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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
76 Results for "
amyloid-β protein
" in MedChemExpress (MCE) Product Catalog:
Products (76)
76 Results for "amyloid-β protein" in MCE Product Catalog:
23
14
14 Cited Publications
2
2 Cited Publications
Synonyms: BIIB067; ISIS-SOD1Rx; ISIS 333611
Target:
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Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC50 of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .
2
2 Cited Publications
Synonyms: BIIB067 sodium; ISIS-SOD1Rx sodium; ISIS 333611 sodium
Target:
Research Areas:
Tofersen (BIIB067) sodium is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC50 of 320 pM. Tofersen sodium mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen sodium downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen sodium can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .
1
1 Cited Publications
Cat. No.: HY-19918A
Research Areas:
Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. Anatabine dicitrate is a potent α4β2 nAChR agonist. Anatabine dicitrate inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of amyloid precursor protein (APP). Anatabine dicitrate has anti-inflammatory effects and has the potential for neurodegenerative disorders treatment .
1
1 Cited Publications
Cat. No.: HY-P704352
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: APP; PreA4; Prev. AD1; CVAP; Alzheimer Disease amyloid A4 protein Homolog; Beta-amyloid Precursor protein; amyloid-Beta Precursor protein; Testicular Tissue protein Li 2; amyloid Precursor protein; Beta-amyloid Peptide(1-40); Alpha-SAPP; Beta-amyloid Pept
Species:
Human
Source:
HEK293
Cat. No.: HY-W010041
CAS No.: 488-59-5
Category:
Target:
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NB-360 is a potent, brain penetrable and orally active β‐secretase 1/2 (BACE1/BACE2) dual inhibitor with IC50 values of 5 and 6 nM. NB-360 can inhibit amyloid-β protein accumulation. NB-360 can be used for the researches of inflammation and neurological disease, such as Alzheimer's disease .
Cat. No.: HY-P991480
Research Areas:
ONC-841 is a blood-brain barrier-permeable, humanized monoclonal antibody targeting SIGLEC10. As an immune checkpoint inhibitor, ONC-841 restores the functions of immune effector cells such as T cells and enhances anti-tumor immune responses by blocking inhibitory signals mediated by SIGLEC10. ONC-841 restores the phagocytic and migratory activities of microglia, and promotes the phagocytosis of Amyloid-β and Tau protein aggregates by microglia. ONC-841 is applicable to research related to solid tumors and Alzheimer's disease .
Synonyms: Dimebolin dihydrochloride
Research Areas:
Latrepirdine dihydrochloride is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-β (Aβ) secretion.
Cat. No.: HY-P990301
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Cat. No.: HY-D1443
CAS No.: 291766-06-8
Synonyms: (trans,trans)-1-Bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene
Research Areas:
Latrepirdine is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-β (Aβ) secretion.
Cat. No.: HY-P10040
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Cat. No.: HY-P990011
CAS No.: 2747959-38-0
Synonyms: ACU-193
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Cat. No.: HY-N13742
CAS No.: 219565-74-9
Synonyms: Dihydrohonokiol
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Cat. No.: HY-12688
CAS No.: 26647-82-5
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DN5355 is a small molecule compound that targets amyloid β protein (Aβ) and hyperphosphorylated tau protein. DN5355 can inhibit the aggregation of Aβ and tau protein and disaggregate the formed Aβ and tau protein fibers. DN5355 can be used in the study of Alzheimer's disease .
Cat. No.: HY-P4885
CAS No.: 161818-04-8
Synonyms: AβpE3-40
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Cat. No.: HY-P991130
CAS No.: 2991369-43-6
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
