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Plasmodium falciparum K1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (1) CDK (1) Drug Derivative (1) Endogenous Metabolite (1) HSV (1) Isotope-Labeled Compounds (1) Parasite (15) PI4K (1) Potassium Channel (1) Virus Protease (1)
By Research Areas:	Cancer (1) Infection (17)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-N6742

Borrelidin 1 Publications Verification Treponemycin	CDK Parasite Apoptosis Antibiotic	Infection
Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor which is a nitrile-containing macrolide antibiotic isolated from Streptomyces rochei . Borrelidin is an inhibitor of Cdc28/Cln2 of the budding yeast, with an IC₅₀ of 24 μM . Borrelidin is a potent angiogenesis inhibitor, with an IC₅₀ of 0.8 nM. Borrelidin induces apoptosis in the tube-forming cells . Borrelidin has strong antimalarial activities, with IC₅₀s of 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum, respectively .

HY-N5109

Cheilanthifoline	Parasite	Infection
Cheilanthifoline, an alkaloid, is isolated from Corydalis calliantha. Cheilanthifoline exhibits antiplasmodial activities against Plasmodium falciparum, with IC₅₀s of 0.90 μg/mL and 1.22 μg/mL for wild type (TM4) and multidrug resistant (K1) strains, respectively .

HY-N5005

Guanfu base H Atisinium chloride	Parasite	Infection
Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial **Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 with IC₅₀** values of 4 μM and 3.6 μM, respectively .

HY-N15748

Pelorol (-)-Pelorol	Parasite	Infection
Pelorol ((-)-Pelorol) is a sesquiterpene found in the tropical marine sponge Dactylospongia elegans. Pelorol has weak antitrypanosomal activity with an IC₅₀ of 17.4 μg/mL and antiplasmodial activity against Plasmodium falciparum clones K1 and NF54 with IC₅₀ values of 786 ng/mL and 1911 ng/mL, respectively. Pelorol is promising for research of parasitic diseases, such as trypanosomiasis and malaria .

HY-126640

Phomoxanthone A	Parasite	Infection Cancer
Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis. Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC₅₀ is 0.11 µg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 µg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC₅₀ is 0.99, 0.51 and 1.4 µg/mL, respectively .

HY-N8383

Butyrolactone V	Parasite	Infection
Butyrolactone V is a butanolide compound. Butyrolactone V shows antiplasmodial activity against Plasmodium falciparum K1 with an IC₅₀ of 7.9 µg/ml .

HY-106515

Tebuquine WR228258	Parasite	Infection
Tebuquine (WR228258), a 4-aminoquinoline, is a potent antimalarial agent. Tebuquine is active against the Chloroquine (HY-17589A) sensitive HB3 strain and the Chloroquine resistant K1 strain of Plasmodium falciparum with IC₅₀s of 0.9 nM and 20.8 nM, respectively .

HY-157892

Antimalarial agent 38	Parasite	Infection
Antimalarial agent 38 is an orally active antimalarial agent, which inhibits Plasmodium falciparum D6 strain, Chloroquine (HY-17589A)-sensitive Thai strain and Chloroquine-resistant FcB1 strain and K1 strain, with IC₅₀s of 0.5, 13, 1 and 13 μM, respectively. Antimalarial agent 38 is non-cytotoxic for mammalian cells MCR58 (IC₅₀ >140 μM). Antimalarial agent 38 improves the survival rate of Plasmodium yoelii nigeriensis infected mouse model .

HY-155354

Antimalarial agent 33	Parasite	Infection
Antimalarial agent 33 (compound 5g) has antiplasmodial activity against erythrocytic and hepatic stages of Plasmodium with an EC₅₀ of 1.1 μM for K1 P. falciparum strain. Antimalarial agent 33 demonstrats enhanced microsomal stability (T_1/2=29 min). Antimalarial agent 33 has no significant cytotoxicity against primary hepatocytes .

HY-170848

Antimalarial agent 48	Parasite	Infection
Antimalarial agent 48 (Compound 15a) is a triazine-class compound with antimalarial activity, showing inhibitory concentrations of 280 nM against Plasmodium falciparum K1 and 290 nM against Plasmodium falciparum FCR3. Antimalarial agent 48 is expected to be useful for research in the field of antimalarial infections .

HY-N8374

Pheanthine	Parasite	Infection
Pheanthine (Compound 2) is an antiplasmodial agent, that inhibits chloroquine-resistant Plasmodium falciparum K-1 (IC₅₀ is 0.8 μM) and chloroquine-sensitive P. falciparum strain NF54 A19A (IC₅₀ of 0.03 μM). Pheanthine exhibits low cytotoxicity in human lung fibrosblast (MRC-5, IC₅₀ is 11.2 μM) and macrophages (PMM, IC₅₀ is 8 μM) .

HY-145379

Miaosporone A	Parasite Endogenous Metabolite	Infection
Miaosporone A, an angucyclic quinone, exhibits antimalarial activity against Plasmodium falciparum K1 and antibacterial activity against Mycobacterium tuberculosis with respective IC₅₀ values of 2.5 and 2.4 μM and displays cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells .

HY-163765

Antimalarial agent 41	PI4K Potassium Channel	Infection
Antimalarial agent 41 (Compound 17) exhibits antimalarial activity, which inhibits Plasmodium falciparum with an IC₅₀ of 40 nM (NF54 strain) and 76 nM (K1 strain). Antimalarial agent 41 is an inhibitor for P. falciparum phosphatidylinositol-4-kinase β (Pf PI4K) and hERG channel, with an IC₅₀ of 53 nM and 3 μM. Antimalarial agent 41 exhibits cytotoxicity to CHO cells with an IC₅₀ of 34 μM. Antimalarial agent 41 ameliorates the malaria infection and exhibits good pharmacokinetic characters in mouse models .

HY-W413619

Cipargamin enantiomer NITD609 enantiomer; KAE609 enantiomer	Parasite	Infection
Cipargamin enantiomer (NITD609 enantiomer) is a Plasmodium falciparum inhibitor that can be characterized as a spirotetrahydro β-carboline (1S,3R stereoisomer). Cipargamin enantiomer exerts antiplasmodial activity against Plasmodium falciparum strains NF54 (IC₅₀ of 77 nM) and K1. Cipargamin enantiomer displays low liver microsomal intrinsic clearance in mouse and human systems. Cipargamin enantiomer does not inhibit CYP2C9. Cipargamin enantiomer can be used for the research of malaria .

HY-137985

Mer-NF5003F Stachybotrydial; F 1839M; Stachybotrydial	HSV Virus Protease	Infection
Mer-NF5003F (Stachybotrydial; F 1839M), a sesquiterpene isolated from Stachybotrys, inhibits avian medulloblastoma virus (AMV) protease (IC₅₀=7.8 μM). Mer-NF5003F inhibits sialyltransferase 6N (ST6N), ST3O, and ST3N (IC₅₀=0.61, 6.7, and 10 μg/mL, respectively), and fucosyltransferase (IC₅₀=11.3 μg/mL). Mer-NF5003F has in vitro activity against herpes simplex virus HSV-1 (IC₅₀=4.32 μg/mL) and multidrug-resistant Plasmodium falciparum K1 strain (IC₅₀=0.85 μg/mL).

HY-N12700S

Puberulic acid-13C8	Isotope-Labeled Compounds Parasite	Infection
Puberulic acid- ¹³C₈ is the ¹³C-labeled Puberulic acid. Puberulic acid possesses anti-malarial activity with an IC₅₀ value of 0.050 μM against Plasmodium falciparum K1 (chloroquine-resistant) .

HY-182319

Dehatrine	Parasite	Infection
Dehatrine is a dibenzylisoquinoline alkaloid with antiplasmodial activity. Dehatrine can be found in the Indonesian medicinal plant Beilschmiedia madang. Dehatrine is applicable to malaria-related research .

HY-W701798

(+)-Laudanidine (S)-Tritopin; D-Laudanine	Drug Derivative	Others
(+)-Laudanidine ((S)-Tritopin) is a benzyltetrahydroisoquinoline alkaloid found in Stephania species .

Cat. No.	Nombre del producto	Category	Target	Chemical Structure

HY-N6742

Borrelidin 1 Publications Verification Treponemycin	Infection Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Anti-parasitic Antibacterial Disease Research Disease Research Fields Source Classification	CDK Parasite Apoptosis Antibiotic
Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor which is a nitrile-containing macrolide antibiotic isolated from Streptomyces rochei . Borrelidin is an inhibitor of Cdc28/Cln2 of the budding yeast, with an IC₅₀ of 24 μM . Borrelidin is a potent angiogenesis inhibitor, with an IC₅₀ of 0.8 nM. Borrelidin induces apoptosis in the tube-forming cells . Borrelidin has strong antimalarial activities, with IC₅₀s of 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum, respectively .

HY-N5109

Cheilanthifoline	Infection Alkaloids Structural Classification Monophenols other families Classification of Application Fields Phenols Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Parasite
Cheilanthifoline, an alkaloid, is isolated from Corydalis calliantha. Cheilanthifoline exhibits antiplasmodial activities against Plasmodium falciparum, with IC₅₀s of 0.90 μg/mL and 1.22 μg/mL for wild type (TM4) and multidrug resistant (K1) strains, respectively .

HY-N5005

Guanfu base H Atisinium chloride	Infection Alkaloids Classification of Application Fields Ranunculaceae Quinoline Alkaloids Aconitum carmichaeli Debx. Plants Disease Research Fields Source Classification	Parasite
Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial **Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 with IC₅₀** values of 4 μM and 3.6 μM, respectively .

HY-N15748

Pelorol (-)-Pelorol	Terpenoids Sesquiterpenes Marine natural products Sponge Source Classification	Parasite
Pelorol ((-)-Pelorol) is a sesquiterpene found in the tropical marine sponge Dactylospongia elegans. Pelorol has weak antitrypanosomal activity with an IC₅₀ of 17.4 μg/mL and antiplasmodial activity against Plasmodium falciparum clones K1 and NF54 with IC₅₀ values of 786 ng/mL and 1911 ng/mL, respectively. Pelorol is promising for research of parasitic diseases, such as trypanosomiasis and malaria .

HY-126640

Phomoxanthone A	Quinones Microorganisms Anthraquinones Source Classification	Parasite
Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis. Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC₅₀ is 0.11 µg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 µg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC₅₀ is 0.99, 0.51 and 1.4 µg/mL, respectively .

HY-N8383

Butyrolactone V	Infection Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Phenols Disease Research Fields Source Classification	Parasite
Butyrolactone V is a butanolide compound. Butyrolactone V shows antiplasmodial activity against Plasmodium falciparum K1 with an IC₅₀ of 7.9 µg/ml .

HY-N8374

Pheanthine	Alkaloids Piperidine Alkaloids Triclisia gilletii (De Wild.) Staner Plants Menispermaceae Source Classification	Parasite
Pheanthine (Compound 2) is an antiplasmodial agent, that inhibits chloroquine-resistant Plasmodium falciparum K-1 (IC₅₀ is 0.8 μM) and chloroquine-sensitive P. falciparum strain NF54 A19A (IC₅₀ of 0.03 μM). Pheanthine exhibits low cytotoxicity in human lung fibrosblast (MRC-5, IC₅₀ is 11.2 μM) and macrophages (PMM, IC₅₀ is 8 μM) .

HY-145379

Miaosporone A	Infection Quinones Structural Classification Monophenols Classification of Application Fields Anthraquinones Phenols Endogenous metabolite Disease Research Fields Source Classification	Parasite Endogenous Metabolite
Miaosporone A, an angucyclic quinone, exhibits antimalarial activity against Plasmodium falciparum K1 and antibacterial activity against Mycobacterium tuberculosis with respective IC₅₀ values of 2.5 and 2.4 μM and displays cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells .

HY-W701798

(+)-Laudanidine (S)-Tritopin; D-Laudanine	Structural Classification Alkaloids Cuscuta reflexa Roxb. Plants Isoquinoline Alkaloids Convolvulaceae Cuscuta chinensis Lam. Source Classification	Drug Derivative
(+)-Laudanidine ((S)-Tritopin) is a benzyltetrahydroisoquinoline alkaloid found in Stephania species .

Cat. No.	Nombre del producto	Chemical Structure

HY-N12700S

Puberulic acid-13C8
Puberulic acid- ¹³C₈ is the ¹³C-labeled Puberulic acid. Puberulic acid possesses anti-malarial activity with an IC₅₀ value of 0.050 μM against Plasmodium falciparum K1 (chloroquine-resistant) .

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Plasmodium falciparum K1

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products