19 Results for "

ageing

" in MedChemExpress (MCE) Product Catalog:
Products (19)

19 Results for "ageing" in MCE Product Catalog:

4
4 Cited Publications
Referencia número: HY-136064
No. CAS: 2373-89-9
Pureza:  99.57%
4,4'-Dimethoxychalcone acts as a natural autophagy inducer with anti-ageing properties .
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3
3 Cited Publications
Referencia número: HY-N0652
No. CAS: 82373-94-2
Synonyms: 2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside
2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside isolats from the roots of Polygonaceae species, inhibits the formation of 5-HETE, HHT and thromboxane B2. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside has hypotensive, anti-ageing, anti-inflammatory, hypolipidemic, cardioprotective, and neuroprotective actions .
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3
3 Cited Publications
Referencia número: HY-114174
No. CAS: 220701-06-4
Pureza:  99.13%
Target:  

Amyloid-β

Áreas de investigación:  

Neurological Disease

Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing .
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1
1 Cited Publications
Referencia número: HY-148089
No. CAS: 1637600-16-8
Target:  

Transthyretin (TTR)

Áreas de investigación:  

Neurological Disease

Eplontersen is a triantennary N-acetyl galactosamine (GalNAc3-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .
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1
1 Cited Publications
Referencia número: HY-N6906
No. CAS: 116383-31-4
Oleuroside is a phenolic secoiridoid in olive. Oleuroside can protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing .
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1
1 Cited Publications
Referencia número: HY-148089A
No. CAS: 2131025-75-5
Pureza:  96.92%
Target:  

Transthyretin (TTR)

Áreas de investigación:  

Neurological Disease

Eplontersen sodium the sodium salt form of Eplontersen (HY-148089). Eplontersen sodium is a triantennary N-acetyl galactosamine (GalNAc3-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .
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Referencia número: HY-P0045
No. CAS: 214047-00-4
Synonyms: Matrixyl; Palmitoyl pentapeptide 3; Matrixyl (Palmitoyl Pentapeptide)
Target:  

Collagen

Áreas de investigación:  

Others

Palmitoyl pentapeptide 4 (Matrixyl; Palmitoyl pentapeptide 3; Matrixyl (Palmitoyl Pentapeptide) is a bioactive peptide with anti-ageing effect and has been reported used as a cosmetic ingredient [1]
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Referencia número: HY-P0102
No. CAS: 823202-99-9
Target:  

nAChR

Áreas de investigación:  

Neurological Disease Metabolic Disease

Dipeptide diaminobutyroyl benzylamide diacetate, a Wagerlin-1-mimicking peptide, is a nAChR antagonist. Dipeptide diaminobutyroyl benzylamide diacetate mimics Waglerin-1 to block neuromuscular junction nicotinic acetylcholine receptors, partially inhibits neuronal signal transduction, and relaxes muscles. Dipeptide diaminobutyroyl benzylamide diacetate reduces appearance of facial wrinkles linked to repeated muscle movement.Dipeptide diaminobutyroyl benzylamide diacetate can be used for the research of mild-to-moderate fine and coarse periocular and perioral wrinkles and periorbital ageing .
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Referencia número: HY-N3383
No. CAS: 35897-92-8
Synonyms: Ligstroside
Ligustroside (Ligstroside), a secoiridoid derivative, has outstanding performance on mitochondrial bioenergetics in models of early Alzheimer's disease (AD) and brain ageing by mechanisms that may not interfere with Aβ production. Ligustroside significantly inhibits nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages .
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Referencia número: HY-N3387
No. CAS: 30508-27-1
Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin (LCD) inhibit SW480 cells (IC50=7.2 μM) by inducing cycle arrest, apoptosis and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer . Licoricidin (LCD) inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect . Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma (OS) cells by inactivation of the Akt and NF-κB pathways in vitro and in vivo . Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of MMP-1, it can be considered as an active ingredient in new topically applied anti-ageing formulations .
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Referencia número: HY-P11212
No. CAS: 1193634-36-4
Target:  

Fluorescent Dye

Áreas de investigación:  

Metabolic Disease Cancer

Ac-RHKK(Ac)-AMC (Compound S1) is a fluorescent substrate for SITR6, that is based on p53 sequence. Ac-RHKK(Ac)-AMC mimics H3K56 deacetylation site and significantly increases the deacetylation signal with low signal-to-background ratio. Ac-RHKK(Ac)-AMC can be used for ageing and cancers research .
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Referencia número: HY-P3121
No. CAS: 1012317-71-3
Target:  

Peptides

Áreas de investigación:  

Metabolic Disease

Caprooyl-tetrapeptide-3 acetate is used for fine lines and wrinkle reduction. Caprooyl-tetrapeptide-3 acetate stimulates the expression of collagen VII and laminin-5 in a model of corticoid-induced skin ageing .
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Referencia número: HY-N0652R
No. CAS: 82373-94-2
Synonyms: 2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside (Standard)
2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Standard) is the analytical standard of 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside. This product is intended for research and analytical applications. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside isolats from the roots of Polygonaceae species, inhibits the formation of 5-HETE, HHT and thromboxane B2. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside has hypotensive, anti-ageing, anti-inflammatory, hypolipidemic, cardioprotective, and neuroprotective actions .
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Referencia número: HY-P11213
Target:  

Fluorescent Dye

Áreas de investigación:  

Metabolic Disease Cancer

Ac-RYQK(Ac)-AMC (Compound S5) is a fluorescent substrate for SITR6, that is based on the H3 sequence. Ac-RYQK(Ac)-AMC mimics H3K56 deacetylation site and significantly increases the deacetylation signal with superior signal-to-background ratio. Ac-RYQK(Ac)-AMC can be used for ageing and cancers research .
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Referencia número: HY-W841438
No. CAS: 5266-20-6
Target:  

Amyloid-β Tau Protein

Áreas de investigación:  

Neurological Disease

Lithium orotate is an orally active lithium supplement with reduced binding that can bypass amyloid sequestration in AD mice models. Lithium orotate can prevent Aβ plaque deposition and phospho-tau accumulation and reverse AD pathology, neuroinflammatory changes and memory loss in AD mice models and ageing wild-type mice. Lithium orotate can be used for the research of alcoholism and Alzheimer’s disease .
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Referencia número: HY-126904
No. CAS: 904513-52-6
Target:  

Sirtuin

Áreas de investigación:  

Metabolic Disease Cancer

ZINC08792355 is a SIRT1 inhibitor and can be used for study of ageing, diabetes, and cancer. .
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Referencia número: HY-N6906R
No. CAS: 116383-31-4
Oleuroside (Standard) is the analytical standard of Oleuroside. This product is intended for research and analytical applications. Oleuroside is a phenolic secoiridoid in olive. Oleuroside can protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing .
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Referencia número: HY-123241
No. CAS: 904514-73-4
Target:  

Sirtuin

Áreas de investigación:  

Metabolic Disease Cancer

ZINC08792229 is a potent SIRT1 inhibitor. ZINC08792229 has the potential for research on SIRT1 related diseases, such as ageing, diabetes, cancers .
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Referencia número: HY-N17816
No. CAS: 571-72-2
Tambulin is an orally active flavonol compound found in Zanthoxylum armatum. Tambulin can inhibit cell proliferation, induce apoptosis and inhibit ROS production. Tambulin upregulates cleaved caspase-3, cleaved caspase-9, and Bax, downregulates Bcl-2 levels. Tambulin can stimulate glucose-dependent insulin secretion and induce endothelium-independent vasorelaxation. Tambulin binds to succinate dehydrogenase (SDH) (Ki = 11.02 μM) and shows significant ferric reducing power. Tambulin can enhances oxidative stress resistance, reduces, lipofuscin deposits, lipid levels, α-synuclein levels, improves locomotary behavior, and dopamine levels in in age-synchronized L1 hermaphrodite Caenorhabditis elegans models of ageing and Parkinson's disease. Tambulin can be used for the researches of Parkinson's disease, lung squamous cell carcinoma, and diabetes .
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