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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
eRF1
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "eRF1" in MCE Product Catalog:
1
1 Cited Publications
Target:
Research Areas:
SRI-41315 induces a prolonged pause at stop codons and suppresses PTCs (premature termination codons) associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells, restoring CFTR (cystic fibrosis transmembrane conductance regulator) expression and function. SRI-41315 suppresses PTCs by reducing the abundance of the termination factor eRF1. SRI-41315 also potentiates aminoglycoside-mediated readthrough, leading to synergistic increases in CFTR activity [1].
Cat. No.: HY-177569
Research Areas:
NVS1.1 is a potent, orally active and brain-penetrant readthrough promoter. NVS1.1 triggers the degradation of eRF1 by activating the ribosome-related quality control pathways (involving GCN1, RNF14, and RNF25), thereby facilitating the reading through of premature termination codons. NVS1.1 can be used for the research of genetic diseases caused by nonsense mutations [1].
Cat. No.: HY-177757
CAS No.: 1831092-94-4
Research Areas:
NVS2.1 is a potent, orally active and brain-penetrant readthrough promoter. NVS2.1 triggers the degradation of eRF1 by activating the ribosome-related quality control pathways (involving GCN1, RNF14, and RNF25), thereby facilitating the reading through of premature termination codons. NVS2.1 can be used for the research of genetic diseases caused by nonsense mutations [1].
Cat. No.: HY-120743
CAS No.: 1421584-86-2
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Triplin is a copper chelator, Triplin perturbs copper ion transport involved in the interaction of RAN1 and ATX1. Triplin suppresses the toxic effects of excess copper ions on plant root growth. Triplin increases the RNA expression of ERF1. Triplin acts through the ethylene signal transduction pathway. Triplin also is a bacterial pore-former [1].
Cat. No.: HY-P702942
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: eRF1; RF1; SUP45L1
Species:
Source:
Cat. No.: HY-P703566
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: eRF1; RF1; SUP45L1
Cat. No.: HY-P81397A
Synonyms: eRF1; TFAP2G; hAP-2g; AP2-GAMMA
Cat. No.: HY-RS16041
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Research Areas:
ZFP36L1 Human Pre-designed siRNA Set A contains three designed siRNAs for ZFP36L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS14410
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TFAP2C Human Pre-designed siRNA Set A contains three designed siRNAs for TFAP2C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS27788
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Research Areas:
Zfp36l1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Zfp36l1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS04554
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Research Areas:
ETF1 Human Pre-designed siRNA Set A contains three designed siRNAs for ETF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS21270
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Research Areas:
Zfp36l1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Zfp36l1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS20729
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Research Areas:
Etf1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Etf1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-184248
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Research Areas:
FM-74-103 is a selective GSPT1 PROTAC degrader and broad-spectrum antiviral agent. FM-74-103 recruits GSPT1 to the Cereblon E3 ligase to form a ternary complex, thereby driving GSPT1 ubiquitination and proteasomal degradation. FM-74-103 inhibits the replication of IAV, SARS-CoV-2 and CMV (including Nucleozin (HY-50001)-resistant influenza A virus). FM-74-103 can be used in research related to influenza A virus infection, SARS-CoV-2 infection and cytomegalovirus infection [1] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
