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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
119 Results for "
MST
" in MedChemExpress (MCE) Product Catalog:
Products (119)
119 Results for "MST" in MCE Product Catalog:
86
86 Publications Verification
Target:
Áreas de investigación:
XMU-MP-1 is a reversible and selective MST1/2 inhibitor with IC50s of 71.1 and 38.1 nM, respectively .
13
13 Cited Publications
Synonyms: LKB1/AAK1 dual inhibitor
Pim1/AAK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AAK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.
6
6 Cited Publications
Synonyms: LY2801653
Áreas de investigación:
Merestinib (LY2801653) is a potent, orally bioavailable c-Met inhibitor (Ki=2 nM) with anti-tumor activities. Merestinib (LY2801653) also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK (IC50=10 nM), TEK (IC50=63 nM), ROS1, DDR1/2 (IC50=0.1/7 nM) and MKNK1/2 (IC50=7 nM) .
6
6 Cited Publications
Synonyms: LY2801653 dihydrochloride
Áreas de investigación:
Merestinib dihydrochloride (LY2801653 dihydrochloride) is a potent, orally bioavailable c-Met inhibitor (Ki=2 nM) with anti-tumor activities. Merestinib dihydrochloride also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK (IC50=10 nM), TEK (IC50=63 nM), ROS1, DDR1/2 (IC50=0.1/7 nM) and MKNK1/2 (IC50=7 nM) .
5
5 Cited Publications
Synonyms: HMPSNE
Target:
Áreas de investigación:
I3MT-3 (HMPSNE) is a potent, selective, and cell-membrane permeable inhibitor of 3-Mercaptopyruvate sulfurtransferase (3MST) (IC50=2.7 μM). I3MT-3 is inactive for other H2S/sulfane sulfur-producing enzymes.?I3MT-3 targets a persulfurated cysteine residue located in the active site of 3MST .
3
3 Cited Publications
Synonyms: Telomerase Inhibitor IX
Target:
Áreas de investigación:
MST-312 is a telomerase inhibitor. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 can be used for the research of cancer, such as multiple myeloma (MM) .
2
2 Cited Publications
Target:
Áreas de investigación:
SBP-3264 is a YAP activator and STK/MST inhibitor with IC50 values of 36 nM against STK3/MST2 and 24 nM against STK4/MST1. SBP-3264 modulates the Hippo signaling pathway. SBP-3264 can be used for the research of acute myeloid leukemia .
2
2 Cited Publications
Referencia número: HY-P74742
Pureza: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: STK4; Kinase Responsive To Stress 2; Serine/Threonine Kinase 4; Mammalian Sterile 20-Like 1; MST1; STE20-Like Kinase MST1; KRS2; Non-Specific Serine/Threonine Protein Kinase; YSK3; Hippo (Drosophila) Homolog; Mammalian STE20-Like Protein Kinase 1; Yeast S
Species:
Human
Source:
Sf9 insect cells
1
1
1 Cited Publications
Referencia número: HY-P701821
Pureza: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: STK3; Serine/Threonine-Protein Kinase Krs-1; Serine/Threonine Kinase 3; MST-2; MST2; Serine/Threonine Kinase 3 (STE20 Homolog, Yeast); KRS1; Non-Specific Serine/Threonine Protein Kinase; Mammalian STE20-Like Protein Kinase 2; Epididymis Secretory Sperm Bi
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Referencia número: HY-P701103
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MST1; NF15S2; Prev. D3F15S2; Macrophage Stimulatory Protein; Prev. DNF15S2; Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like); Prev. HGFL; Hepatocyte Growth Factor-Like Protein Homolog; MSP; Hepatocyte Growth Factor-Like; Hepatocyte Growth Factor-L
Species:
Mouse
Source:
HEK293
Target:
Áreas de investigación:
IHMT-MST1-58 is a potent, selective mammalian and orally active STE20-like protein 1 kinase (MST1) inhibitor with IC50 value of 23 nM. IHMT-MST1-58 can be used for the research of Type 1/2 diabetes .
hnRNPK-IN-1 is a heterogeneous nuclear ribonucleoprotein K (hnRNPK) binding ligand with Kd values of 4.6 μM and 2.6 μM measured with SPR and MST, respectively. hnRNPK-IN-1 inhibits c-myc transcription by disrupting the binding of hnRNPK and c-myc promoter. hnRNPK-IN-1 induces Hela cells apoptosis and has strongly anti-tumor activities .
Referencia número: HY-175207
No. CAS: 3109469-27-1
Target:
Áreas de investigación:
CHI3L1-IN-3 is a CHI3L1 inhibitor. CHI3L1-IN-3 binds to CHI3L1 with Kds of 13.76 μM and 13.5 μM in MST and SPR assays, respectively. CHI3L1-IN-3 demonstrates extended plasma half-lives and microsomal stability, along with reduced intrinsic clearance. CHI3L1-IN-3 induces dose-dependent cytotoxicity, reduces spheroid mass and inhibits migration in a 3D multicellular glioblastoma (GBM) spheroid model. CHI3L1-IN-3 can be used for the study of GBM .
Referencia número: HY-164595
No. CAS: 2414484-01-6
Target:
Áreas de investigación:
IHMT-MST1-39 is an orally active inhibitor for MST kinase, with IC50 of 42, 109, 286, 159 nM for MST1, MST2, MST3, MST4. IHMT-MST1-39 activates the AMPK signaling pathway in liver cells, reduces apoptosis of pancreatic β-cells. IHMT-MST1-39 can be used for the studies of type 1 diabetes (T1D) and type 2 diabetes (T2D) .
Referencia número: HY-160211
No. CAS: 3022928-90-8
Target:
Áreas de investigación:
JA310, a chemical probe, is a highly selective MST3 kinase inhibitor. JA310 has high cellular potency against MST3 with an EC50 value of 106 nM .
Referencia número: HY-P3143
No. CAS: 1629655-80-6
Target:
Áreas de investigación:
BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs .
Referencia número: HY-157932A
Target:
Áreas de investigación:
MR24 TFA, a G-5555 (HY-19635) derivative, is a mammalian STE20-like (MST) kinase inhibitor. MR24 TFA shows selectively to MST3/4 over MST1/2, with EC50 values of 57 and 583 nM, respectively. MR24 TFA induces G1 phase cell cycle arrest. MR24 TFA can be used for cancer research, such as breast, liver and lung cancers .
Referencia número: HY-175208
No. CAS: 3095435-97-2
Target:
Áreas de investigación:
MST3-IN-1 is a selective and orally active MST3 inhibitor, with an IC50 of 122.4 nM. MST3-IN-1 shows antiproliferative activity against HepG2 cell. MST3-IN-1 effectively induces apoptosis in HepG2 cells, and halts the cell cycle at the G2/M transition. MST3-IN-1 significantly suppressed tumor growth in HepG2 xenograft mice. MST3-IN-1 can be used for the study of liver cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
