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Neuraminidase inhibitor

" in MedChemExpress (MCE) Product Catalog:

標的別:	Adenosine Receptor (1) Akt (3) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (5) Apoptosis (2) Bacterial (3) Biochemical Assay Reagents (1) Carboxylesterase (CES) (2) Drug Derivative (2) Drug Isomer (1) Drug Metabolite (4) EGFR (1) Endogenous Metabolite (3) ERK (2) Fluorescent Dye (2) HSV (1) IKK (2) Indoleamine 2,3-Dioxygenase (IDO) (2) Influenza Virus (78) Interleukin Related (1) Isotope-Labeled Compounds (7) JNK (2) MicroRNA (1) MMP (2) P2X Receptor (1) p38 MAPK (3) PPAR (1) Reactive Oxygen Species (ROS) (1) Reference Standards (10) STAT (2) TNF Receptor (1) Topoisomerase (1) Virus Protease (1)
研究分野別:	Cancer (9) Cardiovascular Disease (2) Infection (78) Inflammation/Immunology (12) Metabolic Disease (4) Neurological Disease (9)
クリックケミストリー:	Azide (2) Alkynes (1)

阻害剤およびアゴニスト

蛍光色素

生化学アッセイ試薬

天然物

同位体標識化合物

クリックケミストリー

製品番号	製品名	Target	研究分野	構造式

HY-17016

Oseltamivir phosphate 45+ Cited Publications GS 4104 phosphate	Influenza Virus	Infection Cancer
Oseltamivir phosphate (GS 4104) is a neuraminidase inhibitor recommended for the treatment and prophylaxis of influenza A and B.

HY-13317

Oseltamivir 45+ Cited Publications GS 4104	Influenza Virus	Infection Cancer
Oseltamivir (GS 4104) is an orally active influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀s of 0.67, 0.9, 1.34 and 13 nM, respectively .

HY-13318

Oseltamivir acid Maximum Cited Publications 75 Publications Verification GS 4071; Ro 64-0802; Oseltamivir carboxylate	Influenza Virus Drug Metabolite	Infection Neurological Disease
Oseltamivir acid (GS 4071), the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of *influenza virus neuraminidase* (IC₅₀=2 nM)** with activity against both influenza A and B viruses. Oseltamivir acid has an extremely weak ability to penetrate the BBB under normal physiological conditions, but its blood-brain barrier penetration is significantly enhanced under inflammatory conditions .

HY-W019823

4-MUNANA 2 Publications Verification	Fluorescent Dye	Infection Neurological Disease
4-MUNANA is a substrate of *influenza virus neuraminidase* (NA)** with high selectivity and irreversible reaction. In the enzymatic reaction, 4-MUNANA is hydrolyzed by NA to generate fluorescent 4-methylumbelliferone (4-MU). By detecting the fluorescence intensity of 4-MU, quantitative analysis of NA activity can be achieved. 4-MUNANA can be used in influenza-related research, such as screening NA inhibitors, developing new anti-influenza drugs, and studying the infection mechanism of influenza viruses .

HY-13210

Zanamivir 15+ Cited Publications	Influenza Virus Antibiotic	Infection
Zanamivir is an influenza viral *neuraminidase* inhibitor with IC₅₀ values of 0.95 nM and 2.7 nM for influenza A and B, respectively.

HY-N0736

Coptisine chloride Maximum Cited Publications 11 Publications Verification	Indoleamine 2,3-Dioxygenase (IDO) Bacterial Influenza Virus	Infection Metabolic Disease Cancer
Coptisine chloride is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a K_i value of 5.8 μM and an IC₅₀ value of 6.3 μM. Coptisine chloride is a potent *H1N1 neuraminidase* (NA-1)** inhibitor with an IC₅₀ of 104.6?μg/mL and can be used for influenza A (H1N1) infection.

HY-125798

2,3-Dehydro-2-deoxy-N-acetylneuraminic acid 4 Publications Verification Neu5Ac2en; DANA	Influenza Virus	Infection
N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC₅₀s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity .

HY-N0243

Theaflavin 5+ Cited Publications	Influenza Virus Endogenous Metabolite	Infection
Theaflavin is a suitable natural inhibitor against influenza A (H1N1) neuraminidase.

HY-N7922

Urolithin M5 1 Publications Verification Decarboxyellagic acid	Influenza Virus p38 MAPK EGFR Akt Reactive Oxygen Species (ROS) Apoptosis	Infection Neurological Disease
Urolithin M5 (Decarboxyellagic acid) is an orally active influenza virus neuraminidase inhibitor and neuroprotective agent, with IC₅₀ values of 174.8 μM (HK68), 191.5 μM (pdm09), 243.2 μM (WSN) and 257.1 μM (PR8) against four influenza virus neuraminidases, respectively. Urolithin M5 inhibits viral neuraminidase activity, thereby blocking influenza virus replication (including oseltamivir (HY-13317)-resistant strains), protecting infected mammals from death and improving pulmonary edema. Urolithin M5 forms a hydrogen-bond stabilized complex with IGF1R, and binds to MAPK14, AKT1, NFKB1 and EGFR. Urolithin M5 reduces reactive oxygen species production, inhibits neuronal apoptosis, restores mitochondrial transmembrane potential, and promotes neurite outgrowth of damaged neuronal cells. Urolithin M5 can be used in research related to influenza virus infection and Alzheimer's disease .

HY-17015A

Peramivir 10+ Cited Publications RWJ-270201; BCX-1812	IKK JNK STAT p38 MAPK ERK	Infection Inflammation/Immunology
Peramivir is an novel cyclopentane neuraminidase inhibitor of influenza virus. Peramivir has antiviral activity and anti-cytokines stom effects. Peramivir can be used for the research of COVID-19 .

HY-122575

Aurintricarboxylic acid 3 Publications Verification	P2X Receptor Influenza Virus Topoisomerase MicroRNA Apoptosis	Infection Neurological Disease Inflammation/Immunology
Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC₅₀s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively . Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the *neuraminidase* . Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis . Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway . Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC₅₀ of 0.6 μM . Aurintricarboxylic acid is a modifier of miRNAs that regulate miRNA function, with an IC₅₀ of 0.47 µM .

HY-14818

Laninamivir 5+ Cited Publications R 125489	Influenza Virus	Infection
Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC₅₀s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively .

HY-17015

Peramivir trihydrate 10+ Cited Publications RWJ 270201 trihydrate; BCX 1812 trihydrate	Influenza Virus IKK JNK STAT p38 MAPK ERK	Infection Inflammation/Immunology
Peramivir trihydrate (RWJ-270201 trihydrate) is a highly potent, selective and orally active influenza virus neuraminidase (NA) inhibitor, with IC₅₀ values ranging from 0.9 to 4.3 nM for nine NA subtypes .

HY-N2533

Cyanidin 3-sambubioside chloride Cyanidin-3-O-sambubioside chloride	Influenza Virus Angiotensin-converting Enzyme (ACE) Akt MMP	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Cyanidin 3-sambubioside chloride (Cyanidin-3-O-sambubioside chloride), a major anthocyanin, a natural colorant, and is a potent NO inhibitor. Cyanidin 3-sambubioside chloride is a H274Y mutation inhibitor, and inhibits influenza neuraminidase activity with an IC₅₀ of 72 μM. Cyanidin 3-sambubioside chloride inhibits angiotensin-converting enzyme (ACE) activity and has antioxidant, anti-angiogenic and antiviral properties .

HY-175469

VNT-101	Influenza Virus	Infection
VNT-101 is an orally active influenza A (IAV) inhibitor. VNT-101 disrupts NP-NP PPI to block NP oligomerization and destabilize the viral ribonucleoprotein (RNP) complex, with potent antiviral activity across multiple influenza A subtypes. VNT-101 exhibits EC₅₀ values of 4-5 nM in cellular cytopathic effect (CPE) assay, 4-8 nM in neuraminidase (NA) assay, and 21-45 nM in RNP assay. VNT-101 demonstrates robust in vivo antiviral efficacy in mice infected with lethal H1N1 virus. VNT-101 can be used for the study of influenza A infection .

HY-14818A

Laninamivir octanoate CS-8958	Influenza Virus	Infection
Laninamivir octanoate (CS-8958), a proagent of Laninamivir, is a long-acting neuraminidase (NA) inhibitor with anti-influenza virus activity. Laninamivir octanoate shows anti-influenza activity against Oseltamivir-resistant viruses, and also against the pandemic influenza viruses .

HY-N4194

Glabrone 1 Publications Verification	PPAR Influenza Virus	Infection Metabolic Disease
Glabrone is an isoflavone found in Glycyrrhiza glabra roots. Glabrone exhibits significant PPAR-γ ligand binding activity. Glabrone is a specific UGT1A9 probe substrate, and its metabolites can block influenza virus release by inhibiting neuraminidase (NA). Glabrone can be used to screen for herb-drug interactions and for anti-influenza virus activity .

HY-13318S

Oseltamivir acid-d3 GS 4071-d₃; Ro 64-0802-d₃; Oseltamivir carboxylate-d₃	Isotope-Labeled Compounds Influenza Virus Drug Metabolite	Infection
Oseltamivir acid-d₃ is a deuterium labeled Oseltamivir acid (HY-13318). Oseltamivir acid, the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC₅₀=2 nM) with activity against both influenza A and B viruses. Oseltamivir acid has an extremely weak ability to penetrate the BBB under normal physiological conditions, but its blood-brain barrier penetration is significantly enhanced under inflammatory conditions .

HY-N2394

Emodin-1-O-β-D-glucopyranoside 1 Publications Verification	Bacterial	Inflammation/Immunology
Emodin-1-O-β-D-glucopyranoside, isolated from medicinal plant Polygonum cuspidatum Sieb. & Zucc, is a potent and noncompetitive *bacterial neuraminidase* (BNA)** inhibitor with an IC₅₀ of 0.85 μM .

HY-13317S

Oseltamivir-d3	Influenza Virus	Infection
Oseltamivir-d₃ is a deuterium labeled Oseltamivir. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent .

HY-DY1034

4-MUNANA (solution)	Fluorescent Dye	Infection Neurological Disease
4-MUNANA (solution) is a substrate of *influenza virus neuraminidase* (NA)** with high selectivity and irreversible reaction. In the enzymatic reaction, 4-MUNANA is hydrolyzed by NA to generate fluorescent 4-methylumbelliferone (4-MU). By detecting the fluorescence intensity of 4-MU, quantitative analysis of NA activity can be achieved. 4-MUNANA can be used in influenza-related research, such as screening NA inhibitors, developing new anti-influenza drugs, and studying the infection mechanism of influenza viruses . Solvent and Concentration: Sterile water: 10 mM

HY-N2735

7,3',4'-Trihydroxy-3-benzyl-2H-chromene	Influenza Virus	Infection Inflammation/Immunology
7,3',4'-Trihydroxy-3-benzyl-2H-chromene is an reversible noncompetitive neuraminidase (NA) inhibitor. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be isolated from the dried heartwood of Caesalpinia sappan L. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene has potent NAs inhibitory activities with IC₅₀ values of 34.6 µM [H1N1], 39.5 µM [H3N2], and 50.5µM [H9N2], respectively. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be used for the research of influenza virus .

HY-N9919

Glyasperin C	Others	Others
Glyasperin C is a potent and reversible noncompetitive inhibitor of *neuraminidase* with an IC₅₀ of 20% at 200 μM. Glyasperin C is a polyphenol isolated from the roots of Glycyrrhiza uralensis .

HY-137334

Neuraminidase-IN-1	Influenza Virus	Infection
Neuraminidase-IN-1 is a *neuraminidase* inhibitor, with an IC₅₀ of 0.21 μM. Neuraminidase-IN-1 has excellent activity against H1N1 influenza virus .

HY-13317R

Oseltamivir (Standard) GS 4104 (Standard)	Reference Standards Influenza Virus	Infection
Oseltamivir (Standard) is the analytical standard of Oseltamivir. This product is intended for research and analytical applications. Oseltamivir (GS 4104) is an orally active influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀s of 0.67, 0.9, 1.34 and 13 nM, respectively .

HY-W892911

AV-5080	Influenza Virus	Infection
AV-5080 is an orally active *neuraminidase* inhibitor. AV-5080 can be used for the research of influenza A and B viruses .

HY-N0243R

Theaflavin (Standard)	Reference Standards Influenza Virus Endogenous Metabolite	Infection
Theaflavin (Standard) is the analytical standard of Theaflavin. This product is intended for research and analytical applications. Theaflavin is a suitable natural inhibitor against influenza A (H1N1) neuraminidase.

HY-N3421

Koaburaside	Interleukin Related TNF Receptor Influenza Virus	Infection Inflammation/Immunology Cancer
Koaburaside is a cytoprotective and anti-inflammatory natural compound. Koaburaside shows antioxidant activity with an IC₅₀ of 9.0 μM for DPPH-free radical scavenging assay. Koaburaside inhibits histamine release and expressions of IL-6 and TNF-α in human mast cells. Koaburaside also effectively inhibits influenza A neuraminidase .

HY-A0181AR

Adenosine 5'-monophosphate monohydrate (Standard) 5'-AMP monohydrate (Standard)	Reference Standards Endogenous Metabolite Adenosine Receptor HSV	Infection Metabolic Disease
Cyanidin 3-sambubioside (chloride) (Standard) is the analytical standard of Cyanidin 3-sambubioside (chloride). This product is intended for research and analytical applications. Cyanidin 3-sambubioside chloride (Cyanidin-3-O-sambubioside chloride), a major anthocyanin, a natural colorant, and is a potent NO inhibitor. Cyanidin 3-sambubioside chloride is a H274Y mutation inhibitor, and inhibits influenza neuraminidase activity with an IC50 of 72 μM. Cyanidin 3-sambubioside chloride inhibits angiotensin-converting enzyme (ACE) activity and has antioxidant, anti-angiogenic and antiviral properties .

HY-161943

NEU3-IN-1	Influenza Virus	Neurological Disease
NEU3-IN-1 (compound 963) is a NEU3 inhibitor (Ki: 0.12 μM; IC₅₀: 0.31 μM) based on the 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) scaffold and is a C9 biphenylcarbamate derivative. NEU is a human neuraminidase with 4 isozymes; NEU3-IN-1 is an important tool for studying the function of NEU3 isozymes; its amide and triazole linker analogs are selective for NEU1 and NEU4 isozymes, respectively .

HY-N10843

4-O-Methylepisappanol	Influenza Virus	Infection
4-O-Methylepisappanol (compound 9) is nature product that could be isolated from heartwood of Caesalpinia sappan. 4-O-Methylepisappanol is a potent neuraminidase inhibitor on the surface of influenza viruses with IC₅₀ values of 42.8, 63.2, and 63.2 µM for A/Chicken/Korea/MS96/96 [H9N2], A/PR/8/34 [H1N1], and A/Hong Kong/8/68 [H3N2], respectively .

HY-146306

Neuraminidase-IN-9	Influenza Virus	Infection
Neuraminidase-IN-9 (Compound 6l) is a potent influenza *neuraminidase* inhibitor with IC₅₀ values of 0.12, 0.049 and 0.16 µM against H5N1, H5N2 and H5N6, respectively .

HY-147331

Oseltamivir acid methyl ester	Antibiotic Carboxylesterase (CES)	Neurological Disease
Oseltamivir acid methyl ester is a precursor form of the neuraminidase inhibitor and antiviral oseltamivir acid. Oseltamivir acid methyl ester is converted to oseltamivir acid by carboxylesterase 1 (CES1) .

HY-13210A

Zanamivir hydrate(5:1)	Antibiotic Influenza Virus	Infection
Zanamivir hydrate (5:1) is the hydrate of Zanamivir. Zanamivir is an influenza viral *neuraminidase* inhibitor with IC₅₀ values of 0.95 nM and 2.7 nM for influenza A and B, respectively .

HY-172515

ent-Oseltamivir	Influenza Virus Virus Protease Drug Isomer	Infection
ent-Oseltamivir, the enantiomer of Oseltamivir (HY-13317), is a neuraminidase (NA) of influenza virus inhibitor. ent-Oseltamivir is promising for research of influenza virus infections .

HY-17016R

Oseltamivir phosphate (Standard) GS 4104 phosphate (Standard)	Reference Standards Influenza Virus	Infection
Oseltamivir (phosphate) (Standard) is the analytical standard of Oseltamivir (phosphate). This product is intended for research and analytical applications. Oseltamivir phosphate (GS 4104) is a neuraminidase inhibitor recommended for the treatment and prophylaxis of influenza A and B.

HY-13210R

Zanamivir (Standard)	Reference Standards Influenza Virus Antibiotic	Infection
Zanamivir (Standard) is the analytical standard of Zanamivir. This product is intended for research and analytical applications. Zanamivir is an influenza viral *neuraminidase* inhibitor with IC₅₀ values of 0.95 nM and 2.7 nM for influenza A and B, respectively.

HY-13318R

Oseltamivir acid (Standard) GS 4071 (Standard); Ro 64-0802 (Standard); Oseltamivir carboxylate (Standard)	Reference Standards Influenza Virus Drug Metabolite	Infection
Oseltamivir acid (Standard) is the analytical standard of Oseltamivir acid. This product is intended for research and analytical applications. Oseltamivir acid (GS 4071), the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC₅₀=2 nM) with activity against both influenza A and B viruses .

HY-17015R

Peramivir trihydrate (Standard) RWJ 270201 trihydrate (Standard); BCX 1812 trihydrate (Standard)	Reference Standards Influenza Virus	Infection
Peramivir (trihydrate) (Standard) is the analytical standard of Peramivir (trihydrate). This product is intended for research and analytical applications. Peramivir trihydrate (RWJ-270201 trihydrate;BCX-1812 trihydrate) is a highly potent, selective and orally active influenza virus neuraminidase (NA) inhibitor, with IC₅₀ values ranging from 0.9 to 4.3 nM for nine NA subtypes .

HY-176962

Di(zanamivir-amide(N-Me)-PEG1)-N-PEG4-alkyne	Influenza Virus Drug Derivative	Infection
Di(zanamivir-amide(N-Me)-PEG1)-N-PEG4-alkyne is a conjugate of Zanamivir (a viral *neuraminidase* inhibitor) (HY-13210) and linker. Di(zanamivir-amide(N-Me)-PEG1)-N-PEG4-alkyne can be used for viral infection research .

HY-N0736R

Coptisine chloride (Standard)	Indoleamine 2,3-Dioxygenase (IDO) Reference Standards Bacterial Influenza Virus	Infection Metabolic Disease Cancer
Coptisine (chloride) (Standard) is the analytical standard of Coptisine (chloride). This product is intended for research and analytical applications. Coptisine chloride is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC₅₀ value of 6.3 μM. Coptisine chloride is a potent H1N1 neuraminidase (NA-1) inhibitor with an IC₅₀ of 104.6 μg/mL and can be used for influenza A (H1N1) infection.

HY-129150

Ganoderic acid TR	Influenza Virus	Infection
Ganoderic acid TR is a broad-spectrum inhibitor of influenza neuraminidase enzymes (NAs). Ganoderic acid TR has IC₅₀ values of 10.9 and 4.6 μM for H5N1 and H1N1 NAs, respectively. Ganoderic acid TR is limited by cytotoxicity and shows only weak activity against Oseltamivir (HY-13317)-resistant H1N1 viruses and influenza B viruses .

HY-163521

Neuraminidase-IN-19	Influenza Virus	Cancer
Neuraminidase-IN-19 (compound 5n) is an inhibitor (IC₅₀: 0.13 μM) of neuraminidase with a thiophene ring (neuraminidase) and has anticancer activity .

HY-149060

Neuraminidase-IN-15	Influenza Virus	Infection
Neuraminidase-IN-15 is an inhibitor of *neuraminidase. Neuraminidase-IN-15 inhibits* the activity of La Sota Clone 30 NDV-HN with an IC₅₀ value of 0.06 µM. Neuraminidase-IN-15 can be used for the study of Newcastle disease virus (NDV) .

HY-149059

Neuraminidase-IN-14	Influenza Virus	Infection
Neuraminidase-IN-14 is an inhibitor of *neuraminidase. Neuraminidase-IN-14 inhibits* the activity of La Sota Clone 30 NDV-HN with an IC₅₀ value of 0.20 µM. Neuraminidase-IN-14 can be used for research on Newcastle disease virus (NDV) infection .

HY-144420

Neuraminidase-IN-5	Influenza Virus	Infection
Neuraminidase-IN-5 (Compound 5b) is a potent inhibitor of *neuraminidase* with an IC₅₀ of 0.02 μM. Neuraminidase (NA) is a promising target for development of anti-influenza agents. Neuraminidase-IN-5 is a dihydrofurocoumarin derivative compound .

HY-163392

Neuraminidase-IN-17	Influenza Virus	Infection
Neuraminidase-IN-17 (compound N10) is a *neuraminidase* inhibitor with the EC₅₀ of 0.11 μM. Neuraminidase-IN-17 shows antiviral activity in vitro .

HY-143488

Neuraminidase-IN-8	Influenza Virus	Infection
Neuraminidase-IN-8 (Compound 6d) is a potent *neuraminidase* inhibitor with an IC₅₀ of 0.027 µM. Neuraminidase-IN-8 shows anti-influenza activities .

HY-129666

NSC-65847	Influenza Virus	Neurological Disease
NSC-65847 is a groundbreaking dual inhibitor targeting both viral neuraminidase and Streptococcus pneumoniae neuraminidase.

HY-162801

Neuraminidase-IN-21	Influenza Virus	Infection
Neuraminidase-IN-21 (Compound 6d) is an influenza H1N1 virus Neuraminidase inhibitor, with IC₅₀s of 0.30 µM for Neuraminidase, and 30.01 µM for H1N1 strain of influenza. Neuraminidase-IN-21 formsg three hydrogen bonds with Arg292, Arg371, and Tyr406 of Neuraminidase .

製品番号	製品名	Type

HY-W019823

4-MUNANA

2 Publications Verification

蛍光色素

4-MUNANA is a substrate of influenza virus neuraminidase (NA) with high selectivity and irreversible reaction. In the enzymatic reaction, 4-MUNANA is hydrolyzed by NA to generate fluorescent 4-methylumbelliferone (4-MU). By detecting the fluorescence intensity of 4-MU, quantitative analysis of NA activity can be achieved. 4-MUNANA can be used in influenza-related research, such as screening NA inhibitors, developing new anti-influenza drugs, and studying the infection mechanism of influenza viruses .

HY-DY1034

4-MUNANA (solution)

蛍光色素

4-MUNANA (solution) is a substrate of influenza virus neuraminidase (NA) with high selectivity and irreversible reaction. In the enzymatic reaction, 4-MUNANA is hydrolyzed by NA to generate fluorescent 4-methylumbelliferone (4-MU). By detecting the fluorescence intensity of 4-MU, quantitative analysis of NA activity can be achieved. 4-MUNANA can be used in influenza-related research, such as screening NA inhibitors, developing new anti-influenza drugs, and studying the infection mechanism of influenza viruses .
Solvent and Concentration: Sterile water: 10 mM

製品番号	製品名	Category	Target	構造式

HY-N0736

Coptisine chloride Maximum Cited Publications 11 Publications Verification	Infection Alkaloids Classification of Application Fields Coptis chinensis Franch. Ranunculaceae Metabolic Disease Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Indoleamine 2,3-Dioxygenase (IDO) Bacterial Influenza Virus
Coptisine chloride is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a K_i value of 5.8 μM and an IC₅₀ value of 6.3 μM. Coptisine chloride is a potent *H1N1 neuraminidase* (NA-1)** inhibitor with an IC₅₀ of 104.6?μg/mL and can be used for influenza A (H1N1) infection.

HY-N0243

Theaflavin 5+ Cited Publications	Infection Flavonoids other families Classification of Application Fields Flavanols Phenols Polyphenols Plants Endogenous metabolite Disease Research Fields Source Classification	Influenza Virus Endogenous Metabolite
Theaflavin is a suitable natural inhibitor against influenza A (H1N1) neuraminidase.

HY-N7922

Urolithin M5 1 Publications Verification Decarboxyellagic acid	Structural Classification Canarium album (Lour.) Rauesch. Phenols Polyphenols Plants Burseraceae Source Classification	Influenza Virus p38 MAPK EGFR Akt Reactive Oxygen Species (ROS) Apoptosis
Urolithin M5 (Decarboxyellagic acid) is an orally active influenza virus neuraminidase inhibitor and neuroprotective agent, with IC₅₀ values of 174.8 μM (HK68), 191.5 μM (pdm09), 243.2 μM (WSN) and 257.1 μM (PR8) against four influenza virus neuraminidases, respectively. Urolithin M5 inhibits viral neuraminidase activity, thereby blocking influenza virus replication (including oseltamivir (HY-13317)-resistant strains), protecting infected mammals from death and improving pulmonary edema. Urolithin M5 forms a hydrogen-bond stabilized complex with IGF1R, and binds to MAPK14, AKT1, NFKB1 and EGFR. Urolithin M5 reduces reactive oxygen species production, inhibits neuronal apoptosis, restores mitochondrial transmembrane potential, and promotes neurite outgrowth of damaged neuronal cells. Urolithin M5 can be used in research related to influenza virus infection and Alzheimer's disease .

HY-N2533

Cyanidin 3-sambubioside chloride Cyanidin-3-O-sambubioside chloride	Infection Anthocyans Flavonoids other families Classification of Application Fields Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Influenza Virus Angiotensin-converting Enzyme (ACE) Akt MMP
Cyanidin 3-sambubioside chloride (Cyanidin-3-O-sambubioside chloride), a major anthocyanin, a natural colorant, and is a potent NO inhibitor. Cyanidin 3-sambubioside chloride is a H274Y mutation inhibitor, and inhibits influenza neuraminidase activity with an IC₅₀ of 72 μM. Cyanidin 3-sambubioside chloride inhibits angiotensin-converting enzyme (ACE) activity and has antioxidant, anti-angiogenic and antiviral properties .

HY-N4194

Glabrone 1 Publications Verification	Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Metabolic Disease Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Isoflavones Source Classification	PPAR Influenza Virus
Glabrone is an isoflavone found in Glycyrrhiza glabra roots. Glabrone exhibits significant PPAR-γ ligand binding activity. Glabrone is a specific UGT1A9 probe substrate, and its metabolites can block influenza virus release by inhibiting neuraminidase (NA). Glabrone can be used to screen for herb-drug interactions and for anti-influenza virus activity .

HY-N2394

Emodin-1-O-β-D-glucopyranoside 1 Publications Verification	Quinones Rheum palmatum L. Classification of Application Fields Anthraquinones Polygonaceae Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Bacterial
Emodin-1-O-β-D-glucopyranoside, isolated from medicinal plant Polygonum cuspidatum Sieb. & Zucc, is a potent and noncompetitive *bacterial neuraminidase* (BNA)** inhibitor with an IC₅₀ of 0.85 μM .

HY-N2735

7,3',4'-Trihydroxy-3-benzyl-2H-chromene	Leguminosae Caesalpinia sappan L. Phenols Polyphenols Plants Source Classification	Influenza Virus
7,3',4'-Trihydroxy-3-benzyl-2H-chromene is an reversible noncompetitive neuraminidase (NA) inhibitor. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be isolated from the dried heartwood of Caesalpinia sappan L. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene has potent NAs inhibitory activities with IC₅₀ values of 34.6 µM [H1N1], 39.5 µM [H3N2], and 50.5µM [H9N2], respectively. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be used for the research of influenza virus .

HY-N9919

Glyasperin C	Flavonoids Classification of Application Fields Leguminosae Other Diseases Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Isoflavones Source Classification	Others
Glyasperin C is a potent and reversible noncompetitive inhibitor of *neuraminidase* with an IC₅₀ of 20% at 200 μM. Glyasperin C is a polyphenol isolated from the roots of Glycyrrhiza uralensis .

HY-N0243R

Theaflavin (Standard)	Structural Classification Flavonoids other families Flavanols Phenols Polyphenols Plants Endogenous metabolite Source Classification	Reference Standards Influenza Virus Endogenous Metabolite
Theaflavin (Standard) is the analytical standard of Theaflavin. This product is intended for research and analytical applications. Theaflavin is a suitable natural inhibitor against influenza A (H1N1) neuraminidase.

HY-N3421

Koaburaside	Eucommia ulmoides Oliver Eucommiaceae Plants Saccharides Monosaccharides Source Classification	Interleukin Related TNF Receptor Influenza Virus
Koaburaside is a cytoprotective and anti-inflammatory natural compound. Koaburaside shows antioxidant activity with an IC₅₀ of 9.0 μM for DPPH-free radical scavenging assay. Koaburaside inhibits histamine release and expressions of IL-6 and TNF-α in human mast cells. Koaburaside also effectively inhibits influenza A neuraminidase .

HY-A0181AR

Adenosine 5'-monophosphate monohydrate (Standard) 5'-AMP monohydrate (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Adenosine Receptor HSV
Cyanidin 3-sambubioside (chloride) (Standard) is the analytical standard of Cyanidin 3-sambubioside (chloride). This product is intended for research and analytical applications. Cyanidin 3-sambubioside chloride (Cyanidin-3-O-sambubioside chloride), a major anthocyanin, a natural colorant, and is a potent NO inhibitor. Cyanidin 3-sambubioside chloride is a H274Y mutation inhibitor, and inhibits influenza neuraminidase activity with an IC50 of 72 μM. Cyanidin 3-sambubioside chloride inhibits angiotensin-converting enzyme (ACE) activity and has antioxidant, anti-angiogenic and antiviral properties .

HY-N10843

4-O-Methylepisappanol	Flavanonols Flavonoids Caesalpiniaceae Plants Source Classification	Influenza Virus
4-O-Methylepisappanol (compound 9) is nature product that could be isolated from heartwood of Caesalpinia sappan. 4-O-Methylepisappanol is a potent neuraminidase inhibitor on the surface of influenza viruses with IC₅₀ values of 42.8, 63.2, and 63.2 µM for A/Chicken/Korea/MS96/96 [H9N2], A/PR/8/34 [H1N1], and A/Hong Kong/8/68 [H3N2], respectively .

HY-N0736R

Coptisine chloride (Standard)	Alkaloids Structural Classification Coptis chinensis Franch. Ranunculaceae Plants Isoquinoline Alkaloids Source Classification	Indoleamine 2,3-Dioxygenase (IDO) Reference Standards Bacterial Influenza Virus
Coptisine (chloride) (Standard) is the analytical standard of Coptisine (chloride). This product is intended for research and analytical applications. Coptisine chloride is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC₅₀ value of 6.3 μM. Coptisine chloride is a potent H1N1 neuraminidase (NA-1) inhibitor with an IC₅₀ of 104.6 μg/mL and can be used for influenza A (H1N1) infection.

HY-129150

Ganoderic acid TR	Infection Triterpenes Classification of Application Fields Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields Source Classification	Influenza Virus
Ganoderic acid TR is a broad-spectrum inhibitor of influenza neuraminidase enzymes (NAs). Ganoderic acid TR has IC₅₀ values of 10.9 and 4.6 μM for H5N1 and H1N1 NAs, respectively. Ganoderic acid TR is limited by cytotoxicity and shows only weak activity against Oseltamivir (HY-13317)-resistant H1N1 viruses and influenza B viruses .

HY-N10298

Massarilactone H	Infection 天然物 Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Influenza Virus
Massarilactone H, a polyketide, is a *neuraminidase* inhibitor, with an IC₅₀ of 8.18 µM .

HY-N8399

Yadanziolide B	Simaroubaceae Classification of Application Fields Terpenoids Diterpenoids Plants Disease Research Fields Inflammation/Immunology Source Classification Brucea javanica (L.) Merr.	Influenza Virus
Yadanziolide B, a natural quassinoid, is a potential H5N1 neuraminidase inhibitor .

HY-N2533R

Cyanidin 3-sambubioside chloride (Standard) Cyanidin-3-O-sambubioside chloride (Standard)	Structural Classification Anthocyans Flavonoids other families Phenols Polyphenols Plants Source Classification	Reference Standards Influenza Virus Angiotensin-converting Enzyme (ACE) Akt MMP
Cyanidin 3-sambubioside (chloride) (Standard) is the analytical standard of Cyanidin 3-sambubioside (chloride). This product is intended for research and analytical applications. Cyanidin 3-sambubioside chloride (Cyanidin-3-O-sambubioside chloride), a major anthocyanin, a natural colorant, and is a potent NO inhibitor. Cyanidin 3-sambubioside chloride is a H274Y mutation inhibitor, and inhibits influenza neuraminidase activity with an IC50 of 72 μM. Cyanidin 3-sambubioside chloride inhibits angiotensin-converting enzyme (ACE) activity and has antioxidant, anti-angiogenic and antiviral properties .

製品番号	製品名	構造式

HY-13318S

Oseltamivir acid-d3

Oseltamivir acid-d₃ is a deuterium labeled Oseltamivir acid (HY-13318). Oseltamivir acid, the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC₅₀=2 nM) with activity against both influenza A and B viruses. Oseltamivir acid has an extremely weak ability to penetrate the BBB under normal physiological conditions, but its blood-brain barrier penetration is significantly enhanced under inflammatory conditions .

HY-13317S

Oseltamivir-d3
Oseltamivir-d₃ is a deuterium labeled Oseltamivir. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent .

HY-17016S

Oseltamivir-d5 phosphate
Oseltamivir-d₅ (phosphate) is the deuterium labeled Oseltamivir phosphate. Oseltamivir phosphate (GS 4104) is a neuraminidase inhibitor recommended for the treatment and prophylaxis of influenza A and B .

HY-17016S1

Oseltamivir-d3 phosphate
Oseltamivir-d₃ (phosphate)eis the deuterium labeled Oseltamivir phosphate. Oseltamivir phosphate (GS 4104) is a neuraminidase inhibitor recommended for the treatment and prophylaxis of influenza A and B.

HY-17016S3

Oseltamivir-13C,d3 phosphate
Oseltamivir- ¹³C,d₃ (phosphate) (GS 4104- ¹³C,d₃ (phosphate)) is ¹³C labeled Oseltamivir (phosphate). Oseltamivir phosphate (GS 4104) is a neuraminidase inhibitor recommended for the treatment and prophylaxis of influenza A and B.

HY-13317S3

Oseltamivir-d5
Oseltamivir-d₅ is the deuterium labeled Oseltamivir . Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀ of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent .

HY-13317S4

Oseltamivir-d3 hydrochloride
Oseltamivir-d₃ hydrochloride is the deuterium-labeled Oseltamivir (HY-13317) . Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent .

HY-13317S1

Oseltamivir-d3-1
Oseltamivir-d₃-1 is the deuterium labeled Oseltamivir . Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent .

HY-13318S1

Oseltamivir acid-13C,d3
Oseltamivir acid-13C,d3 (GS 4071-13C,d3; Ro 64-0802-13C,d3) is a 13C- and deuterium-labeled Oseltamivir acid (HY-13318). Oseltamivir acid is the active metabolite of Oseltamivir phosphate and inhibits influenza virus neuraminidase (IC₅₀=2 nM). Oseltamivir acid is orally active and can be used to study influenza A/B infections .

HY-14818S1

Laninamivir-13C,15N2
Laninamivir- ¹³C, ¹⁵N₂ (R 125489- ¹³C, ¹⁵N₂) is ¹³C and ¹⁵N labeled Laninamivir. Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC₅₀s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively .

製品番号	製品名		Classification

HY-176962

Di(zanamivir-amide(N-Me)-PEG1)-N-PEG4-alkyne		Alkynes
Di(zanamivir-amide(N-Me)-PEG1)-N-PEG4-alkyne is a conjugate of Zanamivir (a viral *neuraminidase* inhibitor) (HY-13210) and linker. Di(zanamivir-amide(N-Me)-PEG1)-N-PEG4-alkyne can be used for viral infection research .

HY-149058

Neuraminidase-IN-13		Azide
Neuraminidase-IN-13 (Compound 10) is a *neuraminidase* inhibitor with antiviral activity and low cytotoxicity. Neuraminidase-IN-13 significantly inhibits NDV infection of Vero cells by preventing the release of viral particles from infected cells . Neuraminidase-IN-13 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-149057

Neuraminidase-IN-12		Azide
NDV-IN-1 is an antiviral agent with high *neuraminidase* inhibitory activity. NDV-IN-1 exhibits in vitro inhibitory activity against Newcastle disease virus (NDV). NDV-IN-1 significantly inhibits NDV infection of Vero cells by preventing the release of virus particles from infected cells . Neuraminidase-IN-12 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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