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protein expression

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2

GMP Molecules

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0830
    Palmitic acid
    Maximum Cited Publications
    100 Publications Verification

    		 Environmental Pollutants Endogenous Metabolite HSP Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
    Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid is used to establish a cell steatosis model .
    Palmitic acid
  • HY-15921
    IPTG
    30+ Cited Publications

    Isopropyl β-D-thiogalactoside

    		 Biochemical Assay Reagents Others
    IPTG is a molecular mimic of allolactose, a lactose metabolite that triggers transcription of the lac operon, and it is therefore used to induce protein expression where the gene is under the control of the lac operator.
    IPTG
  • HY-13992
    AP20187
    45+ Cited Publications

    B/B Homodimerizer

    		 FKBP Metabolic Disease
    AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.
    AP20187
  • HY-A0122
    Plicamycin
    50+ Cited Publications

    Mithramycin A

    		 DNA/RNA Synthesis Bacterial Antibiotic Glutathione S-transferase Infection Cancer
    Plicamycin (Mithramycin A) is a selective specificity protein 1 (Sp1) inhibitor. Plicamycin inhibits the growth of various cancers by decreasing Sp1 protein. Plicamycin inhibits GSTM2 promoter activity and protein expression .
    Plicamycin
  • HY-N0830B
    Palmitic acid sodium
    Maximum Cited Publications
    100 Publications Verification

    		 Environmental Pollutants Endogenous Metabolite HSP Cancer
    Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid sodium is used to establish a cell steatosis model .
    Palmitic acid sodium
  • HY-P3160
    Fibronectin
    5+ Cited Publications

    		 Integrin Cardiovascular Disease Inflammation/Immunology
    Fibronectin, a glycoprotein present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans .
    This product is a human Fibronectin obtained by recombinant expression in a rice expression system.
    Fibronectin
  • HY-112210
    Shield-1
    5+ Cited Publications

    Shld1

    		 FKBP Others
    Shield-1 (Shld1) is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD) .
    Shield-1
  • HY-B2230
    Hinokitiol
    5+ Cited Publications

    β-Thujaplicin

    		 Keap1-Nrf2 DNA Methyltransferase Virus Protease Infection Cancer
    Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.
    Hinokitiol
  • HY-N0830S6
    Palmitic acid-13C16
    3 Publications Verification

    		 HSP Endogenous Metabolite Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
    Palmitic acid- 13C16 is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .
    Palmitic acid-13C16
  • HY-13671
    LW6
    55+ Cited Publications

    HIF-1α inhibitor; LW8

    		 HIF/HIF Prolyl-Hydroxylase Apoptosis Cancer
    LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor with an IC50 value of 4.4 μM, and it is also an inhibitor of MDH2. LW6 decreases HIF-1α protein expression without affecting HIF-1β expression.
    LW6
  • HY-111431
    p-Cresyl sulfate
    5+ Cited Publications

    p-Tolyl sulfate

    		 JNK p38 MAPK Reactive Oxygen Species (ROS) Metabolic Disease
    p-Cresyl sulfate (p-Tolyl sulfate) is a uremic toxin, that can cause renal damage and dysfunction. p-Cresyl sulfate shows antiproliferation activity. p-Cresyl sulfate increases the protein expression of HIF-1α and VHL, decreases the protein expression of HIF-2α. p-Cresyl sulfate induces epithelial-mesenchymal transition (EMT). p-Cresyl sulfate activates the JNK and p38 MAPK signaling pathways .
    p-Cresyl sulfate
  • HY-B0084
    Dienogest
    2 Publications Verification

    STS 557

    		 Progesterone Receptor Endocrinology
    Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE2 synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .
    Dienogest
  • HY-112582
    N1-Methylpseudouridine
    1 Publications Verification

    1-Methylpseudouridine; N1-methyl-pseudouridine

    		 Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Inflammation/Immunology
    N1-methyl-pseudouridine (1-Methylpseudouridine), a methylpseudouridine, outperforms 5 mC and 5 mC/N1-methyl-pseudouridine in translation. N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density .
    N1-Methylpseudouridine
  • HY-N0830S2
    Palmitic acid-d31

    		HSP Endogenous Metabolite Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
    Palmitic acid-d31 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .
    Palmitic acid-d31
  • HY-N0830S9
    Palmitic acid-13C

    		Isotope-Labeled Compounds HSP Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
    Palmitic acid- 13C is the 13C-labeled Palmitic acid (HY-N0830). Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .
    Palmitic acid-13C
  • HY-N0774
    Isofraxidin
    4 Publications Verification

    		 ERK COX MMP Toll-like Receptor (TLR) Inflammation/Immunology
    Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells . Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation .
    Isofraxidin
  • HY-121750
    CCG-222740
    1 Publications Verification

    		 Ras ROCK Cancer
    CCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor . CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis .
    CCG-222740
  • HY-N1967
    Dihydrocurcumin

    		PNPLA3 Metabolic Disease
    Dihydrocurcumin, a major metabolites of curcumin, reduces lipid accumulation and oxidative stress. Dihydrocurcumin regulates mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increases protein expression levels of pAKT and PI3K, and reduced the levels of cellular NO and ROS via Nrf2 signaling pathways .
    Dihydrocurcumin
  • HY-N0830S5
    Palmitic acid-d3

    		HSP Endogenous Metabolite Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
    Palmitic acid-d3 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .
    Palmitic acid-d3
  • HY-P1068A
    Recombinant human lysozyme (plant expression)

    		Bacterial Infection
    Recombinant human lysozyme (plant expression) is a conserved anti-bacterial protein that causes bacterial lysis and death by hydrolyzing bacterial cell wall peptidoglycan (PG). Recombinant human lysozyme (plant expression) can be used to study bacterial infections .
    Recombinant human lysozyme (plant expression)
  • HY-P11146
    SppIP

    Sakacin P inducer peptide

    		 Bacterial Infection
    SppIP (Sakacin P inducer peptide) is a peptide consisting of 19 amino acids . SppIP is an essential inducer for sakacin P production . SppIP can induce the expression of PRRSV GP5 and SARS-CoV-2 spike protein in recombinant Lactobacillus plantarum. SppIP can activate the transcription of the sakacin P promoter to drive the expression of downstream heterologous capsid proteins, increasing the proportion of PCV2d capsid proteins displayed on the cell surface of Lactobacillus plantarum. SppIP can be used in studies related to sakacin P induction .
    SppIP
  • HY-18623
    VI 16832

    		Syk Src Cancer
    VI 16832 is a broad spectrum Type I kinase inhibitor which can be used as an enrichment tool for the comparative expression analysis of protein kinases in different cancer cell lines.
    VI 16832
  • HY-N0830R
    Palmitic acid (Standard)
    95+ Cited Publications

    		 Reference Standards HSP Endogenous Metabolite Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
    Palmitic acid (Standard) is the analytical standard of Palmitic acid. This product is intended for research and analytical applications. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .
    Palmitic acid (Standard)
  • HY-D1474
    WNT7A-IN-1 sodium

    		Wnt Cancer
    WNT7A-IN-1 sodium (1365-0109), a WNT7A inhibitor, disrupts the protein-protein interaction between WNT7A and its receptor FZD5, resulting in the upregulation of MHC-I expression. WNT7A-IN-1 sodium significantly increases the expression of MHC-I and p-p65,while concurrently reducing the expression of active β-catenin . WNT7A-IN-1 sodium (compound F) is also a photographic sensitizer in the green spectral region .
    WNT7A-IN-1 sodium
  • HY-P3412
    MMI-0100

    		MAPKAPK2 (MK2) Inflammation/Immunology
    MMI-0100 is a cell-permeant peptide inhibitor of mitogen activated protein kinase activated protein kinase II (MK2). MMI-0100 reduces intimal hyperplasia ex vivo and in vivo. MMI-0100 suppresses IL-6 expression without effect on IL-8 expression. MMI-0100 suppresses fibrotic processes such as vein graft disease .
    MMI-0100
  • HY-107599
    AEG3482

    		JNK Apoptosis Neurological Disease
    AEG3482 is a potent antiapoptotic compound that inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25 .
    AEG3482
  • HY-11095
    NPS 2390

    		mGluR CaSR PI3K Akt mTOR Autophagy Apoptosis Bcl-2 Family Caspase Cardiovascular Disease Neurological Disease
    NPS 2390 is an allosteric antagonist of calcium-sensing receptor (CaSR) and mGluR1/5. NPS 2390 inhibits the PI3K/Akt/mTOR signaling pathway, reduces hypoxia-induced intracellular calcium elevation, decreases the expression of autophagy (autophagy) proteins, regulates the expression of phenotypic marker proteins, and inhibits the proliferation of pulmonary artery smooth muscle cells. NPS 2390 attenuates the endogenous apoptosis (apoptosis) pathway, increases the expression level of Bcl-2, downregulates the expression levels of Bax, cytochrome c and caspase-3, alleviates cerebral edema and improves neurological function in rat models. NPS 2390 can be used in studies related to hypoxic pulmonary hypertension, traumatic brain injury, stroke and pain .
    NPS 2390
  • HY-124344
    Avenanthramide C

    		Interleukin Related Neurological Disease
    Avenanthramide C is an orally active avenanthramide that can be isolated from oat seeds. Avenanthramide C decreases the protein expression of cleaved caspase-3 and increases the expression of p-GSK3β(Ser9) and IL-10 levels. Avenanthramide C has the potential for the research of Alzheimer’s disease .
    Avenanthramide C
  • HY-163794
    DC371739

    		ANGPTL PCSK9 Metabolic Disease
    DC371739 is a potent and orally activity PCSK9 inhibitor. DC371739 decreases the mRNA expression of PCSK9 and ANGPTL3. DC371739 decreases the protein expression of PCSK9 and increases the protein expression of LDLR. DC371739 has the potential for the research of hyperlipidemia .
    DC371739
  • HY-115930
    Bim-IN-1

    		Bcl-2 Family Cardiovascular Disease
    Bim-IN-1 is a potent Bim expression inhibitor. Bim-IN-1 reduces Bim expression levels and has little inhibitory effect upon protein kinase A activity and minimal toxicity .
    Bim-IN-1
  • HY-170411
    WNT7A-IN-1

    		Wnt Cancer
    WNT7A-IN-1 (1365-0109), a WNT7A inhibitor, disrupts the protein-protein interaction between WNT7A and its receptor FZD5, resulting in the upregulation of MHC-I expression. WNT7A-IN-1 significantly increases the expression of MHC-I and p-p65,while concurrently reducing the expression of active β-catenin. WNT7A-IN-1 (compound F) is also a photographic sensitizer in the green spectral region .
    WNT7A-IN-1
  • HY-N0830S18
    Palmitic acid-d1

    		Isotope-Labeled Compounds HSP Endogenous Metabolite Metabolic Disease
    Palmitic acid-d is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .
    Palmitic acid-d1
  • HY-N0830BS1
    Palmitic acid-13C16 sodium
    3 Publications Verification

    		 Isotope-Labeled Compounds HSP Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
    Palmitic acid- 13C16 sodium is the 13C-labeled Palmitic acid sodium. Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .
    Palmitic acid-13C16 sodium
  • HY-N0830S4
    Palmitic acid-d2

    		HSP Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
    Palmitic acid-d2 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .
    Palmitic acid-d2
  • HY-N0830S7
    Palmitic acid-d4

    		HSP Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
    Palmitic acid-d4 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .
    Palmitic acid-d4
  • HY-N0830S3
    Palmitic acid-1-13C
    1 Publications Verification

    		 HSP Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
    Palmitic acid-1- 13C is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .
    Palmitic acid-1-13C
  • HY-147889
    BBR-BODIPY

    		Apoptosis Caspase Bcl-2 Family Others
    BBR-BODIPY is a fluorescent probe that allows screening its interaction with the targeted cells. BBR-BODIPY induces apoptosis and changes the expression of apoptosis-related proteins .
    BBR-BODIPY
  • HY-128912
    Arborinine

    		Histone Demethylase Cancer
    Arborinine is a potent and orally activeLSD1 inhibitor. Arborinine increases the expression of H3K4me1/2, H3K9me1/2, E-cad protein and decreases the expression of UBE2O protein level. Arborinine induces cell cycle arrest at S phase. Arborinine shows antitumor activity .
    Arborinine
  • HY-N0830S10
    Palmitic acid-13C2

    		Isotope-Labeled Compounds HSP Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
    Palmitic acid- 13C2 is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .
    Palmitic acid-13C2
  • HY-173463
    Sirtuin modulator 8

    		Sirtuin Metabolic Disease Inflammation/Immunology
    Sirtuin modulator 8 is a sirtuin modulator that can activate Sirtuin activity. Sirtuin modulator 8 significantly downregulates the expression of monocyte chemoattractant protein-1 (MCP-1) and upregulates the expression of fibroblast growth factor 21 (FGF21). Sirtuin modulator 8 regulates the expression of inflammation- and metabolism-related genes, showing potential for studying metabolic diseases (such as diabetes, obesity) and inflammatory diseases .
    Sirtuin modulator 8
  • HY-P991664
    AG01

    		Src Akt ERK TAM Receptor c-Met/HGFR MMP HIF/HIF Prolyl-Hydroxylase VEGFR Cancer
    AG01 is a monoclonal antibody against progranulin (GP88). AG01 inhibits triple-negative breast cancer (TNBC) cell proliferation and migration, reduces the expression of phosphorylated protein kinases p-Src, p-AKT, and p-ERK, and reduces the expression of oncogenic proteins such as Axl, c-MET, HIF-1α, and VEGF. AG01 inhibits tumor growth and Ki67 expression in a TNBC xenograft mouse model. AG01 can be used in the research of TNBC and other cancers .
    AG01
  • HY-151884
    FUBP1-IN-2

    		c-Myc Cancer
    FUBP1-IN-2 (compound 9) is a potent FUBP1 (far upstream binding protein 1) inhibitor. FUBP1-IN-2 inhibits the KH4 FUBP1-FUSE interaction in a gel shift assay. FUBP1-IN-2 binds to FUBP1 in a ChIP assay. FUBP1-IN-2 reduces both c-Myc mRNA and protein expression, increases p21 mRNA and protein expression, and depletes intracellular polyamines .
    FUBP1-IN-2
  • HY-N8261
    Amicoumacin B

    		Bacterial TGF-beta/Smad Infection
    Amicoumacin B can be produced by actinomycete, strain 04-5195 T.. Amicoumacin B increases the expression of bone morphogenetic protein 2 (BMP-2). Amicoumacin B has inhibitory effect against C. violaceum (MIC = 250 µg/mL). Amicoumacin B has quorum sensing inhibitory activity, and reduces the expression of the C. violaceum operons vioA, vioB, vioD, and vioE, but increases the expression of vioC .
    Amicoumacin B
  • HY-N0830S12
    Palmitic acid-d4-1

    		HSP Endogenous Metabolite Cancer
    Palmitic acid-d4-1 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .
    Palmitic acid-d4-1
  • HY-N5118
    Chimonanthine

    (-)-Chimonanthine

    		 Tyrosinase Cancer
    Chimonanthine is an alkaloid of Chimonanthus praecox, inhibits tyrosinase and tyrosine-related protein-1 mRNA expression, amd inhibits melanogenesis .
    Chimonanthine
  • HY-N0830S19
    Palmitic acid-d2-5

    		Isotope-Labeled Compounds HSP Endogenous Metabolite Metabolic Disease
    Palmitic acid-d2-5 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .
    Palmitic acid-d2-5
  • HY-174795
    mCherry mRNA

    		mRNA Others
    mCherry mRNA encodes the mCherry fluorescent protein, which is derived from Anaplasma marginale. mCherry can be used as a fluorescent tracer in transfection and transgenic experiments or as a reporter of gene expression.
    mCherry mRNA
  • HY-100987
    Lauroylcarnitine chloride

    		Biochemical Assay Reagents Others
    Lauroylcarnitine chloride enhances the absorption of salmon calcitonin in rats. Also in determining in situ bioavailability, increased availability of Lucifer yellow and decreased expression of claudin-4 protein in the colon .
    Lauroylcarnitine chloride
  • HY-163527
    FGFR-IN-13

    		FGFR Cancer
    FGFR-IN-13 (compound III-30) is an irreversible covalent fibroblast growth factor receptor (FGFR) inhibitor. FGFR-IN-13 regulates endogenous FGFR1(IC50=0.20±0.02 nM) and FGFR4(IC50=0.40±0.03 nM) mediated signaling pathways by inhibiting the expression of key proteins. FGFR-IN-13 inhibits total-PARP and Bcl-2 protein expressions, and promote Cleaved-PARP and Bax protein expressions in a dose-dependent manner. FGFR-IN-13 has significant antitumor activity and oral activity .
    FGFR-IN-13
  • HY-177971
    Braxlosiran

    		Antibody-Oligonucleotide Conjugates (AOCs) Neurological Disease
    Braxlosiran, one of the components of the AOC Delpacibart braxlosiran (HY-177566), is composed of a siRNA targeting DUX4 (dual homologous box protein) and SMCC linker (HY-42360). Abnormal expression of the DUX4 protein leads to changes in gene expression in muscle cells, and these changes are associated with the loss of muscle function in facioscapulohumeral muscular dystrophy (FSHD) .
    Braxlosiran

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