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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
90 Results for "
ribonucleoprotein
" in MedChemExpress (MCE) Product Catalog:
Products (90)
90 Results for "ribonucleoprotein" in MCE Product Catalog:
37
37 Publications Verification
Target:
SC75741 is a broad and efficient NF-κB inhibitor with an IC50 of 200 nM for p65 . SC75741 blocks influenza viruses (IV) replication. SC75741 impairs DNA binding of the NF-κB subunit p65, resulting in reduced expression of cytokines, chemokines, and pro-apoptotic factors. SC75741 subsequently inhibits caspase activation and blocks caspase-mediated nuclear export of viral ribonucleoproteins .
3
3 Cited Publications
Cat. No.: HY-P71791
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TRIM21; RING Finger Protein 81; Tripartite Motif Containing 21; 52 KDa Ro Protein; SSA1; Ro/SSA 52kDa; RNF81; Ro(SS-A); SS-A; RO52; E3 Ubiquitin-Protein Ligase TRIM21; RING-Type E3 Ubiquitin Transferase TRIM21; Sjogren Syndrome Antigen A1 (52kDa, ribonucleoprotein Autoantigen SS-A/Ro); Tripartite Motif-Containing 21; 52 KDa ribonucleoprotein Autoantigen Ro/SS-A; Tripartite Motif-Containing Protein 21; Sjoegren Syndrome Type A Antigen; Sicca Syndrome Antigen A; Ro/SSA; SSA
Species:
Human
Source:
P. pastoris
1
1
1 Cited Publications
Cat. No.: HY-N6025
CAS No.: 112747-98-5
Category:
Lignans Isatis tinctoria L. Cruciferae Extract Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology
Target:
1
1 Cited Publications
Cat. No.: HY-P72229
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HNRNPA1; Heterogeneous Nuclear ribonucleoprotein A1B Protein; Prev. HNRPA1; Nuclear ribonucleoprotein Particle A1 Protein; HnRNP-A1; Single-Strand DNA-Binding Protein UP1; ALS20; HnRNP Core Protein A1-Like 3; Epididymis Secretory Sperm Binding Protein; Hn
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P74649
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PCBP1; Nucleic Acid-Binding Protein SUB2.3; Poly(RC) Binding Protein 1; Epididymis Secretory Protein Li 85; Heterogeneous Nuclear ribonucleoprotein E1; Alpha-CP1; Poly(RC)-Binding Protein 1; HEL-S-85; HnRNP-E1; Heterogenous Nuclear ribonucleoprotein E1; H
Species:
Human
Source:
E. coli
Cat. No.: HY-16466
CAS No.: 391611-36-2
Spliceostatin A, the FR901464 (HY-16212) methylated derivative, is a potent anti-tumor agent. Spliceostatin A inhibits splicing and promotes pre-mRNA accumulation by binding SF3B1. SF3B1 is a subcomplex of U2 small nuclear ribonucleoprotein in the spliceosome. Spliceostatin A induces Apoptosis in chronic lymphocytic leukemia (CLL) cells .
Cat. No.: HY-P5307
Synonyms: INF7-A5K-TAT
Target:
Research Areas:
Cat. No.: HY-175469
CAS No.: 2894060-67-2
Target:
Research Areas:
VNT-101 is an orally active influenza A (IAV) inhibitor. VNT-101 disrupts NP-NP PPI to block NP oligomerization and destabilize the viral ribonucleoprotein (RNP) complex, with potent antiviral activity across multiple influenza A subtypes. VNT-101 exhibits EC50 values of 4-5 nM in cellular cytopathic effect (CPE) assay, 4-8 nM in neuraminidase (NA) assay, and 21-45 nM in RNP assay. VNT-101 demonstrates robust in vivo antiviral efficacy in mice infected with lethal H1N1 virus. VNT-101 can be used for the study of influenza A infection .
hnRNPK-IN-1 is a heterogeneous nuclear ribonucleoprotein K (hnRNPK) binding ligand with Kd values of 4.6 μM and 2.6 μM measured with SPR and MST, respectively. hnRNPK-IN-1 inhibits c-myc transcription by disrupting the binding of hnRNPK and c-myc promoter. hnRNPK-IN-1 induces Hela cells apoptosis and has strongly anti-tumor activities .
Cat. No.: HY-105037A
Purity: 98.89%
Synonyms: IPP-201101 TFA; Rigerimod TFA; Peptide P140 TFA
Target:
Research Areas:
Forigerimod TFA (IPP-201101 TFA) is a CD4 T-cell modulator. Forigerimod TFA is a 21-amino-acid fragment of U1 small nuclear ribonucleoprotein 70 kDa that is phosphorylated at Ser140. Forigerimod TFA can potently inhibit autophagy. Forigerimod can be used for the research of autoimmune disorders, such as systemic lupus erythematosus (SLE) .
IRES-C11 is a spectfic c-MYC internal ribosome entry site (IRES) translation inhibitor. IRES-C11 blocks the interaction of a requisite c-MYC IRES trans-acting factor, heterogeneous nuclear ribonucleoprotein A1, with its IRES. IRES-C11 does not inhibits BAG-1, XIAP and p53 IRESes .
Cat. No.: HY-133924
CAS No.: 1200128-66-0
Synonyms: RQN-18690A
Target:
Research Areas:
18-Deoxyherboxidiene (RQN-18690A) is a potent angiogenesis inhibitor. 18-Deoxyherboxidiene targets SF3b, a spliceosome component that is a subcomplex of the U2 small nuclear ribonucleoprotein (snRNP) in the spliceosome. 18-Deoxyherboxidiene inhibits the migration and tube formation of human umbilical vein endothelial cells (HUVECs) without significant cell toxicity. 18-Deoxyherboxidiene has the potential for cancer research .
Cat. No.: HY-105037
CAS No.: 497156-60-2
Synonyms: IPP-201101; Rigerimod; Peptide P140
Target:
Research Areas:
Forigerimod (IPP-201101) is a CD4 T-cell modulator. Forigerimod is a 21-amino-acid fragment of U1 small nuclear ribonucleoprotein 70 kDa that is phosphorylated at Ser140. Forigerimod can potently inhibit autophagy. Forigerimod can be used for the research of autoimmune disorders, such as systemic lupus erythematosus (SLE) .
Cat. No.: HY-P10680
Cat. No.: HY-120907
CAS No.: 1197054-49-1
Sudemycin E is an analog of FR901464 (HY-16212). Sudemycin E can induce reversible changes in alternative splicing and abnormalities in chromatin modifications by binding to SF3B1, a component of the U2 small nuclear ribonucleoprotein (snRNP), thereby leading to the death of cancer cells. Sudemycin E has anti-tumor activity and can be used in tumor research .
Cat. No.: HY-P11000
Research Areas:
INF7TAT is an amphipathic cell-penetrating peptide that mediates intracellular delivery of CRISPR ribonucleoproteins. INF7TAT achieves endosomal escape via the INF7 fragment and cell binding via the TAT fragment. It enables intracellular delivery into primary human T cells and hematopoietic stem and progenitor cells, facilitating gene knockout and AAV-mediated homology-directed repair. INF7TAT can be used for genome editing-related research .
Cat. No.: HY-177791
Target:
Research Areas:
vRNPs degrader-1 is a potent PROTAC viral ribonucleoproteins (vRNPs) degrader. vRNPs degrader-1 shows broad-spectrum anti-influenza A viruses (IAV) activity by targeting the conserved 5′ end of viral RNA, thereby inducing proteasomal degradation of viral proteins. vRNPs degrader-1 inhibits H1N1, H9N2, and H3N2 infection in mice. vRNPs degrader-1 can be used for influenza research .
Cat. No.: HY-P5307A
Synonyms: INF7-A5K-TAT acetate
Target:
Research Areas:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
