extracellular matrix (ECM)

By Targets:	MMP (1) Akt (5) Amino Acid Derivatives (2) Anaplastic lymphoma kinase (ALK) (1) Annexin A (1) Apoptosis (1) Atg8/LC3 (1) Autophagy (1) Bacterial (5) Biochemical Assay Reagents (6) CD44 (2) Collagen (1) Endogenous Metabolite (5) FAK (1) Integrin (2) Lipoxygenase (1) mTOR (1) NF-κB (1) Nuclear Hormone Receptor 4A/NR4A (1) p62 (1) Phosphodiesterase (PDE) (1) PI3K (5) Reactive Oxygen Species (ROS) (2) TGF-beta/Smad (3) TGF-β Receptor (1)
By Research Areas:	Cancer (9) Endocrinology (2) Infection (1) Inflammation/Immunology (12) Metabolic Disease (7) Neurological Disease (5)
Oligonucleotides:	Polymers (1)

Targets Recommended: MMP ERK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0633A

Hyaluronic acid 15+ Cited Publications Hyaluronan; Hyaluronate	Endogenous Metabolite Bacterial Akt PI3K	Infection Neurological Disease Inflammation/Immunology Cancer
Hyaluronic acid is a biopolymer composed of repeating units of disaccharides with various applications. Hyaluronic acid is a major component of the extracellular matrix (ECM). Hyaluronic acid is synthesized at the plasma membrane. Increased hyaluronic acid levels are associated with tumor cell growth, adhesion, migration, invasion and angiogenesis in digestive cancers. Hyaluronic acid participates in tissue remodeling and rapid cell proliferation in some physiological processes including embryonic morphogenesis and wound-healing. Hyaluronic acid activates the PI3K-Akt signaling. Hyaluronic acid acts as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid also enhances cell invasion and angiogenesis by promoting proteolytic MMP-9 binding to cell surface or stimulating MMP-9 binding to cell surface. Hyaluronic acid can be used as drug delivery for sodium butyrate to improve the anti-proliferative activity on breast cancer cell line. Hyaluronic acid can be studied in joint diseases, wound healing and cancer .

HY-B0633

Hyaluronic acid sodium 15+ Cited Publications Sodium hyaluronate	Endogenous Metabolite Bacterial PI3K Akt	Inflammation/Immunology Cancer
Hyaluronic acid sodium (Sodium hyaluronate) is a biopolymer composed of repeating units of disaccharides with various applications. Hyaluronic acid sodium is a major component of the extracellular matrix (ECM). Hyaluronic acid sodium is synthesized at the plasma membrane. Increased hyaluronic acid sodium levels are associated with tumor cell growth, adhesion, migration, invasion and angiogenesis in digestive cancers. Hyaluronic acid sodium participates in tissue remodeling and rapid cell proliferation in some physiological processes including embryonic morphogenesis and wound-healing. Hyaluronic acid sodium activates the PI3K-Akt signaling. Hyaluronic acid sodium acts as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid sodium also enhances cell invasion and angiogenesis by promoting proteolytic MMP-9 binding to cell surface or stimulating MMP-9 binding to cell surface. Hyaluronic acid sodium can be used as drug delivery for sodium butyrate to improve the anti-proliferative activity on breast cancer cell line. Hyaluronic acid sodium can be studied in joint diseases, wound healing and cancer .

HY-13306

Pyrintegrin 4 Publications Verification	Integrin	Metabolic Disease
Pyrintegrin is an β1-integrin agonist and a 2,4-disubstituted pyrimidine that promotes embryonic stem cells survival. Pyrintegrin enhances cell-extracellular matrix (ECM) adhesion-mediated integrin signaling. Pyrintegrin can be used as a podocyte-protective agent and has robustly adipogenic .

HY-W110542J

Poly(ethylene glycol) diacrylate (MW 700) PEGDA (MW 700)	Biochemical Assay Reagents	Others
Poly(ethylene glycol) diacrylate (PEGDA) (MW 700) is a versatile polymer material that is widely used as a building material for hydrogel scaffolds, especially in the fields of tissue engineering and regenerative medicine. Poly(ethylene glycol) diacrylate (MW 700) mimics the extracellular matrix (ECM), providing support and growth space for cells .

HY-W048825

Fmoc-Ala-Ala-OH	Amino Acid Derivatives	Others
Fmoc-Ala-Ala-OH is a self-assembling fluorenylmethoxycarbonyl dipeptide, a small amphiphilic building block composed of a dipeptide linked to a fluorenylmethoxycarbonyl (Fmoc) group. Under conditions of pH < 4, Fmoc-Ala-Ala-OH spontaneously assembles to form a nanofiber network, constructing a hydrogel scaffold with a water content exceeding 99% (w/w). The fibers have a diameter of approximately 22 nm, matching the size of extracellular matrix (ECM) components. Fmoc-Ala-Ala-OH supports cell adhesion, proliferation, and maintains of cell phenotype. Fmoc-Ala-Ala-OH's function is to mimic the ECM, providing a 3D growth microenvironment for cells, and Fmoc-Ala-Ala-OH is primarily used in tissue engineering and 3D cell culture, particularly suitable for in vitro culture studies of cells such as chondrocytes[1] .

HY-P4198

Fmoc-N(Me)-Sar10 Fmoc-Sar10	Biochemical Assay Reagents	Others
Fmoc-N(Me)-Sar10 (Fmoc-Sar10) is an Fmoc-protected derivative of a methylated sarcosine decamer, which supports cell adhesion, proliferation, and maintenance of cell phenotype. Fmoc-N(Me)-Sar10 is primarily used in peptide synthesis to introduce enzymatically stable spacer sequences. By mimicking the extracellular matrix (ECM), Fmoc-N(Me)-Sar10 provides a 3D growth microenvironment for cells and is mainly used in tissue engineering and 3D cell culture, particularly suitable for in vitro culture studies of cells such as chondrocytes .

HY-B0633D

Hyaluronic acid sodium (MW 200-1560)	CD44 Endogenous Metabolite Bacterial Akt PI3K	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Hyaluronic acid sodium (MW 200-1560) is a biopolymer composed of repeating disaccharide units, with a molecular weight of 200-1560. Hyaluronic acid sodium is a major component of the extracellular matrix (ECM). It is synthesized on the plasma membrane. Hyaluronic acid sodium exerts its effects by binding to receptors CD44 and RHAMM. Hyaluronic acid sodium activates PI3K-Akt signaling. Hyaluronic acid sodium also enhances cell invasion and angiogenesis by promoting or stimulating the binding of proteolytic MMP-9 to the cell surface. Elevated hyaluronic acid levels are associated with tumor cell growth, adhesion, migration, invasion, and angiogenesis in digestive system cancers. Hyaluronic acid sodium is involved in tissue remodeling and rapid cell proliferation in several physiological processes, including embryonic morphogenesis and wound healing. Hyaluronic acid sodium can be used as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid sodium can be used as a drug delivery carrier for sodium butyrate, enhancing its anti-proliferative activity against breast cancer cell lines. Hyaluronic acid sodium can lubricate the corneal endothelium. Hyaluronic acid sodium can improve tissue hydration and enhance the resistance of cells to mechanical damage. Hyaluronic acid sodium has been conjugated with antibodies to ensure that the active compound continues to exert its effects at the site of inflammation. Hyaluronic acid sodium can be used in research in the fields of osteoarthritis, ophthalmology, cosmetic dermatology, oncology, and liver diseases .

HY-B0633E

Hyaluronic acid, low endotoxin Hyaluronan, low endotoxin; Hyaluronate, low endotoxin	Endogenous Metabolite CD44 Bacterial Akt PI3K	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Hyaluronic acid, low endotoxin (Hyaluronan, low endotoxin) is a biopolymer composed of repeating disaccharide units containing low levels of endotoxin. Hyaluronic acid is a major component of the extracellular matrix (ECM). It is synthesized on the plasma membrane. Hyaluronic acid exerts its effects by binding to receptors CD44 and RHAMM. Hyaluronic acid activates PI3K-Akt signaling. Hyaluronic acid also enhances cell invasion and angiogenesis by promoting or stimulating the binding of proteolytic MMP-9 to the cell surface. Elevated hyaluronic acid levels are associated with tumor cell growth, adhesion, migration, invasion, and angiogenesis in digestive system cancers. Hyaluronic acid is involved in tissue remodeling and rapid cell proliferation in several physiological processes, including embryonic morphogenesis and wound healing. Hyaluronic acid can be used as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid can be used as a drug delivery carrier for sodium butyrate, enhancing its anti-proliferative activity against breast cancer cell lines. Hyaluronic acid can lubricate the corneal endothelium. Hyaluronic acid can improve tissue hydration and enhance the resistance of cells to mechanical damage. Hyaluronic acid has been conjugated with antibodies to ensure that the active compound continues to exert its effects at the site of inflammation. Hyaluronic acid can be used in research in the fields of osteoarthritis, ophthalmology, cosmetic dermatology, oncology, and liver diseases .

HY-NP156

Type I Collagen, for cell culture, from Bovine	Biochemical Assay Reagents	Others
Type I Collagen, for cell culture, from Bovine plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, for cell culture, from Bovine can mimic the extracellular matrix (ECM) and is suitable for 2D/3D cell culture .

HY-W129161

Acetyl tetrapeptide-3	Amino Acid Derivatives	Metabolic Disease
Acetyl tetrapeptide-3 is a synthetic peptide. Acetyl tetrapeptide-3 enhances the adhesion of hair follicles to the scalp but also promotes the development of new hair follicles. Acetyl tetrapeptide-3 stimulates the synthesis of collagen III in hair follicles. Acetyl tetrapeptide-3 combined with Biochanin A (HY-14595) and ginseng extracts, can stimulate dermal papilla extracellular matrix (ECM) proteins by increasing hydroxyproline, Collagen Type 3, and laminin, yielding a significant improvement in hair follicle size and hair anchoring .

HY-B0633I

Hyaluronic acid sodium (MW 800kDa)	Endogenous Metabolite Bacterial PI3K Akt	Inflammation/Immunology Cancer
Hyaluronic acid sodium (MW 800kDa) is a biopolymer composed of repeating units of disaccharides with various applications. Hyaluronic acid sodium is a major component of the extracellular matrix (ECM). Hyaluronic acid sodium is synthesized at the plasma membrane. Increased hyaluronic acid sodium levels are associated with tumor cell growth, adhesion, migration, invasion and angiogenesis in digestive cancers. Hyaluronic acid sodium participates in tissue remodeling and rapid cell proliferation in some physiological processes including embryonic morphogenesis and wound-healing. Hyaluronic acid sodium activates the PI3K-Akt signaling. Hyaluronic acid sodium acts as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid sodium also enhances cell invasion and angiogenesis by promoting proteolytic MMP-9 binding to cell surface or stimulating MMP-9 binding to cell surface. Hyaluronic acid sodium can be used as drug delivery for sodium butyrate to improve the anti-proliferative activity on breast cancer cell line. Hyaluronic acid sodium can be studied in joint diseases, wound healing and cancer .

HY-171955

LXG6403	Lipoxygenase Apoptosis Reactive Oxygen Species (ROS) FAK	Cancer
LXG6403 is an orally active and irreversible LOX inhibitor (IC₅₀ = 1.3 μM). LXG6403 is ~3.5-fold more specific for LOX than LOXL2 and does not inhibit LOXL1. LXG6403 inhibits FAK signaling and induces ROS generation and DNA damage, leading to G1 arrest and apoptosis in chemoresistant triple-negative breast cancer (TNBC) cell lines. LXG6403 alters the extracellular matrix (ECM) and collagen structure, reducing collagen cross-linking and deposition, thereby increasing drug penetration and reducing tumor stiffness. LXG6403 overcomes Doxorubicin (HY-15142) resistance in chemoresistant TNBC PDX in vivo and can be used to study high-stiffness resistant tumors .

HY-136651

BNTA	Reactive Oxygen Species (ROS)	Inflammation/Immunology
BNTA, a potent **extracellular matrix (ECM) modulator, facilitates cartilage structural molecule synthesis on chondrocytes by activating superoxide dismutase 3 (SOD3)**. BNTA shows a promising potential for osteoarthritis alleviation by modulating cartilage generation .

HY-159621

Endosidine 5 ES5	Annexin A	Endocrinology
Endosidine 5 (ES5) inhibits EPS (extracellular polymeric substance) secretion and cell wall expansion. Endosidine 5 alters secretion of ECM (extracellular matrix) material in Penium margaritaceum by affecting the Golgi apparatus. Endosidine 5 interferes with recycling endosomes through Annexin A6, thereby promoting the release and expression of mRNA into the cytoplasm .

HY-P5232

Tetrapeptide-21	Collagen	Metabolic Disease
Tetrapeptide-21 is a bioactive peptide composed of four amino acids. Tetrapeptide-21 effectively enhances the vitality of human dermal fibroblasts. Tetrapeptide-21 upregulates the expression of key extracellular matrix (ECM) genes and promotes the synthesis of ECM proteins (such as type I collagen, hyaluronic acid synthase 1, and fibronectin). Tetrapeptide-21 has the efficacy of anti-wrinkle and improving skin elasticity, and has been reported to be used as a cosmetic ingredient .

HY-W005379

DGM	TGF-beta/Smad	Inflammation/Immunology
DGM is an inhibitor of the TGF-β1/Smad signaling pathway with significant antifibrotic effects. DGM inhibits the epithelial-mesenchymal transition (EMT) process in alveolar epithelial cells and slows the progression of pulmonary fibrosis in vivo by reducing lung inflammation, improving lung function, and decreasing extracellular matrix (ECM) remodeling. DGM can be used in research on idiopathic pulmonary fibrosis (IPF) and EMT-related diseases .

HY-158220

Hyaluronic acid Methacryloyl (MW 400 kDa) HAMA (MW 400 kDa)	Biochemical Assay Reagents	Others
Hyaluronic acid Methacryloyl (HAMA) is methacrylated hyaluronic acid that is biocompatible. Hyaluronic acid Methacryloyl is also used as a 3D printing hydrogel ink, which has the characteristics of fast photosensitive response, fast gelation speed and stable hydrogel performance. Hyaluronic acid Methacryloyl can quickly induce gelation with lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) under UV irradiation. The combination of Hyaluronic acid Methacryloyl and tissue-specific extracellular matrix (ECM) materials (such as pancreatic extracellular matrix (pECM)) will become an important source material for organoid culture .

HY-158220A

Hyaluronic acid Methacryloyl (MW 150 kDa) HAMA (MW 150 kDa)	Biochemical Assay Reagents	Others
Hyaluronic acid Methacryloyl (HAMA) MW 150 kDa is methacrylated hyaluronic acid that is biocompatible. Hyaluronic acid Methacryloyl is also used as a 3D printing hydrogel ink, which has the characteristics of fast photosensitive response, fast gelation speed and stable hydrogel performance. Hyaluronic acid Methacryloyl can quickly induce gelation with lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) under UV irradiation. The combination of Hyaluronic acid Methacryloyl and tissue-specific extracellular matrix (ECM) materials (such as pancreatic extracellular matrix (pECM)) will become an important source material for organoid culture .

HY-N6812

Karacoline	NF-κB	Endocrinology
Karacoline, a diterpene alkaloid found in the plant Aconitum kusnezoffii, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway .

HY-P3202

Matrix metalloproteinase 3 MMP-3; Stromelysin-1	MMP	Neurological Disease
Matrix metalloproteinase 3 (MMP-3) is a member of the class of zinc-dependent proteases that can degrade the extracellular matrix (ECM). Matrix metalloproteinase 3 palys an important role in the neuronal apoptotic process as well as in neuroinflammation. Matrix metalloproteinase 3 can be used in the study of neurodegenerative diseases including Alzheimer’s disease (AD) and Parkinson’s disease (PD) .

HY-P10984

FNIII14	Integrin	Metabolic Disease Inflammation/Immunology Cancer
FNIII14 is derived from the 14th fibronectin (FN) type III-like (FN-III) repeat of FN molecule. FNIII14 is capable of inhibiting cell adhesion to the extracellular matrix (ECM). FNIII14 induces a conformational change in β1-integrin from the active to the inactive form, and blocks integrin-mediated signaling. FNIII14 has anti-fibrotic, anti-cancer effect. FNIII14 can be used for research of metabolic diseases, organ fibrosis, and malignant tumors .

HY-P11223

CMF9	TGF-beta/Smad	Inflammation/Immunology
CMF9, a cyclic peptide molecule, is an inhibitor of the SMAD2-SMAD4 interaction. CMF9 effectively blocks the formation of the heterodimeric complex of SMAD2 and SMAD4 by inhibiting the phosphorylation of SMAD2. CMF9 has no effect on the phosphorylation of SMAD3 or SMAD1/5/8. CMF9 downregulates the expression of fibrotic markers α-SMA and COL1A1. CMF9 exhibits potent anti-fibrotic effects in mouse models by promoting the degradation of pathological extracellular matrix (ECM) and inhibiting inflammation. CMF9 can be used for the study of liver fibrosis .

HY-158220D

Hyaluronic acid methacryloyl (MW 300000) HAMA (MW 300000)	Biochemical Assay Reagents	Inflammation/Immunology
Hyaluronic acid methacryloyl (MW 300000) (HAMA (MW 300000)), a natural extracellular matrix (ECM) with anti-inflammatory effects, promoting cell adhesion and proliferation. Hyaluronic acid methacryloyl (MW 300000) can be widely used in tissue engineering and regenerative medicine. Hyaluronic acid methacryloyl (MW 300000) can rapidly form a hydrogel after exposure to UV light .

HY-163507

ALK5-IN-79	Anaplastic lymphoma kinase (ALK)	Cancer
ALK5-IN-79 (compound 57) is an ALK inhibitor with anticancer activity, by blocking TGF-β1/SMAD signaling pathway. ALK5-IN-79 attenuates the production of extracellular matrix (ECM) and deposition of collagen. ALK5-IN-79 exhibits adequate pharmacokinetic (PK) properties and good in vivo tolerance.

HY-162147

Nur77 modulator 3	Nuclear Hormone Receptor 4A/NR4A Autophagy mTOR TGF-beta/Smad Atg8/LC3 p62	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Nur77 modulator 3 is a Nur77 modulator. Nur77 modulator 3 induces Nur77 expression, inhibits hepatic stellate cells (HSCs) activation, and reduces extracellular matrix (ECM) deposition. Nur77 modulator 3 enhances Nur77-denpendent autophagic flux and significantly inhibits the mTORC1 signaling pathway. Nur77 modulator 3 ameliorates HSCs activation, inflammation and hepatic fibrosis in vivo .

HY-170227

Autotaxin-IN-7	Phosphodiesterase (PDE) TGF-β Receptor	Inflammation/Immunology
Autotaxin-IN-7 (45), a pyridine-2-carboxylic derivative, demonstrates subnanomolar ATX inhibition (IC₅₀ = 0.086 nM), with a favorable heart safety profile (hERG > 30 μM) and minimal fibroblast toxicity. Autotaxin-IN-7 (45) suppresses the TGF-β/Smad signaling pathway, downregulating α-smooth muscle actin (α-SMA) and extracellular matrix components (ECM). Autotaxin-IN-7 (45) is used in the research for pulmonary fibrosis .

Cat. No.	Product Name

HY-L185

Anti-Fibrosis Compound Library	2,415 compounds
Fibrosis is a kind of repair response to long-term tissue damage, which is mainly manifested by excessive deposition of extracellular matrix (ECM) and scar formation. Myofibroblasts are the main generating cells of extracellular matrix, and their activation process is related to various pathological mechanisms including Oxidative stress, chronic inflammation and cytokine secretion. Fibrosis can occur in many organs, such as kidneys, liver, heart, lungs, etc. Continuous fibrosis can lead to the destruction of the normal structure of tissues and organs, and if not controlled in time, may cause organ failure or even life-threatening. MCE contains 2,415 compounds targeting ant-fibrosis targets such as TGF-β, PI3K, Wnt, MMP, etc. These compounds have clear or potential anti-fibrosis activity and can be used for mechanism research and drug screening of fibrosis diseases.

Anti-Fibrosis Compound Library

2,415 compounds

Fibrosis is a kind of repair response to long-term tissue damage, which is mainly manifested by excessive deposition of extracellular matrix (ECM) and scar formation. Myofibroblasts are the main generating cells of extracellular matrix, and their activation process is related to various pathological mechanisms including Oxidative stress, chronic inflammation and cytokine secretion. Fibrosis can occur in many organs, such as kidneys, liver, heart, lungs, etc. Continuous fibrosis can lead to the destruction of the normal structure of tissues and organs, and if not controlled in time, may cause organ failure or even life-threatening.

MCE contains 2,415 compounds targeting ant-fibrosis targets such as TGF-β, PI3K, Wnt, MMP, etc. These compounds have clear or potential anti-fibrosis activity and can be used for mechanism research and drug screening of fibrosis diseases.

Cat. No.	Product Name	Type

HY-B0633A

Hyaluronic acid 15+ Cited Publications Hyaluronan; Hyaluronate	Biochemical Assay Reagents
Hyaluronic acid is a biopolymer composed of repeating units of disaccharides with various applications. Hyaluronic acid is a major component of the extracellular matrix (ECM). Hyaluronic acid is synthesized at the plasma membrane. Increased hyaluronic acid levels are associated with tumor cell growth, adhesion, migration, invasion and angiogenesis in digestive cancers. Hyaluronic acid participates in tissue remodeling and rapid cell proliferation in some physiological processes including embryonic morphogenesis and wound-healing. Hyaluronic acid activates the PI3K-Akt signaling. Hyaluronic acid acts as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid also enhances cell invasion and angiogenesis by promoting proteolytic MMP-9 binding to cell surface or stimulating MMP-9 binding to cell surface. Hyaluronic acid can be used as drug delivery for sodium butyrate to improve the anti-proliferative activity on breast cancer cell line. Hyaluronic acid can be studied in joint diseases, wound healing and cancer .

Hyaluronic acid

15+ Cited Publications

Hyaluronan; Hyaluronate

Biochemical Assay Reagents

Hyaluronic acid is a biopolymer composed of repeating units of disaccharides with various applications. Hyaluronic acid is a major component of the extracellular matrix (ECM). Hyaluronic acid is synthesized at the plasma membrane. Increased hyaluronic acid levels are associated with tumor cell growth, adhesion, migration, invasion and angiogenesis in digestive cancers. Hyaluronic acid participates in tissue remodeling and rapid cell proliferation in some physiological processes including embryonic morphogenesis and wound-healing. Hyaluronic acid activates the PI3K-Akt signaling. Hyaluronic acid acts as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid also enhances cell invasion and angiogenesis by promoting proteolytic MMP-9 binding to cell surface or stimulating MMP-9 binding to cell surface. Hyaluronic acid can be used as drug delivery for sodium butyrate to improve the anti-proliferative activity on breast cancer cell line. Hyaluronic acid can be studied in joint diseases, wound healing and cancer .

HY-W110542J

Poly(ethylene glycol) diacrylate (MW 700) PEGDA (MW 700)	Biochemical Assay Reagents
Poly(ethylene glycol) diacrylate (PEGDA) (MW 700) is a versatile polymer material that is widely used as a building material for hydrogel scaffolds, especially in the fields of tissue engineering and regenerative medicine. Poly(ethylene glycol) diacrylate (MW 700) mimics the extracellular matrix (ECM), providing support and growth space for cells .

HY-B0633E

Hyaluronic acid, low endotoxin Hyaluronan, low endotoxin; Hyaluronate, low endotoxin	Biochemical Assay Reagents
Hyaluronic acid, low endotoxin (Hyaluronan, low endotoxin) is a biopolymer composed of repeating disaccharide units containing low levels of endotoxin. Hyaluronic acid is a major component of the extracellular matrix (ECM). It is synthesized on the plasma membrane. Hyaluronic acid exerts its effects by binding to receptors CD44 and RHAMM. Hyaluronic acid activates PI3K-Akt signaling. Hyaluronic acid also enhances cell invasion and angiogenesis by promoting or stimulating the binding of proteolytic MMP-9 to the cell surface. Elevated hyaluronic acid levels are associated with tumor cell growth, adhesion, migration, invasion, and angiogenesis in digestive system cancers. Hyaluronic acid is involved in tissue remodeling and rapid cell proliferation in several physiological processes, including embryonic morphogenesis and wound healing. Hyaluronic acid can be used as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid can be used as a drug delivery carrier for sodium butyrate, enhancing its anti-proliferative activity against breast cancer cell lines. Hyaluronic acid can lubricate the corneal endothelium. Hyaluronic acid can improve tissue hydration and enhance the resistance of cells to mechanical damage. Hyaluronic acid has been conjugated with antibodies to ensure that the active compound continues to exert its effects at the site of inflammation. Hyaluronic acid can be used in research in the fields of osteoarthritis, ophthalmology, cosmetic dermatology, oncology, and liver diseases .

Hyaluronic acid, low endotoxin

Hyaluronan, low endotoxin; Hyaluronate, low endotoxin

Biochemical Assay Reagents

Hyaluronic acid, low endotoxin (Hyaluronan, low endotoxin) is a biopolymer composed of repeating disaccharide units containing low levels of endotoxin. Hyaluronic acid is a major component of the extracellular matrix (ECM). It is synthesized on the plasma membrane. Hyaluronic acid exerts its effects by binding to receptors CD44 and RHAMM. Hyaluronic acid activates PI3K-Akt signaling. Hyaluronic acid also enhances cell invasion and angiogenesis by promoting or stimulating the binding of proteolytic MMP-9 to the cell surface. Elevated hyaluronic acid levels are associated with tumor cell growth, adhesion, migration, invasion, and angiogenesis in digestive system cancers. Hyaluronic acid is involved in tissue remodeling and rapid cell proliferation in several physiological processes, including embryonic morphogenesis and wound healing. Hyaluronic acid can be used as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid can be used as a drug delivery carrier for sodium butyrate, enhancing its anti-proliferative activity against breast cancer cell lines. Hyaluronic acid can lubricate the corneal endothelium. Hyaluronic acid can improve tissue hydration and enhance the resistance of cells to mechanical damage. Hyaluronic acid has been conjugated with antibodies to ensure that the active compound continues to exert its effects at the site of inflammation. Hyaluronic acid can be used in research in the fields of osteoarthritis, ophthalmology, cosmetic dermatology, oncology, and liver diseases .

HY-NP156

Type I Collagen, for cell culture, from Bovine	Biochemical Assay Reagents
Type I Collagen, for cell culture, from Bovine plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, for cell culture, from Bovine can mimic the extracellular matrix (ECM) and is suitable for 2D/3D cell culture .

HY-158220

Hyaluronic acid Methacryloyl (MW 400 kDa) HAMA (MW 400 kDa)	Biochemical Assay Reagents
Hyaluronic acid Methacryloyl (HAMA) is methacrylated hyaluronic acid that is biocompatible. Hyaluronic acid Methacryloyl is also used as a 3D printing hydrogel ink, which has the characteristics of fast photosensitive response, fast gelation speed and stable hydrogel performance. Hyaluronic acid Methacryloyl can quickly induce gelation with lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) under UV irradiation. The combination of Hyaluronic acid Methacryloyl and tissue-specific extracellular matrix (ECM) materials (such as pancreatic extracellular matrix (pECM)) will become an important source material for organoid culture .

Hyaluronic acid Methacryloyl (MW 400 kDa)

HAMA (MW 400 kDa)

Biochemical Assay Reagents

Hyaluronic acid Methacryloyl (HAMA) is methacrylated hyaluronic acid that is biocompatible. Hyaluronic acid Methacryloyl is also used as a 3D printing hydrogel ink, which has the characteristics of fast photosensitive response, fast gelation speed and stable hydrogel performance. Hyaluronic acid Methacryloyl can quickly induce gelation with lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) under UV irradiation. The combination of Hyaluronic acid Methacryloyl and tissue-specific extracellular matrix (ECM) materials (such as pancreatic extracellular matrix (pECM)) will become an important source material for organoid culture .

HY-158220A

Hyaluronic acid Methacryloyl (MW 150 kDa) HAMA (MW 150 kDa)	Biochemical Assay Reagents
Hyaluronic acid Methacryloyl (HAMA) MW 150 kDa is methacrylated hyaluronic acid that is biocompatible. Hyaluronic acid Methacryloyl is also used as a 3D printing hydrogel ink, which has the characteristics of fast photosensitive response, fast gelation speed and stable hydrogel performance. Hyaluronic acid Methacryloyl can quickly induce gelation with lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) under UV irradiation. The combination of Hyaluronic acid Methacryloyl and tissue-specific extracellular matrix (ECM) materials (such as pancreatic extracellular matrix (pECM)) will become an important source material for organoid culture .

Hyaluronic acid Methacryloyl (MW 150 kDa)

HAMA (MW 150 kDa)

Biochemical Assay Reagents

Hyaluronic acid Methacryloyl (HAMA) MW 150 kDa is methacrylated hyaluronic acid that is biocompatible. Hyaluronic acid Methacryloyl is also used as a 3D printing hydrogel ink, which has the characteristics of fast photosensitive response, fast gelation speed and stable hydrogel performance. Hyaluronic acid Methacryloyl can quickly induce gelation with lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) under UV irradiation. The combination of Hyaluronic acid Methacryloyl and tissue-specific extracellular matrix (ECM) materials (such as pancreatic extracellular matrix (pECM)) will become an important source material for organoid culture .

HY-158220D

Hyaluronic acid methacryloyl (MW 300000) HAMA (MW 300000)	Biochemical Assay Reagents
Hyaluronic acid methacryloyl (MW 300000) (HAMA (MW 300000)), a natural extracellular matrix (ECM) with anti-inflammatory effects, promoting cell adhesion and proliferation. Hyaluronic acid methacryloyl (MW 300000) can be widely used in tissue engineering and regenerative medicine. Hyaluronic acid methacryloyl (MW 300000) can rapidly form a hydrogel after exposure to UV light .

Cat. No.	Product Name	Target	Research Area

HY-W048825

Fmoc-Ala-Ala-OH	Amino Acid Derivatives	Others
Fmoc-Ala-Ala-OH is a self-assembling fluorenylmethoxycarbonyl dipeptide, a small amphiphilic building block composed of a dipeptide linked to a fluorenylmethoxycarbonyl (Fmoc) group. Under conditions of pH < 4, Fmoc-Ala-Ala-OH spontaneously assembles to form a nanofiber network, constructing a hydrogel scaffold with a water content exceeding 99% (w/w). The fibers have a diameter of approximately 22 nm, matching the size of extracellular matrix (ECM) components. Fmoc-Ala-Ala-OH supports cell adhesion, proliferation, and maintains of cell phenotype. Fmoc-Ala-Ala-OH's function is to mimic the ECM, providing a 3D growth microenvironment for cells, and Fmoc-Ala-Ala-OH is primarily used in tissue engineering and 3D cell culture, particularly suitable for in vitro culture studies of cells such as chondrocytes[1] .

HY-P4198

Fmoc-N(Me)-Sar10 Fmoc-Sar10	Biochemical Assay Reagents	Others
Fmoc-N(Me)-Sar10 (Fmoc-Sar10) is an Fmoc-protected derivative of a methylated sarcosine decamer, which supports cell adhesion, proliferation, and maintenance of cell phenotype. Fmoc-N(Me)-Sar10 is primarily used in peptide synthesis to introduce enzymatically stable spacer sequences. By mimicking the extracellular matrix (ECM), Fmoc-N(Me)-Sar10 provides a 3D growth microenvironment for cells and is mainly used in tissue engineering and 3D cell culture, particularly suitable for in vitro culture studies of cells such as chondrocytes .

HY-W129161

Acetyl tetrapeptide-3	Amino Acid Derivatives	Metabolic Disease
Acetyl tetrapeptide-3 is a synthetic peptide. Acetyl tetrapeptide-3 enhances the adhesion of hair follicles to the scalp but also promotes the development of new hair follicles. Acetyl tetrapeptide-3 stimulates the synthesis of collagen III in hair follicles. Acetyl tetrapeptide-3 combined with Biochanin A (HY-14595) and ginseng extracts, can stimulate dermal papilla extracellular matrix (ECM) proteins by increasing hydroxyproline, Collagen Type 3, and laminin, yielding a significant improvement in hair follicle size and hair anchoring .

HY-P5232

Tetrapeptide-21	Collagen	Metabolic Disease
Tetrapeptide-21 is a bioactive peptide composed of four amino acids. Tetrapeptide-21 effectively enhances the vitality of human dermal fibroblasts. Tetrapeptide-21 upregulates the expression of key extracellular matrix (ECM) genes and promotes the synthesis of ECM proteins (such as type I collagen, hyaluronic acid synthase 1, and fibronectin). Tetrapeptide-21 has the efficacy of anti-wrinkle and improving skin elasticity, and has been reported to be used as a cosmetic ingredient .

HY-P10984

FNIII14	Integrin	Metabolic Disease Inflammation/Immunology Cancer
FNIII14 is derived from the 14th fibronectin (FN) type III-like (FN-III) repeat of FN molecule. FNIII14 is capable of inhibiting cell adhesion to the extracellular matrix (ECM). FNIII14 induces a conformational change in β1-integrin from the active to the inactive form, and blocks integrin-mediated signaling. FNIII14 has anti-fibrotic, anti-cancer effect. FNIII14 can be used for research of metabolic diseases, organ fibrosis, and malignant tumors .

HY-P11223

CMF9	TGF-beta/Smad	Inflammation/Immunology
CMF9, a cyclic peptide molecule, is an inhibitor of the SMAD2-SMAD4 interaction. CMF9 effectively blocks the formation of the heterodimeric complex of SMAD2 and SMAD4 by inhibiting the phosphorylation of SMAD2. CMF9 has no effect on the phosphorylation of SMAD3 or SMAD1/5/8. CMF9 downregulates the expression of fibrotic markers α-SMA and COL1A1. CMF9 exhibits potent anti-fibrotic effects in mouse models by promoting the degradation of pathological extracellular matrix (ECM) and inhibiting inflammation. CMF9 can be used for the study of liver fibrosis .

Cat. No.	Product Name

HY-K6023

Cardiomyocyte Dissociation Kit
MCE ECM Gentle Dissociation Solution is a gentle ECM-degrading enzyme mixture derived from marine bacteria and Bacillus species, specifically formulated for efficient and low-damage digestion of in-vitro cell systems. It selectively degrades extracellular matrix components while minimizing disruption to the cell membrane and intercellular junctions, thereby significantly reducing mechanical stress during dissociation.

Cardiomyocyte Dissociation Kit

MCE ECM Gentle Dissociation Solution is a gentle ECM-degrading enzyme mixture derived from marine bacteria and Bacillus species, specifically formulated for efficient and low-damage digestion of in-vitro cell systems. It selectively degrades extracellular matrix components while minimizing disruption to the cell membrane and intercellular junctions, thereby significantly reducing mechanical stress during dissociation.

HY-K6022

ECM Gentle Dissociation Solution
MCE ECM Gentle Dissociation Solution is a gentle ECM-degrading enzyme mixture derived from marine bacteria and Bacillus species, specifically formulated for efficient and low-damage digestion of in-vitro cell systems. It selectively degrades extracellular matrix components while minimizing disruption to the cell membrane and intercellular junctions, thereby significantly reducing mechanical stress during dissociation. This product is compatible with a wide range of cell types, including stem cell colonies, primary cells, neural cells, and organoids, and is particularly well suited for gentle yet effective dissociation of brain organoids and other complex 3D structures.

ECM Gentle Dissociation Solution

MCE ECM Gentle Dissociation Solution is a gentle ECM-degrading enzyme mixture derived from marine bacteria and Bacillus species, specifically formulated for efficient and low-damage digestion of in-vitro cell systems. It selectively degrades extracellular matrix components while minimizing disruption to the cell membrane and intercellular junctions, thereby significantly reducing mechanical stress during dissociation. This product is compatible with a wide range of cell types, including stem cell colonies, primary cells, neural cells, and organoids, and is particularly well suited for gentle yet effective dissociation of brain organoids and other complex 3D structures.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0633A

Hyaluronic acid 15+ Cited Publications Hyaluronan; Hyaluronate	Structural Classification Zea mays L. Classification of Application Fields Moisture Plants Endogenous metabolite Human Gut Microbiota Metabolites Polysaccharides Gramineae Cosmetic Research Disease Research Fields Saccharides Source Classification Cancer	Endogenous Metabolite Bacterial Akt PI3K
Hyaluronic acid is a biopolymer composed of repeating units of disaccharides with various applications. Hyaluronic acid is a major component of the extracellular matrix (ECM). Hyaluronic acid is synthesized at the plasma membrane. Increased hyaluronic acid levels are associated with tumor cell growth, adhesion, migration, invasion and angiogenesis in digestive cancers. Hyaluronic acid participates in tissue remodeling and rapid cell proliferation in some physiological processes including embryonic morphogenesis and wound-healing. Hyaluronic acid activates the PI3K-Akt signaling. Hyaluronic acid acts as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid also enhances cell invasion and angiogenesis by promoting proteolytic MMP-9 binding to cell surface or stimulating MMP-9 binding to cell surface. Hyaluronic acid can be used as drug delivery for sodium butyrate to improve the anti-proliferative activity on breast cancer cell line. Hyaluronic acid can be studied in joint diseases, wound healing and cancer .

HY-B0633

Hyaluronic acid sodium 15+ Cited Publications Sodium hyaluronate	Structural Classification Microorganisms Animals Classification of Application Fields Cosmetic Research Disease Research Fields Saccharides Source Classification Cancer	Endogenous Metabolite Bacterial PI3K Akt
Hyaluronic acid sodium (Sodium hyaluronate) is a biopolymer composed of repeating units of disaccharides with various applications. Hyaluronic acid sodium is a major component of the extracellular matrix (ECM). Hyaluronic acid sodium is synthesized at the plasma membrane. Increased hyaluronic acid sodium levels are associated with tumor cell growth, adhesion, migration, invasion and angiogenesis in digestive cancers. Hyaluronic acid sodium participates in tissue remodeling and rapid cell proliferation in some physiological processes including embryonic morphogenesis and wound-healing. Hyaluronic acid sodium activates the PI3K-Akt signaling. Hyaluronic acid sodium acts as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid sodium also enhances cell invasion and angiogenesis by promoting proteolytic MMP-9 binding to cell surface or stimulating MMP-9 binding to cell surface. Hyaluronic acid sodium can be used as drug delivery for sodium butyrate to improve the anti-proliferative activity on breast cancer cell line. Hyaluronic acid sodium can be studied in joint diseases, wound healing and cancer .

HY-N6812

Karacoline	Classification of Application Fields Terpenoids Ranunculaceae Diterpenoids Aconitum carmichaeli Debx. Plants Disease Research Fields Endocrinology Source Classification	NF-κB
Karacoline, a diterpene alkaloid found in the plant Aconitum kusnezoffii, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway .

Species:	Human (1) Mouse (3) Rat (1)
Tag:	His (5)
Source:	HEK293 (5)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P75264

	ECM1 Protein, Rat (HEK293, His) extracellular matrix protein 1; Secretory component p85; Ecm1	Rat	HEK293
	The ECM1 protein is a multifaceted player that negatively regulates bone mineralization and affects endochondral bone formation. In addition to bone biology, it stimulates endothelial cell proliferation and angiogenesis and exerts regulatory control on MMP9 proteolytic activity. ECM1 Protein, Rat (HEK293, His) is the recombinant rat-derived ECM1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P75265

	ECM1 Protein, Mouse (HEK293, His) extracellular matrix protein 1; Secretory component p85; Ecm1	Mouse	HEK293
	ECM1 Protein, an extracellular matrix protein, is involved in various biological processes, including skin development, wound healing, and angiogenesis. It supports cell adhesion and migration, and regulates the structure and function of the extracellular matrix. Understanding the functions of ECM1 Protein is important for studying tissue remodeling and developing therapeutic strategies for ECM1-related disorders and diseases. ECM1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ECM1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P704031

	ECM1 Protein, Human (HEK293, His) extracellular matrix protein 1; Secretory component p85	Human	HEK293
	ECM1 Protein, Human (HEK293, His) is the recombinant human-derived ECM1 protein, expressed by HEK293, with C-His tag.

HY-P76651

	SPARCL1 Protein, Mouse (HEK293, His) SPARC-like protein 1; extracellular matrix protein 2; matrix glycoprotein Sc1; ECM2, SC1	Mouse	HEK293
	SPARCL1 protein has important functions such as calcium ion, collagen and extracellular matrix binding. SPARCL1 mainly plays a role in glutamatergic synaptic membrane adhesion. SPARCL1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived SPARCL1 protein, expressed by HEK293 , with C-His, C-10*His labeled tag.

HY-P76652

	SPARCL1 Protein, Mouse (283a.a, HEK293, His) SPARC-like protein 1; extracellular matrix protein 2; matrix glycoprotein Sc1; ECM2, SC1	Mouse	HEK293
	SPARCL1 protein has important functions such as calcium ion, collagen and extracellular matrix binding. SPARCL1 mainly plays a role in glutamatergic synaptic membrane adhesion. SPARCL1 Protein, Mouse (283a.a, HEK293, His) is the recombinant mouse-derived SPARCL1 protein, expressed by HEK293 , with N-His labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2)
Application:	IHC-P (2) ICC/IF (2) IP (2) IHC-F (2) WB (2) FC (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83042

	Extracellular Matrix Protein 1 Antibody (YA2787) ECM1; extracellular matrix protein 1; Secretory component p85	WB, IHC-F, IHC-P, ICC/IF, FC, IP	Human, Rat
	Extracellular Matrix Protein 1 Antibody (YA2787) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Extracellular Matrix Protein 1.

HY-P83042A

	Extracellular Matrix Protein 1 Antibody (YA2787)(PBS only) ECM1; extracellular matrix protein 1; Secretory component p85	WB, IHC-F, IHC-P, ICC/IF, FC, IP	Human, Rat
	Extracellular Matrix Protein 1 Antibody (YA2787) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Extracellular Matrix Protein 1.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-B0633A

Hyaluronic acid 15+ Cited Publications Hyaluronan; Hyaluronate		Polymers
Hyaluronic acid is a biopolymer composed of repeating units of disaccharides with various applications. Hyaluronic acid is a major component of the extracellular matrix (ECM). Hyaluronic acid is synthesized at the plasma membrane. Increased hyaluronic acid levels are associated with tumor cell growth, adhesion, migration, invasion and angiogenesis in digestive cancers. Hyaluronic acid participates in tissue remodeling and rapid cell proliferation in some physiological processes including embryonic morphogenesis and wound-healing. Hyaluronic acid activates the PI3K-Akt signaling. Hyaluronic acid acts as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid also enhances cell invasion and angiogenesis by promoting proteolytic MMP-9 binding to cell surface or stimulating MMP-9 binding to cell surface. Hyaluronic acid can be used as drug delivery for sodium butyrate to improve the anti-proliferative activity on breast cancer cell line. Hyaluronic acid can be studied in joint diseases, wound healing and cancer .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

extracellular matrix (ECM)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

MCE Kits

NaturalProducts

Recombinant Proteins

Antibodies

Oligonucleotides

Natural
Products