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MTT

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By Targets:	ADC Linker (2) Amino Acid Derivatives (2) Amyloid-β (1) Antibiotic (1) Apoptosis (3) Autophagy (1) Bacterial (1) Biochemical Assay Reagents (1) Drug Derivative (2) E1/E2/E3 Enzyme (1) Fluorescent Dye (3) Fungal (1) HIV (1) HIV Integrase (1) HSV (1) Interleukin Related (1) MDM-2/p53 (1) Microtubule/Tubulin (1) PARP (1) RIP kinase (1) Ser/Thr Protease (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (2) Neurological Disease (1)
Click Chemistry:	Azide (1)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15924

Thiazolyl Blue 180+ Cited Publications MTT; Thiazolyl Blue Tetrazolium bromide; Methylthiazolyldiphenyl-tetrazolium bromide	Fluorescent Dye	Others
Thiazolyl Blue (MTT) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis .

HY-12855A

Lys05 4 Publications Verification Lys01 trihydrochloride	Autophagy	Cancer
Lys05 (Lys01 trihydrochloride) is a novel lysosomal autophagy inhibitor with IC₅₀ values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay.

HY-137006

MTT Formazan	Fluorescent Dye	Others
MTT Formazan is a purple water-insoluble product formed by the reduction of yellow soluble MTT by succinate dehydrogenase in the mitochondria of viable cells. The amount of MTT Formazan produced is proportional to cellular metabolic activity, and it can serve as an indicator for evaluating cell viability and proliferation. MTT Formazan exhibits solvent-dependent solubility properties, and its absorbance value can be measured by spectrophotometry to reflect cellular status. MTT Formazan also supports the assessment of cell viability in bacterial MTT assays. MTT Formazan can be used in photoacoustic microscopy to enhance the imaging effect of viable cells, especially in applications in the fields of three-dimensional cell culture and tissue engineering .

HY-W008872

*Fmoc-Lys(Mtt)-OH*	Amino Acid Derivatives	Others
Fmoc-Lys(Mtt)-OH is a lysine derivative .

HY-N2127

Pinostrobin 3 Publications Verification	Amyloid-β Apoptosis Ser/Thr Protease HSV Interleukin Related	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Pinostrobin is a flavonoid with anti-cancer, antioxidant, antiviral and neuroprotective activities. Pinostrobin has oral activity. Pinostrobin is a potent PCSK9 inhibitor that inhibits the catalytic activity of PCSK9. Pinostrobin can be used in the research of viral infections, cancer, leukemia, cardiovascular and cerebrovascular diseases, cirrhosis, inflammation and neurological diseases .

HY-16999

RO8994	MDM-2/p53 E1/E2/E3 Enzyme Apoptosis	Cancer
RO8994 (Compound 4) is an orally active, highly potent and selective spiroindolinone p53-MDM2 inhibitor with an IC₅₀ value of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays). RO8994 induces up-regulation of p53 expression and Apoptosis in wild-type p53 cancer cells. RO8994 also inhibits tumor growth in the tumor xenograft model .

HY-151678

*N3-L-Lys(Mtt)-OH*	ADC Linker	Others
N3-L-Lys(Mtt)-OH is a click chemistry reagent containing an azide group. N3-L-Lys(Mtt)-OH can introduce azide functions into the amino acid building block of peptide sequences at the N-terminal position. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-169017

MTT5	Toll-like Receptor (TLR)	Cancer
MTT5 is a toll-like receptor 7 (TLR7) agonist. MTT5 can couple with Deruxtecan (HY-13631E) and exert anti-tumor activity in HER2 positive solid tumors through tumor cell killing and immune activation .

HY-155791

*SMCC-NH-CH2-triazole-PEG8-oxydiacetamide-Lys(MTT)-PAB*	ADC Linker	Cancer
SMCC-NH-CH2-triazole-PEG8-oxydiacetamide-Lys(MTT)-PAB (Page 7, Compound C) is an ADC linker that can be used for the synthesis of antibody-conjugated active molecules (ADC) .

HY-178937

Anticancer agent 284	RIP kinase	Cancer
Anticancer agent 284 exhibits cytotoxicity against osteosarcoma cell line (Hos), non-small cell lung cancer cell line (A549), and colon cancer cell line (HCT-116). Anticancer agent 284 can impact the pRIPK3 kinase concentration in the A549 (2.97 pg/mL). Anticancer agent 284 can be used for the study of cancer .

HY-12108

S 1360	HIV Integrase HIV	Infection
S 1360 is a potent and selective inhibitor of HIV-1 integrase. S 1360 inhibits the catalytic activity of purified integrase ( IC₅₀: 20 nM). The EC₅₀, and CC₅₀ of S 1360 in MTT assay (MT-4 cells infected with HIV-1 IIIB) are 200 nM and 12 μM, respectively. S 1360 has antiviral activity against both X4 tropic and R5 tropic strains, as well as NRTI, NNRTI and PI drug-resistant variants .

HY-W102335

(Rac)-Threonine	Amino Acid Derivatives	Inflammation/Immunology Cancer
(Rac)-Threonine (Compound 19) is an amino acid derivative that can be found in the methanol (MeOH) extract of Rumex roseus L. The MeOH extract containing (Rac)-Threonine exhibits antioxidant and cytotoxic properties .

HY-138169

*Fmoc-Dap(Mtt)-OH*	Drug Derivative Biochemical Assay Reagents	Others
Fmoc-Dap (Mtt)-OH is an Fmoc-protected derivative of 2,3-diaminopropionic acid (HY-113379). Fmoc-Dap (Mtt)-OH is applicable for polypeptide synthesis .

HY-121349

Aerothionin	Bacterial Fungal Antibiotic	Infection Cancer
Aerothionin is an antibiotic with potent antimicrobial efficacy against bacteria and fungi. Aerothionin exhibits antitumor efficacy against adrenal pheochromocytomas and extra-adrenal paragangliomas (PPGLs) .

HY-N15578

Actinidioionoside	Others	Others
Actinidioionoside (Compound 2) is a megastigmane glucoside compound found in Borago officinalis L. Actinidioionoside has DPPH free radical scavenging activity (IC₅₀: 41.3 μM). Actinidioionoside has no significant cytotoxicity against A549 human lung cancer cells (IC₅₀ > 100 μM). Actinidioionoside can be used in antioxidant studies .

HY-N13136

Timosaponin D	Others	Cancer
Timosaponin D, a natural steroid saponin, can be obtained from the rhizome of Anemarrhena asphodeloides. The IC₅₀ values of Timosaponin D against HepG2 and SGC7901 cells are 43.90 and 57.90 μM, respectively. Timosaponin D can be used in anticancer research .

HY-N10778

(19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol	Others	Others
(19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol is a cucurbitane-type triterpenoid. (19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol has been tested to no effect against 5 cancer cell lines, MCF-7, HepG2, Du145, Colon205 and HL-60 by MTT assay .

HY-W013437

7-Benzoyloxindole	Microtubule/Tubulin	Cancer
7-Benzoyloxindole (Compound 4a) is a tubulin destabilizer. 7-Benzoyloxindole disrupts the structure of microtubulin, thereby inhibiting the growth of tumor cells. 7-Benzoyloxindole can be used in the research of gastric cancer and lung cancer .

HY-149003

PARP1-IN-10	PARP Apoptosis	Cancer
PARP1-IN-10 (compound 12c) is a no-cytotoxicity and potent PARP1 inhibitor with an IC₅₀ value of 50.62 nM in vitro. PARP1-IN-10 causes cell cycle arrest at G2/M phase and apoptosis, and enhances the cytotoxicity of temozolomide (TMZ) .

HY-DY1086

Thiazolyl Blue (solution) MTT (solution); Thiazolyl Blue Tetrazolium bromide (solution); Methylthiazolyldiphenyl-tetrazolium bromide (solution)	Fluorescent Dye	Others
Thiazolyl Blue (solution) (MTT (solution)) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis . Solvent and concentration: PBS: 5 mg/mL

HY-N16844

Steppogenin-5'-C-β-D-glucopyranoside	Drug Derivative	Others
Steppogenin-5'-C-β-D-glucopyranoside is a natural flavonoid.

Cat. No.	Product Name	Type

HY-15924

Thiazolyl Blue 180+ Cited Publications MTT; Thiazolyl Blue Tetrazolium bromide; Methylthiazolyldiphenyl-tetrazolium bromide	Fluorescent Dye
Thiazolyl Blue (MTT) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis .

HY-DY1086

Thiazolyl Blue (solution) MTT (solution); Thiazolyl Blue Tetrazolium bromide (solution); Methylthiazolyldiphenyl-tetrazolium bromide (solution)	Fluorescent Dye
Thiazolyl Blue (solution) (MTT (solution)) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis . Solvent and concentration: PBS: 5 mg/mL

Thiazolyl Blue (solution)

MTT (solution); Thiazolyl Blue Tetrazolium bromide (solution); Methylthiazolyldiphenyl-tetrazolium bromide (solution)

Fluorescent Dye

Thiazolyl Blue (solution) (MTT (solution)) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis .
Solvent and concentration: PBS: 5 mg/mL

*Fmoc-Lys(Mtt)-OH*	Amino Acid Derivatives	Others
Fmoc-Lys(Mtt)-OH is a lysine derivative .

Pinostrobin 3 Publications Verification	Monophenols Flavonoids other families Classification of Application Fields Flavonones Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Amyloid-β Apoptosis Ser/Thr Protease HSV Interleukin Related
Pinostrobin is a flavonoid with anti-cancer, antioxidant, antiviral and neuroprotective activities. Pinostrobin has oral activity. Pinostrobin is a potent PCSK9 inhibitor that inhibits the catalytic activity of PCSK9. Pinostrobin can be used in the research of viral infections, cancer, leukemia, cardiovascular and cerebrovascular diseases, cirrhosis, inflammation and neurological diseases .

Aerothionin	Antibiotics Marine natural products Sponge Source Classification	Bacterial Fungal Antibiotic
Aerothionin is an antibiotic with potent antimicrobial efficacy against bacteria and fungi. Aerothionin exhibits antitumor efficacy against adrenal pheochromocytomas and extra-adrenal paragangliomas (PPGLs) .

Actinidioionoside	Borago officinalis L. Lignans Phenylpropanoids Plants Boraginaceae Source Classification	Others
Actinidioionoside (Compound 2) is a megastigmane glucoside compound found in Borago officinalis L. Actinidioionoside has DPPH free radical scavenging activity (IC₅₀: 41.3 μM). Actinidioionoside has no significant cytotoxicity against A549 human lung cancer cells (IC₅₀ > 100 μM). Actinidioionoside can be used in antioxidant studies .

Timosaponin D	Triterpenes Liliaceae Terpenoids Anemarrhena asphodeloides Bunge Plants Source Classification	Others
Timosaponin D, a natural steroid saponin, can be obtained from the rhizome of Anemarrhena asphodeloides. The IC₅₀ values of Timosaponin D against HepG2 and SGC7901 cells are 43.90 and 57.90 μM, respectively. Timosaponin D can be used in anticancer research .

(19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol	Triterpenes Terpenoids Cucurbitaceae Plants Source Classification Momordica charantia Linn.	Others
(19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol is a cucurbitane-type triterpenoid. (19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol has been tested to no effect against 5 cancer cell lines, MCF-7, HepG2, Du145, Colon205 and HL-60 by MTT assay .

Steppogenin-5'-C-β-D-glucopyranoside	Structural Classification Flavonoids Flavonones Plants Moraceae Morus alba Linn. Source Classification	Drug Derivative
Steppogenin-5'-C-β-D-glucopyranoside is a natural flavonoid.

Cat. No.	Product Name		Classification

HY-151678

*N3-L-Lys(Mtt)-OH*		Azide
N3-L-Lys(Mtt)-OH is a click chemistry reagent containing an azide group. N3-L-Lys(Mtt)-OH can introduce azide functions into the amino acid building block of peptide sequences at the N-terminal position. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

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MTT

Inhibitors & Agonists

Fluorescent Dye

Peptides

NaturalProducts

Click Chemistry

Natural
Products