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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
Phosphoglycerate Dehydrogenase (PHGDH)
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "Phosphoglycerate Dehydrogenase (PHGDH)" in MCE Product Catalog:
21
21 Publications Verification
Research Areas:
CBR-5884 is an active, selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis .
6
6 Cited Publications
Research Areas:
NCT-502 is a human phosphoglycerate dehydrogenase (PHGDH) inhibitor, cytotoxic to PHGDH-dependent cancer cells, and reduces glucose-derived serine production, with an IC50 of 3.7 μM against PHGDH .
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1 Cited Publications
Synonyms: 3-Phospho-D-glyceric acid disodium
Research Areas:
D-(-)-3-Phosphoglyceric acid (3-Phospho-D-glyceric acid) disodium is an important intermediate in the enzyme-catalyzed glycolysis process. D-(-)-3-Phosphoglyceric acid disodium competitively inhibits yeast enolase (enolase). D-(-)-3-Phosphoglyceric acid disodium can regulate the activity of phosphoglycerate dehydrogenase (PHGDH) to modulate p53 protein and apoptosis .
1
1 Cited Publications
Research Areas:
BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis with an IC50 of 2200 nM at 72 h .
1
1 Cited Publications
Research Areas:
PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor. PHGDH-IN-3 inhibits PHGDH with an IC50 value of 2.8 μM. PHGDH-IN-3 can be used for the research of cancer .
Research Areas:
PKUMDL-WQ-2101 is a non-NAD +-competing allosteric phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 34.8 μM. PKUMDL-WQ-2101 exhibits antitumor activity .
Cat. No.: HY-125273
CAS No.: 2196245-98-2
Research Areas:
DNS-pE is a 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor with a Ki of 7.4 μM. DNS-pE selectively and irreversibly covalently modifies endogenous PHGDH in live mammalian cells, its vinyl sulfone moiety acts as a fluorescence quencher that becomes highly fluorescent upon covalent modification of PHGDH. DNS-pE can be used as a fluorescent dye for live-cell imaging .
Cat. No.: HY-160252
CAS No.: 2132969-16-3
Research Areas:
PHGDH-IN-4 is a potent 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor . PHGDH-IN-4 can be used for the research of cancer .
Cat. No.: HY-126278
CAS No.: 2375374-15-3
Research Areas:
Z1609609733 (Compound 18) is a non-covalent 3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 1.46 μM. Z1609609733 significantly inhibits serine synthesis and cancer metabolism with complete abrogation of cell proliferation .
Cat. No.: HY-179652
Research Areas:
PHGDH-IN-6 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.5 μM. PHGDH-IN-6 binds to the allosteric pocket of PHGDH, and its inhibitory activity is not affected by NAD + concentration. PHGDH-IN-6 can be used in research related to cancer and Alzheimer's disease .
Cat. No.: HY-P87288
Synonyms: 3 PGDH antibody; 3-PGDH antibody; 3-Phosphoglycerate Dehydrogenase antibody; 3PGDH antibody; D-3-Phosphoglycerate Dehydrogenase antibody; EC 1.1.1.95 antibody; Epididymis secretory protein Li 113 antibody; HEL S 113 antibody; NLS antibody; NLS1 antibody
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
