of 14.1 μM against hUSP18. ZHAWOC8655 disrupts the intracellular binding of USP18/ISG15 .
    ZHAWOC8655
  • HY-131454A
    SR-717 free acid
    Maximum Cited Publications
    30 Publications Verification

    		 STING Inflammation/Immunology Cancer
    SR-717 free acid is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 free acid is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity .
    SR-717 free acid
  • HY-112951
    ChX710
    4 Publications Verification

    		 STING Cancer
    ChX710 could prime the type I interferon response to cytosolic DNA, which induces the ISRE promoter sequence, specific cellular Interferon-Stimulated Genes (ISGs), and the phosphorylation of Interferon Regulatory Factor (IRF) 3.
    ChX710
  • HY-173425
    STING-IN-15

    		STING IFNAR TNF Receptor Interleukin Related Inflammation/Immunology
    STING-IN-15 is an orally active STING inhibitor, with an IC50 of 116 nM against h-STING and an IC50 of 96.3 nM against m-STING. STING-IN-15 inhibits the STING signaling pathway in cells, reduces the secretion of IFN-β and IP-10, downregulates the expression of ISG15, ISG56 and TNF-α, and suppresses the phosphorylation of TBK1/IRF3. STING-IN-15 alleviates systemic and renal inflammation induced by STING agonists in mice, reduces tissue damage and the expression of interferon pathway genes, and inhibits spontaneous tissue inflammation in mice. STING-IN-15 can be used for the research of acute kidney injury and autoimmune/inflammatory diseases .
    STING-IN-15
  • HY-128854
    Dimethyl biphenyl-4,4'-dicarboxylate
    1 Publications Verification

    		 Biochemical Assay Reagents JAK STAT IFNAR DNA/RNA Synthesis HBV Infection Metabolic Disease
    Dimethyl biphenyl-4,4'-dicarboxylate (Biphenyl dimethyl dicarboxylate) is a hepatoprotective agent. Dimethyl biphenyl-4,4'-dicarboxylate stimulates the Jak/Stat signaling pathway and induces the expression of IFN-α-stimulated genes, particularly 6-16 and ISG12. Dimethyl biphenyl-4,4'-dicarboxylate inhibits the replication of pregenomic RNA and HBeAg. Polymer micelles loaded with Dimethyl biphenyl-4,4'-dicarboxylate can serve as carriers for the compound. Dimethyl biphenyl-4,4'-dicarboxylate can be used as an auxiliary improving agent for chronic hepatitis. Dimethyl biphenyl-4,4'-dicarboxylate is applicable to research related to chronic hepatitis B .\n
    Dimethyl biphenyl-4,4'-dicarboxylate
  • HY-152959
    STING agonist-26

    		STING Infection Cancer
    STING agonist-26 (CF508) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .
    STING agonist-26
  • HY-151262
    JAK-IN-23
    1 Publications Verification

    		 JAK STING NF-κB STAT Inflammation/Immunology
    JAK-IN-23 is an orally active double inhibitor of JAK/STAT and NF-κB. JAK-IN-23 can inhibit JAK1/2/3 with IC50 values of 8.9 nM, 15 nM and 46.2 nM, respectively. JAK-IN-23 has potent inhibitory activities against interferon-stimulated genes (ISG) and NF-κB pathways with IC50 values of 3.3 nM and 150.7 nM, respectively. JAK-IN-23 has great anti-inflammatory that decreases the release of various proinflammatory factors. JAK-IN-23 can be used for the research of inflammatory bowel disease (IBD) .
    JAK-IN-23
  • HY-N0857
    Deoxyandrographolide
    1 Publications Verification

    		 GLUT HDAC Virus Protease PI3K AMPK Akt Histone Demethylase MDM-2/p53 IFNAR Reactive Oxygen Species (ROS) Infection Metabolic Disease Inflammation/Immunology
    Deoxyandrographolide is an orally active lactone found in the Andrographis paniculata Nees. Deoxyandrographolide shows a KD of 38.4 μM of HDAC1. Deoxyandrographolide enhances GLUT4 plasma membrane translocation, activates PI3K and AMPK-dependent signaling pathways, suppresses fasting blood glucose, serum insulin, triglycerides, and LDL-cholesterol levels. Deoxyandrographolide enhances HDAC1 expression via inhibited ubiquitination degradation, represses H3K4me3, improves chromosome stability, and restrains aging biomarkers p16, p21, γH2A.X, p53 and ROS production. Deoxyandrographolide interacts with Foot-and-Mouth Disease Virus 3Cpro active site, inhibits protease and IFN-antagonist activity, derepresses ISG expression, and inhibits viral replication. Deoxyandrographolide can be used for the researches of type 2 diabetes mellitus, vascular senescence and virus infection .
    Deoxyandrographolide
  • HY-163561
    CARM1-IN-6

    		Histone Methyltransferase Estrogen Receptor/ERR IFNAR Cancer
    CARM1-IN-6 is a potent CARM1 inhibitor that inhibits CARM1 enzymatic activity with an IC50 of 12.3 μM and a Kd of 0.6785 μM. CARM1-IN-6 suppresses oncogenic estrogen/ERα-target gene expression, activates type I interferon (IFN) and IFN-induced genes (ISGs), induces cell cycle arrest, and inhibits breast cancer cell proliferation both in vitro and in vivo. CARM1-IN-6 can be used for the research of breast cancer .
    CARM1-IN-6
  • HY-152956
    STING agonist-23

    		STING Infection Cancer
    STING agonist-23 (CF502) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .
    STING agonist-23
  • HY-156442
    MEDS433

    		Lactate Dehydrogenase Infection
    MEDS433 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC50 of 1.2 nM. MEDS433 exerts a potent antiviral activity against RSV-A and RSV-B in the one-digit nanomolar range. MEDS433 induces the expression of antiviral proteins encoded by interferon stimulated genes (ISGs) able to reduce RSV replication .
    MEDS433
  • HY-161344
    Z36-MP5

    		IFNAR Cancer
    Z36-MP5 is an Mi-2β-targeted inhibitor, with IC50 of 0.082 μM. Z36-MP5 can reduce Mi-2β ATPase activity and reactivates ISG transcription. Z36-MP5 can stimulate T-cell-mediated cytotoxicity .
    Z36-MP5
  • HY-RS06929
    ISG15 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ISG15 Human Pre-designed siRNA Set A contains three designed siRNAs for ISG15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ISG15 Human Pre-designed siRNA Set A
    ISG15 Human Pre-designed siRNA Set A
  • HY-125980
    LX-3
    1 Publications Verification

    		 p38 MAPK Cancer
    LX-3 is a selective activator of the p38 MAPK signaling pathway and activates EGFP reporter genes that are silenced by DNA methylation, such as TNF, EGR1, LY6K, and ISG20 .
    LX-3
  • HY-152961
    STING agonist-28

    		STING Infection
    STING agonist-28 (CF510) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .
    STING agonist-28
  • HY-178338
    STING agonist-47

    		STING Cancer
    STING agonist-47 is a STING agonist with an EC50 of 0.72 μM and a Kd of 176 nM. STING agonist-47 is a dimer of MSA-2 (HY-136927). STING agonist-47 can be used for the research of cancer, such as breast cancer .
    STING agonist-47
  • HY-172193
    UBD1031

    SGC-UBD1031

    		 Deubiquitinase HDAC Inflammation/Immunology Cancer
    UBD1031 (SGC-UBD1031) is a selective USP16/HDAC6-UBD antagonist with a human USP16-UBD IC50 of 10.6 μM, KD value of 48 nM, and a human HDAC6-UBD KD of 16 nM. UBD1031 disrupts ISG15 C-terminus interactions with USP16-UBD and HDAC6-UBD, and exhibits cooperative inhibition of full-length USP16 deubiquitinase activity via USP16-UBD binding. UBD1031 can be used in research on cancer, autoimmune diseases, and Down syndrome .
    UBD1031
  • HY-152957
    STING agonist-24

    		STING Infection
    STING agonist-24 (CF504) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .
    STING agonist-24
  • HY-152958
    STING agonist-25

    		STING Infection
    STING agonist-25 (CF505) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .
    STING agonist-25
  • HY-178951
    STING-IN-17

    		STING IKK Reactive Oxygen Species (ROS) IFNAR PARP Caspase Inflammation/Immunology
    STING-IN-17 (compound 10a) is an orally active STING (human STING IC50 = 29 nM, mouse STING IC50 = 15 nM) inhibitor. STING-IN-17 can inhibit the phosphorylation of STING, TBK1 and IRF3. STING-IN-17 dose dependently inhibits the mRNA expression of IP10, IFNB1 and ISG56. STING-IN-17 can reduce ROS and inhibit the expression of cleaved-PARP/caspase-3. STING-IN-17 can improve kidney function. STING-IN-17 can be used for research on inflammatory conditions such as acute kidney injury .
    STING-IN-17
  • HY-RS17041
    Isg15 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Isg15 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Isg15 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Isg15 Mouse Pre-designed siRNA Set A
    Isg15 Mouse Pre-designed siRNA Set A
  • HY-RS06930
    ISG20 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ISG20 Human Pre-designed siRNA Set A contains three designed siRNAs for ISG20 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ISG20 Human Pre-designed siRNA Set A
    ISG20 Human Pre-designed siRNA Set A
  • HY-112880
    c-(2'FdAMP-2'FdIMP)

    		Drug Derivative STING NF-κB IFNAR Interleukin Related Infection Cancer
    c-(2'FdAMP-2'FdIMP) (Compound 52),a derivative of cAIMP (HY-134375), is a cyclic dinucleotide (CDN). c-(2'FdAMP-2'FdIMP) is a STING activator and significantly induce STING-dependent IRF and NF-κB pathway signaling. c-(2'FdAMP-2'FdIMP) can be used for STING-based immunotherapy, such as cancers and infectious diseases research .
    c-(2'FdAMP-2'FdIMP)
  • HY-181057
    STING-IN-18

    		STING Reactive Oxygen Species (ROS) CXCR Interleukin Related Inflammation/Immunology
    STING-IN-18 is an orally active STING inhibitor. STING-IN-18 exhibits an IC50 of 86 nM against STING in murine RAW-Lucia TM ISG cells. STING-IN-18 inhibits STING activation and blocks downstream signaling pathways. STING-IN-18 suppresses kidney injury and inflammation. STING-IN-18 can be used for the research of autoimmune and inflammatory diseases .
    STING-IN-18
  • HY-RS20043
    Isg20 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Isg20 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Isg20 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Isg20 Mouse Pre-designed siRNA Set A
    Isg20 Mouse Pre-designed siRNA Set A
  • HY-RS26546
    Isg20 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Isg20 Rat Pre-designed siRNA Set A contains three designed siRNAs for Isg20 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Isg20 Rat Pre-designed siRNA Set A
    Isg20 Rat Pre-designed siRNA Set A
  • HY-RS23485
    Isg15 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Isg15 Rat Pre-designed siRNA Set A contains three designed siRNAs for Isg15 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Isg15 Rat Pre-designed siRNA Set A
    Isg15 Rat Pre-designed siRNA Set A
  • HY-174663
    Human IFNE mRNA

    		mRNA Inflammation/Immunology
    Human IFNE mRNA encodes the human interferon epsilon (IFNE) protein, a cytokine that belongs to the type I class of interferons. IFNE is required for maintaining basal levels of IFN-regulated genes, including 2''-5''-oligoadenylate synthetase, IRF7 and ISG15.
    Human IFNE mRNA
  • HY-125613
    ML416

    		HIV Influenza Virus Infection
    ML416 is a broad-spectrum antiviral agent. ML416 inhibits host de novo pyrimidine biosynthesis, and induces a variety of interferon-stimulated genes (ISGs). ML416 can be used for the research of viral infections including alphaviruses, influenza virus, and HIV-1 .
    ML416
  • HY-185123
    Pig TRIM56 mRNA

    		Toll-like Receptor (TLR) Infection
    Pig TRIM56 mRNA encodes the pig TRIM56 protein, an interferon-stimulated gene (ISG) that acts as an important innate immune factor. Overexpression of TRIM56 restricts viral replication by enhancing TLR3-TRAF3-mediated IFN-β production .
    Pig TRIM56 mRNA
  • HY-P991956
    ABB071

    		Transmembrane Glycoprotein Toll-like Receptor (TLR) Inflammation/Immunology
    ABB071 is a humanized anti-CD180 monoclonal antibody. ABB071 can down-regulate the highly expressed TLR7 and IRF5 genes in systemic lupus erythematosus and induce the expression of PNPT1 and DNASE1L3 genes. ABB071 can inhibit the expression of genes related to the type I interferon pathway as well as interferon-stimulated genes (ISGs). ABB071 has anti-inflammatory activity and can reduce the levels of inflammatory cytokines. ABB071 can be used for research on systemic lupus erythematosus and psoriasis .
    ABB071
  • HY-181165
    SB2960

    		PKC SARS-CoV IFNAR Infection
    SB2960 is a receptor for activated protein C kinase 1 (RACK1) binder with a human KD of 5.65 μM. SB2960 can promote stress granule (SG) formation and exhibit potent antiviral activity across diverse viral species. SB2960 suppresses viral replication with minimal cytotoxicity by modulating host antiviral immune responses. SB2960 increases the thermal stability of RACK1 and reduces SARS-CoV-2 N protein levels. SB2960 enhances type I interferon (IFN-β) expression and inhibits RIG-I, ISG56, and RANTES expression. SB2960 can be used for the research of virus infection .
    SB2960

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