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NNRTIs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Cytochrome P450 (3) DNA/RNA Synthesis (3) Drug Isomer (1) Endogenous Metabolite (1) Fungal (1) HIV (65) HIV Integrase (1) HIV Protease (1) Isotope-Labeled Compounds (4) MMP (2) Potassium Channel (1) Reference Standards (7) Reverse Transcriptase (45) SARS-CoV (2)
By Research Areas:	Cancer (1) Infection (68) Inflammation/Immunology (3)
Click Chemistry:	Alkynes (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10574

Rilpivirine Maximum Cited Publications 10 Publications Verification R278474; TMC278; DB08864	HIV Reverse Transcriptase	Infection
Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC₅₀=0.4 nM) and mutant viruses (EC₅₀=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .

HY-90005

Etravirine 5 Publications Verification R165335; TMC125	Reverse Transcriptase HIV	Infection
Etravirine (R165335; TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

HY-14267

Lersivirine UK-453061	HIV Reverse Transcriptase	Infection
Lersivirine (UK-453061) is potent and selective non-nucleoside reverse transcription inhibitor (NNRTI; IC₅₀=119 nM) with excellent efficacy against NNRTI-resistant viruses. Lersivirine exhibits potent antiretroviral activity against wild-type HIV virus and clinically relevant NNRTI-resistant strains .

HY-10571A

Delavirdine mesylate 3 Publications Verification U 90152 mesylate; BHAP-U 90152 mesylate	HIV Reverse Transcriptase	Infection
Delavirdine (U 90152) mesylate is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine mesylate selectively inhibits HIV-1 reverse transcriptase (RT) (IC₅₀=0.26 μM) over DNA polymerase α (IC₅₀=440 μM) and polymerase δ (IC₅₀>550 μM). Delavirdine mesylate is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .

HY-10571

Delavirdine 3 Publications Verification U 90152; BHAP-U 90152	HIV Reverse Transcriptase	Infection
Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC₅₀=0.26 μM) over DNA polymerase α (IC₅₀=440 μM) and polymerase δ (IC₅₀>550 μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .

HY-15355

Loviride R 89439	Reverse Transcriptase HIV	Infection
Loviride (R 89439) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), with an IC₅₀ of 0.3 µM for reverse transcriptase from HIV-1. Loviride (R 89439) inhibits HIV-1, HIV-2 and SIV replication in MT-4 cells .

HY-10574A

Rilpivirine hydrochloride Maximum Cited Publications 10 Publications Verification TMC-278 hydrochloride	SARS-CoV MMP	Infection
Rilpivirine (R278474) hydrochloride is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine hydrochloride has high antiviral activity against wild-type HIV (EC₅₀=0.4 nM) and mutant viruses (EC₅₀=0.1-2.0 nM). Rilpivirine hydrochloride has a high genetic barrier to resistance development of HIV .

HY-W325699

HIV-1 inhibitor-48	HIV Reverse Transcriptase	Infection
HIV-1 inhibitor-48 (compound 13o) is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) and exhibits anti-HIV-1 activity .

HY-122470

Stampidine	Reverse Transcriptase HIV	Infection
Stampidine is a nucleoside reverse transcriptase inhibitor (NRTI) with potent and broad-spectrum anti-HIV activity. Stampidine inhibits the laboratory HIV-1 strain HTLV_IIIB (B-envelope subtype) and primary clinical isolates with IC₅₀s of 1 nM and 2 nM, respectively. Stampidine also inhibits NRTI-resistant primary clinical isolates and NNRTI-resistant clinical isolates with IC₅₀s of 8.7 nM and 11.2 nM, respectively .

HY-19509

IQP-0528	Reverse Transcriptase HIV	Infection
IQP-0528 is a highly potent nonnucleoside reverse transcriptase inhibitor (NNRTI). IQP-0528 shows nanomolar activity against both HIV-1 and HIV-2, with EC₅₀s of 0.2 nM and 100 nM, respectively .

HY-13053

Depulfavirine 1 Publications Verification Ro-0335	Reverse Transcriptase	Cancer
RO-0335 is a novel and potent diphenylether nonnucleoside reverse transcriptase inhibitor(NNRTI). RO-0335 inhibits Wt HIV-1 with an IC₅₀ of 1.1 nM and retained activity (IC₅₀< 100 nM) against 92% of a large number of NNRTI-resistant clinical isolates .

HY-14891

Fosdevirine GSK2248761; FDV	HIV Reverse Transcriptase	Infection
Fosdevirine (GSK2248761) is is a potent, selective, non-nucleoside reverse transcriptase inhibitor (NNRTI) of human immunodeficiency virus type 1 (HIV-1) replication with low nanomolar activity in vitro. Fosdevirine shows good activity against a broad range of HIV-1 strains, including efavirenz (HY-10572)-resistant clinical isolates .

HY-152161

HIV-1 inhibitor-51	HIV Reverse Transcriptase	Infection
HIV-1 inhibitor-51, a non-nucleoside reverse transcriptase inhibitor (NNRTI), exhibits outstanding antiviral activity against WT HIV-1 (IIIB) and a panel of mutant strains. HIV-1 inhibitor-51 has high binding affinity (K_D=2.50 μM) and inhibitory activity (IC₅₀=0.03 μM) to WT HIV-1 RT. HIV-1 inhibitor-51 has EC₅₀s of 2.22-53.3 nM for mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L + V106A, RES056) .

HY-90005S

Etravirine D4 TMC-125 d₄; R-165335 d₄	Reverse Transcriptase HIV	Infection
Etravirine-d₄ is the deuterium labeled Etravirine. Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

HY-152160

HIV-1 inhibitor-50	HIV Reverse Transcriptase	Infection
HIV-1 invistor-50 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets HIV-1 reverse transcriptase (RT) (IC₅₀=50 nM). HIV-1 inhibitor-50 shows significant antiviral activity, with EC₅₀s of 2.22-53.3nM against HIV-1 IIIB and its mutant strains .

HY-14361

MK-4965	HIV Reverse Transcriptase	Infection
MK-4965 is a nonnucleoside reverse transcriptase inhibitor (NNRTI). MK-4965 displays excellent activities against not only HIV-1 wild-type (WT) virus but also against a broad panel of NNRTI-resistant viruses and can be used for the research of HIV-1 infection .

HY-105489

UC-84 NSC-615985	Reverse Transcriptase HIV	Infection
UC-84 (NSC-615985) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) with anti-HIV activity .

HY-173427

K-5a2	Reverse Transcriptase HIV	Infection
K-5a2 is the non-isotopic form of ZK-316 (HY-173427S). ZK-316 is a potent and broad-spectrum *NNRTI* inhibitor with an EC₅₀ value ranging from 0.99 to 75.1 nM. ZK-316 can be used in the study of HIV .

HY-162461

HIV-1 inhibitor-66	Reverse Transcriptase HIV	Infection
HIV-1 inhibitor-66 is an orally active non-nucleoside reverse transcription inhibitor (NNRTI). HIV-1 inhibitor-66 shows inhibitory activity against wild-type HIV-1 reverse transcriptase with an IC₅₀ of 40 nM .

HY-163110

NNRT-IN-2	HIV Reverse Transcriptase	Infection
NNRT-IN-2 (compound 7w) is an orally available non-nucleoside reverse transcriptase inhibitor (NNRTI) with broad inhibitory effects on wild-type HIV-1 and mutant strains. NNRT-IN-2 inhibits HIV-1 reverse transcriptase with an EC₅₀ of 22 nM. NNRT-IN-2 is insensitive to CYP and hERG and has good safety and pharmacokinetic characteristics .

HY-123330

GW695634	HIV Reverse Transcriptase	Infection
GW695634 is an orally active prodrug of GW678248. GW695634 undergoes amidolysis in vivo to release the active ingredient GW678248, thereby inhibiting viral replication. GW678248 is a non-nucleoside reverse transcriptase inhibitor (NNRTi) with potent antiviral activity against Efavirenz (HY-10572)-resistant and Nevirapine (HY-10570)-resistant HIV and AIDS viruses .

HY-15353

Emivirine MKC-442	HIV	Infection Inflammation/Immunology
Emivirine (MKC-442) is a non-nucleoside reverse transcriptase inhibitors (NNRTIs) with K_i values of 0.20 and 0.01 μM for dTTP- and dGTP-dependent DNA or RNA polymerase activity, respectively. Emivirine displays potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity .

HY-19869

VRX-480773	HIV Reverse Transcriptase	Infection
VRX-480773 is an efficient non-nucleoside reverse transcriptase inhibitor (NNRTI), used for HIV infection. VRX-480773 has high specificity for HIV-1, with an EC₅₀ for wild-type HIV-1 being 0.14 nM. VRX-480773 does not inhibit HIV-2, HBV or HCV, and has no effect on human DNA polymerase α/β. VRX-480773 retains inhibitory activity against Efavirenz (HY-10572) resistant strains, with EC₅₀s mostly < 1 nM. VRX-480773 can be used for research on AIDS .

HY-105249

RDEA 806	HIV Reverse Transcriptase	Infection
RDEA 806 is an orally active non-nucleoside reverse transcriptase inhibitor (NNRTI) that exhibits potent in vitro inhibitory activity against both wild-type HIV-1 (EC₅₀ = 3.05 nM) and NNRTI-resistant HIV-1 .

HY-15352

BMS 561390 DPC 083	Reverse Transcriptase HIV	Infection
BMS 561390 (DPC 083) is an orally available non-nucleoside reverse transcriptase inhibitor (NNRTI) with broad inhibitory effects on wild-type HIV-1 and mutant strains .

HY-156599

Bavtavirine	HIV	Infection
Bavtavirine is a potent non-nucleoside reverse transcriptase inhibitors (NNRTIs). Bavtavirine is part of highly active antitiretroviral therapy (HAART) treatment regimen. Bavtavirine can be used for HIV disease research .

HY-139158

Ainuovirine	HIV	Infection
Ainuovirine is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI). Ainuovirine inhibits HIV replication by non-competitively binding to HIV reverse transcriptase and blocking the reverse transcription process of viral RNA. Ainuovirine can be used for human immunodeficiency virus (HIV) type 1 infection .

HY-15355R

Loviride (Standard) R 89439 (Standard)	Reverse Transcriptase HIV Reference Standards	Infection
Loviride (Standard) is the analytical standard of Loviride. This product is intended for research and analytical applications. Loviride (R 89439) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), with an IC50 of 0.3 μM for reverse transcriptase from HIV-1. Loviride (R 89439) inhibits HIV-1, HIV-2 and SIV replication in MT-4 cells .

HY-174417

NNRT-IN-10	Reverse Transcriptase HIV Potassium Channel Cytochrome P450	Infection
NNRT-IN-10 is a potent, selective and orally active non-nucleoside HIV-1 reverse transcriptase (NNRTI) inhibitor with with an EC₅₀ values ranging from 1.16 to 18.3 nM for HIV and its mutant strains. NNRT-IN-10 exhibits good pharmacokinetic properties and favorable safety profiles. NNRT-IN-10 can be used for the study of AIDS, caused by HIV-1 .

HY-10574S

Rilpivirine-d6	Isotope-Labeled Compounds HIV Reverse Transcriptase	Infection
Rilpivirine-d₆ is the deuterium labeled Rilpivirine. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC₅₀=0.4 nM) and mutant viruses (EC₅₀=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .

HY-12108

S 1360	HIV Integrase HIV	Infection
S 1360 is a potent and selective inhibitor of HIV-1 integrase. S 1360 inhibits the catalytic activity of purified integrase ( IC₅₀: 20 nM). The EC₅₀, and CC₅₀ of S 1360 in MTT assay (MT-4 cells infected with HIV-1 IIIB) are 200 nM and 12 μM, respectively. S 1360 has antiviral activity against both X4 tropic and R5 tropic strains, as well as NRTI, NNRTI and PI drug-resistant variants .

HY-118711

HI-346	HIV Reverse Transcriptase	Infection
HI-346 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) for HIV-1 with an IC₅₀ value against the HIV-1 virus strain (HTLV-IIIB) of 3 nM. HI-346 is a vaginal bactericidal contraceptive agent, with its sperm-killing activity having an EC₅₀ value of 42 μM. HI-346 shows no cytotoxicity to normal cells at effective concentrations. HI-346 can be used in anti-HIV-1 and contraceptive research .

HY-N16422

Mer-NF5003E	HIV HIV Protease	Infection
Mer-NF5003E is a non-nucleoside reverse transcriptase inhibitor targeting HIV-1 reverse transcriptase (RT) (EC₅₀=50 μM). Mer-NF5003E exhibits inhibitory activity against wild-type HIV-1 and multiple NNRTI-resistant strains (e.g., K103N, Y181C). Mer-NF5003E is promising for research of HIV infections .

HY-149866

HIV-1 inhibitor-58	Cytochrome P450 HIV Reverse Transcriptase	Infection
HIV-1 inhibitor-58 (Compound 10c) is a broad-spectrum antiviral agent. HIV-1 inhibitor-58 is a non-nucleoside reverse transcriptase inhibitor. HIV-1 inhibitor-58 inhibits WT strain IIIB, NNRTI-resistant strains (such as K103N and E138K) in MT-4 cells, with EC₅₀ less than 50 nM. HIV-1 inhibitor-58 also inhibits CYP2C9 and CYP2C19 (IC₅₀: 2.06 μM, 1.91 μM). HIV-1 inhibitor-58 can be used for HIV infection reserch .

HY-14294

Capravirine S-1153	Reverse Transcriptase HIV	Infection
Capravirine (S-1153) is an orally active non-nucleoside reverse transcriptase inhibitor (NNRTI) with potent antiviral activity. Capravirine inhibits replication of HIV-1 strains that are resistant to nucleoside/nucleotide reverse transcriptase inhibitors and other NNRTIs. Capravirine is metabolized by the cytochrome P450 enzyme CYP3A4 .

HY-146746

HIV-1 inhibitor-19	HIV	Infection
HIV-1 inhibitor-19 is a potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI). HIV-1 inhibitor-19 maintains its inhibitory activity against L100I, K103N and V106A/ F227L mutant strains with EC₅₀s of 7.3 nM, 9.2 nM and 21.0 nM, respectively.

HY-19509R

IQP-0528 (Standard)	Reverse Transcriptase HIV	Infection
IQP-0528 (Standard) is the analytical standard of IQP-0528. This product is intended for research and analytical applications. IQP-0528 is a highly potent nonnucleoside reverse transcriptase inhibitor (NNRTI). IQP-0528 shows nanomolar activity against both HIV-1 and HIV-2, with an HIV-1 EC50 of 0.2 nM and an HIV-2 EC50 of 100 nM .

HY-146364

CI-39	DNA/RNA Synthesis HIV	Infection
CI-39 is an antiviral natural product. CI-39 is an NNRTI (non-nucleoside reverse transcriptase inhibit) antiviral agent with an EC₅₀ of 3.40 μM and an CC₅₀ of >30 μM for wild type HIV-1. CI-39 inhibits HIV-1 RT DNA polymerase and ribonuclease H activitiessup .

HY-10571R

Delavirdine (Standard) U 90152 (Standard); BHAP-U 90152 (Standard)	Reference Standards HIV Reverse Transcriptase	Infection
Delavirdine (Standard) is the analytical standard of Delavirdine. This product is intended for research and analytical applications. Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC50=0.26?μM) over DNA polymerase?α?(IC50=440 μM) and polymerase?δ (IC50>550?μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .

HY-10571AR

Delavirdine mesylate (Standard) U 90152 mesylate (Standard); BHAP-U 90152 mesylate (Standard)	Reference Standards HIV Reverse Transcriptase	Infection
Delavirdine (mesylate) (Standard) is the analytical standard of Delavirdine (mesylate). This product is intended for research and analytical applications. Delavirdine (U 90152) mesylate is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine mesylate selectively inhibits HIV-1 reverse transcriptase (RT) (IC50=0.26?μM) over DNA polymerase?α?(IC50=440 μM) and polymerase?δ (IC50>550?μM). Delavirdine mesylate is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .

HY-175491

HIV-1-IN-85	HIV Reverse Transcriptase	Infection
HIV-1-IN-85 is an orally active HIV-1 inhibitor (IC₅₀ = 72 nM). HIV-1-IN-85 exhibits strong inhibitory activity against wild-type (WT) HIV-1 and NNRTI-resistant single mutant strains (L100I, K103N, Y181C, Y188L, E138K) and moderate efficacy against double mutant strains (F227L+V106A, RES056). HIV-1-IN-85 shows good in vivo safety in ICR mice. HIV-1-IN-85 can be used for the study of HIV-1 infection .

HY-147904

HIV-IN-5	HIV	Infection
HIV-IN-5 (compound 5r) is a potent HIV-1 inhibitor, with an IC₅₀ of 0.16 μM. HIV-IN-5 shows inhibition of HIV DNA-dependent DNA polymerization activity, with an IC₅₀ of 2.18 μM. HIV-IN-5 can bind to NNIBP (NNRTIs (non-nucleoside reverse transcriptase inhibitors) binding pocket) .

HY-10574AR

Rilpivirine hydrochloride (Standard) TMC-278 hydrochloride (Standard); TMC278 hydrochloride (Standard); TMC 278 hydrochloride (Standard)	Reference Standards SARS-CoV MMP	Infection
Rilpivirine (hydrochloride) (Standard) is the analytical standard of Rilpivirine (hydrochloride). This product is intended for research and analytical applications. Rilpivirine (R278474) hydrochloride is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine hydrochloride has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine hydrochloride has a high genetic barrier to resistance development of HIV .

HY-10574R

Rilpivirine (Standard) R278474 (Standard); TMC278 (Standard); DB08864 (Standard)	Reference Standards HIV Reverse Transcriptase	Infection
Rilpivirine (Standard) is the analytical standard of Rilpivirine. This product is intended for research and analytical applications. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .

HY-105491

UC-38 NSC-629243	Reverse Transcriptase HIV	Infection
UC-38 (NSC-629243) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) with anti-HIV activity .

HY-132508S

Etravirine-d8	Isotope-Labeled Compounds Reverse Transcriptase HIV	Infection
Etravirine-d₈ is the deuterium labeled Etravirine. Etravirine (R165335) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV .

HY-146031

A3N19	HIV	Infection
A3N19 is a potent HIV-1 non-nucleoside reverse transcriptase inhibitor, with an EC₅₀ of 3.28 nM against HIV-1 IIIB .

HY-139631

HIV-1 inhibitor-9	HIV	Infection
HIV-1 inhibitor-9 is found to be potent inhibitor against the wild-type (WT) HIV-1 strain or multiple NNRTI-resistant strains at low nanomolar levels.

HY-90005R

Etravirine (Standard) R165335 (Standard); TMC125 (Standard)	Reference Standards Reverse Transcriptase HIV	Infection
Etravirine (Standard) is the analytical standard of Etravirine. This product is intended for research and analytical applications. Etravirine (R165335; TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

HY-173427S

ZK-316	Reverse Transcriptase HIV	Infection
ZK-316 is a potent and broad-spectrum *NNRTI* inhibitor with an EC₅₀s ranging from 0.99 to 75.1 nM. ZK-316 can be used in the study of HIV .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-10571

Delavirdine 3 Publications Verification U 90152; BHAP-U 90152	Infection Classification of Application Fields Disease Research Fields	HIV Reverse Transcriptase
Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC₅₀=0.26 μM) over DNA polymerase α (IC₅₀=440 μM) and polymerase δ (IC₅₀>550 μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .

HY-N16422

Mer-NF5003E	Microorganisms Terpenoids Sesquiterpenes Source Classification	HIV HIV Protease
Mer-NF5003E is a non-nucleoside reverse transcriptase inhibitor targeting HIV-1 reverse transcriptase (RT) (EC₅₀=50 μM). Mer-NF5003E exhibits inhibitory activity against wild-type HIV-1 and multiple NNRTI-resistant strains (e.g., K103N, Y181C). Mer-NF5003E is promising for research of HIV infections .

HY-146364

CI-39	Structural Classification Alkaloids Cruciferae Isatis tinctoria L. Plants Indole Alkaloids Source Classification	DNA/RNA Synthesis HIV
CI-39 is an antiviral natural product. CI-39 is an NNRTI (non-nucleoside reverse transcriptase inhibit) antiviral agent with an EC₅₀ of 3.40 μM and an CC₅₀ of >30 μM for wild type HIV-1. CI-39 inhibits HIV-1 RT DNA polymerase and ribonuclease H activitiessup .

Cat. No.	Product Name	Chemical Structure

HY-90005S

Etravirine D4
Etravirine-d₄ is the deuterium labeled Etravirine. Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

HY-10574S

Rilpivirine-d6
Rilpivirine-d₆ is the deuterium labeled Rilpivirine. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC₅₀=0.4 nM) and mutant viruses (EC₅₀=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .

HY-132508S

Etravirine-d8
Etravirine-d₈ is the deuterium labeled Etravirine. Etravirine (R165335) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV .

HY-173427S

ZK-316
ZK-316 is a potent and broad-spectrum *NNRTI* inhibitor with an EC₅₀s ranging from 0.99 to 75.1 nM. ZK-316 can be used in the study of HIV .

HY-W777351

Etravirine-13C3
Etravirine- ¹³C₃ (R165335- ¹³C₃) is the ¹³C-labeled Etravirine (HY-90005). Etravirine (R165335; TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

HY-10574S1

Rilpivirine-13C6

Rilpivirine- ¹³C₆ (R278474- ¹³C₆) is ¹³C labeled Rilpivirine. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC₅₀=0.4 nM) and mutant viruses (EC₅₀=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .

Cat. No.	Product Name		Classification

HY-167690

MK-6186		Alkynes
MK-6186 is a novel non-nucleoside reverse transcriptase inhibitor with sub-nanomolar activity against wild-type viruses and the two most common NNRTI-resistant RT mutants (K103N and Y181C). MK-6186 exhibits excellent antiviral activity against K103N and Y181C mutant viruses. When MK-6186 targets 12 common NNRTI-associated mutant viruses, only two relatively rare mutants (Y188L and V106I/Y188L) show high resistance, with FC values exceeding 100, while the FC values of the remaining viruses are all below 10. In addition, when MK-6186 faces 96 clinical virus isolates carrying NNRTI-resistant mutations, most (70%) viruses show more than 10-fold resistance to efavirenz (EFV), while only 29% of mutant viruses show more than 10-fold resistance to MK-6186 .

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