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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
64 Results for "
rA1
" in MedChemExpress (MCE) Product Catalog:
Products (64)
64 Results for "rA1" in MCE Product Catalog:
2
2 Cited Publications
Synonyms: SA96; Thiobutarit
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Bucillamine (SA96) is an orally active and potent sulfhydryl donor and antioxidant. Bucillamine is also an antirheumatic agent with antiangiogenic properties. Bucillamine can protect against Ischemia/reperfusion (I/R) injury in high-risk organ transplants. Bucillamine inhibits the production of VEGF. Bucillamine can be used for the research of choroidal neovascularization (CNV) and rheumatoid arthritis (RA) .
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1 Cited Publications
Cat. No.: HY-P2171A
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1
1 Cited Publications
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GDC-0834 is an orally active selective, potent, and reversible BTK inhibitor with an IC50 of 5.9 nM. GDC-0834 demonstrates pBTK-Tyr223 inhibition in mice and rats. GDC-0834 can be used for research of rheumatoid arthritis (RA) .
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Cat. No.: HY-N2506
CAS No.: 83459-41-0
Category:
Cardiovascular Disease Panax ginseng C. A. Meyer Triterpenes Terpenoids Plants Disease Research Fields Araliaceae
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Cat. No.: HY-175701
CAS No.: 2810808-95-6
Synonyms: RO7795081; RG6652
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CT-996 is an orally active GLP-1RA agonist with an EC50 of 0.49 nM. CT-996 reduces the recruitment of β-arrestin and the internalization of GLP-1R. CT-996 suppresses postprandial blood glucose in mice expressing human GLP-1 receptors and enhances glucose-stimulated insulin secretion (GSIS) in obese monkeys during intravenous glucose challenge. CT-996 can be used for the research of type 2 diabetes (T2D) and obesity [1] .
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A2B receptor antagonist 2 (compound 18) is an adenosine receptor A2B antagonist, with Ki values of 2.30 μM, 6.8 μM and 3.44 μM for rA1, rA2A and hA2B, respectively [1].
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MRS1334 is a potent and selective human adenosine A3 receptor antagonist with Kis of 2.69 nM, >100 nM, >100 nM for hA3, rA1, rA2A, respectively. MRS1334 blocks the protective effect of Cl-IB-MECA leading to significant bradycardia and elevated ST segment [1] . MRS1334 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-P99642
CAS No.: 1648796-29-5
Synonyms: MOrAb-022
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Cat. No.: HY-P990016
CAS No.: 2639874-57-8
Synonyms: ARGX-112; LEO-138559; LP-0145
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Cat. No.: HY-P99870
CAS No.: 2445460-16-0
Synonyms: ASLAN004; CSL-334; MK-6105
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Cat. No.: HY-P99287
CAS No.: 468715-71-1
Synonyms: B-E8; Anti-IL-6 MAB B-E8
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Cat. No.: HY-P991513
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Cat. No.: HY-164416
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DBCO-Dextran sulfate (MW 40000) can be used to construct DS-EXOs in cells via click chemistry, that can be used for the research of rheumatoid arthritis (RA) .
Cat. No.: HY-P2171
CAS No.: 277748-59-1
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Cat. No.: HY-P99790
CAS No.: 147191-91-1
Synonyms: CEN 000029; cM-T412
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Cat. No.: HY-15427A
CAS No.: 1133432-46-8
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GDC-0834 Racemate is the racemic form of GDC-0834 (HY-15427). GDC-0834 is an orally active selective, potent, and reversible BTK inhibitor with an IC50 of 5.9 nM. GDC-0834 demonstrates pBTK-Tyr223 inhibition in mice and rats. GDC-0834 can be used for research of rheumatoid arthritis (RA) .
Cat. No.: HY-RS06737
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IL22RA1 Human Pre-designed siRNA Set A contains three designed siRNAs for IL22RA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-103177
CAS No.: 591771-91-4
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PSB-10 hydrochloride is a potent and selective antagonist of human adenosine A3 receptor (A3AR), with a Ki of 0.44 nM. PSB-10 hydrochloride shows more than 800-fold selectivity for hA3 over rA1, rA2A, hA1, hA2A and hA2B receptors (Ki=805, 6040, 1700, 2700, 30000 nM, respectively). PSB-10 hydrochloride produces thermal hyperalgesia in mice [1] .
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PF-4693627 is a potent, selective and orally bioavailable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor (IC50=3 nM) for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
