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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
p73
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "p73" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-19726
CAS No.: 803647-40-7
NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway . NSC59984 acts by targeting GOF-mutant p53 and stimulates p73 to restore the p53 pathway signaling .
Research Areas:
RETRA is a RIPK1/RIPK3/MLKL and p73 activator. RETRA mediates plasma membrane disruption, induces ROS accumulation, triggers early mitochondrial hyperpolarization, and synergistically drives necroptosis. RETRA inhibits cancer cells carrying mutant p53 via a p73-dependent salvage pathway. RETRA can be used in research related to cervical cancer and cancers with mutant p53 .
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NSC194598 is a p53 DNA-binding inhibitor with an IC50 value of 180 nM. NSC194598 inhibits p53 DNA binding and induction of target genesn when p53 is stabilized and activated by irradiation or chemotherapy. NSC194598 can interfere with transcriptional activation of mutated rearranged during transfection (RET) gene, induce apoptosis and G0/G1 phase arrest. NSC194598 can be used for the researches of acute radiation toxicity and medullary thyroid carcinoma .
Cat. No.: HY-113843
CAS No.: 1035875-01-4
RETRA (hydrobromide) is a mutant p53-dependent activator of p73 that can inhibit cancer cells carrying mutant p53. RETRA (hydrobromide) increases the expression level of p73, induces transcriptional activation of several common to transcriptional targets p53 and p73, which leads to mutant p53- and p73-dependent inhibition of tumor growth, reduction of colony formation and induction of effector caspases .
Cat. No.: HY-P702989
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: p73
Species:
Source:
Cat. No.: HY-P702990
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: p73
Species:
Source:
Cat. No.: HY-P702991
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: p73; p73 alpha Protein; Tp73
Species:
Source:
Cat. No.: HY-P81495A
Synonyms: Tp73; p73; Tumor protein p73; p53-like transcription factor; p53-related protein
Cat. No.: HY-115797
CAS No.: 2180931-49-9
LQFM030 is a novel small molecule MDM2 inhibitor. LQFM030 exhibits concentration dependent cytotoxicity in K562 cells (IC50 = 0.28 mM). LQFM030 induces cell apoptosis through G0/G1 phase cell cycle arrest and increased Caspase activity. LQFM030 downregulates the mRNA expression of MDM2, MDMX, p73, MYC, and NF-κB. LQFM030 is commonly used in research on cancers such as leukemia .
Cat. No.: HY-RS14924
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Research Areas:
TP73 Human Pre-designed siRNA Set A contains three designed siRNAs for TP73 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS26467
Target:
Research Areas:
Tp73 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tp73 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS00924
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Research Areas:
ARHGAP24 Human Pre-designed siRNA Set A contains three designed siRNAs for ARHGAP24 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P86227
Synonyms: KET, P63, p73H, p73L, Tp73L, TP63, Tumor protein 63, p63, Chronic ulcerative stomatitis protein, Keratinocyte transcription factor KET, Transformation-related protein 63, Tumor protein p73-like, p40, p51, CUSP, p73L
Cat. No.: HY-P73734
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Tumor protein 63; p63; CUSP; TP63; p73L
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
