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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
458 Results for "
finger tapping task
" in MedChemExpress (MCE) Product Catalog:
Products (458)
458 Results for "finger tapping task" in MCE Product Catalog:
30
12
12 Cited Publications
Target:
Domaines de recherche:
DCPIB is a selective, reversible and potent inhibitor of volume-regulated anion channels (VRAC). DCPIB voltage-dependently activates potassium channels TREK1 and TRAAK, and inhibits TRESK, TASK1 and TASK3 (IC50s: 0.14, 0.95, 50.72 μM, respectively). DCPIB is also a selective blocker of swelling-induced chloride current (ICl,swell), with an IC50 of 4.1 μM. DCPIB is a useful tool for investigating structure-function studies of K2P channels .
6
6 Cited Publications
Target:
Domaines de recherche:
ML365 is a selective two-pore domain potassium channel KCNK3/TASK1 inhibitor, with an IC50 of 4 nM. ML365 acts as a pharmacological tool that can be used to examine the specific roles of TASK1 channels .
3
3 Cited Publications
Target:
Domaines de recherche:
USP5-IN-1 (compound 64) is a selective competitive inhibitor of USP5 zinc finger ubiquitin binding domain (ZnF-UBD) (KD=2.8 μM). USP5-IN-1 competitively blocks the binding of ubiquitin to ZnF-UBD, inhibits the catalytic activity of USP5, and thus hinders the hydrolysis of ubiquitin chains. USP5-IN-1 can inhibit USP5 cleavage of Lys48-linked diubiquitin substrates in vitro and is a potential USP5 chemical probe and potential inhibitor of USP5-related cancers.
3
3 Cited Publications
Cat. No.: HY-163731
CAS No.: 3077196-25-6
Domaines de recherche:
EGR-1-IN-1 is a EGR-1 inhibitor with an IC50 of 1.86 μM. EGR-1-IN-1 binds to the zinc finger DNA-binding domain of EGR-1 and promotes the dissociation of the EGR-1-DNA complex. EGR-1-IN-1 reduces the mRNA expression levels of EGR-1-regulated inflammatory genes induced by TNFα. EGR-1-IN-1 alleviates atopic dermatitis-like lesions in the ear skin of mice. EGR-1-IN-1 serves as a lead compound for the development of targeted compounds for inflammatory skin diseases. EGR-1-IN-1 can be used in studies related to atopic dermatitis .
3
3 Cited Publications
Cat. No.: HY-P71791
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TRIM21; RING finger Protein 81; Tripartite Motif Containing 21; 52 KDa Ro Protein; SSA1; Ro/SSA 52kDa; RNF81; Ro(SS-A); SS-A; RO52; E3 Ubiquitin-Protein Ligase TRIM21; RING-Type E3 Ubiquitin Transferase TRIM21; Sjogren Syndrome Antigen A1 (52kDa, Ribonucleoprotein Autoantigen SS-A/Ro); Tripartite Motif-Containing 21; 52 KDa Ribonucleoprotein Autoantigen Ro/SS-A; Tripartite Motif-Containing Protein 21; Sjoegren Syndrome Type A Antigen; Sicca Syndrome Antigen A; Ro/SSA; SSA
Species:
Human
Source:
P. pastoris
2
2 Cited Publications
Cat. No.: HY-N2112
CAS No.: 79498-31-0
2
2 Cited Publications
Target:
Domaines de recherche:
TASK-1-IN-1 is a potent and selective TASK-1 (Potassium Channel) inhibitor with an IC50 of 148 nM. TASK-1-IN-1 shows a reduced inhibition of TASK-3 channels (IC50 of 1750 nM) and not a significant effect on other K+ channels. TASK-1-IN-1 has anticancer effects.
1
Target:
Domaines de recherche:
Doxapram is a respiratory stimulant. Doxapram increases breathing rate and depth by acting on the brain's respiratory centers and peripheral chemoreceptors. Doxapram inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50s of 410 nM, 37 μM, 9 μM, respectively. Doxapram inhibits the Ca²⁺-activated potassium current (IC50 ≈ 13 μM) and Ca²⁺-independent potassium current (IC50 ≈ 20 μM) in type I cells of the carotid body. Doxapram significantly prolongs the effective refractory period of the atrium and has an anti-arrhythmic effect. Doxapram can be used for the study of respiratory depression such as post-anesthesia respiratory depression, chronic obstructive pulmonary disease and apnea of prematurity .
1
Target:
Domaines de recherche:
Doxapram hydrochloride hydrate is a respiratory stimulant. Doxapram hydrochloride hydrate increases breathing rate and depth by acting on the brain's respiratory centers and peripheral chemoreceptors. Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50s of 410 nM, 37 μM, 9 μM, respectively. Doxapram hydrochloride hydrate inhibits the Ca²⁺-activated potassium current (IC50 ≈ 13 μM) and Ca²⁺-independent potassium current (IC50 ≈ 20 μM) in type I cells of the carotid body. Doxapram hydrochloride hydrate significantly prolongs the effective refractory period of the atrium and has an anti-arrhythmic effect. Doxapram hydrochloride hydrate can be used for the study of respiratory depression such as post-anesthesia respiratory depression, chronic obstructive pulmonary disease and apnea of prematurity .
1
Target:
Domaines de recherche:
2-Deoxy-D-galactose is a glucose analog. 2-Deoxy-D-galactose inhibits glycolysis to inhibits tumor growth. 2-Deoxy-D-galactose is a substance interfering with the fucosylation of glycomacromolecules and impairing memory consolidation in various learning tasks. 2-Deoxy-d-galactose hinders glycoprotein fucosylation in vivo .
1
1 Cited Publications
Cat. No.: HY-19537
CAS No.: 1883548-89-7
Target:
Domaines de recherche:
NI-57, a chemical probe, is an inhibitor of bromodomain and plant homeodomain finger-containing (BRPF) famlily of proteins, with IC50s of 3.1, 46 and 140 nM for BRPF1, BRPF2 (BRD1) and BRPF3, respectively.
1
1 Cited Publications
Target:
Domaines de recherche:
ALV2 is a potent and selective Helios molecular glue degrader. ALV2 binds CRBN, with an IC50 of 0.57 μM. Helios is the zinc-finger transcription factor that can maintain a stable Treg cell phenotype in the inflammatory tumor microenvironment .
1
1
Target:
Domaines de recherche:
Doxapram (hydrochloride) is a ventilatory stimulant. Doxapram (hydrochloride) inhibits TASK Tandem Pore (K2P) potassium channel function. Doxapram (hydrochloride) inhibits TASK-1 and TASK-3 with an EC50 values of 410 and 37 nM, respectively. Doxapram (hydrochloride) inhibits TASK-1/TASK-3 heterodimeric channel function with an EC50 value of 9 μM. Doxapram (hydrochloride) can be studied in research on apnea in preterm infants .
1
1 Cited Publications
Cat. No.: HY-P701224
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BMI1; BMI1 Polycomb Ring finger Proto-Oncogene; Prev. PCGF4; Polycomb Group Ring finger 4; RNF51; Polycomb Group Protein Bmi1; Polycomb Group RING finger Protein 4; Ring finger Protein 51; Polycomb Complex Protein BMI-1; RING finger Protein 51; B Lymphoma
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P70039
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTCF; CFAP108; CCCTC-Binding Factor; FAP108; Transcriptional Repressor CTCF; CCCTC-Binding Factor (Zinc finger Protein); 11-Zinc finger Protein; 11 Zinc finger Transcriptional Repressor; CTCFL Paralog; MRD21
Species:
Human
Source:
E. coli
1
1
1 Cited Publications
Cat. No.: HY-155938
CAS No.: 2801702-34-9
Target:
Domaines de recherche:
Cyano-myracrylamide is an inhibitor of zinc finger DHHC domain-containing palmitoyltransferase 20 (zDHHC20) with an IC50 value of 1.35 µM. Cyano-myracrylamide also inhibits the S-Acylation of EGFR and CD36. Cyano-myracrylamide also inhibits S-acylation of Legionella E3 ligase GobX, MyD88, and Ras, which are substrates of zDHHC20, zDHHC9, and zDHHC6, respectively, in HEK293T cells expressing recombinant Legionella GobX, recombinant human MyD88, or endogenous Ras .
1
1 Cited Publications
Cat. No.: HY-P83731
Synonyms: Gli 1; Gli1; Gli-1; GLI; GLI Kruppel family member 1; Glioma associated oncogene; Glioma associated oncogene homolog 1 (zinc finger protein); Oncogene GLI; Zfp 5; Zfp5; Zinc finger protein GLI 1; Zinc finger protein GLI1; GLI1_HUMAN.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
