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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
Spns2
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "Spns2" in MCE Product Catalog:
4
4 Cited Publications
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Research Areas:
SLF1081851 is a Spns2 inhibitor, inhibits S1P release (IC50=1.93 μM). SLF1081851 plays a key role in development and immune system [2].
1
1 Cited Publications
Cat. No.: HY-162655
CAS No.: 2764877-61-2
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SLF80821178 is an orally active Spns2 inhibitor that inhibits S1P release with an IC50 of 51 nM in HeLa cells. SLF80821178 blocks Spns2-mediated S1P transport/release, induces lymphopenia, and reduces circulating B cell, NK cell, and T cell populations. SLF80821178 can be used for research on multiple sclerosis [2] .
1
1 Cited Publications
Cat. No.: HY-150254A
Purity: 99.91%
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SLB1122168 formic is a Spinster Homolog 2 (Spns2) inhibitor. SLB1122168 formic inhibits Spns2-mediated sphingosine-1-phosphate (S1P) release with an IC50 of 94 nM. SLB1122168 formic induces lymphopenia in circulating lymphocytes in mice and rats .
Cat. No.: HY-RS13691
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SPNS2 Human Pre-designed siRNA Set A contains three designed siRNAs for SPNS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS19483
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Spns2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Spns2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS25976
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Spns2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Spns2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-156408
CAS No.: 3049214-20-9
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Spns2-IN-1 is a potent inhibitor of Spns2-dependent S1P transport (Spns2), with IC50 of 1.4±0.3 μM that plays an important role in immune response .
Cat. No.: HY-150254
CAS No.: 2999629-17-1
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Research Areas:
SLB1122168 is a Spinster Homolog 2 (Spns2) inhibitor. SLB1122168 inhibits Spns2-mediated sphingosine-1-phosphate (S1P) release with an IC50 of 94 nM. SLB1122168 induces lymphopenia in circulating lymphocytes in mice and rats .
Cat. No.: HY-162655A
CAS No.: 2764877-62-3
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SLF80821178 hydrochloride is an orally active Spns2 inhibitor that inhibits S1P release with an IC50 of 51 nM in HeLa cells. SLF80821178 hydrochloride blocks Spns2-mediated S1P transport/release, induces lymphopenia, and reduces circulating B cell, NK cell, and T cell populations. SLF80821178 hydrochloride can be used for research on multiple sclerosis [2] .
Cat. No.: HY-149004B
CAS No.: 2999629-35-3
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Research Areas:
SLF1081851 (hydrochloride) is a Spns2 inhibitor, inhibits S1P release (IC50=1.93 μM). SLF1081851 (hydrochloride) plays a key role in the development and immune system .
Cat. No.: HY-149004A
CAS No.: 2763730-98-7
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SLF1081851 (TFA) is a Spns2 inhibitor, inhibits S1P release (IC50=1.93 μM). SLF1081851 (TFA) plays a key role in development and immune system [2].
Cat. No.: HY-176500
CAS No.: 3035022-30-8
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Sphingolipid E is a synthetic pseudoceramide sphingolipid similar to type 2 ceramide with a metastable lamellar structure. Sphingolipid E ??can be used as a potential drug carrier to control the penetration of molecules as a lipid component of the intercellular space of the stratum corneum .
Cat. No.: HY-182375A
CAS No.: 2764877-95-2
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SLB1122168 free base is a Spinster Homolog 2 (Spns2) inhibitor. SLB1122168 free base inhibits Spns2-mediated sphingosine-1-phosphate (S1P) release with an IC50 of 94 nM. SLB1122168 free base induces lymphopenia in circulating lymphocytes in mice and rats .
Cat. No.: HY-190684
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SLH1102405 is a Spinster homolog 2 (Spns2) inhibitor. SLH1102405 inhibits Spns2-mediated release of sphingosine-1-phosphate (S1P) with an IC50 of 651 nM. SLH1102405 blocks the export of S1P from endothelial cells and other cells to the extracellular space through hydrogen bonding and hydrophobic interactions via targeted binding to the Spns2 transporter, thereby locally modulating S1P signaling and inhibiting the chemotaxis and migration of immune cells such as lymphocytes. SLH1102405 can be used for research on autoimmune diseases .
Cat. No.: HY-182375
CAS No.: 2764877-97-4
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(R)-SLB1122168 free base, an isomer of SLB1122168 free base (HY-182375A), is a spinster homolog 2 (SPNS2) inhibitor with an IC50 ≤2 μM .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
