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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
311 Results for "
killer
" in MedChemExpress (MCE) Product Catalog:
Products (311)
311 Results for "killer" in MCE Product Catalog:
28
28 Publications Verification
Synonyms: INCB 024360
Research Areas:
Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC50 of 71.8 nM . Epacadostat can effectively reduce Trp metabolism, entailing increased activation and maturation of dendritic cells, and enhanced proliferation of effector T cells and natural killer cells (NKs), as well as attenuated Tregs expansion.
14
14 Cited Publications
OTS964 hydrochloride is an orally active, high affinity and selective TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor with an IC50 of 28 nM . OTS964 hydrochloride is also a potent inhibitor of the cyclin-dependent kinase CDK11, which binds to CDK11B with a Kd of 40 nM .
7
Target:
Research Areas:
3
3
3 Cited Publications
Cat. No.: HY-P7032
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL12A; Cytotoxic Lymphocyte Maturation Factor 1, P35; Prev. NKSF1; NK Cell Stimulatory Factor Chain 1; IL-12A; Interleukin-12 Alpha Chain; Interleukin-12 Subunit Alpha; Interleukin 12, P35; CLMF; IL-12, Subunit P35; NFSK; IL35 Subunit; P35; CLMF P35; Interleukin 12A (Natural killer Cell Stimulatory Factor 1, Cytotoxic Lymphocyte Maturation Factor 1, P35); Natural killer Cell Stimulatory Factor 1, 35 KD Subunit; Cytotoxic Lymphocyte Maturation Factor 35 KDa Subunit; IL-12 Subunit P35; Interleukin 12A; NF Cell Stimulatory Factor Chain 1; IL12B; Interleukin-12 Subunit Beta; Prev. NKSF2; Interleukin 12, P40; IL-12B; IL12, Subunit P40; CLMF2; IL-12 Subunit P40; NKSF; CLMF P40; CLMF; Cytotoxic Lymphocyte Maturation Factor 2, P40; Interleukin 12B (Natural killer Cell Stimulatory Factor 2, Cytotoxic Lymphocyte Maturation Factor 2, P40); Natural killer Cell Stimulatory Factor-2; Natural killer Cell Stimulatory Factor, 40 KD Subunit; Truncated Interleukin 12B; Cytotoxic Lymphocyte Maturation Factor 40 KDa Subunit; IMD29; NK Cell Stimulatory Factor Chain 2; IMD28; Interleukin 12B; Interleukin-12 Beta Chain
Species:
Human
Source:
HEK293
3
3 Cited Publications
Cat. No.: HY-P71231
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PRDX1; TDPX2; Prev. PAGA; PAG; Thioredoxin-Dependent Peroxide Reductase 2; Epididymis Secretory Sperm Binding Protein; Thioredoxin-Dependent Peroxiredoxin 1; Thioredoxin-Dependent Peroxiredoxin; Thioredoxin Peroxidase 2; Natural killer-Enhancing Factor A
Species:
Human
Source:
E. coli
1
Target:
Research Areas:
Urelumab, a fully human, non-ligand binding, CD137 agonist IgG4 monoclonal antibody, enhances T-cell and natural killer-cell antitumor activity, and may enhance cytotoxic activity of Rituximab (HY-P9913). Urelumab can be used for the research of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and other types of non-Hodgkin lymphoma (NHL) .
1
1 Cited Publications
Cat. No.: HY-164426
CAS No.: 2377167-56-9
Target:
Research Areas:
HEI3090 is a P2X7R activator. HEI3090 stimulates dendritic cells expressing P2X7R to produce IL-18, which subsequently promotes Natural Killer cells and CD4 T cells within tumors to produce IFN-γ, leading to a sustained antitumor response. HEI3090 can be used to enhance the efficacy of αPD-1 therapy in non-small cell lung cancer (NSCLC) .
1
1 Cited Publications
Cat. No.: HY-P700797
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KLRC2; NK Cell Receptor C; killer Cell Lectin Like Receptor C2; NKG2-C; NKG2-C Type II Integral Membrane Protein; CD159c; NKG2C; killer Cell Lectin-Like Receptor Subfamily C, Member 2; CD159 Antigen-Like Family Member C; Natural killer Cell Receptor G2-C
Species:
Human
Source:
HEK293
1
1
1 Cited Publications
Cat. No.: HY-P77806
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: KLRC1; NKG2-A/B-Activating NK Receptor; Prev. NKG2; NKG2-B; NKG2-A; NKG2A; CD159a; NKG2-A/B Type II Integral Membrane Protein; killer Cell Lectin-Like Receptor Subfamily C, Member 1; Natural killer Group Protein 2; NKG2-A/NKG2-B Type II Integral Membrane
Species:
Human
Source:
HEK293
1
1 Cited Publications
Synonyms: Cycloartenol ferulate; Cycloartenol ferulic acid ester
1
1 Cited Publications
Cat. No.: HY-P72503
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KLRK1; CD314; Prev. D12S2489E; killer Cell Lectin-Like Receptor Subfamily K, Member 1; NKG2D; NKG2-D-Activating NK Receptor; NKG2-D Type II Integral Membrane Protein; DNA Segment On Chromosome 12 (Unique) 2489 Expressed Sequence; NK Cell Receptor D; Kille
Species:
Mouse
Source:
HEK293
Synonyms: (E)-Urocanic acid; trans-UCA
Category:
Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-P9965
CAS No.: 915296-00-3
Synonyms: HuLuc 63; PDL 063; BMS 901608
Target:
Research Areas:
Cat. No.: HY-Y0493
CAS No.: 28230-32-2
Synonyms: HOOBt
HODHBt (HOOBt) inhibits STAT5-SUMO interaction by blocking SUMOylation of phosphorylated STAT5. HODHBt enhances the magnitude of IL-15 signaling and significantly increases the natural killer (NK) cell cytotoxicity phenotype and function and the generation of cytokine-induced memory-like (CIML) natural killer (NK) cells. HODHBt can be used for research of HIV-infection and cancer .
Cat. No.: HY-172240
CAS No.: 1418305-55-1
Synonyms: TU2218 free base
Research Areas:
Tosposertib (TU2218 free base) is an ALK5/VEGFR2 dual inhibitor (IC50 = 1.2 nM/4.9 nM). Tosposertib directly restores the activity of damaged cytotoxic T lymphocytes (CTLs) and natural killer cells inhibited by TGFβ and suppresses the activity and viability of regulatory T cells. Tosposertib can be used for the study of melanoma and colon cancer .
Synonyms: IY-81149
Target:
Research Areas:
Ilaprazole (IY-81149) is an orally active proton pump inhibitor. Ilaprazole irreversibly inhibits H +/K +-ATPase in a dose-dependent manner with an IC50 of pump inhibitory activity of 6 μM in rabbit parietal cell preparation. Ilaprazole is used for the research of gastric ulcers. Ilaprazole is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor .
Cat. No.: HY-P990053
CAS No.: 2645437-82-5
Synonyms: GSK-6097608
Target:
Research Areas:
Cat. No.: HY-B2145
CAS No.: 172152-50-0
Synonyms: IY-81149 sodium
Target:
Research Areas:
Ilaprazole (IY-81149) sodium is an orally active proton pump inhibitor. Ilaprazole sodium irreversibly inhibits H +/K +-ATPase in a dose-dependent manner with an IC50 of 6 μM in rabbit parietal cell preparation. Ilaprazole sodium is used for the research of gastric ulcers. Ilaprazole sodium is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
