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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
49 Results for "
cell-permeable probe
" in MedChemExpress (MCE) Product Catalog:
Products (49)
49 Results for "cell-permeable probe" in MCE Product Catalog:
818
98
98 Cited Publications
Cat. No.: HY-128868A
CAS No.: 60842-46-8
98
98 Cited Publications
Cat. No.: HY-128868
CAS No.: 60842-46-8
25
21
21 Cited Publications
Cat. No.: HY-D0090
CAS No.: 162558-52-3
16
16 Cited Publications
Cat. No.: HY-128868D
CAS No.: 60842-46-8
15
12
5
5 Cited Publications
Cat. No.: HY-128868G
CAS No.: 60842-46-8
5
5 Cited Publications
Target:
Research Areas:
PFI-3, a chemical probe, is a selective, potent and cell-permeable SMARCA2/4 bromodomain inhibitor with a Kd of 89 nM.
2
2 Cited Publications
Cat. No.: HY-128868B
CAS No.: 60842-46-8
2
2 Cited Publications
Target:
Research Areas:
BI-9564, a chemical probe, is a potent, selective and cell-permeable BRD9/BRD7 bromodomains inhibitor, with IC50s of 75 nM and 3.4 μM and Kds of 14 nM and 239 nM, respectively. BI-9564 has an IC50 of > 100 μM for BET family .
1
1 Cited Publications
Cat. No.: HY-119977
CAS No.: 359010-70-1
Research Areas:
APF is a cell-permeable fluorogenic probe to measure hydroxyly radical of ROS. APF is nonfluorescent and produces bright green fluorescence upon reaction with hydroxyl radical. APF can be used to detect intracellular reactive oxygen species (ROS) (Ex/Em=490/525 nm) .
1
1 Cited Publications
Target:
Research Areas:
BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).
1
1 Cited Publications
Cat. No.: HY-DY1002
Solvent and concentration: DMSO: 10 mM.
The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
1
1 Cited Publications
Target:
Research Areas:
PCI-33380 is a fluorescent probe ( (Ex=532 nm, Em=555 nm). PCI-33380 consists of a (BTK) inhibitor PCI-32765 (HY-10997) attaching with a Bodipy-FL fluorophore via a piperazine linker. PCI-33380 binds predominantly to Btk in B cell lysates with cell permeable activity. PCI-33380 can be used for imaging live cancer cells such as non-Hodgkin lymphoma research
1
1 Cited Publications
Target:
Research Areas:
BAY-677 is an inactive control for BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM . BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC) .
Cat. No.: HY-D1458
CAS No.: 817170-66-4
Cat. No.: HY-DY1046
CAS No.: 136832-63-8
Solvent and concentration: DMSO: 10 mM
Cat. No.: HY-121970
CAS No.: 27031-00-1
Target:
Phosphoglycerate Dehydrogenase (PHGDH) Reactive Oxygen Species (ROS) HIF/HIF Prolyl-Hydroxylase
Research Areas:
iGP-1 is a cell-permeable, selective mixed inhibitor of mitochondrial sn-glycerol-3-phosphate dehydrogenase (mGPDH), with IC50s of 6.3 μM and 13.6 μM for rat mGPDH activity and H2O2 production, respectively. iGP-1 specifically blocks the mitochondrial component of the glycerophosphate shuttle without affecting cytosolic GPDH. iGP-1 not only inhibits cell proliferation and glutaminolysis, and enhances glycolysis, but also significantly alters key cellular physiological processes such as apoptosis, ROS production, HIF-1α stability and mitochondrial membrane potential. iGP-1 remains active in neutrophil cultures under both normoxic and hypoxic conditions, and serves as an ideal probe for glycerol-3-phosphate metabolic mechanisms. iGP-1 has been applied to studies on prostate cancer and related metabolic pathways .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
