Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
31 Results for "
sST2
" in MedChemExpress (MCE) Product Catalog:
Products (31)
31 Results for "sST2" in MCE Product Catalog:
6
Target:
Research Areas:
6
6 Publications Verification
Cat. No.: HY-79135
Synonyms: SOM230 ditrifluoroacetate; Pasireotide TFA salt
Target:
Research Areas:
Pasireotide (SOM230) ditrifluoroacetate, a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide ditrifluoroacetate exhibits antisecretory, antiproliferative, and proapoptotic activity [2].
6
Target:
Research Areas:
6
Target:
Research Areas:
3
3 Cited Publications
Cat. No.: HY-P1202
CAS No.: 183658-72-2
Target:
Research Areas:
3
3 Cited Publications
Cat. No.: HY-P1202A
CAS No.: 2828432-46-6
Target:
Research Areas:
2
Target:
Research Areas:
1
1 Cited Publications
Cat. No.: HY-P1206
CAS No.: 174688-78-9
Target:
Research Areas:
CH 275 is a peptidic somatostatin analog that acts as an agonist of SST1 (IC50 = 30.9 nM, Ki = 52 nM). The IC50 values of CH 275 for sst3, sst4, sst2, and sst5 are 345 nM, >1 μM, >10 μM, and >10 μM, respectively. CH 275 binds to SSTR1 via the IAmp9-Asp137 ion pair interaction and the hydrophobic interaction between the isopropyl group of IAmp9 and Leu107, and reduces the extracellular acidification rate. CH 275 induces weak sst1 internalization, exerts immunosuppressive effects on macrophages, and decreases macrophage viability, MCP-1 expression/secretion, and IL-8 secretion, but does not alter proMMP-9 secretion or IL-8 mRNA levels. CH 275 reduces hippocampal β-amyloid levels and alleviates plaque pathology without inducing hippocampal microglial activation. CH 275 is used in research on Alzheimer's disease, Parkinson's disease, and depression [2] .
Target:
Research Areas:
Cat. No.: HY-111615
CAS No.: 848647-56-3
Target:
Research Areas:
Cat. No.: HY-P10239
CAS No.: 302794-43-0
Research Areas:
Cat. No.: HY-155193
Purity: 99.77%
Target:
Research Areas:
XY-52 (Compound 32) is a Stimulation-2 (ST2) inhibitor, with an IC50 value of 5.68 μM in AlphaLISA assay, and 4.59 μM in HEK-Blue assay. XY-52 increases proinflammatory T-cell proliferation. XY-52 reduces the plasma sST2 and IFNγ biomarkers in the graft versus host disease (GVHD) mice model .
Cat. No.: HY-P10758
Target:
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Cat. No.: HY-110161
CAS No.: 1021912-42-4
Target:
Research Areas:
sst2 Receptor agonist-1 is a potent somatostatin receptor subtype 2 (sst2) agonist with a Ki value of 0.025 nM and a cAMP IC50 value of 4.8 nM. sst2 Receptor agonist-1 can inhibit rat growth hormone (GH) secretion and ocular neovascular lesion formation. Antiangiogenic effect .
Cat. No.: HY-P4469
CAS No.: 341519-04-8
Research Areas:
Cat. No.: HY-P2090A
CAS No.: 2478421-60-0
Research Areas:
Cat. No.: HY-P3958
CAS No.: 78981-49-4
Research Areas:
Cat. No.: HY-108501
CAS No.: 208706-12-1
Target:
Research Areas:
(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 is a selective non-peptide human somatostatin receptor subtype 2 (sst2) agonist. (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 can be used in the study of retinal neuromodulation [2].
Cat. No.: HY-P0042
CAS No.: 168016-90-8
Target:
Research Areas:
Cat. No.: HY-P2090
CAS No.: 113294-82-9
Research Areas:
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
