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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
85 Results for "
PAH BOEC
" in MedChemExpress (MCE) Product Catalog:
Products (85)
85 Results for "PAH BOEC" in MCE Product Catalog:
14
14 Publications Verification
Synonyms: ACT-064992
Target:
Research Areas:
Macitentan (ACT-064992) is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) .
4
4 Cited Publications
Cat. No.: HY-W011845
CAS No.: 57-97-6
Synonyms: 7,12-DMBA; 7,12-Dimethylbenzanthracene
Target:
Research Areas:
DMBA has carcinogenic activity as a polycyclic aromatic hydrocarbon (PAH). DMBA is used to induce tumor formation in various rodent models .
3
3 Cited Publications
Cat. No.: HY-A0124A
CAS No.: 69056-38-8
Synonyms: (6R)-BH4 dihydrochloride; (6R)-Tetrahydro-L-biopterin dihydrochloride
Target:
2
2 Cited Publications
Cat. No.: HY-P0012
CAS No.: 40077-57-4
Synonyms: Vasoactive Intestinal Peptide (human, rat, mouse, rabbit, canine, porcine)
Target:
Research Areas:
2
2 Cited Publications
Cat. No.: HY-P0012A
CAS No.: 1444827-29-5
Synonyms: Vasoactive Intestinal Peptide acetate salt (human, rat, mouse, rabbit, canine, porcine)
Target:
Research Areas:
1
1 Cited Publications
Cat. No.: HY-A0126A
CAS No.: 61849-14-7
Synonyms: Prostaglandin I2 sodium salt; Prostacyclin sodium salt; Flolan
Category:
Cardiovascular Disease Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields
Target:
1
Target:
Research Areas:
Phenanthrene is an orally active polycyclic aromatic hydrocarbon (PAH) that induces inflammation, oxidative stress, and apoptosis. Additionally, phenanthrene is commonly used to detect or assess PAH pollution in the environment .
1
1 Cited Publications
Synonyms: Benzo[def]phenanthrene
1
1 Cited Publications
Cat. No.: HY-W026772
CAS No.: 86-73-7
Target:
Environmental Pollutants Fluorescent Dye TNF Receptor Interleukin Related SOD Reactive Oxygen Species (ROS)
Research Areas:
Fluorene is an orally active polycyclic aromatic hydrocarbon (PAH) and a precursor to other fluorene-based compounds. Fluorene and its derivatives serve as dye precursors for fluorene synthesis. In A549 cells, Fluorene induces oxidative stress and inflammatory responses by increasing ROS and SOD generation, exacerbating lipid peroxidation, modulating antioxidant enzyme activity, and upregulating the expression of pro-inflammatory factors TNF-α and IL-6. In vivo, Fluorene exhibits anxiolytic activity. Fluorene holds potential for research in inflammation and neurological disorders .
1
1 Cited Publications
Cat. No.: HY-W013570
CAS No.: 208-96-8
1
Target:
1
1 Cited Publications
Cat. No.: HY-P73733
Purity: ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: PAH; PH; Phenylalanine Hydroxylase; L-Phenylalanine Hydroxylase; Phenylalanine-4-Hydroxylase; PAH Protein; Phe-4-Monooxygenase; PKU1; Phenylalanine 4-Monooxygenase; PKU
Species:
Human
Source:
Sf9 insect cells
Synonyms: KAR5585
Target:
Research Areas:
Rodatristat ethyl (KAR5585) is a first-in-class oral tryptophan hydroxylase 1 (TPH1) Inhibitor with nanomolar in vitro potency. Rodatristat ethyl reduces the level of 5-HT and significantly reduces pulmonary arterial hypertension (PAH) .
Cat. No.: HY-W014075
CAS No.: 5315-79-7
Synonyms: BBI 4000
Target:
Research Areas:
Sofpironium bromide (BBI 4000) is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH). Sofpironium bromide reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium bromide also has a high afnity for the M1, M2, M4 and M5 subtypes .
Cat. No.: HY-P990733
CAS No.: 2769700-97-0
Synonyms: KER-012
Target:
Research Areas:
Target:
Research Areas:
NTP42 is a thromboxane A2 (TXA2) receptor antagonist with an IC50 of 3.278 nM for antagonizing T prostanoid receptor (TP)- mediated [Ca 2+] mobilization following stimulation of cells with the alternative TP agonist U46619 . NTP42 can be used for the treatment of pulmonary arterial hypertension (PAH) .
Research Areas:
PRX-08066 is a selective and orally active 5-hydroxytryptamine receptor 2B (5-HT2BR) antagonist with a Ki of 3.4 nM. PRX-08066 inhibits the MAPK pathway, 5-HT release and fibrotic factor (TGFβ1, CTGF and FGF2) expression. PRX-08066 inhibits the proliferation of KRJ-I cells and induces apoptosis (caspase-3 activation). PRX-08066 inhibits pulmonary vascular remodeling. PRX-08066 can be used of pulmonary Arterial Hypertension (PAH) and neuroendocrine tumor (NET) .
Cat. No.: HY-W014075S
CAS No.: 132603-37-3
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
