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Results for "

glucuronidase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	β-glucuronidase (44) ADC Linker (1) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (3) Bacterial (8) Biochemical Assay Reagents (7) Carbonic Anhydrase (3) Carboxylesterase (CES) (1) Cholinesterase (ChE) (1) Cytochrome P450 (1) DNA/RNA Synthesis (1) Drug Intermediate (1) Drug Metabolite (4) Drug-Linker Conjugates for ADC (3) Endogenous Metabolite (7) Fluorescent Dye (7) Glycosidase (1) Herbicide (1) Influenza Virus (1) Isotope-Labeled Compounds (1) Phosphatase (2) Photosensitizer (1) Platelet-activating Factor Receptor (PAFR) (1) RSV (1) Topoisomerase (3)
By Research Areas:	Cancer (16) Cardiovascular Disease (1) Infection (6) Inflammation/Immunology (9) Metabolic Disease (21) Neurological Disease (3)
Click Chemistry:	Azide (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: β-glucuronidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2803

*Beta-glucuronidase* (Escherichia coli)** 1 Publications Verification	β-glucuronidase	Metabolic Disease
Beta-glucuronidase is a glycosyl hydrolase that hydrolyzes β-glucuronic acid and sulfate esters in urine and other biological fluids, and then releases β-glucuronate .

HY-134453A

D-Saccharic acid 1,4-lactone hydrate 1 Publications Verification	β-glucuronidase Apoptosis	Cancer
D-Saccharic acid 1,4-lactone hydrate is an orally active *β-glucuronidase* inhibitor (IC₅₀=48.4 μM). D-Saccharic acid 1,4-lactone hydrate can be used as a standard agent compared with novel β-glucuronidase inhibitors. D-Saccharic acid 1,4-lactone hydrate possesses anticarcinogenic, detoxifying, and antioxidant properties .

HY-D0935A

4-Methylumbelliferyl-β-D-glucuronide hydrate 1 Publications Verification MUG	β-glucuronidase Fluorescent Dye	Others
4-Methylumbelliferyl-β-D-glucuronide hydrate is a fluorogenic substrat (λ_ex=362 nm, λ_em=445 nm). 4-Methylumbelliferyl-β-D-glucuronide hydrate has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli .

HY-P2803A

*Beta-glucuronidase* (bovine liver)** 1 Publications Verification	β-glucuronidase	Metabolic Disease
Beta-glucuronidase (bovine liver) is a glycosyl hydrolase that hydrolyzes β-glucuronic acid and sulfate esters in urine and other biological fluids, and then releases β-glucuronate .

HY-P2803B

*Beta-glucuronidase* (helix pomatia)** 1 Publications Verification	β-glucuronidase	Metabolic Disease
Beta-glucuronidase (helix pomatia) is a glycosyl hydrolase that hydrolyzes β-glucuronic acid and sulfate esters in urine and other biological fluids, and then releases β-glucuronate .

HY-137522

Zidovudine O-β-D-glucuronide sodium 3'-Azido-3'-deoxythymidine β-D-glucuronide sodium	Drug Metabolite	Others
Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .

HY-173639

AZD0516	Antibody-Drug Conjugates (ADCs) Topoisomerase Apoptosis	Cancer
AZD0516 is a first-in-class antibody-drug conjugate (ADC) targeting six-transmembrane epithelial antigen of the prostate-2 (STEAP2). The anti-STEAP2 monoclonal antibody (mAb) is conjugated via interchain cysteines to a maleimide-reactive, β-glucuronidase-cleavable linker (HY-173635) bearing the topoisomerase 1 inhibitor, Exatecan (HY-13631). AZD0516 can be used for the study of prostate cancer .

HY-W039892

4-Nitrophenyl β-D-glucuronide 1 Publications Verification pNPG_1	β-glucuronidase	Others
4-Nitrophenyl β-D-glucuronide (pNPG_1) is aderivative of 4-Nitrophenol. 4-Nitrophenyl β-D-glucuronide is the chromogenic substrate for *β-glucuronidase* .

HY-15935B

*X-Gluc* cyclohexanamine**	β-glucuronidase Fluorescent Dye	Others
X-Gluc cyclohexanamine is a dye reagent for the detection of *β-glucuronidase* (GUS), an enzyme produced by E. coli. X-Gluc cyclohexanamine can be used to detect E. coli contamination in food, water and the urinary tract (GUS as a specific detection indicator). X-Gluc cyclohexanamine is also widely used in molecular biology experiments to label and detect the expression of target genes (reacts with the GUS gene, appears blue) .

HY-W345885

Saccharic acid	β-glucuronidase	Metabolic Disease
Saccharic acid is a competitive and potent inhibitor of *β-glucuronidase*. Saccharic acid inhibits glucuronide synthesis. Saccharic acid as an efficient iron chelate to enhance photo-Fenton degradation of organic contaminants .

HY-128943

MAC glucuronide phenol-linked SN-38 1 Publications Verification	Drug-Linker Conjugates for ADC	Cancer
MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) agent linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC₅₀ values of 113 and 67 ng/mL, respectively.Albumin-coupled MAC glucosidol-linked SN-38 shows good stability in mouse plasma .

HY-15935C

*X-Gluc* sodium**	β-glucuronidase Fluorescent Dye	Others
X-Gluc sodium is a dye reagent for the detection of *β-glucuronidase* (GUS), an enzyme produced by E. coli. X-Gluc sodium can be used to detect E. coli contamination in food, water and the urinary tract (GUS as a specific detection indicator). X-Gluc sodium is also widely used in molecular biology experiments to label and detect the expression of target genes (reacts with the GUS gene, appears blue) .

HY-103081

*β-Glucuronidase-IN-1* 1 Publications Verification	β-glucuronidase Bacterial	Infection Cancer
β-Glucuronidase-IN-1 is a potent, selective, uncompetitive, and orally active E. coli bacterial β-glucuronidase inhibitor, exhibiting an IC₅₀ and a K_i of 283 nM and 164 nM, respectively .

HY-137959

Telmisartan acyl-β-D-glucuronide	β-glucuronidase Drug Metabolite	Metabolic Disease
Telmisartan acyl-β-D-glucuronide is an acyl-β-D-glucuronide and a metabolite of Telmisartan (HY-13955). Telmisartan acyl-β-D-glucuronide can be converted back to Telmisartan upon incubation with Glucuronidase. Partial acyl migration of Telmisartan acyl-β-D-glucuronide occurs under physiological conditions .

HY-N1735

2′-Hydroxygenistein 2 Publications Verification	β-glucuronidase Bacterial	Inflammation/Immunology
2′-Hydroxygenistein is a natural product that can be isolated from Crotalaria pallida and C. assamica. 2′-Hydroxygenistein shows anti-inflammatory activity. 2′-Hydroxygenistein shows significant concentration-dependent inhibitory effects on the release of *β-glucuronidase* and lysozyme from rat neutrophils, with IC₅₀ values of 5.9 ± 1.4 and 9.7 ± 3.5 μM, respectively .

HY-N7529

Siastatin B	Endogenous Metabolite β-glucuronidase	Others
Siastatin B is an effective broad-spectrum glycosidase inhibitor that can effectively inhibit the activities of sialidase, *β-D-glucuronidase, N-acetyl-glucosaminidase, β-glucuronidase, and human heparinase* .

HY-D0164

Naphthol AS-BI	Fluorescent Dye β-glucuronidase	Others
Naphthol AS-BI is a substrate of β-glucuronidase and produces a bright red effect after staining biological tissues.

HY-N1733

2′-Hydroxydaidzein 2 Publications Verification	β-glucuronidase	Inflammation/Immunology
2′-Hydroxydaidzein is a metabolite. 2′-Hydroxydaidzein inhibits the release of chemical mediator from inflammatory cells. 2′-Hydroxydaidzein significantly inhibits lysozyme and β-glucuronidase release from rat neutrophils, which is stimulated with fMLP/CB, respectively .

HY-D0935

4-Methylumbelliferyl-β-D-glucuronide 1 Publications Verification	β-glucuronidase Fluorescent Dye	Others
4-Methylumbelliferyl-β-D-glucuronide is a fluorogenic substrat (λ_ex=362 nm, λ_em=445 nm). 4-Methylumbelliferyl-β-D-glucuronide has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli .

HY-151168

3-Chlorogentisyl alcohol	β-glucuronidase Bacterial	Inflammation/Immunology Cancer
3-Chlorogentisyl alcohol is a potent E. coli *β-glucuronidase* inhibitor with an IC₅₀ value of 0.74 μM, an K_i value of 0.58 μM. 3-Chlorogentisyl alcohol shows antiproliferative activity. 3-Chlorogentisyl alcohol has the potential for the research of anti-cancer and anti-inflammatory therapies .

HY-15935

*X-Gluc* Dicyclohexylamine**	β-glucuronidase Fluorescent Dye	Others
X-Gluc Dicyclohexylamine is a dye reagent for the detection of β-glucuronidase, an enzyme produced by Escherichia coli. X-Gluc sodium can be used to detect E. coli contamination in food, water and the urinary tract. X-Gluc sodium is also widely used in molecular biology experiments to label and detect the expression of target genes (GUS reporter system) .

HY-N16039

TAN-1030A	β-glucuronidase	Inflammation/Immunology
TAN-1030A is an indolocarbazole alkaloid with macrophage-activating properties. TAN-1030A induces spreading of a murine macrophage cell line, Mm 1, and augmentes the phagocytic activity, Fc gamma receptor expression and β-glucuronidase activity of murine macrophage cell lines, Mm 1 and J774A.1. TAN-1030A can activate macrophage functions in mice .

HY-148044

UNC10201652	β-glucuronidase Bacterial	Infection
UNC10201652 is a potent Loop 1 (L1)-specific gut bacterial β-glucuronidase (GUSs) inhibitor with an IC₅₀ value of 0.117 μM for E. coli GUS. UNC10201652 can block SN-38 glucuronide (HY-126373) processing only in individuals whose fecal gut microbiota is highly abundant in L1 GUS enzymes .

HY-N6851

Glycyrrhetic acid 3-O-β-D-glucuronide Glycyrrhetic acid 3-O-mono-β-D-glucuronide; 3-monoglucuronyl-glycyrrhetinic acid	Others	Inflammation/Immunology
Glycyrrhetic acid 3-O-β-D-glucuronide, isolated from glycyrrhiza, is an important derivative of glycyrrhizin (GL) with an anti -allergic activity . Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) shows that β-glucuronidases (β-GUS) are key GAMG-producing enzymes, displaying a high potential to convert GL directly into GAMG .Glycyrrhetic acid 3-O-β-D-glucuronide is valuable as a sweetener.

HY-137426A

Phenolphthalein glucuronide sodium	Biochemical Assay Reagents β-glucuronidase	Others
Phenolphthalein glucuronide sodium is a substrate to determine the β –glucuronidase .

HY-D1460

Fluorescein Di-β-D-Glucuronide	Bacterial β-glucuronidase	Infection
Fluorescein Di-β-D-Glucuronide is an orally active fluorescent probe substrate and an indicator of β-glucuronidase (βG) activity in intestinal bacteria. Fluorescein Di-β-D-Glucuronide can be used for non-invasive time-lapse optical imaging of βG activity in intestinal bacteria in nude mice. Fluorescein Di-β-D-Glucuronide supports the quantitative analysis of bacterial βG enzyme activity and inhibition .

HY-W154341

3-Indolyl-β-D-glucuronide cyclohexanamine	Biochemical Assay Reagents	Others
3-Indolyl-β-D-glucuronide cyclohexanamine is the glucose component of X-Gluc staining buffer. 3-Indolyl-β-D-glucuronide cyclohexanamine can be used to detect gene expression. The active ingredient of the stain, β-Glucuronidase (GUS), reacts with the enzyme, causing the target gene to appear blue-purple in tissues or cells, so that the expression level and tissue distribution of the gene can be visually observed .

HY-N9970

Apigenin 7-O-β-D-glucuronide ethyl ester	Others	Inflammation/Immunology
Apigenin 7-O-β-D-glucuronide ethyl ester is a flavonoid glucuronate ester that can be isolated from Scutellaria regeliana. Apigenin 7-O-β-D-glucuronide ethyl ester possesses anti-inflammatory activity on the release of β-glucuronidase from rat polymorphonuclear leukocytes (PNMs) induced by platelet activating-factor. Apigenin 7-O-β-D-glucuronide ethyl ester can be used for anti-inflammatory research .

HY-173703

β-Glu-PAB(CH2NH2)-Exatecan	Topoisomerase Drug Intermediate	Cancer
β-Glu-PAB(CH2NH2)-Exatecan (Compound 9a) is a topoisomerase I inhibitor. β-Glu-PAB(CH2NH2)-Exatecan binds to the topoisomerase I-DNA complex to prevent DNA strand reconnection, thereby inducing DNA breakage and cell apoptosis. β-Glu-PAB(CH2NH2)-Exatecan can be specifically cleaved by β-glucuronidase highly expressed in the tumor microenvironment to release Exatecan for cytotoxic effect. β-Glu-PAB(CH2NH2)-Exatecan is also an intermediate of Mal((3S,3aR,6S,6aR) -hexahydrofuro [3, 2-B]furan-3,6-diamine-PEG12)-β -Glu-Pab-Exatecan. β-Glu-PAB(CH2NH2)-Exatecan is promising for research of cancers .

HY-N9975

4'',5''-Dehydroisopsoralidin	β-glucuronidase	Inflammation/Immunology Cancer
4'',5''-Dehydroisopsoralidin is a *β-glucuronidase* inhibitor (IC₅₀: 6.3 μM). 4'',5''-Dehydroisopsoralidin has anti-inflammatory and anti-oxidative effects. 4'',5''-Dehydroisopsoralidin can be used in the research of inflammation and cancners .

HY-N2998

Ganoderenic acid A	β-glucuronidase	Metabolic Disease
Ganoderenic acid A is a lanostane-type triterpene. Ganoderenic acid A is a potent inhibitor of *β-glucuronidase*. Ganoderenic acid A has a potent hepatoprotective effect against CCl4-induced liver injury .

HY-N1322

Sanggenol A	Bacterial β-glucuronidase	Others
Sanggenol A acts as a dual inhibitor of nitrofuranone reduction mediated by the intestinal microbial nitrification reductases EcNfsA and EcNfsB. In addition, Sanggenol A is also an effective inhibitor of intestinal bacterial β-glucuronidase .

HY-150973

hCAII-IN-4	Carbonic Anhydrase β-glucuronidase	Neurological Disease Metabolic Disease Cancer
hCAII-IN-4 (Compound 12j) is a potent hCA II inhibitor with an IC₅₀ of 7.78 μM. hCAII-IN-4 also inhibits *β-glucuronidase* with an IC₅₀ of 773.9 μM .

HY-113245

3-Indolyl-β-D-glucuronide	Endogenous Metabolite	Others
3-Indolyl-β-D-glucuronide, a chromogenic substrate for β-D-glucuronidase, employs in the detection and enumeration of E. coli, yielding a blue precipitate upon cleavage. 3-Indolyl-β-D-glucuronide in? patients' plasma act as a new indicator of renal failure .

HY-173635

Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB	ADC Linker	Cancer
Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB is an interchain cysteines to a Maleimide-reactive, β-glucuronidase-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as AZD0516 (HY-173639) .

HY-N3413

Kushenol X	Carboxylesterase (CES) β-glucuronidase	Metabolic Disease
Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent *β-glucuronidase* and human carboxylesterase 2 (hCE2) inhibitor with IC₅₀s of 2.07 μM and 3.05 μM, respectively .

HY-N17236

Forsyshiyanine A	β-glucuronidase Influenza Virus RSV	Infection
Foryshiyanine A is a triterpenoid alkaloid. Foryshiyanine A possesses anti-inflammatory activity, inhibiting the release of *β-glucuronidase* from rat polymorphonuclear leukocytes. Foryshiyanine A exhibits antiviral activity, with an EC₅₀ of 4.5 μM against respiratory syncytial virus (RSV) and an IC₅₀ of 7.3 μM against influenza A virus (H1N1). Foryshiyanine A reduces viral load by disrupting viral replication and entry. Foryshiyanine A may be used for the researches of inflammation and infection .

HY-155313

β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE	Drug-Linker Conjugates for ADC	Cancer
β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE (compound 20) is auristatins-glucuronide conjugate. Antitumor agent-122 shows in vitro antiproliferative activities against β-glucuronidase pretreated and untreated cancer cells with an IC₅₀ value of 5.7 nM - 9.7 nM. Antitumor agent-122 shows potent antitumor efficacy in HCT-116 xenograft mouse model without inducing side effects .

HY-137522S

Zidovudine O-β-D-glucuronide-d3 sodium 3'-Azido-3'-deoxythymidine β-D-glucuronide-d3 sodium	Isotope-Labeled Compounds Drug Metabolite	Others
Zidovudine O-β-D-glucuronide-d₃ sodium (3'-Azido-3'-deoxythymidine β-D-glucuronide-d₃ sodium) is a deuterium labeled Zidovudine O-β-D-glucuronide sodium (HY-137522). Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .

HY-173397

*β-Glucuronidase-IN-3*	β-glucuronidase Bacterial	Metabolic Disease
β-Glucuronidase-IN-3 (Compound 49) is a covalent allosteric *β-glucuronidase* inhibitor. β-Glucuronidase-IN-3 has potent inhibitory activity against Escherichia coli β-glucuronidase (EcGUS) (IC₅₀: 12.9 nM). β-Glucuronidase-IN-3 exerts its inhibitory effect by reversibly covalently modifying the cysteine residues (Cys28, Cys443, and Cys197) of EcGUS. β-Glucuronidase-IN-3 can be used in the study of intestinal microbiota-related diseases, especially to alleviate the toxic side effects of Irinotecan (HY-16562) and nonsteroidal anti-inflammatory drugs (NSAIDs) .

HY-150977

*β-Glucuronidase/hCAII-IN-2*	Carbonic Anhydrase	Neurological Disease Metabolic Disease Cancer
β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a potent *β-glucuronidase* and hCA II inhibitor with an IC₅₀ of 670.7 μM and 21.77 μM, respectively .

HY-150976

*β-Glucuronidase/hCAII-IN-1*	Carbonic Anhydrase β-glucuronidase	Neurological Disease Metabolic Disease Cancer
β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a potent *β-glucuronidase* and hCA II inhibitor with an IC₅₀ of 440.1 μM and 4.91 μM, respectively .

HY-161341

*β-Glucuronidase* responsive conjugate 1**	Photosensitizer	Cancer
β-Glucuronidase responsive conjugate 1 (compound 3) is a well-balanced photosensitizer which has photodynamic activity. β-Glucuronidase responsive conjugate 1 inhibits T-24 cell viability and growth with an IC₅₀ of 0.2 μM. β-Glucuronidase responsive conjugate 1 can used to study bladder cancers .

HY-162884

*β-Glucuronidase-IN-4*	β-glucuronidase	Infection
EcGUS-IN-1 (Compound E-9) is a non-competitive *β-glucuronidase* inhibitor, with an IC₅₀ of 2.68 μM and a K_i value of 1.64 μM. EcGUS-IN-1 can improve gastrointestinal adverse events (GIAE) caused by Escherichia coli infection by inhibiting E. coli *β-glucuronidase* activity .

HY-137783

Resorufin β-D-glucuronide sodium	Biochemical Assay Reagents β-glucuronidase	Others
Resorufin β-D-glucuronide sodium can be used as a substrate for β-glucuronidase .

HY-D1578

C12FDGlcU	Fluorescent Dye β-glucuronidase	Others
C12FDGlcU is a lipophilic analog of fluorescein di-β-D-glucuronic acid. C12FDGlcU can be useful for the detection of *β-glucuronidase* (GUS) gene expression. C12FDGlcU can enter the cells and then be cleaved by β-glucuronidase, generating the yellow-colored, green-fluorescent fluorescein (Abs/Em of the reaction product: 495/518 nm) .

HY-155411

HPSE1-IN-2	Endogenous Metabolite	Metabolic Disease
HPSE1-IN-2 (compound 2) is a Heparanase-1 (HPSE1) inhibitor that also inhibits exo-β-d-glucuronidase (GUSβ) and glucocerebrosidase (GBA) activity .

HY-155410

HPSE1-IN-1	Endogenous Metabolite	Metabolic Disease
HPSE1-IN-1 (compound 16) is a selective inhibitor of Heparanase-1 (HPSE1) with moderate inhibitory activity against exo-β-d-glucuronidase (GUSβ) and glucocerebrosidase (GBA) .

HY-N2247A

(+)-Guaiacin	Platelet-activating Factor Receptor (PAFR)	Metabolic Disease
(+)-Guaiacin is a compound extracted of the bark of Machilus wangchiana Chun. (Lauraceae). (+)-Guaiacin shows potent in vitro activities against the release of β-glucuronidase in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor (PAF) .

HY-119621

Aceglatone	β-glucuronidase DNA/RNA Synthesis Apoptosis	Cancer
Aceglatone, an antineoplastic agent, is a *β-glucuronidase* inhibitor. Aceglatone is a compound that inhibits colon carcinogenesis and prevents the induction of colon cancer by inhibiting the hydrolysis of glucuronides. Aceglatone reduces cell proliferation, induces apoptosis and inhibits DNA synthesis in human colon cancer cells .

Cat. No.	Product Name	Type

HY-D0935A

4-Methylumbelliferyl-β-D-glucuronide hydrate 1 Publications Verification MUG	Fluorescent Dye
4-Methylumbelliferyl-β-D-glucuronide hydrate is a fluorogenic substrat (λ_ex=362 nm, λ_em=445 nm). 4-Methylumbelliferyl-β-D-glucuronide hydrate has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli .

HY-173639

AZD0516

Fluorescent Dye

AZD0516 is a first-in-class antibody-drug conjugate (ADC) targeting six-transmembrane epithelial antigen of the prostate-2 (STEAP2). The anti-STEAP2 monoclonal antibody (mAb) is conjugated via interchain cysteines to a maleimide-reactive, β-glucuronidase-cleavable linker (HY-173635) bearing the topoisomerase 1 inhibitor, Exatecan (HY-13631). AZD0516 can be used for the study of prostate cancer .

HY-15935C

X-Gluc sodium

Fluorescent Dye

X-Gluc sodium is a dye reagent for the detection of β-glucuronidase (GUS), an enzyme produced by E. coli. X-Gluc sodium can be used to detect E. coli contamination in food, water and the urinary tract (GUS as a specific detection indicator). X-Gluc sodium is also widely used in molecular biology experiments to label and detect the expression of target genes (reacts with the GUS gene, appears blue) .

HY-D0164

Naphthol AS-BI	Fluorescent Dye
Naphthol AS-BI is a substrate of β-glucuronidase and produces a bright red effect after staining biological tissues.

HY-15935

*X-Gluc* Dicyclohexylamine**	Fluorescent Dye
X-Gluc Dicyclohexylamine is a dye reagent for the detection of β-glucuronidase, an enzyme produced by Escherichia coli. X-Gluc sodium can be used to detect E. coli contamination in food, water and the urinary tract. X-Gluc sodium is also widely used in molecular biology experiments to label and detect the expression of target genes (GUS reporter system) .

HY-D1460

Fluorescein Di-β-D-Glucuronide

Fluorescent Dye

Fluorescein Di-β-D-Glucuronide is an orally active fluorescent probe substrate and an indicator of β-glucuronidase (βG) activity in intestinal bacteria. Fluorescein Di-β-D-Glucuronide can be used for non-invasive time-lapse optical imaging of βG activity in intestinal bacteria in nude mice. Fluorescein Di-β-D-Glucuronide supports the quantitative analysis of bacterial βG enzyme activity and inhibition .

HY-D1578

C12FDGlcU	Fluorescent Dye
C12FDGlcU is a lipophilic analog of fluorescein di-β-D-glucuronic acid. C12FDGlcU can be useful for the detection of *β-glucuronidase* (GUS) gene expression. C12FDGlcU can enter the cells and then be cleaved by β-glucuronidase, generating the yellow-colored, green-fluorescent fluorescein (Abs/Em of the reaction product: 495/518 nm) .

Cat. No.	Product Name	Type

HY-137959

Telmisartan acyl-β-D-glucuronide	Biochemical Assay Reagents
Telmisartan acyl-β-D-glucuronide is an acyl-β-D-glucuronide and a metabolite of Telmisartan (HY-13955). Telmisartan acyl-β-D-glucuronide can be converted back to Telmisartan upon incubation with Glucuronidase. Partial acyl migration of Telmisartan acyl-β-D-glucuronide occurs under physiological conditions .

HY-D0935

4-Methylumbelliferyl-β-D-glucuronide 1 Publications Verification	Biochemical Assay Reagents
4-Methylumbelliferyl-β-D-glucuronide is a fluorogenic substrat (λ_ex=362 nm, λ_em=445 nm). 4-Methylumbelliferyl-β-D-glucuronide has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli .

HY-137783

Resorufin β-D-glucuronide sodium	Biochemical Assay Reagents
Resorufin β-D-glucuronide sodium can be used as a substrate for β-glucuronidase .

HY-W283888

5-Bromo-4-chloro-1H-indol-3-yl nonanoate	Biochemical Assay Reagents
5-Bromo-4-chloro-1H-indol-3-yl nonanoate is a fluorescent substrate used to detect enzymes. The substrate reacts with various enzymes to produce a fluorescent product, which has been shown to be active against β-galactosidase, α-chymotrypsin, and β-glucuronidase.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W345885

Saccharic acid	Human Gut Microbiota Metabolites Endogenous metabolite Source Classification	β-glucuronidase
Saccharic acid is a competitive and potent inhibitor of *β-glucuronidase*. Saccharic acid inhibits glucuronide synthesis. Saccharic acid as an efficient iron chelate to enhance photo-Fenton degradation of organic contaminants .

HY-N1735

2′-Hydroxygenistein 2 Publications Verification	Flavonoids Leguminosae Crotalaria pallida Ait. Plants Isoflavones Source Classification	β-glucuronidase Bacterial
2′-Hydroxygenistein is a natural product that can be isolated from Crotalaria pallida and C. assamica. 2′-Hydroxygenistein shows anti-inflammatory activity. 2′-Hydroxygenistein shows significant concentration-dependent inhibitory effects on the release of *β-glucuronidase* and lysozyme from rat neutrophils, with IC₅₀ values of 5.9 ± 1.4 and 9.7 ± 3.5 μM, respectively .

HY-N1733

2′-Hydroxydaidzein 2 Publications Verification	Flavonoids Leguminosae Crotalaria pallida Ait. Plants Isoflavones Source Classification	β-glucuronidase
2′-Hydroxydaidzein is a metabolite. 2′-Hydroxydaidzein inhibits the release of chemical mediator from inflammatory cells. 2′-Hydroxydaidzein significantly inhibits lysozyme and β-glucuronidase release from rat neutrophils, which is stimulated with fMLP/CB, respectively .

HY-N16039

TAN-1030A	Alkaloids Microorganisms Indole Alkaloids Source Classification	β-glucuronidase
TAN-1030A is an indolocarbazole alkaloid with macrophage-activating properties. TAN-1030A induces spreading of a murine macrophage cell line, Mm 1, and augmentes the phagocytic activity, Fc gamma receptor expression and β-glucuronidase activity of murine macrophage cell lines, Mm 1 and J774A.1. TAN-1030A can activate macrophage functions in mice .

HY-N6851

Glycyrrhetic acid 3-O-β-D-glucuronide Glycyrrhetic acid 3-O-mono-β-D-glucuronide; 3-monoglucuronyl-glycyrrhetinic acid	Triterpenes Classification of Application Fields Leguminosae Terpenoids Plants Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields Sweeteners Source Classification Food Research	Others
Glycyrrhetic acid 3-O-β-D-glucuronide, isolated from glycyrrhiza, is an important derivative of glycyrrhizin (GL) with an anti -allergic activity . Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) shows that β-glucuronidases (β-GUS) are key GAMG-producing enzymes, displaying a high potential to convert GL directly into GAMG .Glycyrrhetic acid 3-O-β-D-glucuronide is valuable as a sweetener.

HY-N9970

Apigenin 7-O-β-D-glucuronide ethyl ester	Structural Classification Flavonoids Scutellaria regeliana Nakai Flavones Labiatae Plants Source Classification	Others
Apigenin 7-O-β-D-glucuronide ethyl ester is a flavonoid glucuronate ester that can be isolated from Scutellaria regeliana. Apigenin 7-O-β-D-glucuronide ethyl ester possesses anti-inflammatory activity on the release of β-glucuronidase from rat polymorphonuclear leukocytes (PNMs) induced by platelet activating-factor. Apigenin 7-O-β-D-glucuronide ethyl ester can be used for anti-inflammatory research .

HY-N9975

4'',5''-Dehydroisopsoralidin	Classification of Application Fields Solanum lyratum Thunberg Coumarins Phenylpropanoids Solanaceae Plants Inflammation/Immunology Disease Research Fields Cancer	β-glucuronidase
4'',5''-Dehydroisopsoralidin is a *β-glucuronidase* inhibitor (IC₅₀: 6.3 μM). 4'',5''-Dehydroisopsoralidin has anti-inflammatory and anti-oxidative effects. 4'',5''-Dehydroisopsoralidin can be used in the research of inflammation and cancners .

HY-N2998

Ganoderenic acid A	Triterpenes Structural Classification Human Gut Microbiota Metabolites other families Classification of Application Fields Terpenoids Metabolic Disease Plants Endogenous metabolite Disease Research Fields Source Classification	β-glucuronidase
Ganoderenic acid A is a lanostane-type triterpene. Ganoderenic acid A is a potent inhibitor of *β-glucuronidase*. Ganoderenic acid A has a potent hepatoprotective effect against CCl4-induced liver injury .

HY-N1322

Sanggenol A	Structural Classification Flavonoids Flavones Plants Moraceae Morus alba Linn. Source Classification	Bacterial β-glucuronidase
Sanggenol A acts as a dual inhibitor of nitrofuranone reduction mediated by the intestinal microbial nitrification reductases EcNfsA and EcNfsB. In addition, Sanggenol A is also an effective inhibitor of intestinal bacterial β-glucuronidase .

HY-113245

3-Indolyl-β-D-glucuronide	Alkaloids Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Indole Alkaloids Source Classification	Endogenous Metabolite
3-Indolyl-β-D-glucuronide, a chromogenic substrate for β-D-glucuronidase, employs in the detection and enumeration of E. coli, yielding a blue precipitate upon cleavage. 3-Indolyl-β-D-glucuronide in? patients' plasma act as a new indicator of renal failure .

HY-N3413

Kushenol X	Flavanonols Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Metabolic Disease Sophora flavescens Aiton Plants Disease Research Fields Source Classification	Carboxylesterase (CES) β-glucuronidase
Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent *β-glucuronidase* and human carboxylesterase 2 (hCE2) inhibitor with IC₅₀s of 2.07 μM and 3.05 μM, respectively .

HY-N17236

Forsyshiyanine A	Structural Classification Alkaloids Oleaceae Pyridine Alkaloids Forsythia suspensa (Thunb.) Vahl Plants Source Classification	β-glucuronidase Influenza Virus RSV
Foryshiyanine A is a triterpenoid alkaloid. Foryshiyanine A possesses anti-inflammatory activity, inhibiting the release of *β-glucuronidase* from rat polymorphonuclear leukocytes. Foryshiyanine A exhibits antiviral activity, with an EC₅₀ of 4.5 μM against respiratory syncytial virus (RSV) and an IC₅₀ of 7.3 μM against influenza A virus (H1N1). Foryshiyanine A reduces viral load by disrupting viral replication and entry. Foryshiyanine A may be used for the researches of inflammation and infection .

HY-155411

HPSE1-IN-2	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
HPSE1-IN-2 (compound 2) is a Heparanase-1 (HPSE1) inhibitor that also inhibits exo-β-d-glucuronidase (GUSβ) and glucocerebrosidase (GBA) activity .

HY-155410

HPSE1-IN-1	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
HPSE1-IN-1 (compound 16) is a selective inhibitor of Heparanase-1 (HPSE1) with moderate inhibitory activity against exo-β-d-glucuronidase (GUSβ) and glucocerebrosidase (GBA) .

HY-N2247A

(+)-Guaiacin	Classification of Application Fields Lignans Phenols Polyphenols Metabolic Disease Phenylpropanoids Plants Lauraceae Machilus wangchiana Chun Disease Research Fields Source Classification	Platelet-activating Factor Receptor (PAFR)
(+)-Guaiacin is a compound extracted of the bark of Machilus wangchiana Chun. (Lauraceae). (+)-Guaiacin shows potent in vitro activities against the release of β-glucuronidase in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor (PAF) .

HY-119609

Ilicicolin C	Structural Classification Microorganisms Antibiotics Source Classification	Bacterial Cholinesterase (ChE) β-glucuronidase
Ilicicolin C exhibits antibacterial activity against Pseudomonas syringae with IC₅₀ of 28.5 µg/mL. Ilicicolin C exhibits weak inhibitory activities against acetylcholinesterase (AChE) and *β-glucuronidase* with IC₅₀ of 30-43 µg/mL. Ilicicolin C exhibits weak cytoxicity in human lung fibroblasts with IC₅₀ of 64-120 µg/mL. Ilicicolin C affects seed germination and root tip growth of lettuce .

Species:	Human (1) E.coli (1)
Tag:	His (2)
Source:	HEK293 (1) E. coli (1)

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HY-P70258

	*Beta-glucuronidase/GUSB Protein, E.coli (N-His, solution)* rE.coBeta-glucuronidase/GUSB, His; Beta-glucuronidase; uidA; GUS	E.coli	E. coli
	The beta-glucuronidase/GUSB protein displays activity with PNPG and 4-methylumbelliferyl-glucuronide. It scavenges glucuronate from various xenobiotic and endobiotic glucuronides in the GI tract, utilizing diverse carbon sources. As part of the GI microbiome, it can reactivate glucuronide drug conjugates, potentially harming the GI tract. Beta-glucuronidase/GUSB Protein, E.coli (N-His, solution) is the recombinant E. coli-derived Beta-glucuronidase/GUSB protein, expressed by E. coli , with N-6*His labeled tag.

HY-P705499

	*Beta-glucuronidase/GUSB Protein, Human (HEK293, His)* Beta-glucuronidase; GUSB; Beta-G1; BG; MPS7	Human	HEK293

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HY-137522S

Zidovudine O-β-D-glucuronide-d3 sodium

Zidovudine O-β-D-glucuronide-d₃ sodium (3'-Azido-3'-deoxythymidine β-D-glucuronide-d₃ sodium) is a deuterium labeled Zidovudine O-β-D-glucuronide sodium (HY-137522). Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .

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HY-P83108

	*beta Glucuronidase* Antibody (YA2853)** GUSB; Beta-glucuronidase; Beta-G1	WB, IHC-P, ICC/IF, FC	Human
	beta Glucuronidase Antibody (YA2853) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to beta Glucuronidase.

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HY-137522

Zidovudine O-β-D-glucuronide sodium 3'-Azido-3'-deoxythymidine β-D-glucuronide sodium		Azide
Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .

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