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noradrenaline uptake

" in MedChemExpress (MCE) Product Catalog:

38

Inhibitors & Agonists

4

Natural
Products

6

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14560C
    Reboxetine mesylate
    2 Publications Verification

    FCE20124 mesylate; PNU155950E mesylate

    		 Adrenergic Receptor Neurological Disease
    Reboxetine mesylate (FCE20124 mesylate) is a potent, selective, and specific noradrenaline reuptake inhibitor (NARI) for the research of depression. Reboxetine mesylate inhibits the uptake of norepinephrine, with a Ki of 8 nM .
    Reboxetine mesylate
  • HY-B0528A
    Octopamine hydrochloride
    5 Publications Verification

    (±)-p-Octopamine hydrochloride

    		 Adrenergic Receptor Endogenous Metabolite Neurological Disease Endocrinology
    Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .
    Octopamine hydrochloride
  • HY-B1396
    Nefazodone hydrochloride
    4 Publications Verification

    BMY-13754; MJ-13754-1

    		 5-HT Receptor Adrenergic Receptor Neurological Disease Endocrinology
    Nefazodone hydrochloride (BMY-13754) is a potent and selective 5HT2A (Ki=5.8 nM) antagonist with moderate inhibition of 5-HT and noradrenaline uptake (IC50 of 290 and 300 nM, respectively). Nefazodone hydrochloride is a phenylpiperazine antidepressant with less alpha-adrenergic blocking activity .
    Nefazodone hydrochloride
  • HY-12390
    Lofepramine

    Lopramine

    		 5-HT Receptor Adrenergic Receptor Neurological Disease
    Lofepramine (Lopramine) is a modified tricyclic and orally active antidepressant. Lofepramine inhibits the uptake of Noradrenaline (NA) (HY-13715) and 5-hydroxytryptamine (5-HT) with IC50s of 2.7 μM and 11 μM, respectively. Lofepramine exerts its antidepressant activity by promoting noradrenergic neurotransmission. Lofepramine also enhances serotonergic neurotransmission by inhibiting neuronal uptake of 5-HT and tryptophan pyrrolase. Lofepramine exhibits significant anxiolytic properties. .
    Lofepramine
  • HY-B1704
    Nisoxetine
    1 Publications Verification

    		 Monoamine Transporter Sodium Channel Neurological Disease
    Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. Nisoxetine is an antidepressant and local anesthetic, it can block voltage-gated sodium channels .
    Nisoxetine
  • HY-B1233
    Octodrine

    2-Amino-6-methylheptane; 1,5-Dimethylhexylamine; 6-Methyl-2-heptylamine

    		 Dopamine Receptor Others
    Octodrine (2-Amino-6-methylheptane) is a central nervous stimulant that increases the uptake of dopamine and noradrenaline. Octodrine is found to increase the pain threshold, cardiac rate (positive chronotropic effect) and myocardial contractility (positive inotropic effect) .
    Octodrine
  • HY-B1704A
    Nisoxetine hydrochloride
    1 Publications Verification

    		 Monoamine Transporter Sodium Channel Neurological Disease
    Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. Nisoxetine hydrochloride is an antidepressant and local anesthetic, it can block voltage-gated sodium channels .
    Nisoxetine hydrochloride
  • HY-U00050
    (E)-10-Hydroxynortriptyline

    E-10-OH-NT

    		 Drug Metabolite Adrenergic Receptor mAChR Neurological Disease
    (E)-10-Hydroxynortriptyline (E-10-OH-NT) is a blood-brain barrier-permeable norepinephrine uptake inhibitor. (E)-10-Hydroxynortriptyline effectively promotes central norepinephrine neuronal transmission, with little interindividual variation in in vivo potency. (E)-10-Hydroxynortriptyline has low affinity for muscarinic receptors, exhibits only extremely weak anticholinergic activity, and does not inhibit salivary secretion. (E)-10-Hydroxynortriptyline can be used in studies related to depression .
    (E)-10-Hydroxynortriptyline
  • HY-32126
    1-Fluoronaphthalene

    		Drug Intermediate Others
    1-Fluoronaphthalene is an organofluorine compound derived from naphthalene derivatives and fluorinated aromatics. 1-Fluoronaphthalene can be used to synthesize LY248686, a potent inhibitor of serotonin and noradrenaline uptake .
    1-Fluoronaphthalene
  • HY-12394
    Dothiepin

    Dosulepin; Dothep

    		 Histamine Receptor 5-HT Receptor Neurological Disease
    Dothiepin (Dosulepin; Dothep) is an antidepressant agent with sedative/anxiolytic activity. Dothiepin is an inhibitor preferring of noradrenaline uptake than serotonin uptake. Dothiepin facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. Dothiepin is also an antagonist of histamine H1-receptor without cardiotoxicity. Dothiepin exhibits significant analgesic activity in psychogenic facial pain，idiopathic fibromyalgia syndrome or rheumatoid arthritis .
    Dothiepin
  • HY-B0528AR
    Octopamine hydrochloride (Standard)

    (±)-p-Octopamine hydrochloride (Standard)

    		 Reference Standards Adrenergic Receptor Endogenous Metabolite Neurological Disease Endocrinology
    Octopamine (hydrochloride) (Standard) is the analytical standard of Octopamine (hydrochloride). This product is intended for research and analytical applications. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .
    Octopamine hydrochloride (Standard)
  • HY-B1233A
    Octodrine hydrochloride

    2-Amino-6-methylheptane hydrochloride; 1,5-Dimethylhexylamine hydrochloride; 6-Methyl-2-heptylamine hydrochloride

    		 Dopamine Receptor Neurological Disease
    Octodrine (2-Amino-6-methylheptane) is a central nervous activator that increases the uptake of dopamine and noradrenaline. Octodrine is found to increase the pain threshold, cardiac rate (positive chronotropic effect) and myocardial contractility (positive inotropic effect) .
    Octodrine hydrochloride
  • HY-B0528
    Octopamine

    		Adrenergic Receptor Endogenous Metabolite Neurological Disease Endocrinology
    Octopamine is a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .
    Octopamine
  • HY-18610A
    Diclofensine

    Ro 8-4650

    		 Dopamine Transporter Adrenergic Receptor 5-HT Receptor Neurological Disease
    Diclofensine (Ro 8-46500) is an orally active neuronal monoamine uptake inhibitor. Diclofensine blocks the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3 and 3.7 nM, respectively. Diclofensine potentiates norepinephrine-induced hypertension and attenuates Tyramine (HY-W007606)-induced hypertension. Diclofensine produces psychostimulant and mood-elevating effects without causing sudden disappearance or withdrawal reactions. Diclofensine can be used in the research of moderate to severe depression .
    Diclofensine
  • HY-14560
    Reboxetine

    		Adrenergic Receptor Neurological Disease
    Reboxetine is an orally active, potent and selective noradrenaline uptake blocker. Reboxetine can be used for antidepressant research .
    Reboxetine
  • HY-W284026
    PIM-35

    		Drug Derivative 5-HT Receptor Dopamine Receptor Adrenergic Receptor Neurological Disease
    PIM-35 is a derivative of Indole (HY-W001132). PIM-35 significantly inhibits serotonin (5HT) and dopamine (DA) uptake with a weak inhibitory effect on noradrenaline (NA) uptake.PIM-35 has antidepressant activity and can be used for depression research .
    PIM-35
  • HY-12390A
    Lofepramine hydrochloride

    Lopramine hydrochloride

    		 5-HT Receptor Adrenergic Receptor Neurological Disease
    Lofepramine (Lopramine) is a modified tricyclic and orally active antidepressant. Lofepramine inhibits the uptake of Noradrenaline (NA) (HY-13715) and 5-hydroxytryptamine (5-HT) with IC50s of 2.7 μM and 11 μM, respectively. Lofepramine exerts its antidepressant activity by promoting noradrenergic neurotransmission. Lofepramine also enhances serotonergic neurotransmission by inhibiting neuronal uptake of 5-HT and tryptophan pyrrolase. Lofepramine exhibits significant anxiolytic properties. .
    Lofepramine hydrochloride
  • HY-18610
    Diclofensine hydrochloride

    Ro 8-4650 hydrochloride

    		 Dopamine Transporter Adrenergic Receptor 5-HT Receptor Neurological Disease
    Diclofensine (Ro 8-46500) hydrochloride is an orally active neuronal monoamine uptake inhibitor. Diclofensine hydrochloride blocks the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3 and 3.7 nM, respectively. Diclofensine hydrochloride potentiates norepinephrine-induced hypertension and attenuates Tyramine (HY-W007606)-induced hypertension. Diclofensine hydrochloride produces psychostimulant and mood-elevating effects without causing sudden disappearance or withdrawal reactions. Diclofensine hydrochloride can be used in the research of moderate to severe depression .
    Diclofensine hydrochloride
  • HY-32126R
    1-Fluoronaphthalene (Standard)

    		Adrenergic Receptor Serotonin Transporter Reference Standards Others
    1-Fluoronaphthalene (Standard) is the analytical standard of 1-Fluoronaphthalene. This product is intended for research and analytical applications. 1-Fluoronaphthalene is an organofluorine compound derived from naphthalene derivatives and fluorinated aromatics. 1-Fluoronaphthalene can be used to synthesize LY248686, a potent inhibitor of serotonin and noradrenaline uptake .
    1-Fluoronaphthalene (Standard)
  • HY-105521A
    Dexnafenodone hydrochloride

    (S)-Nafenodone; LU-43706

    		 Adrenergic Receptor Neurological Disease
    Dexnafenodone hydrochloride ((S)-Nafenodone) as an antidepressant compound, is a potent and selective inhibitor of the synaptosomal uptake of noradrenaline, but has a less potent effect on serotonin uptake and a negligible effect on dopamine uptake.
    Dexnafenodone hydrochloride
  • HY-122300A
    Oxaprotiline

    (Rac)-Levoprotiline

    		 Adrenergic Receptor Neurological Disease
    Oxaprotiline ((Rac)-Levoprotiline) is a potent Norepinephrine (NE)/Noradrenaline (NA) uptake inhibitor. Oxaprotiline has antidepressant activity .
    Oxaprotiline
  • HY-A0171
    Benzoctamine

    Ba-30803 free base

    		 5-HT Receptor Neurological Disease
    Benzoctamine is an orally active and potent psychoactive agent which possesses tranquillizing properties. Benzoctamine increases the turnover rate of catecholamines. Benzoctamine enhances the [3H]noradrenaline uptake in the rat heart. Benzoctamine also accelerated the disappearance of intracisternally injected [3H]noradrenaline .
    Benzoctamine
  • HY-14560S
    Reboxetine-d5 mesylate

    		Isotope-Labeled Compounds Others
    Reboxetine-d5 mesylate is the deuterium labeled Reboxetine mesylatea (HY-14560). Reboxetine is an orally active, potent and selective noradrenaline uptake blocker. Reboxetine can be used for antidepressant research .
    Reboxetine-d5 mesylate
  • HY-14560CR
    Reboxetine mesylate (Standard)

    FCE20124 mesylate (Standard); PNU155950E mesylate (Standard)

    		 Reference Standards Adrenergic Receptor Neurological Disease
    Reboxetine (mesylate) (Standard) is the analytical standard of Reboxetine (mesylate). This product is intended for research and analytical applications. Reboxetine mesylate (FCE20124 mesylate) is a potent, selective, and specific noradrenaline reuptake inhibitor (NARI) for the research of depression. Reboxetine mesylate inhibits the uptake of norepinephrine, with a Ki of 8 nM .
    Reboxetine mesylate (Standard)
  • HY-B1704R
    Nisoxetine (Standard)

    		Monoamine Transporter Sodium Channel Neurological Disease
    Nisoxetine (Standard) is the analytical standard of Nisoxetine. This product is intended for research and analytical applications. Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. Nisoxetine is an antidepressant and local anesthetic, it can block voltage-gated sodium channels .
    Nisoxetine (Standard)
  • HY-165378
    (E)-Dothiepin hydrochloride

    (E)-Dosulepin hydrochloride; (E)-Dothep hydrochloride

    		 Histamine Receptor Neurological Disease
    (E)-Dothiepin ((E)-Dosulepin;(E)-Dothep) hydrochloride is an antidepressant agent with sedative/anxiolytic activity. (E)-Dothiepin hydrochloride is an inhibitor preferring of noradrenaline uptake than serotonin uptake. (E)-Dothiepin hydrochloride facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. (E)-Dothiepin hydrochloride is also an antagonist of histamine H1-receptor without cardiotoxicity. (E)-Dothiepin hydrochloride exhibits significant analgesic activity in psychogenic facial pain，idiopathic fibromyalgia syndrome or rheumatoid arthritis .
    (E)-Dothiepin hydrochloride
  • HY-100651R
    Desmethylnortriptyline (Standard)

    		Reference Standards Drug Metabolite Neurological Disease
    Desmethylnortriptyline (Standard) is the analytical standard of Desmethylnortriptyline (HY-100651). This product is intended for research and analytical applications. Desmethylnortriptyline is a metabolite of Amitriptyline (HY-B0527) and Nortriptyline (HY-118620). Desmethylnortriptylineinhibits serotonin and noradrenaline uptake, antagonizes acetylcholine-induced contraction. Desmethylnortriptyline can be used for the research of depression .
    Desmethylnortriptyline (Standard)
  • HY-B1396S
    Nefazodone-d6 hydrochloride

    BMY-13754-d6; MJ-13754-1-d6

    		 Isotope-Labeled Compounds 5-HT Receptor Adrenergic Receptor Neurological Disease Endocrinology
    Nefazodone-d6 (hydrochloride) is the deuterium labeled Nefazodone hydrochloride. Nefazodone hydrochloride (BMY-13754) is a potent and selective 5HT2A (Ki=5.8 nM) antagonist with moderate inhibition of 5-HT and noradrenaline uptake (IC50 of 290 and 300 nM, respectively). Nefazodone hydrochloride is a phenylpiperazine antidepressant with less alpha-adrenergic blocking activity .
    Nefazodone-d6 hydrochloride
  • HY-B1396S1
    Nefazodone-d6 dihydrochloride

    BMY-13754-d6 dihydrochloride; MJ-13754-1-d6 dihydrochloride

    		 Isotope-Labeled Compounds 5-HT Receptor Adrenergic Receptor Neurological Disease Endocrinology
    Nefazodone-d6 (dihydrochloride) is deuterium labeled Nefazodone (hydrochloride). Nefazodone hydrochloride (BMY-13754) is a potent and selective 5HT2A (Ki=5.8 nM) antagonist with moderate inhibition of 5-HT and noradrenaline uptake (IC50 of 290 and 300 nM, respectively). Nefazodone hydrochloride is a phenylpiperazine antidepressant with less alpha-adrenergic blocking activity .
    Nefazodone-d6 dihydrochloride
  • HY-105973
    Clemeprol

    BRL 14342

    		 Serotonin Transporter Neurological Disease
    Clemeprol (BRL 14342) is an orally active Noradrenaline (NA) and 5-HT uptake blocker. Clemeprol inhibits 6- Hydroxydopamine (HY-B1081)-induced depletion of brain NA. Clemeprol exerts a dose-dependent inhibition of Reserpine (HY-N0480)-induced hypothermia. Clemeprol can be used in the research of depression .
    Clemeprol
  • HY-B1396R
    Nefazodone hydrochloride (Standard)

    BMY-13754 (Standard); MJ-13754-1 (Standard)

    		 Reference Standards 5-HT Receptor Adrenergic Receptor Neurological Disease Endocrinology
    Nefazodone (hydrochloride) (Standard) is the analytical standard of Nefazodone (hydrochloride). This product is intended for research and analytical applications. Nefazodone hydrochloride (BMY-13754) is a potent and selective 5HT2A (Ki=5.8 nM) antagonist with moderate inhibition of 5-HT and noradrenaline uptake (IC50 of 290 and 300 nM, respectively). Nefazodone hydrochloride is a phenylpiperazine antidepressant with less alpha-adrenergic blocking activity .
    Nefazodone hydrochloride (Standard)
  • HY-106617
    Etoperidone

    		5-HT Receptor Adrenergic Receptor Neurological Disease
    Etoperidone, an antidepressant agent, is an orally active serotonin and nor-adrenaline re-uptake antagonist. Etoperidone shows Kd values of 36 nM, 38 nM, 85 nM, and 570 nM for 5-HT2 receptor, α1-adrenergic receptor, 5-HT1A receptor, and α2-adrenergic receptor, respectively .
    Etoperidone
  • HY-106617A
    Etoperidone hydrochloride

    		5-HT Receptor Adrenergic Receptor Neurological Disease
    Etoperidone hydrochloride, an antidepressant agent, is an orally active serotonin and nor-adrenaline re-uptake antagonist. Etoperidone hydrochloride shows Kd values of 36 nM, 38 nM, 85 nM, and 570 nM for 5-HT2 receptor, α1-adrenergic receptor, 5-HT1A receptor, and α2-adrenergic receptor, respectively .
    Etoperidone hydrochloride
  • HY-B1396S3
    Nefazodone-d4 hydrochloride

    BMY-13754-d; MJ-13754-1-d

    		 Isotope-Labeled Compounds Adrenergic Receptor 5-HT Receptor Neurological Disease Endocrinology
    Nefazodone-d4 (hydrochloride) (BMY-13754-d4) is deuterium labeled Nefazodone (hydrochloride). Nefazodone hydrochloride (BMY-13754) is a potent and selective 5HT2A (Ki=5.8 nM) antagonist with moderate inhibition of 5-HT and noradrenaline uptake (IC50 of 290 and 300 nM, respectively). Nefazodone hydrochloride is a phenylpiperazine antidepressant with less alpha-adrenergic blocking activity .
    Nefazodone-d4 hydrochloride
  • HY-18610R
    Diclofensine hydrochloride (Standard)

    Ro 8-4650 hydrochloride (Standard)

    		 Reference Standards Dopamine Transporter Adrenergic Receptor 5-HT Receptor Neurological Disease
    Diclofensine (Ro 8-4650) hydrochloride (Standard) is the analytical standard of Diclofensine hydrochloride. This product is intended for research and analytical applications. Diclofensine hydrochloride is an orally active neuronal monoamine uptake inhibitor. Diclofensine hydrochloride blocks the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3 and 3.7 nM, respectively. Diclofensine hydrochloride potentiates norepinephrine-induced hypertension and attenuates Tyramine (HY-W007606)-induced hypertension. Diclofensine hydrochloride produces psychostimulant and mood-elevating effects without causing sudden disappearance or withdrawal reactions. Diclofensine hydrochloride can be used in the research of moderate to severe depression.
    Diclofensine hydrochloride (Standard)
  • HY-12390R
    Lofepramine (Standard)

    Lopramine (Standard)

    		 5-HT Receptor Adrenergic Receptor Reference Standards Neurological Disease
    Lofepramine (Standard) is the analytical standard of Lofepramine. This product is intended for research and analytical applications. Lofepramine (Lopramine) is a modified tricyclic and orally active antidepressant. Lofepramine inhibits the uptake of Noradrenaline (NA) (HY-13715) and 5-hydroxytryptamine (5-HT) with IC50s of 2.7 μM and 11 μM, respectively. Lofepramine exerts its antidepressant activity by promoting noradrenergic neurotransmission. Lofepramine also enhances serotonergic neurotransmission by inhibiting neuronal uptake of 5-HT and tryptophan pyrrolase. Lofepramine exhibits significant anxiolytic properties. .
    Lofepramine (Standard)
  • HY-B0528AS
    Octopamine-d4 hydrochloride

    (±)-p-Octopamine-d4 hydrochloride

    		 Adrenergic Receptor Endogenous Metabolite Neurological Disease Endocrinology
    Octopamine-d4 (hydrochloride) is the deuterium labeled Octopamine hydrochloride. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .
    Octopamine-d4 hydrochloride
  • HY-18610S
    Diclofensine-d3 hydrochloride

    		Isotope-Labeled Compounds Dopamine Transporter Adrenergic Receptor 5-HT Receptor Neurological Disease
    Diclofensine-d3 (Ro-8-4650-d3) hydrochloride is the deuterium labeled Diclofensine hydrochloride. Diclofensine hydrochloride is an orally active neuronal monoamine uptake inhibitor. Diclofensine hydrochloride blocks the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3 and 3.7 nM, respectively. Diclofensine hydrochloride potentiates norepinephrine-induced hypertension and attenuates Tyramine (HY-W007606)-induced hypertension. Diclofensine hydrochloride produces psychostimulant and mood-elevating effects without causing sudden disappearance or withdrawal reactions. Diclofensine hydrochloride can be used in the research of moderate to severe depression.
    Diclofensine-d3 hydrochloride

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