175 Results for "

lipid tissue

" in MedChemExpress (MCE) Product Catalog:
Products (175)

175 Results for "lipid tissue" in MCE Product Catalog:

20
20 Publications Verification
Cat. No.: HY-13738A
CAS No.: 82640-04-8
Purity:  99.78%
Synonyms: Keoxifene hydrochloride; LY156758; LY139481 hydrochloride
Raloxifene hydrochloride (Keoxifene hydrochloride) is a second generation selective and orally active estrogen receptor modulator. Raloxifene hydrochloride produces estrogen-agonistic effects on bone and lipid metabolism and estrogen-antagonistic effects on uterine endometrium and breast tissue .
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13
13 Cited Publications
Cat. No.: HY-B0331
CAS No.: 75847-73-3
Synonyms: MK-421
Enalapril (MK-421) is an orally active angiotensin-converting enzyme inhibitor. Enalapril blocks the conversion of angiotensin I to angiotensin II, regulates the renin-angiotensin system, reduces preload and afterload, and decreases plasma angiotensin II levels. Enalapril inhibits apoptosis, reduces nitric oxide metabolite levels, stabilizes endothelial cells, enhances endothelial antioxidant defense, scavenges reactive oxygen species (ROS), and alleviates neuronal damage. Enalapril attenuates glutathione depletion, protein/lipid oxidation, tissue damage, and type III collagen immunolabeling in organs of diabetic rats. Enalapril reduces systolic blood pressure and urinary albumin excretion, and delays the progression of diabetic cardiac/renal injury. Enalapril is used in research related to asymptomatic left ventricular dysfunction, congestive heart failure, Alzheimer's disease, diabetes mellitus, acute myocardial infarction, atrial fibrillation, hypertension, cerebral ischemia, chronic heart failure, and single-ventricle physiology .
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13
13 Cited Publications
Cat. No.: HY-B0331A
CAS No.: 76095-16-4
Synonyms: MK-421 maleate
Enalapril maleate (MK-421 maleate) is an orally active angiotensin-converting enzyme inhibitor. Enalapril maleate blocks the conversion of angiotensin I to angiotensin II, regulates the renin-angiotensin system, reduces preload and afterload, and decreases plasma angiotensin II levels. Enalapril maleate inhibits apoptosis, reduces nitric oxide metabolite levels, stabilizes endothelial cells, enhances endothelial antioxidant defense, scavenges reactive oxygen species (ROS), and alleviates neuronal damage. Enalapril maleate attenuates glutathione depletion, protein/lipid oxidation, tissue damage, and type III collagen immunolabeling in organs of diabetic rats. Enalapril maleate reduces systolic blood pressure and urinary albumin excretion, and delays the progression of diabetic cardiac/renal injury. Enalapril maleate is used in research related to asymptomatic left ventricular dysfunction, congestive heart failure, Alzheimer's disease, diabetes mellitus, acute myocardial infarction, atrial fibrillation, hypertension, cerebral ischemia, chronic heart failure, and single-ventricle physiology .
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12
12 Cited Publications
Cat. No.: HY-D1168
CAS No.: 1320-06-5
Oil Red O is a fat-soluble diazol dye, with a maximum absorption at 518 nm. Oil Red O stains neutral lipids and cholesteryl esters but not biological membranes. Oil Red O can be used for detecting and quantifying hepatic steatosis in mouse liver biopsies. Oil Red O staining efficiently helps to visualize the radical changes that occur in tissues as metabolic disease occurs and progresses .
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10
10 Cited Publications
Cat. No.: HY-K0319

MCE Lipid Peroxidation (MDA) Assay Kit is suitable for measuring MDA levels in a variety of samples including plasma, serum, urine, tissues or cell lysates.

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2
2 Cited Publications
Cat. No.: HY-46760
CAS No.: 1799316-64-5
Target:  

Liposome

Research Areas:  

Others

LP01 (Example 13) is a cationic lipid used in the delivery of biologically active agents to cells and tissues .
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2
2 Cited Publications
Cat. No.: HY-N2118
CAS No.: 521-32-4
Bilobetin, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity .
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2
2 Cited Publications
Cat. No.: HY-101017
CAS No.: 6865-14-1
Purity:  ≥98.0%
Palmitoylcarnitine chloride is a C16:0 long-chain acylcarnitine and an intermediate product of fatty acid oxidation. The level of Palmitoylcarnitine chloride in human prostate cancer tissues is higher than that in non-cancerous tissues. Palmitoylcarnitine chloride can be used in studies related to lipid metabolism associated with prostate cancer .
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2
2 Cited Publications
Cat. No.: HY-126357
CAS No.: 1935-18-8
Category:  

Lipids

Target:  

Endogenous Metabolite

Palmitoylcarnitine is a C16:0 long-chain acylcarnitine and an intermediate product of fatty acid oxidation. The level of Palmitoylcarnitine in human prostate cancer tissues is higher than that in non-cancerous tissues. Palmitoylcarnitine can be used in studies related to lipid metabolism associated with prostate cancer .
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1
1 Cited Publications
Cat. No.: HY-B0415
CAS No.: 67-73-2
Fluocinolone is a glucocorticoid glucocorticoid receptor agonist. Fluocinolone is effective in preventing both lipid accumulation and inflammation. Fluocinolone can promote the proliferation of DPCs and has the potential role in repairing injured pulp tissues. Fluocinolone can be used to study the prevention of chemotherapy-induced peripheral neuropathy caused by Paclitaxel (HY-B0015) .
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1
1 Cited Publications
Cat. No.: HY-N7127
CAS No.: 14755-02-3
Synonyms: trans-3-Hydroxycinnamic acid
(E)-m-Coumaric acid (trans-3-Hydroxycinnamic acid) is a natural phenolic cinnamic acid derivative with antioxidant activity, and it is found in the young shoots of Limonium densiflorum. (E)-m-Coumaric acid upregulates the levels of SOD and GSH and reduces MDA levels, thereby alleviating oxidative stress and lipid peroxidation in liver tissue. (E)-m-Coumaric acid can be used in studies related to oxidative stress-mediated liver injury .
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1
1 Cited Publications
Cat. No.: HY-156010
CAS No.: 2682078-97-1
Purity:  99.57%
Target:  

PPAR

Research Areas:  

Metabolic Disease

PPARγ-IN-2 (Compound 5a) is a PPARγ inhibitor. PPARγ-IN-2 inhibits TG accumulation in 3T3-L1 preadipocytes (EC50: 0.106 μM). PPARγ-IN-2 inhibits high-cholesterol diet (HFC)-induced obesity and related metabolic syndrome, and reduces lipid accumulation in adipose tissue .
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1
1 Cited Publications
Cat. No.: HY-N1964
CAS No.: 77-06-5
Synonyms: Gibberellin A3
Gibberellic acid (GA3) is a natural plant growth regulator with oral bioactivity. Gibberellic acid governs multiple plant developmental events, including seed germination, cell elongation, floral organ formation, and rice spikelet fertility. Gibberellic acid optimizes root morphology and secondary metabolite production in Echinacea purpurea hairy roots, and serves as a bioactive seed priming agent to improve chilling stress tolerance in chickpea. Gibberellic acid mediates modulation of enzyme activity and secondary metabolism in plants and exerts tissue-specific regulatory effects on antioxidant systems and lipid peroxidation in rats. Gibberellic acid can be used in studies of plant growth, metabolism, and abiotic stress responses .
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1
1 Cited Publications
Cat. No.: HY-143712
CAS No.: 2276-94-0
Purity:  98.70%
Allolithocholic acid is an orally active metabolite of Lithocholic acid (HY-B0172). Allolithocholic acid is a dual GPBAR1 agonist (EC50 = 2.7 μM) and RORγt inverse agonist (IC50 = 3.4 μM). Allolithocholic acid modulates immune and metabolic pathways, regulates immune cell polarization, prevents M1 macrophage and Th17 CD4 cell polarization. Allolithocholic acid improves insulin sensitivity, reduces liver lipid accumulation, reverses liver immunological, inflammatory and metabolic signaling dysregulation, restores bile acid homeostasis, adipose tissue histopathology/function, and intestinal microbiota composition, modulates intestinal immunity. Allolithocholic acid can be used for the researches of cancer, inflammayion, immunology and metabolic disease .
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1
1 Cited Publications
Cat. No.: HY-N4280
CAS No.: 2445-80-9
7,8-Dimethoxycoumarin is a coumarin compound derived from Artemisia caruifolia with oral activity. 7,8-Dimethoxycoumarin inhibits mitochondrial permeability transition pore and H +/K +-ATPase, and exhibits antioxidant, anti-inflammatory, renoprotective, neuroprotective and gastroprotective effects. 7,8-Dimethoxycoumarin reduces lipid peroxidation (TBARS), increases GSH levels, inhibits myeloperoxidase (MPO) activity, and regulates the expression of inflammatory factors by inhibiting the NF‑κB and MAPK pathways. 7,8-Dimethoxycoumarin ameliorates gastric mucosal injury, alleviates renal tissue lesions and relieves neuropathic pain. 7,8-Dimethoxycoumarin can be used in studies related to acute renal failure, trigeminal neuralgia and gastritis .
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1
1 Cited Publications
Cat. No.: HY-N0468
CAS No.: 63279-13-0
Rebaudioside D is an orally active sweetener that targets and activates FXR, modulates Acetyl-CoA Carboxylase, and inhibits 3-hydroxy-3-methylglutaryl-CoA reductase. Rebaudioside D regulates bile acid homeostasis and lipid metabolism, reduces the synthesis rates of fatty acids and cholesterol, and exerts multiple effects including anti-adipogenesis, hepatoprotection, anti-steatosis, gut microbiota modulation, enhancement of secondary bile acid metabolism, anti-endotoxin activity, regulation of bile acid transport, and inhibition of bile acid efflux. Rebaudioside D also reduces body weight gain, visceral fat accumulation, hepatic triglyceride and cholesterol accumulation, hepatic lipid peroxidation, and decreases the circulating level of lipopolysaccharide-binding protein. Rebaudioside D additionally enhances the secondary bile acid metabolic pathway of intestinal bacteria, upregulates the gene expression of ileal organic solute transporter α, and downregulates the gene expression of hepatic bile salt export pump. Rebaudioside D does not affect glucose homeostasis, alter total caloric intake or fecal energy excretion, induce weight gain, exacerbate obesity, promote hepatic steatosis, impair brown adipose tissue function, nor change skeletal muscle metabolism-related proteins. Rebaudioside D can be used in diet-induced obesity and obesity-related research .
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Cat. No.: HY-W006405
CAS No.: 574-12-9
Isoflavone is an orally available bioactive component of soy phytoestrogen with lipid-lowering and antioxidant activities. Isoflavone prevents a variety of chronic diseases by regulating fatty acid oxidation in the liver and gene expression in adipose tissue. In addition, isoflavone has important value in the research of cancer and cardiovascular diseases .
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Cat. No.: HY-D0286
CAS No.: 81-37-8
Synonyms: 2,8-Dimethylnaphtho[3,2,1-kl]xanthene
Fluorol Yellow 088 is a fluorescent dye that can be used as a biological material or an organic compound for life science research. Fluorol Yellow 088 is suitable for lipid staining in plant tissues, particularly for the fluorescence imaging of suberized cell walls and hydrophobic structures, with an excitation wavelength of 365 nm and an emission wavelength of ≥420 nm .
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Cat. No.: HY-B1189
CAS No.: 503-49-1
Synonyms: Dicrotalic acid; 3-Hydroxy-3-methylglutaric acid
Meglutol is a lipid-lowering agent. Meglutol can reduces cholesterol, triglycerides, serum β-lipoprotein, and phospholipids, and inhibits the activity of HMG-CoA reductase (a rate-limiting enzyme in cholesterol biosynthesis). Meglutol can induce significant lipid oxidative damage in brain tissue. It is promising for research in the field of cardiovascular diseases and metabolic diseases .
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Cat. No.: HY-P2752
CAS No.: 9004-02-8
Synonyms: LPL
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease Cancer

Lipoprotein lipase, Pseudomonas sp (LPL) is a multifunctional enzyme from adipose tissue, heart and skeletal muscle, islets and macrophages. Lipoprotein lipase promotes normal lipoprotein metabolism, delivery and utilization of tissue-specific substrates. Lipoprotein lipase catalyzes the rate-limiting step of lipids in blood circulation .
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