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Results for "

S6

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ribosomal S6 Kinase (RSK) (52) 5-HT Receptor (8) Acyltransferase (1) ADC Linker (1) Adrenergic Receptor (1) Akt (34) Amino Acid Derivatives (3) Aminopeptidase (2) AMPK (11) Amyloid-β (1) Androgen Receptor (2) Antibiotic (1) Apoptosis (33) ATM/ATR (1) ATP Citrate Lyase (2) Autophagy (16) Bacterial (6) Bcl-2 Family (3) Biochemical Assay Reagents (22) c-Myc (1) Calcium Channel (3) Casein Kinase (2) Caspase (1) CCR (1) CDK (5) Cholinesterase (ChE) (1) COX (4) Cytochrome P450 (1) DNA/RNA Synthesis (6) Drug Derivative (1) Drug Intermediate (9) Drug-Linker Conjugates for ADC (2) Dynamin (2) E3 Ligase Ligand-Linker Conjugates (1) EGFR (8) Endogenous Metabolite (11) Endothelin Receptor (5) Enteropeptidase (2) Environmental Pollutants (1) Epigenetic Reader Domain (2) ERK (9) FAK (1) FBPase (1) Ferroptosis (4) FGFR (2) FLT3 (1) FOXO (2) Fungal (3) GABA Receptor (1) Glucocorticoid Receptor (1) GLUT (1) Glycosidase (1) GSK-3 (1) HBV (1) HDAC (1) Herbicide (1) HIF/HIF Prolyl-Hydroxylase (2) HSP (3) HSV (1) iGluR (1) IKK (2) Insulin Receptor (1) Isotope-Labeled Compounds (16) JAK (1) JNK (4) Keap1-Nrf2 (5) Leukotriene Receptor (3) MAGL (1) MARK (1) MDM-2/p53 (1) MNK (1) mTOR (31) nAChR (2) Necroptosis (1) NF-κB (11) Notch (1) Opioid Receptor (2) P-selectin (1) p38 MAPK (6) p62 (1) Parasite (3) PARP (1) PDK-1 (7) Phosphoramidites (4) PI3K (13) Pim (1) PKA (3) PKC (6) Potassium Channel (1) Prostaglandin Receptor (2) PROTACs (3) Proteasome (1) PTEN (1) Raf (4) Ras (2) Reactive Oxygen Species (ROS) (5) Reference Standards (27) RET (4) ROCK (3) SGK (3) Sirtuin (2) Small Interfering RNA (siRNA) (3) Src (4) SRPK (1) STAT (3) Survivin (1) Syk (1) TAM Receptor (1) Target Protein Ligand-Linker Conjugates (1) TGF-beta/Smad (3) TGF-β Receptor (1) Topoisomerase (3) VEGFR (2) Wee1 (1) Wnt (1) YB-1 (1) γ-secretase (1)
By Research Areas:	Cancer (125) Cardiovascular Disease (21) Endocrinology (1) Infection (12) Inflammation/Immunology (26) Metabolic Disease (29) Neurological Disease (27)
Click Chemistry:	Labeling and Fluorescence Imaging (1) Alkynes (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (3) Other Phosphoramidite (4) Phosphoramidites (4) siRNAs (3)

248

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Ribosomal S6 Kinase (RSK)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0643

Carnosol Maximum Cited Publications 16 Publications Verification	Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite	Cancer
Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC₅₀ of ~5.5 μM . Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .

HY-148273

Setidegrasib ASP-3082; KRAS G12D inhibitor 17	PROTACs Ras ERK Akt	Cancer
Setidegrasib (KRAS G12D inhibitor 17, ASP3082) is a PROTAC KRAS degrader (DC₅₀: 37 nM). Setidegrasib induces the degradation of G12D-mutation KRAS protein. Setidegrasib suppresses p-ERK, p-AKT, *p-S6* levels in AsPC-1 cells. Setidegrasib exhibits anti-tumor activity in various cancer xenograft models in mice. Setidegrasib can be used for the study of KRAS(G12D)-mutated solid tumors. (Blue: VHL ligase ligand (HY-168699); Black: linker (HY-168698); Pink: G12D ligand (HY-168700)) .

HY-14463

Onalespib 10+ Cited Publications AT13387	HSP	Cancer
Onalespib (AT13387) is a potent and cross the blood-brain barrier heat-shock-protein-90 (Hsp90) inhibitor. Onalespib inhibits the proliferation, survival and migration. Onalespib decreases the expression of EGFR, p-EGFR, AKT, P-AKT, ERK1/2, P-ERK1/2, S6, P-S6 protein. Onalespib shows antitumor activity. Onalespib has the potential for the research of non-small cell lung cancer (NSCLC) .

HY-50908

Ridaforolimus 10+ Cited Publications MK-8669; Deforolimus; AP23573	mTOR Autophagy Bacterial	Cancer
Ridaforolimus (MK-8669) is a potent and selective mTOR inhibitor; inhibits ribosomal protein S6 phosphorylation with an IC₅₀ of 0.2 nM in HT-1080 cells .

HY-14153

Tegaserod 4 Publications Verification	5-HT Receptor Apoptosis	Metabolic Disease Cancer
Tegaserod is an orally active serotonin receptor 4 (HTR4; 5-HT₄R) agonist and a 5-HT_2B receptor antagonist. Tegaserod has pK_is of 7.5, 8.4 and 7.0 for human recombinant 5-HT_2A, 5-HT_2B and 5-HT_2C receptors, respectively. Tegaserod causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research .

HY-14153A

Tegaserod maleate 4 Publications Verification SDZ-HTF-919; HTF-919	5-HT Receptor Apoptosis	Neurological Disease Metabolic Disease Cancer
Tegaserod maleate (SDZ-HTF-919) is an orally active serotonin receptor 4 (HTR4; 5-HT₄R) agonist and a 5-HT_2B receptor antagonist. Tegaserod maleate has pK_is of 7.5, 8.4 and 7.0 for human recombinant 5-HT_2A, 5-HT_2B and 5-HT_2C receptors, respectively. Tegaserod maleate causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod maleate has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research .

HY-19713

LJI308 4 Publications Verification	Ribosomal S6 Kinase (RSK) YB-1	Cancer
LJI308 is a potent pan-ribosomal S6 kinase (RSK) inhibitor, with IC₅₀s of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively. LJI308 inhibits the phosphorylation of RSK (T359/S363) and YB-1 (S102) after irradiation, treatment with EGF, and in cells expressing a KRAS mutation .

HY-W011109

CKI-7 1 Publications Verification	Casein Kinase CDK SGK Ribosomal S6 Kinase (RSK)	Cancer
CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC₅₀ of 6 μM and a K_i of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 has a much weaker effect on casein kinase II and other protein kinases .

HY-15237

SL 0101-1 5+ Cited Publications SL0101	Ribosomal S6 Kinase (RSK)	Cancer
SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC₅₀ of 89 nM . SL 0101-1 (SL0101) is a selective RSK1/2 inhibitor, with a K_i of 1 μM .

HY-107198

(2S)-6-Prenylnaringenin 1 Publications Verification	GABA Receptor	Neurological Disease
(2S)-6-Prenylnaringenin is the most efficient compound in forebrain. (2S)-6-Prenylnaringenin acts as a GABA_A positive allosteric modulator at α+β- binding interface .

HY-16104

BIX 02565 5+ Cited Publications	Ribosomal S6 Kinase (RSK)	Cardiovascular Disease
BIX 02565 is a potent ribosomal S6 kinase 2 (RSK2) inhibitor with IC₅₀ of 1.1 nM.

HY-173634

Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB-Exatecan	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB-Exatecan (LP1) is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor Exatecan (HY-13631) and a linker Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB (HY-173635) to make antibody agent conjugate (ADC), AZD0516 (HY-173639) .

HY-133028

CKI-7 free base 1 Publications Verification	Casein Kinase CDK SGK Ribosomal S6 Kinase (RSK)	Cancer
CKI-7 free base is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC₅₀ of 6 μM and a K_i of 8.5 μM. CKI-7 free base is a selective Cdc7 kinase inhibitor. CKI-7 free base also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 free base has a much weaker effect on casein kinase II and other protein kinases .

HY-18313

S6K1-IN-1	Ribosomal S6 Kinase (RSK) JAK CDK	Metabolic Disease
S6K1-IN-1 is a selective *S6K1* inhibitor with an IC₅₀ value of 52 nM. S6K1-IN-1 can be used in the research of obesity and insulin resistance-related diseases .

HY-W390763B

*(S)-6-Methyl-1,4-oxazepan-6-ol hydrochloride*	Drug Intermediate	Others
(S)-6-Methyl-1,4-oxazepan-6-ol hydrochloride is a drug intermediate for synthesis of various active compounds.

HY-P99463

Batiraxcept 2 Publications Verification AVB-500; AVB-S6-500	TAM Receptor PI3K Akt p38 MAPK	Cancer
Batiraxcept (AVB-500; AVB-S6-500) is a selective, soluble AXL receptor and *GAS6* inhibitor that targets the GAS6-AXL signaling axis. Batiraxcept is orally inactive and does not cross the blood-brain barrier. Batiraxcept competitively binds to GAS6 ((K_D <1 nM), preventing its interaction with the AXL receptor tyrosine kinase, thereby inhibiting downstream PI3K/AKT and MAPK signaling pathways, reducing tumor cell glycolysis, angiogenesis, and metastatic potential. Batiraxcept has demonstrated antitumor activity in preclinical models of endometrial, cholangiocarcinoma, and ovarian cancer by inhibiting tumor growth, invasion, and metastasis .

HY-101955

(2S,6S)-Hydroxynorketamine hydrochloride (2S,6S)-HNK hydrochloride	mTOR nAChR	Neurological Disease
(2S,6S)-Hydroxynorketamine hydrochloride is a neurorelaxant with potential antidepressant and analgesic effects. (2S,6S)-Hydroxynorketamine hydrochloride can activate the mTOR pathway, increase the phosphorylation level of downstream targets, and antagonize α7-nicotinic acetylcholine receptor (nAChR) to exert neuroactive properties .

HY-151622

PI3K/mTOR Inhibitor-11 2 Publications Verification	PI3K mTOR	Cancer
PI3K/mTOR Inhibitor-11 is an orally active PI3K/mTOR inhibitor (IC₅₀: 3.5, 4.6, and 21.3 nM for PI3Kα, PI3Kδ, and mTOR). PI3K/mTOR Inhibitor-11 regulates the PI3K/AKT/mTOR signaling pathway by inhibiting the phosphorylation of AKT and S6 proteins. PI3K/mTOR Inhibitor-11 can be used in the research of cancers .

HY-175256

RSK2-IN-5	Ribosomal S6 Kinase (RSK)	Cancer
RSK2-IN-5 (compoud C24) is a p90 ribosomal S6 kinase 2 (RSK2) inhibitor with a K_d of 317 nM. RSK2-IN-5 exhibits antitumor activity against breast cancer and melanoma cancer cells .

HY-147204

Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE (compound S6) is a potent anticancer agent, which can be specific activated by tumor microenvironment. Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE can suppress tumor growth in mice (extracted from patent CN104147612A) .

HY-P3054

S6 peptide	Ribosomal S6 Kinase (RSK)	Cardiovascular Disease
S6 peptide is a potentially important lamin kinase. S6 peptide is involved in the process of cardiac hypertrophy induced by mechanical loading. S6 peptide can be activated by many kinds of growth factors .

HY-117393

Bisindolylmaleimide III 1 Publications Verification	PKC	Cancer
Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC). Bisindolylmaleimide III selectively interacts with either PKCα or ribosomal S6 protein kinase 1 after activation of these kinases .

HY-W348485

WRX606	mTOR	Cancer
WRX606 is an orally active nonrapalog inhibitor for mTOR complex 1 (mTORC1M). WRX606 inhibits the phosphorylation of mTORC1 substrate S6 kinase 1 (S6K1) (IC₅₀ = 10 nM) and eukaryotic translation initiation factor 4E binding protein (p-4E-BP1) (IC₅₀ = 0.27 μM) in MCF-7 cells. WRX606 suppresses tumor growth in mice without promotion of metastasis. WRX606 can be studied in research as an antitumor agent .

HY-152944

S6K1-IN-DG2	Ribosomal S6 Kinase (RSK)	Cancer
S6K1-IN-DG2 (Compound 66) is a *p70S6K* inhibitor (IC₅₀: < 100 nM) .

HY-P10042

S6K Substrate	Ribosomal S6 Kinase (RSK)	Others
S6K Substrate is a substrate for active protein kinases, including CLK2, MRCKalpha, MRCKbeta, p70S6K, ROCK1, ROCK2, RSK1, RSK3, PIM1 .

HY-P1112

Sarafotoxin S6a	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Sarafotoxin S6a, a sarafotoxin analogue, is a endothelin receptor agonist and has an ET_A/ET_B selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a elicits the pig coronary artery with an EC₅₀ value of 7.5 nM .

HY-102029

Sarafotoxin S6c SRTX-c	Endothelin Receptor	Cardiovascular Disease
Sarafotoxin S6c (SRTX-c) is a potent endothelin-B receptor agonist. Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels .

HY-W011049

*(S)-6-(((Benzyloxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)hexanoic acid*	Amino Acid Derivatives	Others
(S)-6-(((Benzyloxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)hexanoic acid is a lysine derivative .

HY-W578482

(1S,6R)-6-Amino-2,2-difluorocyclohexan-1-ol	Drug Intermediate	Others
(1S,6R)-6-Amino-2,2-difluorocyclohexan-1-ol is a drug intermediate for synthesis of various active compounds.

HY-52101C

FMK-MEA	Ribosomal S6 Kinase (RSK)	Cancer
FMK-MEA is a potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor.

HY-113916

Onalespib lactate AT13387 lactate	HSP	Cancer
Onalespib lactate is a potent and cross the blood-brain barrier heat-shock-protein-90 (Hsp90) inhibitor with an K_d value of 0.71 nM. Onalespib lactate inhibits the proliferation, survival and migration. Onalespib lactate decreases the expression of EGFR, p-EGFR, AKT, P-AKT, ERK1/2, P-ERK1/2, S6, P-S6 protein. Onalespib lactate shows antitumor activity. Onalespib lactate has the potential for the research of non-small cell lung cancer (NSCLC) .

HY-13787

XL-418	Akt Ribosomal S6 Kinase (RSK) GSK-3	Cancer
XL-418 is an orally active dual Akt and *p70S6K* inhibitor with IC₅₀s of 1 nM for Akt1 and 2 nM for p70S6K. XL-418 inhibits the phosphorylation of ribosomal protein S6 and GSK3β. XL-418 can be used for the study of prostate carcinoma and breast cancer .

HY-P3814

S6 Kinase Substrate Peptide 32	Ribosomal S6 Kinase (RSK)	Cancer
S6 Kinase Substrate Peptide 32 is a substrate of Ribosomal S6 Kinase (RSK). S6 Kinase Substrate Peptide 32 can be used to measure the activity of RSKs which phosphorylate ribosomal protein S6 .

HY-156672

S6K2-IN-1	FGFR	Cancer
S6K2-IN-1 (Compound 2) is a *S6K2* inhibitor (IC₅₀: 22 nM). S6K2-IN-1 also inhibits FGFR4 (IC₅₀: 216 nM). S6K2-IN-1 has acceptable stability in mouse liver microsomes .

HY-12296A

(3S,5S,6R)-Navtemadlin (3S,5S,6R)-AMG 232; (3S,5S,6R)-KRT-232	MDM-2/p53	Cancer
(3S,5S,6R)-Navtemadlin is the isomer of Navtemadlin (HY-12296), and can be used as an experimental control. Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC₅₀ of 0.6 nM. Navtemadlin binds to MDM2 with a K_d of 0.045 nM .

HY-W110146

(3aS,4S,6aR)-Biotin-PEG4-Alkyne	Biochemical Assay Reagents	Others
(3aS,4S,6aR)-Biotin-PEG4-Alkyne is an alkyne-activated biotinylation reagent. (3aS,4S,6aR)-Biotin-PEG4-Alkyne can be reacted with azides via a copper-catalyzed click reaction. Biotin-labeled biomolecules can be bound to avidin or streptavidin for further purification and detection .

HY-P5449

p70 S6 Kinase substrate	Ribosomal S6 Kinase (RSK)	Others
p70 S6 Kinase substrate is a biological active peptide. (This peptide is a substrate for p70 ribosomal S6 kinase.)

HY-124348

DM-PIT-1 3,5-Dimethyl PIT-1	PI3K	Cancer
DM-PIT-1 is a PIP3/PH (phosphatidylinositol-3,4,5-triphosphate/Pleckstrin) interaction inhibitor. DM-PIT-1 decreases he expression of P-Akt, P-GSK-3-β, P-p70S6K, P-S6, P-4E-BP1. DM-PIT-1 induces apoptosis and shows anticancer activity. DM-PIT-1 has the potential for the research of ovarian cancer .

HY-131495

*(S)-6-O-Desmethylnaproxen* (S)-6-Desmethyl Naproxen	COX	Inflammation/Immunology
(S)-6-O-Desmethylnaproxen ((S)-6-Desmethyl Naproxen) is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (+)-naproxen ((S)-naproxen). (S)-6-O-Desmethylnaproxen is formed from (S)-naproxen by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2C9.

HY-P3563

[Lys4] Sarafotoxin S6c	Endothelin Receptor	Cardiovascular Disease
[Lys4] Sarafotoxin S6c, a sarafotoxin analogue, is a potent and partial agonist of endothelin receptor. [Lys4] Sarafotoxin S6c elicits contraction of pig coronary artery, with an EC₅₀ of 1.5 nM .

HY-115681

*(2R/S)-6-PNG* 1 Publications Verification 6-Prenylnaringenin; (±)-6-Prenylnaringenin	Calcium Channel	Neurological Disease
(2R/S)-6-PNG (6-Prenylnaringenin) is a potent and reversible Ca_v3.2 T-type Ca ²⁺ channels (T-channels) blocker. (2R/S)-6-PNG can penetrate the blood-brain barrier (BBB). (2R/S)-6-PNG suppresses neuropathic and visceral pain in mice .

HY-173635

Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB	ADC Linker	Cancer
Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB is an interchain cysteines to a Maleimide-reactive, β-glucuronidase-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as AZD0516 (HY-173639) .

HY-B0352A

(S)-Mirtazapine (S)-Org3770; (S)-6-Azamianserin	5-HT Receptor	Neurological Disease
(S)-Mirtazapine ((S)-Org3770) is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception. (S)-Mirtazapine is a stereoselective 5-HT₂ receptor antagonist. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2 .

HY-156872

MTX-216	PI3K EGFR Syk Apoptosis	Cancer
MTX-216 is a dual ATP-competitive inhibitor of PI3K and EGFR. MTX-216 cosuppresses Ki-67 and ribosomal S6 phosphorylation and induces apoptosis in NF1 ^LOF cells. MTX-216 suppresses the activity of SYK kinase, with an IC₅₀ of 281 nM. MTX-216 is used in the research of Melanoma .

HY-N0643R

Carnosol (Standard)	Reference Standards Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite	Cancer
Carnosol (Standard) is the analytical standard of Carnosol. This product is intended for research and analytical applications. Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC₅₀ of ~5.5 μM . Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .

HY-172140

Ebio3	Potassium Channel	Neurological Disease
Ebio3 is a selective potassium channel (KCNQ2) inhibitor with an IC₅₀ of 1.2 nM. Ebio3 binds to the KCNQ2 channel through its hydrophobic tail, causing the S6 helix to move inward, which leads to the closure of the inner gate. The inhibitory effect of Ebio3 is also effective in pathogenic mutants of KCNQ2 (such as R75C and I238L), where it can inhibit outward currents by more than 80%. Ebio3 is expected to be used in the research of neurological diseases such as epilepsy .

HY-P5467

S6(229-239), Amide, biotinalyted	ROCK	Others
S6(229-239), Amide, biotinalyted is a biological active peptide. (substrate for Rho-Kinase II)

HY-N16612

(3S,5S)-[6]-Gingerdiol	Parasite	Infection
(3S,5S)-[6]-Gingerdiol is a cestocidal agent. (3S,5S)-[6]-Gingerdiol can be isolate from the roots of ginger. (3S,5S)-[6]-Gingerdiol shows cestocidal activity against H. nana .

HY-P10042A

S6K Substrate acetate	Ribosomal S6 Kinase (RSK)	Others
S6K Substrate acetate is a substrate for active protein kinases, including CLK2, MRCKalpha, MRCKbeta, p70S6K, ROCK1, ROCK2, RSK1, RSK3, PIM1 .

HY-P3433

Sarafotoxin S6b	Endothelin Receptor	Cardiovascular Disease
Sarafotoxin S6b is a vasoconstrictor peptide, and a non-selective endothelin receptor agonist. Sarafotoxin S6b can induce contraction in isolated human coronary arteries , the K_i values of Coronary artery, Saphenous vein and Coronary artery are 0.27, 0.55 and 19.5 nM, respectively .

Cat. No.	Product Name	Type

HY-W338584

Hydroxycitric acid tripotassium

1 Publications Verification

Biochemical Assay Reagents

Tripotassium hydroxycitrate is an orally active, multi-target, multi-bioactive organic acid. Tripotassium hydroxycitrate activates Nrf2 and its downstream molecule GPX4, increases glutathione levels, and thereby inhibits ferroptosis. Tripotassium hydroxycitrate activates the Nrf2/Keap1 and ACLY/NF-κB signaling pathways, upregulates the activities of antioxidant enzymes such as superoxide dismutase, reduces MDA content, thereby alleviating oxidative stress and renal tubular epithelial cell apoptosis, and improves pulmonary vascular and right ventricular remodeling. Tripotassium hydroxycitrate activates both the AMPK and mTORC1/S6K pathways, triggers the unfolded protein response, arrests the cancer cell cycle, and induces DNA fragmentation .

HY-40351

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine	Biochemical Assay Reagents
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine is a nitrogen-containing heterocyclic organic synthesis intermediate that can be used for the synthesis of JAK and PKB/Akt inhibitors .

HY-W070306

PDK1-IN-1	Biochemical Assay Reagents
PDK1-IN-1 (Compound 2-11) is a PDK1 inhibitor. PDK1-IN-1 is also useful as inhibitor of other kinases such as FGFR3, NTRK3, *RP-S6K* and WEE1. PDK1-IN-1 selectively inhibits microtubule affinity regulating kinase (MARK). PDK1-IN-1 can be used for researches of myeloproliferative disorders, cancer and Alzheimer's disease .

HY-158506

A2G2S2 glycan (G2S2) A2G2S2 N-linked oligosaccharide; A2G(4)2S(6)2 glycan	Biochemical Assay Reagents
A2G2S2 glycan (G2S2) (A2G2S2 N-linked oligosaccharide; A2G(4)2S(6)2 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158513

FA2G2S2 glycan (G2FS2) FA2G2S2 N-linked oligosaccharide; F(6)A2G(4)2S(6)2 glycan	Biochemical Assay Reagents
FA2G2S2 glycan (G2FS2) (FA2G2S2 N-linked oligosaccharide; F(6)A2G(4)2S(6)2 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158477

FA2G2S1 glycan (G2FS1) FA2G2S1 N-linked oligosaccharide; α(2,6)/FA2G2S(6)1 glycan; F(6)A2G(4)2S(6)1 glycan	Biochemical Assay Reagents
FA2G2S1 glycan (G2FS1) (FA2G2S1 N-linked oligosaccharide; α(2,6)/FA2G2S(6)1 glycan; F(6)A2G(4)2S(6)1 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158475

A2G2S1 glycan (G2S1) A2G2S1 N-linked oligosaccharide; A2G(4)2S(6)1 glycan	Biochemical Assay Reagents
A2G2S1 glycan (G2S1) (A2G2S1 N-linked oligosaccharide; A2G(4)2S(6)1 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158508

A2G2S2 glycan (G2S2), 2-AA labelled A2G2S2 N-linked oligosaccharide, 2-AA labelled; A2G(4)2S(6)2 glycan, 2-AA labelled	Biochemical Assay Reagents
A2G2S2 glycan (G2S2), 2-AA labelled (A2G2S2 N-linked oligosaccharide, 2-AA labelled; A2G(4)2S(6)2 glycan, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158512

A2G2S2 glycan (G2S2), 2-AB labelled A2G2S2 N-linked oligosaccharide, 2-AB labelled; A2G(4)2S(6)2 glycan, 2-AB labelled	Biochemical Assay Reagents
A2G2S2 glycan (G2S2), 2-AB labelled (A2G2S2 N-linked oligosaccharide, 2-AB labelled; A2G(4)2S(6)2 glycan, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158476

FA2G2S1 glycan (G2FS1), procainamide labelled FA2G2S1 N-linked oligosaccharide, procainamide labelled; α(2,6)/FA2G2S(6)1 glycan, procainamide labelled; F(6)A2G(4)2S(6)1 glycan, procainamide labelled	Biochemical Assay Reagents
FA2G2S1 glycan (G2FS1), procainamide labelled (FA2G2S1 N-linked oligosaccharide, procainamide labelled; α(2,6)/FA2G2S(6)1 glycan, procainamide labelled; F(6)A2G(4)2S(6)1 glycan, procainamide labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158510

A2G2S2 glycan (G2S2), APTS labelled A2G2S2 N-linked oligosaccharide, APTS labelled; A2G(4)2S(6)2 glycan, APTS labelled	Biochemical Assay Reagents
A2G2S2 glycan (G2S2), APTS labelled (A2G2S2 N-linked oligosaccharide, APTS labelled; A2G(4)2S(6)2 glycan, APTS labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158517

FA2G2S2 glycan (G2FS2), APTS labelled FA2G2S2 N-linked oligosaccharide, APTS labelled; F(6)A2G(4)2S(6)2 glycan, APTS labelled	Biochemical Assay Reagents
FA2G2S2 glycan (G2FS2), APTS labelled (FA2G2S2 N-linked oligosaccharide, APTS labelled; F(6)A2G(4)2S(6)2 glycan, APTS labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158515

FA2G2S2 glycan (G2FS2), 2-AB labelled FA2G2S2 N-linked oligosaccharide, 2-AB labelled; F(6)A2G(4)2S(6)2 glycan, 2-AB labelled	Biochemical Assay Reagents
FA2G2S2 glycan (G2FS2), 2-AB labelled (FA2G2S2 N-linked oligosaccharide, 2-AB labelled; F(6)A2G(4)2S(6)2 glycan, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158518

FA2G2S2 glycan (G2FS2), 2-AA labelled FA2G2S2 N-linked oligosaccharide, 2-AA labelled; F(6)A2G(4)2S(6)2 glycan, 2-AA labelled	Biochemical Assay Reagents
FA2G2S2 glycan (G2FS2), 2-AA labelled (FA2G2S2 N-linked oligosaccharide, 2-AA labelled; F(6)A2G(4)2S(6)2 glycan, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

Cat. No.	Product Name	Target	Research Area

HY-P1925A

GO-203 TFA 2 Publications Verification	PI3K Reactive Oxygen Species (ROS) Apoptosis	Cancer
GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the *PI3K-AKT-S6K1* pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice .

HY-132828

Odatroltide LT3001; DHDMIQK(KAP)	P-selectin	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Odatroltide (LT3001; DHDMIQK(KAP)) is a P-selectin inhibitor. Odatroltide is a peptide molecule comprising a tripeptide Pro-Ala-Lys (PAK) and an (S)-6,7-dihydroxy-1,1-dimethyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid domain. Odatroltide can restore cerebral blood flow, scavenge free radicals, and inhibit leukocyte migration. Odatroltide possesses thrombolytic and anti-thrombotic activities .

HY-P3054

S6 peptide	Ribosomal S6 Kinase (RSK)	Cardiovascular Disease
S6 peptide is a potentially important lamin kinase. S6 peptide is involved in the process of cardiac hypertrophy induced by mechanical loading. S6 peptide can be activated by many kinds of growth factors .

HY-P10042

S6K Substrate	Ribosomal S6 Kinase (RSK)	Others
S6K Substrate is a substrate for active protein kinases, including CLK2, MRCKalpha, MRCKbeta, p70S6K, ROCK1, ROCK2, RSK1, RSK3, PIM1 .

HY-P1112

Sarafotoxin S6a	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Sarafotoxin S6a, a sarafotoxin analogue, is a endothelin receptor agonist and has an ET_A/ET_B selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a elicits the pig coronary artery with an EC₅₀ value of 7.5 nM .

HY-102029

Sarafotoxin S6c SRTX-c	Endothelin Receptor	Cardiovascular Disease
Sarafotoxin S6c (SRTX-c) is a potent endothelin-B receptor agonist. Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels .

HY-W011049

*(S)-6-(((Benzyloxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)hexanoic acid*	Amino Acid Derivatives	Others
(S)-6-(((Benzyloxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)hexanoic acid is a lysine derivative .

HY-P3814

S6 Kinase Substrate Peptide 32	Ribosomal S6 Kinase (RSK)	Cancer
S6 Kinase Substrate Peptide 32 is a substrate of Ribosomal S6 Kinase (RSK). S6 Kinase Substrate Peptide 32 can be used to measure the activity of RSKs which phosphorylate ribosomal protein S6 .

HY-P5449

p70 S6 Kinase substrate	Ribosomal S6 Kinase (RSK)	Others
p70 S6 Kinase substrate is a biological active peptide. (This peptide is a substrate for p70 ribosomal S6 kinase.)

HY-P3563

[Lys4] Sarafotoxin S6c	Endothelin Receptor	Cardiovascular Disease
[Lys4] Sarafotoxin S6c, a sarafotoxin analogue, is a potent and partial agonist of endothelin receptor. [Lys4] Sarafotoxin S6c elicits contraction of pig coronary artery, with an EC₅₀ of 1.5 nM .

HY-148218

Glycyl-L-alpha-amino-epsilon-pimelyl-D-alanyl-D-alanine N-[(6S)-6-Carboxy-6-(glycylamino)hexanoyl]-D-alanyl-D-alanine	Amino Acid Derivatives	Metabolic Disease
Glycyl-L-alpha-amino-epsilon-pimelyl-D-alanyl-D-alanine is a specific peptide substrate of Streptomyces R1 d-alanyl-d-alanine(dd)-peptidases .

HY-P5467

S6(229-239), Amide, biotinalyted	ROCK	Others
S6(229-239), Amide, biotinalyted is a biological active peptide. (substrate for Rho-Kinase II)

HY-P10042A

S6K Substrate acetate	Ribosomal S6 Kinase (RSK)	Others
S6K Substrate acetate is a substrate for active protein kinases, including CLK2, MRCKalpha, MRCKbeta, p70S6K, ROCK1, ROCK2, RSK1, RSK3, PIM1 .

HY-P3433

Sarafotoxin S6b	Endothelin Receptor	Cardiovascular Disease
Sarafotoxin S6b is a vasoconstrictor peptide, and a non-selective endothelin receptor agonist. Sarafotoxin S6b can induce contraction in isolated human coronary arteries , the K_i values of Coronary artery, Saphenous vein and Coronary artery are 0.27, 0.55 and 19.5 nM, respectively .

HY-P10320

T3 Peptide Tumstatin (69-88), human	PI3K Akt	Cardiovascular Disease
T3 Peptide is an active fragment of tumstatin. T3 Peptide binds integrin α_vβ₃/α_vβ₅, activates the PI3K/Akt/p70S6K signaling pathway, and thus stimulates the proliferation and migration of rat cardiac fibroblasts .

HY-P5466

S6(229-239)	Peptides	Others
S6(229-239) is a biological active peptide. (This is a synthetic peptide substrate for S6 kinase shown to be phosphorylated by protein kinase c with phosphorylation site identified at Ser235)

HY-P11642A

Sialorphin TFA	Enteropeptidase Aminopeptidase Opioid Receptor ERK mTOR Androgen Receptor	Inflammation/Immunology
Sialorphin TFA is a neutral endopeptidase (NEP) and aminopeptidase N (APN) inhibitor that responds to androgen signals. Sialorphin TFA blocks the degradation of endogenous opioid peptides and interacts with μ-, δ-, κ-opioid receptors. Sialorphin TFA regulates the ERK/mTOR signaling pathway by inducing cell cycle arrest, enhancing ERK1/2 activity, and reducing the phosphorylation levels of mTOR, 4E-BP1, p70S6K; accordingly, Sialorphin TFA exhibits antiproliferative activity against colorectal cancer, glioma and prostate cancer cells without cytotoxicity. In addition, Sialorphin TFA also produces antinociceptive responses, regulates sexual behavior, relaxes corpus cavernosum smooth muscle, and alleviates experimental colitis. Sialorphin TFA is also a copper (II) ion-binding ligand. Sialorphin TFA has been used in mechanistic studies related to cancer, pain management and inflammatory bowel disease .

HY-P3565

Sarafotoxin S6d STX-b	Calcium Channel	Cardiovascular Disease
Sarafotoxin S6d (STX-b) is a polypeptide toxin isolated from the venom of the Israeli sand boa constrictor. Sarafotoxin S6d induces multiple electrocardiogram (ECG) changes including myocardial ischemia and hyperkalemia. Sarafotoxin S6d induces strong extracellular calcium-dependent vasoconstriction in rat aorta and exhibits positive inotropic effects in rat atria. Sarafotoxin S6d can be used in the study of cardiovascular diseases .

HY-W009477

*(S)-6-Amino-2-((S)-2-aminopropanamido)hexanoic acid hydrochloride*	Amino Acid Derivatives	Others
(S)-6-Amino-2-((S)-2-aminopropanamido)hexanoic acid hydrochloride is a lysine derivative .

HY-P1112A

Sarafotoxin S6a TFA	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Sarafotoxin S6a TFA , a sarafotoxin analogue, is a endothelin receptor agonist and has an ET_A/ET_B selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a TFA elicits the pig coronary artery with an EC₅₀ value of 7.5 nM .

HY-P0141

Akt/SKG Substrate Peptide	Akt	Others
Akt/SKG Substrate Peptide is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or MAPK1 .

HY-P0141A

Akt/SKG Substrate Peptide TFA	Akt	Others
Akt/SKG Substrate Peptide TFA is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or MAPK1 .

HY-P11642

Sialorphin	ERK Androgen Receptor Opioid Receptor Enteropeptidase mTOR Aminopeptidase	Neurological Disease Inflammation/Immunology Cancer
Sialorphin is a neutral endopeptidase (NEP) and aminopeptidase N (APN) inhibitor that responds to androgen signals. Sialorphin blocks the degradation of endogenous opioid peptides and interacts with μ-, δ-, κ-opioid receptors. Sialorphin regulates the ERK/mTOR signaling pathway by inducing cell cycle arrest, enhancing ERK1/2 activity, and reducing the phosphorylation levels of mTOR, 4E-BP1, p70S6K; accordingly, Sialorphin exhibits antiproliferative activity against colorectal cancer, glioma and prostate cancer cells without cytotoxicity. In addition, Sialorphin also produces antinociceptive responses, regulates sexual behavior, relaxes corpus cavernosum smooth muscle, and alleviates experimental colitis. Sialorphin is also a copper (II) ion-binding ligand. Sialorphin has been used in mechanistic studies related to cancer, pain management and inflammatory bowel disease .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99507

Zenocutuzumab MCLA-128; PB4188; R040517	EGFR	Cancer
Zenocutuzumab (MCLA-128) is a bispecific humanized IgG1 antibody containing two different Fab arms, targeting extracellular domains of HER2 and HER3 .

HY-P99463

Batiraxcept 2 Publications Verification AVB-500; AVB-S6-500	TAM Receptor PI3K Akt p38 MAPK	Cancer
Batiraxcept (AVB-500; AVB-S6-500) is a selective, soluble AXL receptor and *GAS6* inhibitor that targets the GAS6-AXL signaling axis. Batiraxcept is orally inactive and does not cross the blood-brain barrier. Batiraxcept competitively binds to GAS6 ((K_D <1 nM), preventing its interaction with the AXL receptor tyrosine kinase, thereby inhibiting downstream PI3K/AKT and MAPK signaling pathways, reducing tumor cell glycolysis, angiogenesis, and metastatic potential. Batiraxcept has demonstrated antitumor activity in preclinical models of endometrial, cholangiocarcinoma, and ovarian cancer by inhibiting tumor growth, invasion, and metastasis .

HY-P990296

Anti-Mouse CCR3/CD193 Antibody (6S2-19-4)	CCR	Infection Inflammation/Immunology Cancer
Anti-Mouse CCR3/CD193 Antibody (6S2-19-4) is a rat-derived IgG2b λ type antibody inhibitor, targeting to mouse CCR3/CD193. Anti-Mouse CCR3/CD193 Antibody (6S2-19-4) can deplete eosinophils. Anti-Mouse CCR3/CD193 Antibody (6S2-19-4) can be used for the researches of cancer, infection, inflammation and immunology, such as lymphoma, ileitis and strongyloides stercoralis infection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0643

Carnosol Maximum Cited Publications 16 Publications Verification	Classification of Application Fields Paramacrolobium coeruleum (Taub.) J.Léonard Food Preservation Research Plants Agricultural Research Terpenoids Labiatae Phenols Polyphenols Diterpenoids Disease Research Fields Source Classification Cancer	Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite
Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC₅₀ of ~5.5 μM . Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .

HY-14615

[6]-Gingerol 10+ Cited Publications (S)-(+)-[6]Gingerol	Zingiber officinale Roscoe Structural Classification Monophenols Classification of Application Fields Phenols Plants Disease Research Fields Source Classification Zingiberaceae Cancer	AMPK Apoptosis
[6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.

HY-13595

Chrysophanol 5+ Cited Publications Chrysophanic acid	Quinones Rheum palmatum L. Classification of Application Fields Anthraquinones Polygonaceae Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	EGFR
Chrysophanol (Chrysophanic acid) is a natural anthraquinone, which inhibits EGF-induced phosphorylation of EGFR and suppresses activation of AKT and *mTOR/p70S6K*.

HY-N1437

Hydroxycitric acid 1 Publications Verification	Structural Classification Ketones, Aldehydes, Acids Guttiferae Plants Garcinia gummi-gutta (L.) Roxb. Source Classification	Apoptosis Ferroptosis mTOR DNA/RNA Synthesis Keap1-Nrf2 Ribosomal S6 Kinase (RSK) NF-κB ATP Citrate Lyase AMPK
Hydroxycitric acid is an orally active, multi-target, multi-bioactive organic acid. activates Nrf2 and its downstream molecule GPX4, increases glutathione levels, and thereby inhibits ferroptosis. Hydroxycitric acid activates the Nrf2/Keap1 and ACLY/NF-κB signaling pathways, upregulates the activities of antioxidant enzymes such as superoxide dismutase, reduces MDA content, thereby alleviating oxidative stress and renal tubular epithelial cell apoptosis, and improves pulmonary vascular and right ventricular remodeling. Hydroxycitric acid activates both the AMPK and *mTORC1/S6K* pathways, triggers the unfolded protein response, arrests the cancer cell cycle, and induces DNA fragmentation .

HY-W021448

Glycocyamine 1 Publications Verification Guanidinoacetic acid	Structural Classification Other disease Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Glycocyamine (Guanidinoacetic acid) is a direct precursor of creatine and an orally active energy metabolism regulator and myogenic differentiation inducer. Glycocyamine can activate the Akt/mTOR/S6K signaling pathway via miR-133a-3p and miR-1a-3p, and stimulate the mRNA expression of myogenic differentiation factor 1 (MyoD) and myopoietin (MyoG). Glycocyamine can increase muscle creatine concentration and maintain ATP homeostasis through the creatine phosphate/creatine kinase system. Glycocyamine can be used in research on feed additives for poultry farming .

HY-B0167A

Sodium Salicylate 10+ Cited Publications Salicylic acid sodium salt; 2-Hydroxybenzoic acid sodium salt	Classification of Application Fields Ketones, Aldehydes, Acids Asclepiadaceae Phenols Plants Periploca sepium Bunge Inflammation/Immunology Disease Research Fields Source Classification Cancer	Environmental Pollutants Ribosomal S6 Kinase (RSK) Endogenous Metabolite Apoptosis COX Autophagy NF-κB
Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation . Sodium Salicylate is also a *S6K* inhibitor.Sodium Salicylate is a NF-κB inhibitor that decreases inflammatory gene expression and improves repair in aged muscle .

HY-112234

L-Sepiapterin 1 Publications Verification Sepiapterin	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
L-Sepiapterin (Sepiapterin), is a phenylalanine hydroxylase activator, is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70 ^S6K-dependent VEGFR-2 expression. L-Sepiapterin can be used for the study of hyperphenylalaninemia .

HY-N0847

Micheliolide 5+ Cited Publications	Other Monoterpenes other families Classification of Application Fields Terpenoids Other Diseases Plants Disease Research Fields Source Classification	NF-κB PI3K Akt TGF-beta/Smad
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis .

HY-15237

SL 0101-1 5+ Cited Publications SL0101	Flavonols Flavonoids other families Classification of Application Fields Pityrogramma triangularis Plants Disease Research Fields Cancer	Ribosomal S6 Kinase (RSK)
SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC₅₀ of 89 nM . SL 0101-1 (SL0101) is a selective RSK1/2 inhibitor, with a K_i of 1 μM .

HY-107198

(2S)-6-Prenylnaringenin 1 Publications Verification	Flavonoids Humulus lupulus L. Flavonones Phenols Polyphenols Plants Moraceae Source Classification	GABA Receptor
(2S)-6-Prenylnaringenin is the most efficient compound in forebrain. (2S)-6-Prenylnaringenin acts as a GABA_A positive allosteric modulator at α+β- binding interface .

HY-N0656A

(+)-Usnic acid 2 Publications Verification	other families Classification of Application Fields Ketones, Aldehydes, Acids Plants Lichen Disease Research Fields Cancer	mTOR Bacterial Autophagy
(+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer and anti-inflammatory activity. (+)-Usnic acid possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium .

HY-N10303

Withangulatin A 1 Publications Verification	Cardiacglycosides Physalis angulata L. Solanaceae Plants Steroids Source Classification	COX Parasite Reactive Oxygen Species (ROS) Apoptosis p38 MAPK NF-κB Akt mTOR TGF-beta/Smad
Withangulatin A is the inhibitor for COX-2. Withangulatin A inhibits MAPK, NF-κB, *Akt/mTOR/p70S6K* pathway, exhibits antitumor, anti-inflammatory and trypanocidal activities .

HY-N2357

Eudesmin (-)-Eudesmin; Eudesmine; (-)-Eudesmine	Infection Classification of Application Fields Magnoliaceae Lignans Metabolic Disease Magnolia Liliflora Desr. Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Ribosomal S6 Kinase (RSK)
Eudesmin ((-)-Eudesmin) impairs adipogenic differentiation via inhibition of *S6K1* signaling pathway. Eudesmin possesses diverse therapeutic effects, including anti-tumor, anti-inflammatory, and anti-bacterial activities .

HY-N0008

Orcinol glucoside	Curculigo orchioides Gaertn. Structural Classification Monophenols Phenols Plants Amaryllidaceae Source Classification	Wnt p38 MAPK mTOR Keap1-Nrf2 TGF-β Receptor
Orcinol glucoside is an orally active, blood-brain barrier permeable osteoblast proliferation promoter that targets the Nrf2/Keap1, mTOR and p38 signaling pathways. Orcinol glucoside promotes Nrf2 nuclear translocation, upregulates antioxidant enzyme levels, enhances the phosphorylation of mTOR and *p70S6K, and inhibits the enzymatic activity of HAS2* as well as the nuclear translocation of GR. Orcinol glucoside also alleviates oxidative stress, inhibits autophagic flux, osteoclastogenesis and TGF-β1-induced M2 polarization, while reducing collagen deposition and effectively promoting the proliferation, differentiation and mineralization of osteoblasts. Orcinol glucoside also exhibits anti-pulmonary fibrosis, anxiolytic and antidepressant activities. Orcinol glucoside can be used in the research of senile and glucocorticoid-induced osteoporosis, idiopathic pulmonary fibrosis (IPF), anxiety and other related diseases .

HY-N1677

2,6-Dimethoxy-1,4-benzoquinone	Infection Quinones other families Classification of Application Fields Metabolic Disease Benzene Quinones Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Akt mTOR Bacterial Fungal AMPK
2,6-Dimethoxy-1,4-benzoquinone is a 1,4-benzoquinone derivative. 2,6-Dimethoxy-1,4-benzoquinone promotes phosphorylation of AKT, *S6K, mTOR, 4E-BP1, and AMPK, and attenuates mTORC1* activity as part of the AKT/mTOR pathway. 2,6-Dimethoxy-1,4-benzoquinone stimulates myoblast differentiation, increases myotube size, elevates MHC protein expression, enhances mitochondrial biogenesis, respiration, and DNA content, and increases skeletal muscle weights, fiber size, grip strength, and treadmill performance. 2,6-Dimethoxy-1,4-benzoquinone exerts anti-cancer, anti-inflammatory, anti-adipogenic, antibacterial, and antimutagenic effects, inhibits adipogenic transcription factors, nitric oxide production, skin tumor development, Magnaporthe oryzae growth, spore germination, appressorium formation, and growth of select bacterial species, induces H₂O₂ generation and rice defense gene expression, and reduces rice blast lesion formation. 2,6-Dimethoxy-1,4-benzoquinone can be used for the research of obesity, skin tumorigenesis, rice blast disease, and food-borne illness .

HY-14615R

[6]-Gingerol (Standard) 1 Publications Verification (S)-(+)-[6]Gingerol (Standard)	Zingiber officinale Roscoe Structural Classification Monophenols Phenols Plants Source Classification Zingiberaceae	Reference Standards AMPK Apoptosis
^[6]-Gingerol (Standard) is the analytical standard of ^[6]-Gingerol. This product is intended for research and analytical applications. ^[6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.

HY-N1050

Zederone	Terpenoids Sesquiterpenes Plants Curcuma elata Roxb. Source Classification Zingiberaceae	mTOR Ribosomal S6 Kinase (RSK) Bacterial
Zederone is a sesquiterpene. Zederone inhibits ovarian cancer cell proliferation through *mTOR/p70s6K* signalling pathway. Zederone inhibits CYP activities with IC₅₀s of 2.9 μM (CYP2B6), 9.2 μM (CYP2C9), 11,2 μM (CYP2C19) and >30 μM (CYP1A2 and CYP2D6). Zederone is hepatotoxic with LD₅₀ value at 24 hours in mice of approximately 223 mg/kg and cytotoxic against the KG1a cell line. Zederone shows antibacterial activity against a number of multi-drug resistant and Methicillin (HY-121544)-resistant Staphylococcus aureus strain. Zederone shows cognition improving capacity and assists in the modulation of gut bacterial dysbiosis ^[6].

HY-N0597

Panaxatriol 3 Publications Verification	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Other Diseases Plants Disease Research Fields Araliaceae Source Classification	Others Insulin Receptor
Panaxatriol is an orally active insulin sensitizer. Panaxatriol enhances the phosphorylation levels of Akt, insulin receptor and p70S6K in skeletal muscle. Panaxatriol reduces the mRNA expression level of Atrogin1 in skeletal muscle. Panaxatriol induces apoptosis, pre-G1 cell cycle arrest and increased intracellular ROS levels in prostate cancer cells, decreases mitochondrial membrane potential, inhibits cell migration and reduces colony formation. Panaxatriol can be used in research related to insulin resistance, myocardial ischemia/reperfusion injury and prostate cancer .

HY-N11709

Theasaponin E1	Triterpenes Structural Classification Terpenoids Camellia sinensis (L.) O. Ktze. Plants Source Classification Theaceae	Apoptosis VEGFR ATM/ATR PTEN Akt mTOR HIF/HIF Prolyl-Hydroxylase NF-κB Notch Cholinesterase (ChE) Amyloid-β γ-secretase Ferroptosis Fungal
Theasaponin E1 is an orally effective tea saponin. Theasaponin E1 inhibits the proliferation of cancer cells by activating apoptosis. Theasaponin E1 inhibits angiogenesis in ovarian cancer cells and HUVECs by reducing the expression of VEGF. Theasaponin E1 upregulates the phosphorylation level of ATM protein and the expression level of PTEN protein in cancer cells, decreases the phosphorylation levels of Akt, mTOR, *p70S6K* and 4E-BP1 proteins, downregulates the expression of HIF-1α and NF-κB, and reduces the protein expression of Notch ligands Dll4 and Jagged1. Theasaponin E1 exerts neuroprotective effects by inhibiting the activity of acetylcholinesterase, activating α-secretase and neprilysin, reducing the concentration of Aβ, and inhibiting the activities of β-secretase and γ-secretase. Theasaponin E1 exhibits toxic effects on cancer cells and quinone reductase-inducing activity, and inhibits tumor growth in vivo. Theasaponin E1 induces ferroptosis in Pomacea canaliculata by synergistically disrupting cholesterol homeostasis and sphingolipid metabolism. Theasaponin E1 possesses anti-biofilm activity against Candida albicans. Theasaponin E1 can be used in the research of ovarian cancer, obesity, Alzheimer's disease and fungal infections ^[6] .

HY-13595R

Chrysophanol (Standard) Chrysophanic acid (Standard)	Quinones Rheum palmatum L. Classification of Application Fields Polygonaceae Phenols Plants Disease Research Fields Source Classification Cancer	Reference Standards EGFR
Chrysophanol (Standard) is the analytical standard of Chrysophanol. This product is intended for research and analytical applications. Chrysophanol (Chrysophanic acid) is a natural anthraquinone, which inhibits EGF-induced phosphorylation of EGFR and suppresses activation of AKT and *mTOR/p70S6K*.

HY-N0643R

Carnosol (Standard)	Structural Classification Paramacrolobium coeruleum (Taub.) J.Léonard Terpenoids Labiatae Phenols Polyphenols Diterpenoids Plants Source Classification	Reference Standards Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite
Carnosol (Standard) is the analytical standard of Carnosol. This product is intended for research and analytical applications. Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC₅₀ of ~5.5 μM . Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .

HY-N16612

(3S,5S)-[6]-Gingerdiol	Zingiber officinale Roscoe Structural Classification Monophenols Phenols Plants Source Classification Zingiberaceae	Parasite
(3S,5S)-[6]-Gingerdiol is a cestocidal agent. (3S,5S)-[6]-Gingerdiol can be isolate from the roots of ginger. (3S,5S)-[6]-Gingerdiol shows cestocidal activity against H. nana .

HY-B0167AR

Sodium Salicylate (Standard) Salicylic acid sodium salt (Standard); 2-Hydroxybenzoic acid sodium salt (Standard)	Ketones, Aldehydes, Acids Asclepiadaceae Phenols Plants Periploca sepium Bunge Source Classification	Reference Standards COX NF-κB Ribosomal S6 Kinase (RSK) Autophagy Apoptosis Endogenous Metabolite
Sodium Salicylate (Standard) is the analytical standard of Sodium Salicylate. This product is intended for research and analytical applications. Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation . Sodium Salicylate is also a *S6K* inhibitor.Sodium Salicylate is a NF-κB inhibitor that decreases inflammatory gene expression and improves repair in aged muscle .

HY-B1167A

Ajmaline hydrochloride Cardiorythmine hydrochloride; (+)-Ajmaline hydrochloride	Rauvolfia verticillata (Lour.) Baill. Apocynaceae Natural Products Plants Source Classification	Others
Ajmaline hydrochloride is a Class Ia antiarrhythmic agent. It inhibits HERG potassium channels with IC50s of 1.0 μmol/l and 42.3 μmol/l in HEK cells and moth spider oocytes respectively. The inhibitory effect of Ajmaline hydrochloride is rapid, reversible, and positive frequency dependent. It acts primarily on the open state of the HERG channel and may also be combined with the inactivated state. The inhibitory effect of ajmaline hydrochloride is dependent on aromatic residues in the S6 domain, and the sensitivity is significantly reduced in the inactivation-deficient HERG S620T channel. It can also slightly affect the activation voltage of HERG channels. Ajmaline hydrochloride's inhibitory effect on HERG channels may contribute to both its potent antiarrhythmic effects and its potential proarrhythmic risk.

HY-N9739

(2S)-6,4'-Dihydroxy-7-methoxyflavan	Flavonoids Dalbergia odorifera T. Chen Leguminosae Plants Other Flavonoids Source Classification	Others
(2S)-6,4'-Dihydroxy-7-methoxyflavan is a natural product .

HY-N1333

Rubioncolin C	Quinones Monophenols Classification of Application Fields Rubia podantha Rubiaceae Phenols Plants Naphthalene Quinones Disease Research Fields Cancer Source Classification	NF-κB
Rubioncolin C exerts anti-tumor activity by inducing apoptotic and autophagic Cell Death and inhibiting the NF-κB and *Akt/mTOR/P70S6K* Pathway in Human Cancer Cells .

HY-N3628

Coronarin A	Hedychium coronarium Koen. Structural Classification Terpenoids Diterpenoids Plants Zingiberaceae	mTOR Ribosomal S6 Kinase (RSK)
Coronarin A is an orally active natural compound that inhibits mTORC1 and *S6K1* to increase IRS1 activity. Coronarin A shows anti-inflammatory activity and can also be used for type 2 diabetes mellitus research .

HY-N8380

(-)-Latifolin	Dalbergia hupeana Hance Phenols Polyphenols Plants Source Classification Fabaceae	Apoptosis Autophagy PI3K Necroptosis
(-)-Latifolin, a flavonoid, induces apoptotic cell death by targeting *PI3K/AKT/mTOR/p70S6K* signaling. (-)-Latifolin significantly inhibits the cell proliferation of oral squamous cell carcinoma (OSCC), and causes the anti-metastatic activities by effectively blocking cell migration, invasion, and adhesion via the inactivation of FAK/Src. (-)-Latifolin suppresses autophagic-related proteins and autophagosome formation. (-)-Latifolin inhibits necroptosis by dephosphorylating necroptosis-regulatory proteins (RIP1, RIP3, and MLKL). (-)-Latifolin has beneficial effects on anti-aging, anti-carcinogenic, anti-inflammatory, and cardio-protective activities .

HY-N2383

Validamine (1R,2S,3S,4S,6R)-4-Amino-6-(hydroxymethyl)cyclohexane-1,2,3-triol	Microorganisms Ketones, Aldehydes, Acids Source Classification	Glycosidase
Validamine competitively inhibits β-glucosidase in a pH-dependent and dose-dependent manner, with an IC₅₀ value of 2.92mM, and the maximum inhibitory ability is at the optimum pH value of this enzyme .

HY-N0847R

Micheliolide (Standard)	Structural Classification Other Monoterpenes other families Terpenoids Plants Source Classification	Reference Standards NF-κB PI3K Akt TGF-beta/Smad
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis .

HY-N0656AR

(+)-Usnic acid (Standard)	Structural Classification other families Ketones, Aldehydes, Acids Plants Lichen	Reference Standards mTOR Bacterial Autophagy
(+)-Usnic acid (Standard) is the analytical standard of (+)-Usnic acid. This product is intended for research and analytical applications. (+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer activity . (+)-Usnic acid possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium .

HY-N13338

Avicin D	Structural Classification Leguminosae Acacia farnesiana (Linn.) Willd. Terpenoids Plants Pentacyclic Triterpenoids Source Classification	AMPK Autophagy mTOR Ribosomal S6 Kinase (RSK) Apoptosis STAT Bcl-2 Family Survivin Glucocorticoid Receptor NF-κB
Avicin D is a plant triterpenoid. Avicin D induces Autophagy by activation of AMPK. Avicin D inhibits mTOR and S6 kinase activity. Avicin D selectively induces Apoptosis and downregulates p-STAT-3, bcl-2, and Survivin. Avicin D has properties of being a selective Glucocorticoid receptor modulator. Avicin D inhibits NF-κB activation. Avicin D shows anti-tumor effects against cutaneous T-cell lymphomas .

HY-N1677R

2,6-Dimethoxy-1,4-benzoquinone (Standard)	Quinones other families Benzene Quinones Plants Endogenous metabolite Source Classification	Reference Standards Akt mTOR Bacterial Fungal AMPK
2,6-Dimethoxy-1,4-benzoquinone (Standard) is the analytical standard of 2,6-Dimethoxy-1,4-benzoquinone (HY-N1677). This product is intended for research and analytical applications. 2,6-Dimethoxy-1,4-benzoquinone is a 1,4-benzoquinone derivative. 2,6-Dimethoxy-1,4-benzoquinone promotes phosphorylation of AKT, S6K, mTOR, 4E-BP1, and AMPK, and attenuates mTORC1 activity as part of the AKT/mTOR pathway. 2,6-Dimethoxy-1,4-benzoquinone stimulates myoblast differentiation, increases myotube size, elevates MHC protein expression, enhances mitochondrial biogenesis, respiration, and DNA content, and increases skeletal muscle weights, fiber size, grip strength, and treadmill performance. 2,6-Dimethoxy-1,4-benzoquinone exerts anti-cancer, anti-inflammatory, anti-adipogenic, antibacterial, and antimutagenic effects, inhibits adipogenic transcription factors, nitric oxide production, skin tumor development, Magnaporthe oryzae growth, spore germination, appressorium formation, and growth of select bacterial species, induces H2O2 generation and rice defense gene expression, and reduces rice blast lesion formation. 2,6-Dimethoxy-1,4-benzoquinone can be used for the research of obesity, skin tumorigenesis, rice blast disease, and food-borne illness.

HY-N18316

*(2"S)-6"-Methyl-2",3"-Dihydrodelicaflavone*	Structural Classification Flavonoids Selaginella doederleinii Hieron. Selaginellaceae Plants Biflavones Source Classification	Others
(2''S)-6''-Methyl-2'',3''-Dihydrodelicaflavone is a biflavonoid compound present in the whole herb of Selaginella doederleinii. (2''S)-6''-Methyl-2'',3''-Dihydrodelicaflavone exhibits antiproliferative activity against non-small cell lung cancer cells (IC₅₀ = 3.1-6.8 μM) with low cytotoxicity toward normal cells. (2''S)-6''-Methyl-2'',3''-Dihydrodelicaflavone can be used in studies related to non-small cell lung cancer .

HY-N19882

*(1'S,6'R)-4-(2',2',6'-Trimethyl-6'-vinylcyclohexyl)-2-butanone*	Structural Classification Nicotiana tabacum L. Terpenoids Sesquiterpenes Solanaceae Plants Source Classification

HY-N15121

4-O-Methyl-ascochlorin	Structural Classification Monophenols Microorganisms Phenols Source Classification	Drug Derivative Apoptosis c-Myc AMPK mTOR
4-O-Methyl-ascochlorin (Compound MAC) is a derivative of Ascochlorin (HY-101021). 4-O-Methyl-ascochlorin can selectively induce apoptosis of K562 leukemia cells, cause G1 phase arrest and downregulate c-Myc expression. 4-O-Methyl-ascochlorin can promote the phosphorylation of AMPK and inhibit the phosphorylation of mTOR and its target proteins, including p70S6 K and 4E-BP-1. 4-O-Methyl-ascochlorin can be used for research of leukemia .

Species:	Human (13)
Tag:	His (5) Tag Free (3) GST (7)
Source:	HEK293 (1) sf9 insect cells (1) Sf9 insect cells (9) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702651

	RPS6KA6 Protein, Human (Active, sf9, GST) RPS6KA6; ribosomal protein S6 kinase, 90kDa, polypeptide 6; ribosomal protein S6 kinase, 90kD, polypeptide 6; ribosomal protein S6 kinase alpha-6; RSK4; RSK-4; p90RSK6; p90-RSK 6; S6K-alpha 6; S6K-alpha-6; ribosomal S6 kinase 4; 90 kDa ribosomal protein S6 kinase 6; PP90RSK4	Human	Sf9 insect cells
	RSK4 (ribosomal S6 kinase 4) is a serine/threonine protein kinase that is constitutively active and does not require the presence of growth factors to function. It is involved in cell signaling pathways related to cell growth arrest, especially those mediated by p53/TP53 proteins. RPS6KA6 Protein, Human (sf9, GST) is the recombinant human-derived RPS6KA6, expressed by Sf9 insect cells, with GST labeled tag.

HY-P702650

	RPS6KA4 Protein, Human (Active, sf9, His, GST) RPS6KA4; ribosomal protein S6 kinase, 90kDa, polypeptide 4; ribosomal protein S6 kinase, 90kD, polypeptide 4; ribosomal protein S6 kinase alpha-4; MSK2; RSK B; RSKB; S6K-alpha-4; ribosomal protein kinase B; ribosomal protein S6 kinase alpha 4; 90 kDa ribosomal protein S6 kinase 4; mitogen- and stress-activated protein kinase 2; nuclear mitogen- and stress-activated protein kinase 2; RSK-B	Human	Sf9 insect cells
	RPS6KA4 Protein, Human (sf9, His, GST) is the recombinant human-derived RPS6KA4, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. ,

HY-P705570

	S6K1/RPS6KB1 Protein, Human (T412E, sf9, His-GST) Ribosomal protein S6 kinase beta-1; S6K-beta-1; S6K1; 70 kDa ribosomal protein S6 kinase 1 (P70S6K1; p70-S6K 1); Ribosomal protein S6 kinase I; Serine/threonine-protein kinase 14A; STK14A; EC:2.7.11.1	Human	Sf9 insect cells

HY-P701771

	RSK1 Protein, Human (sf9) RPS6KA1; Ribosomal protein S6 kinase alpha-1; S6K-alpha-1; 90 kDa ribosomal protein S6 kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; Ribosomal S6 kinase 1; RSK-1	Human	Sf9 insect cells
	RSK1 is a kinase downstream of ERK signaling and is critical for mitosis and stress-induced responses. It activates transcription factors (CREB1, ETV1, NR4A1), affecting proliferation, survival and differentiation. RSK1 Protein, Human (sf9) is the recombinant human-derived RSK1 protein, expressed by sf9 insect cells , with tag free.

HY-P703033

	p70S6KL1 Protein, Human (sf9, GST) ibosomal protein S6 kinase-like 1; RPS6KL1	Human	Sf9 insect cells
	p70S6KL1 Protein, Human (sf9, GST) is the recombinant human-derived p70S6KL1, expressed by Sf9 insect cells , with GST labeled tag. ,

HY-P701819

	MSK1 Protein, Human (Active, sf9, GST) RPS6KA5; Ribosomal protein S6 kinase alpha-5; S6K-alpha-5; 90 kDa ribosomal protein S6 kinase 5; Nuclear mitogen- and stress-activated protein kinase 1; RSK-like protein kinase; RSKL	Human	Sf9 insect cells
	MSK1 is a serine/threonine protein kinase that centralizes multiple cellular processes by phosphorylating key transcription factors. In response to stimuli such as UV-C irradiation, EGF, and anisomycin, MSK1 activates CREB1 and ATF1, affecting gene expression through histone phosphorylation. MSK1 Protein, Human (sf9, GST) is the recombinant human-derived MSK1 protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P701772

	RSK1 Protein, Human (sf9, His) RPS6KA1; Ribosomal protein S6 kinase alpha-1; S6K-alpha-1; 90 kDa ribosomal protein S6 kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; Ribosomal S6 kinase 1; RSK-1	Human	Sf9 insect cells
	RSK1 is a kinase downstream of ERK signaling and is critical for mitosis and stress-induced responses. It activates transcription factors (CREB1, ETV1, NR4A1), affecting proliferation, survival and differentiation. RSK1 Protein, Human (sf9, His) is the recombinant human-derived RSK1 protein, expressed by sf9 insect cells , with N-8*His labeled tag.

HY-P701773

	RSK2 Protein, Human RPS6KA3; Ribosomal protein S6 kinase alpha-3; S6K-alpha-3; 90 kDa ribosomal protein S6 kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; Ribosomal S6 kinase 2; RSK-2; pp90RSK2	Human	E. coli
	RSK2 is a kinase downstream of ERK signaling and plays a critical role in mediating mitosis and stress responses. It activates transcription factors (CREB1, ETV1, NR4A1), affecting proliferation, survival and differentiation. RSK2 Protein, Human is the recombinant human-derived RSK2 protein, expressed by E. coli , with tag free.

HY-P701774

	RSK2 Protein, Human (His) RPS6KA3; Ribosomal protein S6 kinase alpha-3; S6K-alpha-3; 90 kDa ribosomal protein S6 kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; Ribosomal S6 kinase 2; RSK-2; pp90RSK2	Human	E. coli
	RSK2 is a kinase downstream of ERK signaling and plays a critical role in mediating mitosis and stress responses. It activates transcription factors (CREB1, ETV1, NR4A1), affecting proliferation, survival and differentiation. RSK2 Protein, Human (His) is the recombinant human-derived RSK2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P705881

	RSK2 Protein, Human (sf9) RPS6KA3; Ribosomal protein S6 kinase alpha-3; S6K-alpha-3; 90 kDa ribosomal protein S6 kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; Ribosomal S6 kinase 2; RSK-2; pp90RSK2	Human	sf9 insect cells

HY-P76588

	S6K1/RPS6KB1 Protein, Human (Inactive, sf9, GST) Ribosomal protein S6 kinase beta-1; S6K1; P70S6K1; p70 S6KA; RPS6KB1; STK14A	Human	Sf9 insect cells
	S6K1/RPS6KB1 is a kinase downstream of mTOR that regulates cellular processes critical for proliferation, growth, and cell cycle. It phosphorylates EIF4B, RPS6 and EEF2K and regulates protein synthesis by inhibiting the pro-apoptotic function of BAD, thereby enhancing cell survival. S6K1/RPS6KB1 Protein, Human (sf9, GST) is the recombinant human-derived S6K1/RPS6KB1 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P76011

	RSK3 Protein, Human (Active, sf9, GST) Ribosomal protein S6 kinase alpha-2; S6K-alpha-2; p90-RSK 2; RSK-3; RPS6KA2; MAPKAPK1C	Human	Sf9 insect cells
	RSK3, a kinase downstream of ERK signaling, crucially mediates mitogenic and stress-induced transcription factor activation. It regulates translation, impacting proliferation, survival, and differentiation. In epithelial ovarian cancer cells, RSK3 may act as a tumor suppressor, highlighting its diverse roles in cellular homeostasis and potential implications in cancer biology. RSK3 Protein, Human (Active, sf9, GST) is the recombinant human-derived RSK3 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P76258

	CHST15 Protein, Human (HEK293, His) Carbohydrate sulfotransferase 15; hBRAG; GalNAc4S-6ST; BRAG	Human	HEK293
	The CHST15 protein is a sulfotransferase that catalyzes the transfer of sulfate to GalNAc 4-sulfate in chondroitin sulfate A to form chondroitin sulfate E with GlcA-GalNAc(4,6-SO(4)) units. It also sulfates the unique non-reducing terminal sequence GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), similar to thrombomodulin chondroitin sulfate. CHST15 Protein, Human (HEK293, His) is the recombinant human-derived CHST15 protein, expressed by HEK293 , with N-His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-W021448S1

Glycocyamine-15N,13C2

Glycocyamine- ¹⁵N, ¹³C₂ (Guanidinoacetic acid- ¹⁵N, ¹³C₂) is the ¹³C and ¹⁵N labeled Glycocyamine (HY-W021448) . Clycocyamine is a direct precursor of creatine and an orally active energy metabolism regulator and myogenic differentiation inducer. Glycocyamine can activate the Akt/mTOR/S6K signaling pathway via miR-133a-3p and miR-1a-3p, and stimulate the mRNA expression of myogenic differentiation factor 1 (MyoD) and myopoietin (MyoG). Glycocyamine can increase muscle creatine concentration and maintain ATP homeostasis through the creatine phosphate/creatine kinase system. Glycocyamine can be used in research on feed additives for poultry farming.

HY-W021448S

Glycocyamine-d2

Glycocyamine-d₂ (Guanidinoacetic acid-d₂) is the deuterium labeled Glycocyamine (HY-W021448). Glycocyamine is a direct precursor of creatine and an orally active energy metabolism regulator and myogenic differentiation inducer. Glycocyamine can activate the Akt/mTOR/S6K signaling pathway via miR-133a-3p and miR-1a-3p, and stimulate the mRNA expression of myogenic differentiation factor 1 (MyoD) and myopoietin (MyoG). Glycocyamine can increase muscle creatine concentration and maintain ATP homeostasis through the creatine phosphate/creatine kinase system. Glycocyamine can be used in research on feed additives for poultry farming.

HY-W767601

(3S,6S)-3,6-Dimethyl-1,4-dioxane-2,5-dione-13C2
(3S,6S)-3,6-Dimethyl-1,4-dioxane-2,5-dione- ¹³C₂ (L-Lactide- ¹³C₂) is the ¹³C-labeled L-Lactide (HY-W020691A). (3S,6S)-3,6-Dimethyl-1,4-dioxane-2,5-dione is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-14153S

Tegaserod-d11

Tegaserod-d₁₁ is deuterated labeled Tegaserod (HY-14153). Tegaserod is an orally active serotonin receptor 4 (HTR4; 5-HT₄R) agonist and a 5-HT_2B receptor antagonist. Tegaserod has pK_is of 7.5, 8.4 and 7.0 for human recombinant 5-HT_2A, 5-HT_2B and 5-HT_2C receptors, respectively. Tegaserod causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research .

HY-146940S

*CER7-2’S,6R-d9*
CER7-2’S,6R-d₉ is deuterium labeled CER7-2’S,6R.

HY-W334800S2

(2S,6S)-2,6-Diaminoheptanedioic acid-13C7
(2S,6S)-2,6-Diaminoheptanedioic acid- ¹³C₇ (L-threo-2,6-Diaminopimelic acid- ¹³C₇) is ¹³C-labeled (2S,6S)-2,6-diaminoheptanedioic acid (HY-W334800).

HY-W334800S1

(2S,6S)-2,6-Diaminoheptanedioic acid-15N2
(2S,6S)-2,6-Diaminoheptanedioic acid- ¹⁵N₂ (L-threo-2,6-Diaminopimelic acid- ¹⁵N₂) is ¹⁵N labeled (2S,6S)-2,6-diaminoheptanedioic acid (HY-W334800).

HY-W334800S

(2S,6S)-2,6-Diaminoheptanedioic acid-13C7,15N2
(2S,6S)-2,6-Diaminoheptanedioic acid- ¹³C₇, ¹⁵N₂ (L-threo-2,6-Diaminopimelic acid- ¹³C₇, ¹⁵N₂) is ¹³C and ¹⁵N-labeled (2S,6S)-2,6-diaminoheptanedioic acid (HY-W334800).

HY-W725464

4-Methylsyringol Gentiobioside-d6
4-Methylsyringol Gentiobioside-d₆ is the deuterium labeled (2S,3R,4S,5S,6R)-2-(2,6-Dimethoxy-4-methylphenoxy)-6-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-3,4,5-triol (HY-W725468).

HY-146905S

CER6-2’S-d9
CER6-2’S-d₉ is deuterium labeled CER6-2’S.

HY-W759099

3-O-a-d-glucosyl isomaltol-d3
3-O-a-d-glucosyl isomaltol-d₃ is the deuterium labeled 1-(3-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)furan-2-yl)ethan-1-one (HY-W715028).

HY-W714797

Nintedanib demethyl-O-glucuronic acid-d3
Nintedanib demethyl-O-glucuronic acid-d₃ is the deuterium labeled (2R,3R,4R,5S,6S)-3,4,5-Trihydroxy-6-(((Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carbonyl)oxy)tetrahydro-2H-pyran-2-carboxylic acid (HY-W712456).

HY-B0352AS

(S)-Mirtazapine-d3
(S)-Mirtazapine-d₃ is a deuterium labeled (S)-Mirtazapine. (S)-Mirtazapine is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception.(S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2[1].

HY-W767542

Dihydro Isoferulic Acid-d3 3-O-b-D-Glucuronide
Dihydro Isoferulic Acid-d₃ 3-O-b-D-Glucuronide is the deuterium labeled (2S,3S,4S,5R,6S)-6-(5-(2-Carboxyethyl)-2-methoxyphenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid (HY-W703563).

HY-W754199

Glycocyamine-13C

Glycocyamine- ¹³C (Guanidinoacetic acid- ¹³C) is the ¹³C-labeled Glycocyamine (HY-W021448). Glycocyamine is a direct precursor of creatine and an orally active energy metabolism regulator and myogenic differentiation inducer. Glycocyamine can activate the Akt/mTOR/S6K signaling pathway via miR-133a-3p and miR-1a-3p, and stimulate the mRNA expression of myogenic differentiation factor 1 (MyoD) and myopoietin (MyoG). Glycocyamine can increase muscle creatine concentration and maintain ATP homeostasis through the creatine phosphate/creatine kinase system. Glycocyamine can be used in research on feed additives for poultry farming.

HY-166887S

Tiotropium bromide impurity-d3
Tiotropium bromide impurity-d₃ is deuterium labeled (2S,3aR,5S,6S,6aS)-6-Hydroxy-4,4-dimethylhexahydro-2H-2,5-methanofuro[3,2-b]pyrrol-4-ium bromide (Tiotropium Bromide Impurity) .

HY-W769530

Diosmetin 3',7-diglucuronide-d3
Diosmetin 3',7-diglucuronide-d₃ is the deuterium labeled (2S,3S,4S,5R,6S)-6-((2-(3-(((2S,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-4-methoxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid (HY-W401408).

HY-W749528

3-Deoxyglucosone-13C6
3-Deoxyglucosone- ¹³C₆ is the ¹³C-labeled (5s,6r)-2,5-dihydroxy-6-(hydroxymethyl)dihydro-2h-pyran-3(4h)-one (HY-W759076).

Host:	Mouse (12) Rabbit (36)
Reactivity:	Human (48) Rat (36) Mouse (36) Monkey (6) Hamster (4)
Application:	IHC-P (29) ICC/IF (36) IF-Tissue (3) IP (23) IHC-F (10) WB (43) FC (5) ELISA (10)
Isotype:	IgG, Kappa (1) IgG (33) IgG, Kappa (1) IgG1 (9) IgG2a (2) IgG/Kappa (1)
Conjugation:	Non-conjugated (47)
Clonality:	Monoclonal (34) Recombinant (17)
Modification:	Phosphorylated (15) Unmodified (19)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86528

	S6K1 Antibody (YA6220) RPS6KB1; STK14A; Ribosomal protein S6 kinase beta-1; S6K-beta-1; S6K1; 70 kDa ribosomal protein S6 kinase 1; P70S6K1; p70-S6K 1; Ribosomal protein S6 kinase I; Serine/threonine-protein kinase 14A; p70 ribosomal S6 kinase alpha; p70 S6 kinas	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	S6K1 Antibody (YA6220) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to S6K1.

HY-P81769

	P70 S6 Kinase beta Antibody (YA1514) RPS6KB2; STK14B; Ribosomal protein S6 kinase beta-2; S6K-beta-2; S6K2; 70 kDa ribosomal protein S6 kinase 2; P70S6K2; p70-S6K 2; S6 kinase-related kinase; SRK; Serine/threonine-protein kinase 14B; p70 ribosomal S6 kinase beta; S6K-beta; p70	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	P70 S6 Kinase beta Antibody (YA1514) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to P70 S6 Kinase beta.

HY-P82145

	P70 S6 Kinase beta/SRK (phospho S371) Antibody (YA1890) RPS6KB2; STK14B; Ribosomal protein S6 kinase beta-2; S6K-beta-2; S6K2; 70 kDa ribosomal protein S6 kinase 2; P70S6K2; p70-S6K 2; S6 kinase-related kinase; SRK; Serine/threonine-protein kinase 14B; p70 ribosomal S6 kinase beta; S6K-beta; p70	WB	Human, Mouse, Rat
	P70 S6 Kinase beta/SRK (phospho S371) Antibody (YA1890) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to P70 S6 Kinase beta/SRK (phospho S371).

HY-P81769A

	P70 S6 Kinase beta Antibody (YA1514)(PBS only) RPS6KB2; STK14B; Ribosomal protein S6 kinase beta-2; S6K-beta-2; S6K2; 70 kDa ribosomal protein S6 kinase 2; P70S6K2; p70-S6K 2; S6 kinase-related kinase; SRK; Serine/threonine-protein kinase 14B; p70 ribosomal S6 kinase beta; S6K-beta; p70	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	P70 S6 Kinase beta Antibody (YA1514) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to P70 S6 Kinase beta.

HY-P82145A

	P70 S6 Kinase beta/SRK (phospho S371) Antibody (YA1890)(PBS only) RPS6KB2; STK14B; Ribosomal protein S6 kinase beta-2; S6K-beta-2; S6K2; 70 kDa ribosomal protein S6 kinase 2; P70S6K2; p70-S6K 2; S6 kinase-related kinase; SRK; Serine/threonine-protein kinase 14B; p70 ribosomal S6 kinase beta; S6K-beta; p70	WB	Human, Mouse, Rat
	P70 S6 Kinase beta/SRK (phospho S371) Antibody (YA1890) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to P70 S6 Kinase beta/SRK (phospho S371).

HY-P810610

	Phospho-p70 S6 Kinase (Ser434) Antibody (YA9872) 70 kDa ribosomal protein S6 kinase 1; KS6B1_HUMAN; p70 alpha; P70 beta 1 p70 ribosomal S6 kinase alpha; p70 ribosomal S6 kinase beta 1; p70 S6 kinase alpha; P70 S6 Kinase; p70 S6 kinase, alpha 1; p70 S6 kinase, alpha 2; p70 S6K; p70 S6K-alpha; p70 S6KA; p70(S6K) alpha; p70(S6K)-alpha; p70-alpha; p70-S6K 1; p70-S6K; P70S6K; P70S6K1; p70S6Kb; PS6K; Ribosomal protein S6 kinase 70kDa polypeptide 1; Ribosomal protein S6 kinase beta 1; Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase I; RPS6KB1; S6K; S6K-beta-1; S6K1; Serine/threonine kinase 14 alpha; Serine/threonine-protein kinase 14A; STK14A	WB, IP, IF-Tissue, ICC/IF, IP	Human, Mouse, Rat
	Phospho-p70 S6 Kinase (Ser434) Antibody (YA9872) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to Phospho-p70 S6 Kinase (Ser434).

HY-P87710

	Phospho-p70 S6 Kinase (Thr389) Antibody (YA7395)	WB, ICC/IF, ELISA	Human, Mouse, Rat
	Phospho-p70 S6 Kinase (Thr389) Antibody (YA7395) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Phospho-p70 S6 Kinase (Thr389).

HY-P83767

	Phospho-RPS6 (Ser235/Ser236) Antibody (YA3570) 40S ribosomal protein S6; Phosphoprotein NP33; ribosomal protein S6; RPS6; RS6	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Phospho-RPS6 (Ser235/Ser236) Antibody (YA3570) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-RPS6 (Ser235/Ser236).

HY-P87835

	Phospho-p70 S6 kinase β (Ser371) Antibody (YA7520)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	Phospho-p70 S6 kinase β (Ser371) Antibody (YA7520) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Phospho-p70 S6 kinase β (Ser371).

HY-P87259

	Phospho-p70 S6 Kinase (T389) Antibody (YA6944) 70 kDa ribosomal protein S6 kinase 1 antibody; p70 alpha antibody; p70 S6 kinase alpha antibody; p70 S6K antibody; p70 S6KA antibody; p70(S6K) alpha antibody; p70S6kA antibody; PS6K antibody; Ribosomal protein S6 kinase 70kDa polypeptide 1 antibody; RPS6KB1 antibody; S6K antibody; S6K1 antibody; STK14A antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Phospho-p70 S6 Kinase (T389) Antibody (YA6944) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-p70 S6 Kinase (T389).

HY-P81209

	S6K1 Antibody (YA7740) 70 kDa ribosomal protein S6 kinase 1 antibody; KS6B1_HUMAN antibody; p70 alpha antibody; P70 beta 1 antibody p70 ribosomal S6 kinase alpha antibody; p70 ribosomal S6 kinase beta 1 antibody; p70 S6 kinase alpha antibody; P70 S6 Kinase antibody; p70 S6 kinase, alpha 1 antibody; p70 S6 kinase, alpha 2 antibody; p70 S6K antibody; p70 S6K-alpha antibody; p70 S6KA antibody; p70(S6K) alpha antibody; p70(S6K)-alpha antibody; p70-alpha antibody; p70-S6K 1 antibody; p70-S6K antibody; P70S6K antibody; P70S6K1 antibody; p70S6Kb antibody; PS6K antibody; Ribosomal protein S6 kinase 70kDa polypeptide 1 antibody; Ribosomal protein S6 kinase beta 1 antibody; Ribosomal protein S6 kinase beta-1 antibody; Ribosomal protein S6 kinase I antibody; RPS6KB1 antibody; S6K antibody; S6K-beta-1 antibody; S6K1 antibody; Serine/threonine kinase 14 alpha antibody; Serine/threonine-protein kinase 14A antibody; STK14A antibody;	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Rat
	S6K1 Antibody is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to S6K1.

HY-P81209A

	S6K1 Antibody (YA7740)(PBS only) 70 kDa ribosomal protein S6 kinase 1 antibody; KS6B1_HUMAN antibody; p70 alpha antibody; P70 beta 1 antibody p70 ribosomal S6 kinase alpha antibody; p70 ribosomal S6 kinase beta 1 antibody; p70 S6 kinase alpha antibody; P70 S6 Kinase antibody; p70 S6 kinase, alpha 1 antibody; p70 S6 kinase, alpha 2 antibody; p70 S6K antibody; p70 S6K-alpha antibody; p70 S6KA antibody; p70(S6K) alpha antibody; p70(S6K)-alpha antibody; p70-alpha antibody; p70-S6K 1 antibody; p70-S6K antibody; P70S6K antibody; P70S6K1 antibody; p70S6Kb antibody; PS6K antibody; Ribosomal protein S6 kinase 70kDa polypeptide 1 antibody; Ribosomal protein S6 kinase beta 1 antibody; Ribosomal protein S6 kinase beta-1 antibody; Ribosomal protein S6 kinase I antibody; RPS6KB1 antibody; S6K antibody; S6K-beta-1 antibody; S6K1 antibody; Serine/threonine kinase 14 alpha antibody; Serine/threonine-protein kinase 14A antibody; STK14A antibody;	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Rat
	S6K1 Antibody is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to S6K1.

HY-P80851

	Phospho-RSK4 (Ser232) Antibody (YA155) RPS6KA6; RSK4; Ribosomal protein S6 kinase alpha-6; S6K-alpha-6; 90 kDa ribosomal protein S6 kinase 6; p90-RSK 6; p90RSK6; Ribosomal S6 kinase 4; RSK-4; pp90RSK4	WB, ICC/IF	Human
	Phospho-RSK4 (Ser232) Antibody (YA155) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-RSK4 (Ser232).

HY-P80851A

	Phospho-RSK4 (Ser232) Antibody (YA155)(PBS only) RPS6KA6; RSK4; Ribosomal protein S6 kinase alpha-6; S6K-alpha-6; 90 kDa ribosomal protein S6 kinase 6; p90-RSK 6; p90RSK6; Ribosomal S6 kinase 4; RSK-4; pp90RSK4	WB, ICC/IF	Human
	Phospho-RSK4 (Ser232) Antibody (YA155) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-RSK4 (Ser232).

HY-P80885

	RPS6 Antibody (YA677) RPS6; OK/SW-cl.2; 40S ribosomal protein S6; Phosphoprotein NP33	WB, ICC/IF, IP	Human, Mouse, Rat, Monkey
	RPS6 Antibody (YA677) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RPS6.

HY-P86216

	RPS6 Antibody (YA5908) RPS6; OK/SW-cl.2; 40S ribosomal protein S6; Phosphoprotein NP33	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	RPS6 Antibody (YA5908) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RPS6.

HY-P80835

	Phospho-MSK1 (Ser360) Antibody (YA173) RPS6KA5; MSK1; Ribosomal protein S6 kinase alpha-5; S6K-alpha-5; 90 kDa ribosomal protein S6 kinase 5; Nuclear mitogen- and stress-activated protein kinase 1; RSK-like protein kinase; RSKL	WB, ICC/IF, IP	Human, Mouse, Rat, Hamster
	Phospho-MSK1 (Ser360) Antibody (YA173) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-MSK1 (Ser360).

HY-P80836

	Phospho-MSK1 (Ser376) Antibody (YA172) RPS6KA5; MSK1; Ribosomal protein S6 kinase alpha-5; S6K-alpha-5; 90 kDa ribosomal protein S6 kinase 5; Nuclear mitogen- and stress-activated protein kinase 1; RSK-like protein kinase; RSKL	WB, IHC-P, IP	Human, Rat
	Phospho-MSK1 (Ser376) Antibody (YA172) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-MSK1 (Ser376).

HY-P86551

	Phospho-MSK1(Ser360) Antibody (YA6243) RPS6KA5; MSK1; Ribosomal protein S6 kinase alpha-5; S6K-alpha-5; 90 kDa ribosomal protein S6 kinase 5; Nuclear mitogen- and stress-activated protein kinase 1; RSK-like protein kinase; RSKL	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-MSK1(Ser360) Antibody (YA6243) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-MSK1(Ser360).

HY-P86159

	RSK2 Antibody (YA5851) Ribosomal protein S6 kinase alpha-3; S6K-alpha-3; 90 kDa ribosomal protein S6 kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; Ribosomal S6 kinase 2; RSK-2; pp90RSK2;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	RSK2 Antibody (YA5851) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RSK2.

HY-P80835A

	Phospho-MSK1 (Ser360) Antibody (YA173)(PBS only) RPS6KA5; MSK1; Ribosomal protein S6 kinase alpha-5; S6K-alpha-5; 90 kDa ribosomal protein S6 kinase 5; Nuclear mitogen- and stress-activated protein kinase 1; RSK-like protein kinase; RSKL	WB, ICC/IF, IP	Human, Mouse, Rat, Hamster
	Phospho-MSK1 (Ser360) Antibody (YA173) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-MSK1 (Ser360).

HY-P80836A

	Phospho-MSK1 (Ser376) Antibody (YA172)(PBS only) RPS6KA5; MSK1; Ribosomal protein S6 kinase alpha-5; S6K-alpha-5; 90 kDa ribosomal protein S6 kinase 5; Nuclear mitogen- and stress-activated protein kinase 1; RSK-like protein kinase; RSKL	WB, IHC-P, IP	Human, Rat
	Phospho-MSK1 (Ser376) Antibody (YA172) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-MSK1 (Ser376).

HY-P86216A

	RPS6 Antibody (YA5908)(PBS only) RPS6; OK/SW-cl.2; 40S ribosomal protein S6; Phosphoprotein NP33	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	RPS6 Antibody (YA5908) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RPS6.

HY-P80885A

	RPS6 Antibody (YA677)(PBS only) RPS6; OK/SW-cl.2; 40S ribosomal protein S6; Phosphoprotein NP33	WB, ICC/IF, IP	Human, Mouse, Rat, Monkey
	RPS6 Antibody (YA677) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RPS6.

HY-P86147

	Phospho-RPS6(Ser240/Ser244) Antibody (YA5839) RPS6; OK/SW-cl.2; 40S ribosomal protein S6; Phosphoprotein NP33	WB, IHC-P, ICC/IF	Human, Mouse
	Phospho-RPS6(Ser240/Ser244) Antibody (YA5839) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-RPS6(Ser240/Ser244).

HY-P86147A

	Phospho-RPS6(Ser240/Ser244) Antibody (YA5839)(PBS only) RPS6; OK/SW-cl.2; 40S ribosomal protein S6; Phosphoprotein NP33	WB, IHC-P, ICC/IF	Human, Mouse
	Phospho-RPS6(Ser240/Ser244) Antibody (YA5839) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-RPS6(Ser240/Ser244).

HY-P80886

	RSK1 p90 Antibody (YA676) RPS6KA1; MAPKAPK1A; RSK1; Ribosomal protein S6 kinase alpha-1; S6K-alpha-1; 90 kDa ribosomal protein S6 kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAP	WB, IP	Human, Mouse, Monkey
	RSK1 p90 Antibody (YA676) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RSK1 p90.

HY-P80887

	RSK3 Antibody (YA087) RPS6KA2; MAPKAPK1C; RSK3; Ribosomal protein S6 kinase alpha-2; S6K-alpha-2; 90 kDa ribosomal protein S6 kinase 2; p90-RSK 2; p90RSK2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; Ri	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Hamster
	RSK3 Antibody (YA087) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RSK3.

HY-P85356

	RSK2 Antibody (YA5048) RPS6KA3; ISPK1; MAPKAPK1B; RSK2; Ribosomal protein S6 kinase alpha-3; S6K-alpha-3; 90 kDa ribosomal protein S6 kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated	WB, IHC-P, IHC-F, FC, IF-Tissue	Human, Mouse, Rat
	RSK2 Antibody (YA5048) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to RSK2.

HY-P80848

	Phospho-RSK1 p90 (Ser380) Antibody (YA158) RPS6KA1; MAPKAPK1A; RSK1; Ribosomal protein S6 kinase alpha-1; S6K-alpha-1; 90 kDa ribosomal protein S6 kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAP	WB, ICC/IF, IP	Human, Rat, Mouse
	Phospho-RSK1 p90 (Ser380) Antibody (YA158) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-RSK1 p90 (Ser380).

HY-P80849

	Phospho-RSK1 p90 (Thr359/Ser363) Antibody (YA157) RPS6KA1; MAPKAPK1A; RSK1; Ribosomal protein S6 kinase alpha-1; S6K-alpha-1; 90 kDa ribosomal protein S6 kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAP	WB, IP	Human, Mouse, Rat
	Phospho-RSK1 p90 (Thr359/Ser363) Antibody (YA157) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-RSK1 p90 (Thr359/Ser363).

HY-P86213

	RSK1 p90 Antibody (YA5905) (YA5905) RPS6KA1; MAPKAPK1A; RSK1; Ribosomal protein S6 kinase alpha-1; S6K-alpha-1; 90 kDa ribosomal protein S6 kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAP	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	RSK1 p90 Antibody (YA5905) (YA5905) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RSK1 p90.

HY-P86364

	Phospho-RSK1 p90(Ser380) Antibody (YA6056) (YA6056) RPS6KA1; MAPKAPK1A; RSK1; Ribosomal protein S6 kinase alpha-1; S6K-alpha-1; 90 kDa ribosomal protein S6 kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAP	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-RSK1 p90(Ser380) Antibody (YA6056) (YA6056) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-RSK1 p90(Ser380).

HY-P80886A

	RSK1 p90 Antibody (YA676)(PBS only) RPS6KA1; MAPKAPK1A; RSK1; Ribosomal protein S6 kinase alpha-1; S6K-alpha-1; 90 kDa ribosomal protein S6 kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAP	WB, IP	Human, Mouse, Monkey
	RSK1 p90 Antibody (YA676) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RSK1 p90.

HY-P80850

	Phospho-RSK2 (Ser227) Antibody (YA156) RPS6KA3; ISPK1; MAPKAPK1B; RSK2; Ribosomal protein S6 kinase alpha-3; S6K-alpha-3; 90 kDa ribosomal protein S6 kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated	WB, IP	Human, Mouse, Rat
	Phospho-RSK2 (Ser227) Antibody (YA156) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-RSK2 (Ser227).

HY-P80887A

	RSK3 Antibody (YA087)(PBS only) RPS6KA2; MAPKAPK1C; RSK3; Ribosomal protein S6 kinase alpha-2; S6K-alpha-2; 90 kDa ribosomal protein S6 kinase 2; p90-RSK 2; p90RSK2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; Ri	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Hamster
	RSK3 Antibody (YA087) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RSK3.

HY-P86403

	Phospho-RSK1 p90(Thr359/Ser363) Antibody (YA6095) (YA6095) RPS6KA1; MAPKAPK1A; RSK1; Ribosomal protein S6 kinase alpha-1; S6K-alpha-1; 90 kDa ribosomal protein S6 kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAP	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-RSK1 p90(Thr359/Ser363) Antibody (YA6095) (YA6095) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-RSK1 p90(Thr359/Ser363).

HY-P80849A

	Phospho-RSK1 p90 (Thr359/Ser363) Antibody (YA157)(PBS only) RPS6KA1; MAPKAPK1A; RSK1; Ribosomal protein S6 kinase alpha-1; S6K-alpha-1; 90 kDa ribosomal protein S6 kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAP	WB, IP	Human, Mouse, Rat
	Phospho-RSK1 p90 (Thr359/Ser363) Antibody (YA157) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-RSK1 p90 (Thr359/Ser363).

HY-P89072

	RPS6KC1 Antibody (YA8756) humS6PKh1; RPK118; S6K-delta-1; S6PKh1	IHC-P	Human
	RPS6KC1 Antibody (YA8756) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RPS6KC1.

HY-P89072A

	RPS6KC1 Antibody (YA8756)(PBS only) humS6PKh1; RPK118; S6K-delta-1; S6PKh1	IHC-P	Human
	RPS6KC1 Antibody (YA8756) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RPS6KC1.

HY-P85754

	S6K1 Antibody (YA5446) RPS6KB1	IHC-P, ICC/IF	Human, Rat, Mouse
	S6K1 Antibody (YA5446) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to S6K1.

HY-P83081

	eIF3E Antibody (YA2826) eIF3e; EIF3S6; eIFe	WB, ICC/IF	Human, Mouse, Rat
	eIF3E Antibody (YA2826) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to eIF3E.

HY-P88496

	AKR1A1 Antibody (YA8180) ALDR1; ALR; ARM; DD3; HEL-S-6	IHC-P, ICC/IF, FC	Human, Mouse, Rat
	AKR1A1 Antibody (YA8180) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to AKR1A1.

HY-P83081A

	eIF3E Antibody (YA2826)(PBS only) eIF3e; EIF3S6; eIFe	WB, ICC/IF	Human, Mouse, Rat
	eIF3E Antibody (YA2826) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to eIF3E.

HY-P88496A

	AKR1A1 Antibody (YA8180)(PBS only) ALDR1; ALR; ARM; DD3; HEL-S-6	IHC-P, ICC/IF, FC	Human, Mouse, Rat
	AKR1A1 Antibody (YA8180) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to AKR1A1.

HY-P80778

	PAK2 Antibody (YA695) PAK2; Serine/threonine-protein kinase PAK 2; Gamma-PAK; PAK65; S6/H4 kinase; p21-activated kinase 2; PAK-2; p58	WB, IHC-F, IHC-P, ICC/IF	Human, Monkey
	PAK2 Antibody (YA695) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PAK2.

HY-P85312

	PAK2 Antibody (YA5004) PAK2; Serine/threonine-protein kinase PAK 2; Gamma-PAK; PAK65; S6/H4 kinase; p21-activated kinase 2; PAK-2; p58	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, FC	Human, Mouse, Rat
	PAK2 Antibody (YA5004) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to PAK2.

HY-P80778A

	PAK2 Antibody (YA695)(PBS only) PAK2; Serine/threonine-protein kinase PAK 2; Gamma-PAK; PAK65; S6/H4 kinase; p21-activated kinase 2; PAK-2; p58	WB, IHC-F, IHC-P, ICC/IF	Human, Monkey
	PAK2 Antibody (YA695) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PAK2.

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Cat. No.	Product Name		Classification

HY-W110146

(3aS,4S,6aR)-Biotin-PEG4-Alkyne		Labeling and Fluorescence Imaging
(3aS,4S,6aR)-Biotin-PEG4-Alkyne is an alkyne-activated biotinylation reagent. (3aS,4S,6aR)-Biotin-PEG4-Alkyne can be reacted with azides via a copper-catalyzed click reaction. Biotin-labeled biomolecules can be bound to avidin or streptavidin for further purification and detection .

HY-172140

Ebio3		Alkynes
Ebio3 is a selective potassium channel (KCNQ2) inhibitor with an IC₅₀ of 1.2 nM. Ebio3 binds to the KCNQ2 channel through its hydrophobic tail, causing the S6 helix to move inward, which leads to the closure of the inner gate. The inhibitory effect of Ebio3 is also effective in pathogenic mutants of KCNQ2 (such as R75C and I238L), where it can inhibit outward currents by more than 80%. Ebio3 is expected to be used in the research of neurological diseases such as epilepsy .

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