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anticodon

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By Targets:	Antibiotic (1) Bacterial (1) Endogenous Metabolite (3) Epigenetic Reader Domain (1) Isotope-Labeled Compounds (1) Nucleoside Antimetabolite/Analog (5)
By Research Areas:	Cancer (3) Infection (1) Metabolic Disease (1)
Oligonucleotides:	Adenosine (1) Nucleoside Analogs (1) Nucleotide Analogs (1)

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Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113139

1-Methylinosine 3 Publications Verification N1-Methylinosine	Nucleoside Antimetabolite/Analog Endogenous Metabolite	Cancer
1-Methylinosine (N1-MetHYlinosine) is a modified nucleotide located at position 37 of eukaryotic tRNA, 3' to the tRNA anticodon. 1-Methylinosine is a minor metabolite of 1-methyladenosine (HY-113081). The level of 1-Methylinosine is significantly elevated in urine samples from breast cancer models .

HY-18398

N6-Threonylcarbamoyladenosine N6-(N-Threonylcarbonyl)adenosine	Nucleoside Antimetabolite/Analog	Others
N6-Threonylcarbamoyladenosine (N6-(N-Threonylcarbonyl) adenosine) is a ubiquitous nucleoside that modifies tRNA .

HY-113139S

1-Methylinosine-d3 N1-Methylinosine-d₃	Isotope-Labeled Compounds Endogenous Metabolite Nucleoside Antimetabolite/Analog	Cancer
1-Methylinosine-d₃ (N1-MetHYlinosine-d₃) is the deuterium labeled 1-Methylinosine. 1-Methylinosine is a modified nucleotide located at position 37 of eukaryotic tRNA, 3' to the tRNA anticodon. 1-Methylinosine is a minor metabolite of 1-methyladenosine (HY-113081). The level of 1-Methylinosine is significantly elevated in urine samples from breast cancer models.

HY-131481

Mnm5s2U	Nucleoside Antimetabolite/Analog	Others
Mnm5s2U, found in lysine and glutamate tRNA anticodon, has an wobble modification function in tRNA .

HY-159850

CAU CpApU	Epigenetic Reader Domain	Cancer
CAU (FCpApU) is an anticodon of the initiator tRNA (tRNAfMet). CAU is the major determinant for aminoacylation of tRNAfMet by MetRS .

HY-169810

PKZ18	Antibiotic Bacterial	Infection
PKZ18 is an antibiotic and inhibits bacterial growth, with MIC values of 32-64 μg/mL against most Gram-positive bacteria. PKZ18 inhibits in vivo transcription and translation of glycyl-tRNA synthetase mRNA. PKZ18 selectively targets stem I specifier loops in Gram-positive bacteria and directly reduces T-box transcriptional read-through of the associated genes. PKZ18 prevents the codon-anticodon reading required for tRNA binding and is refractory to resistance .

HY-182338

2’-Thiouridine	Nucleoside Antimetabolite/Analog	Others
2'-Thiouridine is a key modified nucleoside at the wobble position of tRNA anticodons. 2'-Thiouridine mainly exists in tRNAs for glutamic acid, glutamine, lysine, etc., and participates in precise decoding regulation .

HY-149193

5-Taurinomethyluridine	Endogenous Metabolite	Metabolic Disease
5-Taurinomethyluridine is a taurine-containing modified uridine and translation regulator that exists in Trp and Leu (UUR) tRNAs of mammalian mitochondria. 5-Taurinomethyluridine is located at the first position of the anticodon of these mitochondrial tRNAs. 5-Taurinomethyluridine is synthesized from taurine and one-carbon metabolites by GTPBP3/MTO1, and its deficiency directly causes abnormal mitochondrial translation and various human mitochondrial diseases .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113139

1-Methylinosine 3 Publications Verification N1-Methylinosine	Structural Classification Natural Products Other disease Classification of Application Fields Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Nucleoside Antimetabolite/Analog Endogenous Metabolite
1-Methylinosine (N1-MetHYlinosine) is a modified nucleotide located at position 37 of eukaryotic tRNA, 3' to the tRNA anticodon. 1-Methylinosine is a minor metabolite of 1-methyladenosine (HY-113081). The level of 1-Methylinosine is significantly elevated in urine samples from breast cancer models .

HY-131481

Mnm5s2U	Microorganisms Source Classification	Nucleoside Antimetabolite/Analog
Mnm5s2U, found in lysine and glutamate tRNA anticodon, has an wobble modification function in tRNA .

Cat. No.	Product Name	Chemical Structure

HY-113139S

1-Methylinosine-d3
1-Methylinosine-d₃ (N1-MetHYlinosine-d₃) is the deuterium labeled 1-Methylinosine. 1-Methylinosine is a modified nucleotide located at position 37 of eukaryotic tRNA, 3' to the tRNA anticodon. 1-Methylinosine is a minor metabolite of 1-methyladenosine (HY-113081). The level of 1-Methylinosine is significantly elevated in urine samples from breast cancer models.

Cat. No.	Product Name		Classification

HY-18398

N6-Threonylcarbamoyladenosine N6-(N-Threonylcarbonyl)adenosine		Nucleoside Analogs Adenosine
N6-Threonylcarbamoyladenosine (N6-(N-Threonylcarbonyl) adenosine) is a ubiquitous nucleoside that modifies tRNA .

HY-159850

CAU CpApU		Nucleotide Analogs
CAU (FCpApU) is an anticodon of the initiator tRNA (tRNAfMet). CAU is the major determinant for aminoacylation of tRNAfMet by MetRS .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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