107 Results for "

cognition

" in MedChemExpress (MCE) Product Catalog:
Products (107)

107 Results for "cognition" in MCE Product Catalog:

41
41 Publications Verification
Cat. No.: HY-N0293
CAS No.: 23180-57-6
Synonyms: Peoniflorin
Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity .
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22
22 Cited Publications
Cat. No.: HY-W010892
CAS No.: 6533-68-2
Synonyms: Hyoscine hydrobromide trihydrate
Scopolamine (Hyoscine) hydrobromide trihydrate is a high-affinity muscarinic antagonist that can cross the blood-brain barrier. Scopolamine hydrobromide trihydrate competitively antagonizes 5-HT3 receptors with an IC50 of 2.09 μM. Scopolamine hydrobromide trihydrate can induce cognitive and memory deficits in animals. Scopolamine hydrobromide trihydrate can be used in the research of preventing postoperative nausea and vomiting, motion sickness, nervous system diseases, etc .
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22
22 Cited Publications
Cat. No.: HY-B2065
CAS No.: 55-16-3
Synonyms: (-)-Scopolamine hydrochloride; Hyoscine hydrochloride
Scopolamine (Hyoscine) hydrochloride is a high-affinity muscarinic antagonist that can cross the blood-brain barrier. Scopolamine hydrochloride competitively antagonizes 5-HT3 receptors with an IC50 of 2.09 μM. Scopolamine hydrochloride can induce cognitive and memory deficits in animals. Scopolamine hydrochloride can be used in the research of preventing postoperative nausea and vomiting, motion sickness, nervous system diseases, etc .
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16
16 Cited Publications
Cat. No.: HY-14564A
CAS No.: 156223-05-1
Purity:  99.65%
Synonyms: DMXB-A; DMBX-anabaseine
Target:  

nAChR 5-HT Receptor

Research Areas:  

Inflammation/Immunology

GTS-21 dihydrochloride is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist with anti inflammatory and cognition enhancing activities. GTS-21 dihydrochloride is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist .
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6
6 Cited Publications
Cat. No.: HY-W094474
CAS No.: 85144-11-2
Synonyms: hydrate/monohydrateortrihydrate
Target:  

GSK-3 Apoptosis

Research Areas:  

Infection Neurological Disease

Lithium chloride hydrate, an orally active mood stabilizer, is a potent virus inhibitor and effective immunomodulatory agent. Lithium chloride hydrate has antidepressant activity by inhibiting GSK3β and promoting neurogenesis. Lithium chloride hydrate alleviates cognition dysfunction and the symptoms of acute mania and depression. Lithium chloride hydrate can also be used for research of virus infection and Alzheimer's disease .
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4
4 Cited Publications
Cat. No.: HY-W040821
CAS No.: 454-29-5
DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain. DL-Homocysteine is correlated with Vitamin B12, renal functions and folate levels, affects the cross-sectional cognition indirectly through white matter microstructural integrity .
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3
3 Cited Publications
Cat. No.: HY-N0824
CAS No.: 118-34-3
Synonyms: Eleutheroside B
Syringin (Eleutheroside B) is an active natural phenolic glycoside possessing various pharmacological activities, including anti-inflammatory, anti-irradiation, anti-osteoporosis and anticancer activities. Syringin also can be used to enhance memory, relieve fatigue, improve human cognition and protect ischemia heart against cerebrovascular damage, etc .
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2
2 Cited Publications
Cat. No.: HY-14380
CAS No.: 1196109-52-0
Purity:  99.95%
Target:  

FAAH Autophagy

Research Areas:  

Inflammation/Immunology Cancer

PF-3845 is a potent, selective, irreversible and orally active inhibitor of fatty acid amide hydrolase (FAAH), with a Ki of 0.23 μM. PF-3845 is a covalent inhibitor that carbamylates FAAH's serine nucleophile. PF-3845 can reduce pain sensation, inflammation, and anxiety/depression without substantial effects on motility or cognition .
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2
2 Cited Publications
Cat. No.: HY-W014971
CAS No.: 343-94-2
Tryptamine hydrochloride belongs to the class of indole alkaloids and is a derivative of the amino acid tryptophan. Tryptamine hydrochloride is psychoactive and acts as a neurotransmitter in the body, affecting mood, perception and cognition. In its hydrochloride form, Tryptamine hydrochloride hydrochloride, it is commonly used as a research chemical and as a starting material for the synthesis of other organic compounds. It can also occur naturally in certain plants and animals, including fungi and mammals. Due to the psychoactive properties of Tryptamine hydrochloride and its derivatives, its use and possession are controlled substances in many countries.
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2
2 Cited Publications
Cat. No.: HY-W020468
CAS No.: 105431-72-9
Synonyms: DuP 996
Research Areas:  

Neurological Disease

Linopirdine (DuP 996) is an orally active, selective M-type K + current (IM; Kv7; KCNQ Channels) inhibitor with an IC50 of 2.4 μM. Linopirdine is a TRPV1 agonist. Linopirdine, a putative cognition enhancing agent, increases acetylcholine release in rat brain tissue .
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1
1 Cited Publications
Cat. No.: HY-105321
CAS No.: 747408-78-2
Purity:  99.51%
Synonyms: PBT 2
Target:  

Bacterial

Research Areas:  

Neurological Disease

PBT 1033 (PBT 2) is an orally active copper/zinc ionophore. PBT 1033 restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria .
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1
1 Cited Publications
Cat. No.: HY-W250122
CAS No.: 32221-81-1
Synonyms: Monosodium glutamate
Glutamic acid sodium salt (Monosodium glutamate) is an orally active food flavor enhancer. Glutamic acid sodium salt causes ROS generation, mitochondrial dysfunction, and Apoptosis. Glutamic acid sodium salt upregulates CHOP, Grp78, and Bcl-2. Glutamic acid sodium salt impairs cognition, induces depressive-like behavior, induces hyperalgesia, and induces obesity and insulin resistance. Glutamic acid sodium salt can be used to study neurotoxicity (e.g., brain damage, cognitive impairment), metabolic disorders (e.g., obesity, insulin resistance), hepatotoxicity, and renal toxicity, as well as pain-related disorders .
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1
1 Cited Publications
Cat. No.: HY-N3121
CAS No.: 33708-72-4
Pachypodol is an orally active methoxyflavonoid compound. Pachypodol activates the ERK-dependent Nrf2 pathway and inhibits Apoptosis. Pachypodol exhibits activities such as antioxidant, cytoprotective, anti-inflammatory effects. Pachypodol improves cognition. Pachypodol exerts protective effects against cardiac and liver damage. Pachypodol has anticancer activity against colon cancer .
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Cat. No.: HY-B0340
CAS No.: 77191-36-7
Synonyms: DM9384; DZL-221
Nefiracetam is a cognition-enhancing agent. Nefiracetam is an activator of nAChR, N-methyl-D-aspartate receptor (NMDAR), mGluR5, PKC, gamma-aminobutyric acid (GABA), and N/L-type Ca 2+ channels. Nefiracetam promotes neuroplasticity and enhances neuroprotection. Nefiracetam can be used in Alzheimer's disease, epilepsy, and cerebral ischemia research .
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Cat. No.: HY-P99555
CAS No.: 1449294-76-1
Synonyms: OPN-305
Tomaralimab (OPN-305) is a humanized anti-TLR2 IgG4 monoclonal antibody. Tomaralimab inhibits TLR2, MyD88, NLRP3, and reduces pro-inflammatory cytokine (IL-1β, IL-6, IL-8) production. Tomaralimab reduces tau pathology. Tomaralimab improves cognition, atopic dermatitis. Tomaralimab has anticancer effects on pancreatic ductal adenocarcinoma. Tomaralimab is being studied in myelodysplastic syndrome (MDS), atopic dermatitis, pancreatic ductal adenocarcinoma, Alzheimer's disease, and myocardial ischemia/reperfusion injury .
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Cat. No.: HY-122924
CAS No.: 17365-11-6
Purity:  99.93%
Synonyms: 3-Galloylquinic acid
Theogallin (3-Galloylquinic acid) is an active ingredient in decaffeinated green tea extract. Theogallin has antidepressive and cognition enhancing effect .
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Cat. No.: HY-17555
CAS No.: 3685-84-5
Synonyms: Centrophenoxine hydrochloride
Target:  

nAChR iGluR

Research Areas:  

Neurological Disease

Meclofenoxate (Centrophenoxine) hydrochloride is an ester synthesized from DMAE and pCPA, capable of crossing the blood-brain barrier, and can stimulate memory and enhance cognition .
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Cat. No.: HY-108403
CAS No.: 1078-21-3
Purity:  99.88%
Synonyms: β-Phenyl-GABA; 4-Amino-3-phenylbutanoic acid
Target:  

GABA Receptor

Research Areas:  

Neurological Disease

Phenibut (β-Phenyl-GABA) is a GABA-B agonist . Phenibut acts as a GABA-mimetic, primarily at GABAB receptors. Phenibut has anxiolytic and nootropic (cognition enhancing) effects .
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Cat. No.: HY-W041333
CAS No.: 3060-41-1
Synonyms: β-Phenyl-GABA hydrochloride; 4-Amino-3-phenylbutanoic acid hydrochloride; 4-Amino-3-phenylbutyric acid hydrochloride
Target:  

GABA Receptor

Research Areas:  

Neurological Disease

Phenibut (β-Phenyl-GABA) hydrochloride is an orally active GABA-B agonist . Phenibut hydrochloride acts as a GABA-mimetic, primarily at GABAB?receptors. Phenibut hydrochloride has anxiolytic and nootropic (cognition enhancing) effects .
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Cat. No.: HY-14880
CAS No.: 929622-08-2
Purity:  96.60%
Synonyms: JNJ-31001074
Bavisant (JNJ-31001074) is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H3 receptor. Bavisant can be used for attention-deficit hyperactivity disorder (ADHD) research .
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